Búsqueda | BVS Medicinas Tradicionales, Complementarias, e Integrativas en las Américas

1.

The Homeodomain Transcription Factor NKX2.1 Is Essential for the Early Specification of Melanocortin Neuron Identity and Activates Pomc Expression in the Developing Hypothalamus.

Orquera, Daniela P; Tavella, M Belén; de Souza, Flavio S J; Nasif, Sofía; Low, Malcolm J; Rubinstein, Marcelo.

J Neurosci ; 39(21): 4023-4035, 2019 05 22.

Artículo en Inglés | MEDLINE | ID: mdl-30886014

2.

Islet 1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthood.

Nasif, Sofia; de Souza, Flavio S J; González, Laura E; Yamashita, Miho; Orquera, Daniela P; Low, Malcolm J; Rubinstein, Marcelo.

Proc Natl Acad Sci U S A ; 112(15): E1861-70, 2015 Apr 14.

Artículo en Inglés | MEDLINE | ID: mdl-25825735

3.

Essential function of the transcription factor Rax in the early patterning of the mammalian hypothalamus.

Orquera, Daniela P; Nasif, Sofia; Low, Malcolm J; Rubinstein, Marcelo; de Souza, Flávio S J.

Dev Biol ; 416(1): 212-224, 2016 08 01.

Artículo en Inglés | MEDLINE | ID: mdl-27212025

4.

Temporal changes in nutritional state affect hypothalamic POMC peptide levels independently of leptin in adult male mice.

Mercer, Aaron J; Stuart, Ronald C; Attard, Courtney A; Otero-Corchon, Veronica; Nillni, Eduardo A; Low, Malcolm J.

Am J Physiol Endocrinol Metab ; 306(8): E904-15, 2014 Apr 15.

Artículo en Inglés | MEDLINE | ID: mdl-24518677

5.

Developmental single-cell transcriptomics of hypothalamic POMC neurons reveal the genetic trajectories of multiple neuropeptidergic phenotypes.

Yu, Hui; Rubinstein, Marcelo; Low, Malcolm J.

Elife ; 112022 01 19.

Artículo en Inglés | MEDLINE | ID: mdl-35044906

6.

Adult-born proopiomelanocortin neurons derived from Rax-expressing precursors mitigate the metabolic effects of congenital hypothalamic proopiomelanocortin deficiency.

Wittmann, Gábor; Low, Malcolm J; Lechan, Ronald M.

Mol Metab ; 53: 101312, 2021 11.

Artículo en Inglés | MEDLINE | ID: mdl-34329773

7.

The transcriptional regulator PRDM12 is critical for Pomc expression in the mouse hypothalamus and controlling food intake, adiposity, and body weight.

Hael, Clara E; Rojo, Daniela; Orquera, Daniela P; Low, Malcolm J; Rubinstein, Marcelo.

Mol Metab ; 34: 43-53, 2020 04.

Artículo en Inglés | MEDLINE | ID: mdl-32180559

8.

Decreased sensitivity to the anorectic effects of leptin in mice that lack a Pomc-specific neural enhancer.

Na, Elisa S; Lam, Daniel D; Yokosawa, Eva; Adams, Jessica M; Olson, David P; Low, Malcolm J.

PLoS One ; 15(12): e0244793, 2020.

Artículo en Inglés | MEDLINE | ID: mdl-33382813

9.

Sex differences in the effect of bupropion and naltrexone combination on alcohol drinking in mice.

Zhou, Yan; Leri, Francesco; Low, Malcolm J; Kreek, Mary Jeanne.

Pharmacol Biochem Behav ; 181: 28-36, 2019 06.

Artículo en Inglés | MEDLINE | ID: mdl-30991059

10.

Nuclear transcriptional changes in hypothalamus of Pomc enhancer knockout mice after excessive alcohol drinking.

Zhou, Yan; Liang, Yupu; Low, Malcolm J; Kreek, Mary J.

Genes Brain Behav ; 18(8): e12600, 2019 11.

Artículo en Inglés | MEDLINE | ID: mdl-31339663

11.

Reduced Stability and pH-Dependent Activity of a Common Obesity-Linked PCSK1 Polymorphism, N221D.

Jarvela, Timothy S; Shakya, Manita; Bachor, Tomas; White, Anne; Low, Malcolm J; Lindberg, Iris.

Endocrinology ; 160(11): 2630-2645, 2019 11 01.

Artículo en Inglés | MEDLINE | ID: mdl-31504391

12.

Hypothalamic POMC or MC4R deficiency impairs counterregulatory responses to hypoglycemia in mice.

Tooke, Benjamin P; Yu, Hui; Adams, Jessica M; Jones, Graham L; Sutton-Kennedy, Talisha; Mundada, Lakshmi; Qi, Nathan R; Low, Malcolm J; Chhabra, Kavaljit H.

Mol Metab ; 20: 194-204, 2019 02.

Artículo en Inglés | MEDLINE | ID: mdl-30503832

13.

Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis.

Gong, Lijie; Yao, Fayi; Hockman, Kristin; Heng, Henry H; Morton, Gregory J; Takeda, Kiyoshi; Akira, Shizuo; Low, Malcolm J; Rubinstein, Marcelo; MacKenzie, Robert G.

Endocrinology ; 149(7): 3346-54, 2008 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-18403487

14.

17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior.

Steyn, Frederik J; Ngo, Shyuan T; Chen, Vicky Ping; Bailey-Downs, Lora C; Xie, Teresa Y; Ghadami, Martin; Brimijoin, Stephen; Freeman, Willard M; Rubinstein, Marcelo; Low, Malcolm J; Stout, Michael B.

Aging Cell ; 17(1)2018 02.

Artículo en Inglés | MEDLINE | ID: mdl-29168299

15.

Hypothalamic ER-associated degradation regulates POMC maturation, feeding, and age-associated obesity.

Kim, Geun Hyang; Shi, Guojun; Somlo, Diane Rm; Haataja, Leena; Song, Soobin; Long, Qiaoming; Nillni, Eduardo A; Low, Malcolm J; Arvan, Peter; Myers, Martin G; Qi, Ling.

J Clin Invest ; 128(3): 1125-1140, 2018 03 01.

Artículo en Inglés | MEDLINE | ID: mdl-29457782

16.

The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis.

Cowley, Michael A; Smith, Roy G; Diano, Sabrina; Tschöp, Matthias; Pronchuk, Nina; Grove, Kevin L; Strasburger, Christian J; Bidlingmaier, Martin; Esterman, Michael; Heiman, Mark L; Garcia-Segura, Luis Miguel; Nillni, Eduardo A; Mendez, Pablo; Low, Malcolm J; Sotonyi, Peter; Friedman, Jeffrey M; Liu, Hongyan; Pinto, Shirly; Colmers, William F; Cone, Roger D; Horvath, Tamas L.

Neuron ; 37(4): 649-61, 2003 Feb 20.

Artículo en Inglés | MEDLINE | ID: mdl-12597862

17.

Central dysregulation of the hypothalamic-pituitary-adrenal axis in neuron-specific proopiomelanocortin-deficient mice.

Smart, James L; Tolle, Virginie; Otero-Corchon, Veronica; Low, Malcolm J.

Endocrinology ; 148(2): 647-59, 2007 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-17095588

18.

Reduced renal sympathetic nerve activity contributes to elevated glycosuria and improved glucose tolerance in hypothalamus-specific Pomc knockout mice.

Chhabra, Kavaljit H; Morgan, Donald A; Tooke, Benjamin P; Adams, Jessica M; Rahmouni, Kamal; Low, Malcolm J.

Mol Metab ; 6(10): 1274-1285, 2017 10.

Artículo en Inglés | MEDLINE | ID: mdl-29031726

19.

Differential regulation of synaptic inputs by constitutively released endocannabinoids and exogenous cannabinoids.

Hentges, Shane T; Low, Malcolm J; Williams, John T.

J Neurosci ; 25(42): 9746-51, 2005 Oct 19.

Artículo en Inglés | MEDLINE | ID: mdl-16237178

20.

Lack of prolactin receptor signaling in mice results in lactotroph proliferation and prolactinomas by dopamine-dependent and -independent mechanisms.

Schuff, Kathryn G; Hentges, Shane T; Kelly, Michele A; Binart, Nadine; Kelly, Paul A; Iuvone, P Michael; Asa, Sylvia L; Low, Malcolm J.

J Clin Invest ; 110(7): 973-81, 2002 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-12370275

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