Búsqueda | BVS Medicinas Tradicionales, Complementarias, e Integrativas en las Américas

1.

Imidazo[1,2-a]pyrimidines as functionally selective and orally bioavailable GABA(A)alpha2/alpha3 binding site agonists for the treatment of anxiety disorders.

Goodacre, Simon C; Street, Leslie J; Hallett, David J; Crawforth, James M; Kelly, Sarah; Owens, Andrew P; Blackaby, Wesley P; Lewis, Richard T; Stanley, Joanna; Smith, Alison J; Ferris, Pushpinder; Sohal, Bindi; Cook, Susan M; Pike, Andrew; Brown, Nicola; Wafford, Keith A; Marshall, George; Castro, José L; Atack, John R.

J Med Chem ; 49(1): 35-8, 2006 Jan 12.

Artículo en Inglés | MEDLINE | ID: mdl-16392789

2.

The discovery of potent nonstructural protein 5A (NS5A) inhibitors with a unique resistance profile-Partâ1.

Tran, Thien Duc; Wakenhut, Florian; Pickford, Chris; Shaw, Stephen; Westby, Mike; Smith-Burchnell, Caroline; Watson, Lesa; Paradowski, Michael; Milbank, Jared; Brimage, Rebecca A; Halstead, Rebecca; Glen, Rebecca; Wilson, Craig P; Adam, Fiona; Hay, Duncan; Chiva, Jean-Yves; Nichols, Carly; Blakemore, David C; Gardner, Iain; Dayal, Satish; Pike, Andrew; Webster, Rob; Pryde, David C.

ChemMedChem ; 9(7): 1378-86, 2014 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-24729513

3.

The discovery of potent nonstructural protein 5A (NS5A) inhibitors with a unique resistance profile-Partâ2.

Wakenhut, Florian; Tran, Thien Duc; Pickford, Chris; Shaw, Stephen; Westby, Mike; Smith-Burchnell, Caroline; Watson, Lesa; Paradowski, Michael; Milbank, Jared; Stonehouse, David; Cheung, Kathy; Wybrow, Robert; Daverio, Felice; Crook, Samuel; Statham, Keith; Leese, David; Stead, Darren; Adam, Fiona; Hay, Duncan; Roberts, Lee R; Chiva, Jean-Yves; Nichols, Carly; Blakemore, David C; Goetz, Gilles H; Che, Ye; Gardner, Iain; Dayal, Satish; Pike, Andrew; Webster, Rob; Pryde, David C.

ChemMedChem ; 9(7): 1387-96, 2014 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-24729518

4.

Potent, selective inhibitors of fibroblast growth factor receptor define fibroblast growth factor dependence in preclinical cancer models.

Squires, Matthew; Ward, George; Saxty, Gordan; Berdini, Valerio; Cleasby, Anne; King, Peter; Angibaud, Patrick; Perera, Tim; Fazal, Lynsey; Ross, Douglas; Jones, Charlotte Griffiths; Madin, Andrew; Benning, Rajdeep K; Vickerstaffe, Emma; O'Brien, Alistair; Frederickson, Martyn; Reader, Michael; Hamlett, Christopher; Batey, Michael A; Rich, Sharna; Carr, Maria; Miller, Darcey; Feltell, Ruth; Thiru, Abarna; Bethell, Susanne; Devine, Lindsay A; Graham, Brent L; Pike, Andrew; Cosme, Jose; Lewis, Edward J; Freyne, Eddy; Lyons, John; Irving, Julie; Murray, Christopher; Newell, David R; Thompson, Neil T.

Mol Cancer Ther ; 10(9): 1542-52, 2011 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-21764904

5.

TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates.

Atack, John R; Wafford, Keith A; Tye, Spencer J; Cook, Susan M; Sohal, Bindi; Pike, Andrew; Sur, Cyrille; Melillo, David; Bristow, Linda; Bromidge, Fran; Ragan, Ian; Kerby, Julie; Street, Les; Carling, Robert; Castro, José L; Whiting, Paul; Dawson, Gerard R; McKernan, Ruth M.

J Pharmacol Exp Ther ; 316(1): 410-22, 2006 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-16183706

6.

An evaluation of a low-density DNA microarray using cytochrome P450 inducers.

Meneses-Lorente, Georgina; de Longueville, Françoise; Dos Santos-Mendes, Sofia; Bonnert, Timothy P; Jack, Andrew; Evrard, Stéphanie; Bertholet, Vincent; Pike, Andrew; Scott-Stevens, Paul; Remacle, José; Sohal, Bindi.

Chem Res Toxicol ; 16(9): 1070-7, 2003 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-12971794

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Imidazo[1,2-a]pyrimidines as functionally selective and orally bioavailable GABA(A)alpha2/alpha3 binding site agonists for the treatment of anxiety disorders.

The discovery of potent nonstructural protein 5A (NS5A) inhibitors with a unique resistance profile-Partâ1.

The discovery of potent nonstructural protein 5A (NS5A) inhibitors with a unique resistance profile-Partâ2.

Potent, selective inhibitors of fibroblast growth factor receptor define fibroblast growth factor dependence in preclinical cancer models.

TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates.

An evaluation of a low-density DNA microarray using cytochrome P450 inducers.

BVS Medicinas Tradicionales, Complementarias, e Integrativas en las Américas - MTCI

Configurar filtros

Su selección (0)

Formato de exportación:

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Imidazo[1,2-a]pyrimidines as functionally selective and orally bioavailable GABA(A)alpha2/alpha3 binding site agonists for the treatment of anxiety disorders.

The discovery of potent nonstructural protein 5A (NS5A) inhibitors with a unique resistance profile-Partâ 1.

The discovery of potent nonstructural protein 5A (NS5A) inhibitors with a unique resistance profile-Partâ 2.

Potent, selective inhibitors of fibroblast growth factor receptor define fibroblast growth factor dependence in preclinical cancer models.

TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates.

An evaluation of a low-density DNA microarray using cytochrome P450 inducers.

The discovery of potent nonstructural protein 5A (NS5A) inhibitors with a unique resistance profile-Partâ1.

The discovery of potent nonstructural protein 5A (NS5A) inhibitors with a unique resistance profile-Partâ2.