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2.
Crit Care ; 18(1): R8, 2014 Jan 09.
Artículo en Inglés | MEDLINE | ID: mdl-24401636

RESUMEN

INTRODUCTION: Glutamine supplementation is supposed to reduce mortality and nosocomial infections in critically ill patients. However, the recently published reducing deaths due to oxidative stress (REDOX) trials did not provide evidence supporting this. This study investigated the impact of glutamine-supplemented nutrition on the outcomes of critically ill patients using a meta-analysis. METHODS: We searched for and gathered data from the Cochrane Central Register of Controlled Trials, MEDLINE, Elsevier, Web of Science and ClinicalTrials.gov databases reporting the effects of glutamine supplementation on outcomes in critically ill patients. We produced subgroup analyses of the trials according to specific patient populations, modes of nutrition and glutamine dosages. RESULTS: Among 823 related articles, eighteen Randomized Controlled Trials (RCTs) met all inclusion criteria. Mortality events among 3,383 patients were reported in 17 RCTs. Mortality showed no significant difference between glutamine group and control group. In the high dosage subgroup (above 0.5 g/kg/d), the mortality rate in the glutamine group was significantly higher than that of the control group (relative risk (RR) 1.18; 95% confidence interval (CI), 1.02 to 1.38; P = 0.03). In 15 trials, which included a total of 2,862 patients, glutamine supplementation reportedly affected the incidence of nosocomial infections in the critically ill patients observed. The incidence of nosocomial infections in the glutamine group was significantly lower than that of the control group (RR 0.85; 95% CI, 0.74 to 0.97; P = 0.02). In the surgical ICU subgroup, glutamine supplementation statistically reduced the rate of nosocomial infections (RR 0.70; 95% CI, 0.52 to 0.94; P = 0.04). In the parental nutrition subgroup, glutamine supplementation statistically reduced the rate of nosocomial infections (RR 0.83; 95% CI, 0.70 to 0.98; P = 0.03). The length of hospital stay was reported in 14 trials, in which a total of 2,777 patients were enrolled; however, the patient length of stay was not affected by glutamine supplementation. CONCLUSIONS: Glutamine supplementation conferred no overall mortality and length of hospital stay benefit in critically ill patients. However, this therapy reduced nosocomial infections among critically ill patients, which differed according to patient populations, modes of nutrition and glutamine dosages.


Asunto(s)
Enfermedad Crítica/mortalidad , Enfermedad Crítica/terapia , Infección Hospitalaria/tratamiento farmacológico , Infección Hospitalaria/mortalidad , Suplementos Dietéticos , Glutamina/administración & dosificación , Infección Hospitalaria/diagnóstico , Humanos , Tiempo de Internación/tendencias , Mortalidad/tendencias , Ensayos Clínicos Controlados Aleatorios como Asunto/métodos , Resultado del Tratamiento
3.
Zhongguo Zhong Yao Za Zhi ; 27(11): 805-7, 2002 Nov.
Artículo en Chino | MEDLINE | ID: mdl-12776580

RESUMEN

OBJECTIVE: To review the study of estrogen receptor modulator and correlative Chinese herbs. METHOD: Based on to the documents in the world, the estrogen receptor modulator and correlative Chinese herbs summarized. RESULT AND CONCLUSION: Estrogen receptor modulator is biological compounds in botany. It can exert faint estrogen-like effects by low affinity with estrogen receptor. Some of the Chinese herbs have the estrogen-like activity, but further and more systemic research work are to be done.


Asunto(s)
Medicamentos Herbarios Chinos/farmacología , Plantas Medicinales/química , Moduladores Selectivos de los Receptores de Estrógeno/farmacología , Envejecimiento/efectos de los fármacos , Animales , Antineoplásicos Fitogénicos/aislamiento & purificación , Antineoplásicos Fitogénicos/farmacología , Cumarinas/aislamiento & purificación , Cumarinas/farmacología , Medicamentos Herbarios Chinos/aislamiento & purificación , Genisteína/aislamiento & purificación , Genisteína/farmacología , Humanos , Lignanos/aislamiento & purificación , Lignanos/farmacología , Moduladores Selectivos de los Receptores de Estrógeno/aislamiento & purificación
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