Búsqueda | BVS Medicinas Tradicionales, Complementarias, e Integrativas en las Américas

1.

Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial.

Thomas, Huw D; Calabrese, Christopher R; Batey, Michael A; Canan, Stacie; Hostomsky, Zdenek; Kyle, Suzanne; Maegley, Karen A; Newell, David R; Skalitzky, Donald; Wang, Lan-Zhen; Webber, Stephen E; Curtin, Nicola J.

Mol Cancer Ther ; 6(3): 945-56, 2007 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-17363489

2.

An evaluation of thymidine phosphorylase as a means of preventing thymidine rescue from the thymidylate synthase inhibitor raltitrexed.

Graham-Cole, Claire L; Thomas, Huw D; Taylor, Gordon A; Newell, David R; Melton, Roger G; Hesp, Richard; Boddy, Alan V.

Cancer Chemother Pharmacol ; 59(2): 197-206, 2007 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-16721548

3.

Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation.

Pennati, Marzia; Campbell, Allyson J; Curto, Maria; Binda, Mara; Cheng, Yuzhu; Wang, Lan-Zeng; Curtin, Nicola; Golding, Bernard T; Griffin, Roger J; Hardcastle, Ian R; Henderson, Andrew; Zaffaroni, Nadia; Newell, David R.

Mol Cancer Ther ; 4(9): 1328-37, 2005 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-16170024

4.

TP53 mutant MDM2-amplified cell lines selected for resistance to MDM2-p53 binding antagonists retain sensitivity to ionizing radiation.

Drummond, Catherine J; Esfandiari, Arman; Liu, Junfeng; Lu, Xiaohong; Hutton, Claire; Jackson, Jennifer; Bennaceur, Karim; Xu, Qing; Makimanejavali, Aditya Rao; Del Bello, Fabio; Piergentili, Alessandro; Newell, David R; Hardcastle, Ian R; Griffin, Roger J; Lunec, John.

Oncotarget ; 7(29): 46203-46218, 2016 Jul 19.

Artículo en Inglés | MEDLINE | ID: mdl-27323823

5.

Searching for Dual Inhibitors of the MDM2-p53 and MDMX-p53 Protein-Protein Interaction by a Scaffold-Hopping Approach.

Zaytsev, Andrey; Dodd, Barry; Magnani, Matteo; Ghiron, Chiara; Golding, Bernard T; Griffin, Roger J; Liu, Junfeng; Lu, Xiaohong; Micco, Iolanda; Newell, David R; Padova, Alessandro; Robertson, Graeme; Lunec, John; Hardcastle, Ian R.

Chem Biol Drug Des ; 86(2): 180-9, 2015 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-25388787

6.

Preclinical evaluation of a novel ATM inhibitor, KU59403, in vitro and in vivo in p53 functional and dysfunctional models of human cancer.

Batey, Michael A; Zhao, Yan; Kyle, Suzanne; Richardson, Caroline; Slade, Andrew; Martin, Niall M B; Lau, Alan; Newell, David R; Curtin, Nicola J.

Mol Cancer Ther ; 12(6): 959-67, 2013 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-23512991

7.

Comparative pre-clinical evaluation of receptor tyrosine kinase inhibitors for the treatment of multiple myeloma.

de Brito, Luis R; Batey, Mike A; Zhao, Yan; Squires, Matt S; Maitland, Helen; Leung, Hing Y; Hall, Andrew G; Jackson, Graham; Newell, David R; Irving, Julie A E.

Leuk Res ; 35(9): 1233-40, 2011 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-21316102

8.

Potent, selective inhibitors of fibroblast growth factor receptor define fibroblast growth factor dependence in preclinical cancer models.

Squires, Matthew; Ward, George; Saxty, Gordan; Berdini, Valerio; Cleasby, Anne; King, Peter; Angibaud, Patrick; Perera, Tim; Fazal, Lynsey; Ross, Douglas; Jones, Charlotte Griffiths; Madin, Andrew; Benning, Rajdeep K; Vickerstaffe, Emma; O'Brien, Alistair; Frederickson, Martyn; Reader, Michael; Hamlett, Christopher; Batey, Michael A; Rich, Sharna; Carr, Maria; Miller, Darcey; Feltell, Ruth; Thiru, Abarna; Bethell, Susanne; Devine, Lindsay A; Graham, Brent L; Pike, Andrew; Cosme, Jose; Lewis, Edward J; Freyne, Eddy; Lyons, John; Irving, Julie; Murray, Christopher; Newell, David R; Thompson, Neil T.

Mol Cancer Ther ; 10(9): 1542-52, 2011 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-21764904

9.

Randomized cross-over clinical trial to study potential pharmacokinetic interactions between cisplatin or carboplatin and etoposide.

Thomas, Huw D; Porter, David J; Bartelink, Imke; Nobbs, Joy R; Cole, Michael; Elliott, Suzie; Newell, David R; Calvert, A Hilary; Highley, Martin; Boddy, Alan V.

Br J Clin Pharmacol ; 53(1): 83-91, 2002 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-11849199

BVS Medicinas Tradicionales, Complementarias, e Integrativas en las Américas - MTCI

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