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1.
Chemosphere ; 339: 139674, 2023 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-37517668

RESUMEN

This comprehensive study analysed 55 articles published between 2011 and 2022 on the use of metal organic frameworks (MOFs) for phosphate adsorption. The study found that the performance of MOFs in phosphate adsorption is influenced by various factors such as the type of MOF, synthesis method, modification/alteration, and operational conditions (initial concentration, adsorbent dose, pH, contact time, and temperature). Most of the MOFs have a wide range of theoretical maximum adsorption capacity for phosphate, but their long-term use in phosphorus recovery may be limited due to the adsorption mechanisms being dominated by inner sphere complexation. The study employed machine learning to construct artificial neural network (ANN) models for predicting phosphate adsorption capacity based on input features from operation and synthesis procedures. The initial phosphate concentration was the most important input from the operational features, while the modulator agent was consistently relevant during MOF synthesis. The models showed strong fitting for most MOF types recorded for the study, such as UIO-66, MIL-100, ZIF-8, Al-MOFs, La-MOFs, and Ce-MOFs. Overall, this study provides valuable insights for the design of MOF adsorbents for phosphate adsorption and offers guidance for future research in this area.


Asunto(s)
Estructuras Metalorgánicas , Fosfatos , Adsorción , Fósforo , Redes Neurales de la Computación
2.
Methods Mol Biol ; 1438: 199-224, 2016.
Artículo en Inglés | MEDLINE | ID: mdl-27150092

RESUMEN

A large variety of mouse models for human skin, hair, and nail diseases are readily available from investigators and vendors worldwide. Mouse skin is a simple organ to observe lesions and their response to therapy, but identifying and monitoring the progress of treatments of mouse skin diseases can still be challenging. This chapter provides an overview on how to use the laboratory mouse as a preclinical tool to evaluate efficacy of new compounds or test potential new uses for compounds approved for use for treating an unrelated disease. Basic approaches to handling mice, applying compounds, and quantifying effects of the treatment are presented.


Asunto(s)
Modelos Animales de Enfermedad , Sistemas de Liberación de Medicamentos/métodos , Enfermedades de la Piel/tratamiento farmacológico , Animales , Relación Dosis-Respuesta a Droga , Vías de Administración de Medicamentos , Evaluación Preclínica de Medicamentos , Humanos , Ratones , Piel/efectos de los fármacos
3.
Environ Technol ; 32(9-10): 1053-62, 2011 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-21882558

RESUMEN

Active slag filters are an emerging technology for removing phosphorus (P) from wastewaters. Recent research revealed that adsorption onto Fe oxides/oxyhydroxides at near-neutral pH and oxidizing Eh is the key mechanism of P removal by melter slag filters. Currently, filter lifespan is limited by available adsorption sites. This study examined whether the performance and longevity of active filters could be improved via chemical treatment to create additional reactive sites as well as regenerate exhausted ones. Fresh original melter slag as well as slag from an exhausted full-scale filter was tested. Chemical reagents that could manipulate the pH/Eh of the slag granule surfaces and potentially activate them for further P removal were used, namely hydrochloric acid (HCI), sodium hydroxide (NaOH) and sodium dithionite (Na2S2O4). Waste stabilization pond effluent was then applied to the treated slag to assess the effectiveness of the treatments at improving P removal. Fresh slag treated with Na2S204 and HCl, respectively, retained 1.9 and 1.4 times more P from the effluent than the untreated fresh slag. These reagents were even more effective at regenerating the exhausted slag, increasing total retained P by a factor of 13 and six, respectively, compared with untreated slag. Sodium hydroxide was ineffective at increasing P removal. The higher P retention by the 'treated exhausted slag' compared with the 'treated fresh media' indicates that adsorption sites on melter slag filters become increasingly reactive with time. This research is the first study to provide evidence that P retention by active slag filters can be increased by both (1) chemical pre treatment and (2) chemical post-treatment once their P removal is exhausted, thereby potentially transforming them from a single use system to a more viable, reusable treatment technology.


Asunto(s)
Filtración/instrumentación , Fósforo/química , Fósforo/aislamiento & purificación , Diseño de Equipo , Análisis de Falla de Equipo , Equipo Reutilizado
4.
Water Sci Technol ; 62(8): 1713-8, 2010.
Artículo en Inglés | MEDLINE | ID: mdl-20962385

RESUMEN

Active filtration, where effluent is passed through a reactive substrate such as steel slag, offers a simple and cost-effective option for removing phosphorus (P) from effluent. This work summarises a series of studies that focused on the world's only full-scale active slag filter operated through to exhaustion. The filter achieved 75% P-removal during its first 5 years, reaching a retention capacity of 1.23 g P/kg slag but then its performance sharply declined. Scanning electron microscopy, X-ray diffraction, X-ray fluorescence, and chemical extractions revealed that P sequestration was primarily achieved via adsorption onto iron (Fe) oxyhydroxides on the slag's surface. It was concluded that batch equilibrium tests, whose use has been repeatedly proposed in the literature, cannot be used as an accurate predictor of filter adsorption capacity because Fe oxyhydroxides form via chemical weathering in the field, and laboratory tests don't account for this. Research into how chemical conditions affect slag's P retention capacity demonstrated that near-neutral pH and high redox are optimal for Fe oxyhydroxide stability and overall filter performance. However, as Fe oxyhydroxide sites fill up, removal capacity becomes exhausted. Attempts to regenerate P removal efficiency using physical techniques proved ineffective contrary to dogma in the literature. Based on the newly-developed understanding of the mechanisms of P removal, chemical regeneration techniques were investigated and were shown to strip large quantities of P from filter adsorption sites leading to a regenerated P removal efficiency. This raises the prospect of developing a breakthrough technology that can repeatedly remove and recover P from effluent.


Asunto(s)
Filtración/métodos , Metalurgia , Fósforo/aislamiento & purificación , Acero/química , Contaminantes Químicos del Agua/aislamiento & purificación , Purificación del Agua/métodos , Concentración de Iones de Hidrógeno , Microscopía Electrónica de Rastreo , Oxidación-Reducción , Propiedades de Superficie
5.
Water Sci Technol ; 59(8): 1673-8, 2009.
Artículo en Inglés | MEDLINE | ID: mdl-19403982

RESUMEN

Active slag filters are an emerging technology for removing phosphorus (P) from wastewater. A number of researchers have suggested that adsorption isotherms are a useful tool for predicting P retention capacity. However, to date the appropriateness of using isotherms for slag filter design remains unverified due to the absence of benchmark data from a full-scale, field filter operated to exhaustion. This investigation compared the isotherm-predicted P retention capacity of a melter slag with the P adsorption capacity determined from a full-scale, melter slag filter which had reached exhaustion after five years of successfully removing P from waste stabilization pond effluent. Results from the standard laboratory batch test showed that P adsorption correlated more strongly with the Freundlich Isotherm (R(2)=0.97, P<0.01) than the Langmuir Isotherm, a similar finding to previous studies. However, at a P concentration of 10 mg/L, typical of domestic effluent, the Freundlich equation predicted a retention capacity of 0.014 gP/kg slag; markedly lower than the 1.23 gP/kg slag adsorbed by the field filter. Clearly, the result generated by the isotherm bears no resemblance to actual field capacity. Scanning electron microscopy analysis revealed porous, reactive secondary minerals on the slag granule surfaces from the field filter which were likely created by weathering. This slow weathering effect, which generates substantial new adsorption sites, is not accounted for by adsorption isotherms rendering them ineffective in slag filter design.


Asunto(s)
Filtración/instrumentación , Filtración/métodos , Fósforo/química , Contaminantes Químicos del Agua/química , Purificación del Agua/métodos , Adsorción , Hierro/química , Metalurgia , Microscopía Electrónica de Rastreo , Modelos Químicos , Residuos
6.
Water Res ; 43(2): 277-82, 2009 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-18976787

RESUMEN

Active slag filters are an emerging technology for removing phosphorus (P) from wastewater. Currently, the lifespan of these filters is limited by their available reactive sites. An increasing number of researchers suggest that drying active filters can renew their P removal capacity, although there has only been one research paper that has achieved regeneration. Hence, this study investigated techniques to regenerate the P removal efficiency of exhausted melter slag filter media which had successfully treated effluent for 5 years in the field before becoming inactive. Several techniques were performed to expose fresh surface sites on the slag, including: (1) drying; (2) agitation; and (3) crushing of the slag granules. Crushing resulted in the best regeneration of P removal efficiency by the slag, however, after just 2 months the renewed P removal efficiency of the crushed slag fell back to a similar level to that exhibited by exhausted slag. Furthermore, none of the other physical methods caused long-term rejuvenation of the exhausted slag to remove P from effluent. Scanning electron microscopy revealed that none of the regeneration techniques exposed substantial new phosphorus adsorption sites on the slag granules. These findings therefore challenge the validity of the existing dogma that active slag filters can be effectively regenerated by simple physical treatments, indicating further research is required to optimise active filter performance.


Asunto(s)
Fósforo/química , Eliminación de Residuos Líquidos/métodos , Purificación del Agua/métodos , Filtración/instrumentación , Filtración/métodos , Residuos Industriales , Microscopía Electrónica de Rastreo , Propiedades de Superficie
7.
Environ Sci Technol ; 41(18): 6585-90, 2007 Sep 15.
Artículo en Inglés | MEDLINE | ID: mdl-17948812

RESUMEN

The release of phosphorus (P) and iron (Fe) from a melter slag filter in solutions of varying Eh and pH was examined. The filter had been removing P from waste stabilization pond effluent for several years. The study revealed that the highest P (95% of total P) and Fe (25% of total Fe) release from the slag occurred in the solution with the lowest Eh (-400 mV, relative to the standard hydrogen electrode, SHE) and lowest pH (4.9). Solutions with high pH (9.1) also proved favorable for P release (20 to 40% of total P) from the slag, at both reducing (-400 mV) and oxidizing (+300 mV) Eh. By contrast, solutions with pH 4.9 and 6.7 and oxidizing Eh (+300 mV) liberated the lowest P and Fe contents into the aqueous phase (<1% for both elements). The findings showed that Eh and pH are important parameters affecting P release from slag filters. At low Eh and low pH, P is released due to the dissolution of Fe oxides/oxyhydroxides, as supported by scanning electron microscopy (SEM)/energy dispersive spectrometry (EDS). At high pH, P is desorbed from negatively charged Fe oxide/oxyhydroxide surfaces. The results of this investigation are pertinentto the design and operation of melter slag filters that treat all forms of P-rich waters, such as wastewater, stormwater, and farm runoff. The study demonstrated that P retention by melter slag filters is optimal in water bodies characterized by near-neutral pH and oxidizing Eh because these conditions favor P adsorption onto Fe oxides/oxyhydroxides.


Asunto(s)
Fósforo/química , Eliminación de Residuos Líquidos/métodos , Purificación del Agua/métodos , Filtración/instrumentación , Filtración/métodos , Concentración de Iones de Hidrógeno , Hierro/química , Microscopía Electrónica de Rastreo , Oxidación-Reducción
9.
Circulation ; 95(8): 2037-43, 1997 Apr 15.
Artículo en Inglés | MEDLINE | ID: mdl-9133513

RESUMEN

BACKGROUND: Patients with ischemia during stress testing and ambulatory ECG monitoring have an increased risk of cardiac events, but it is not known whether their prognosis is improved by more aggressive treatment with anti-ischemic drugs or revascularization. METHODS AND RESULTS: The Asymptomatic Cardiac Ischemia Pilot study randomized 558 such patients who had coronary anatomy suitable for revascularization to three treatment strategies: angina-guided drug therapy (n=183), angina plus ischemia-guided drug therapy (n=183), or revascularization by angioplasty or bypass surgery (n=192). Two years after randomization, the total mortality was 6.6% in the angina-guided strategy, 4.4% in the ischemia-guided strategy, and 1.1% in the revascularization strategy (P<.02). The rate of death or myocardial infarction was 12.1% in the angina-guided strategy, 8.8% in the ischemia-guided strategy, and 4.7% in the revascularization strategy (P<.04). The rate of death, myocardial infarction, or recurrent cardiac hospitalization was 41.8% in the angina-guided strategy, 38.5% in the ischemia-guided strategy, and 23.1% in the revascularization strategy (P<.001). Pairwise testing revealed significant differences between the revascularization and angina-guided strategies for each comparison. CONCLUSIONS: A strategy of initial revascularization appears to improve the prognosis of this population compared with angina-guided medical therapy. A larger long-term study is needed to confirm this benefit and to adequately test the potential of more aggressive drug therapy.


Asunto(s)
Antagonistas Adrenérgicos beta/uso terapéutico , Atenolol/uso terapéutico , Bloqueadores de los Canales de Calcio/uso terapéutico , Diltiazem/uso terapéutico , Dinitrato de Isosorbide/uso terapéutico , Isquemia Miocárdica/terapia , Revascularización Miocárdica , Nifedipino/uso terapéutico , Vasodilatadores/uso terapéutico , Antagonistas Adrenérgicos beta/administración & dosificación , Anciano , Angioplastia Coronaria con Balón , Atenolol/administración & dosificación , Bloqueadores de los Canales de Calcio/administración & dosificación , Puente Cardiopulmonar , Enfermedades Cardiovasculares/mortalidad , Comorbilidad , Diltiazem/administración & dosificación , Quimioterapia Combinada , Electrocardiografía Ambulatoria , Prueba de Esfuerzo , Femenino , Estudios de Seguimiento , Humanos , Dinitrato de Isosorbide/administración & dosificación , Tablas de Vida , Masculino , Persona de Mediana Edad , Infarto del Miocardio/epidemiología , Isquemia Miocárdica/diagnóstico , Isquemia Miocárdica/tratamiento farmacológico , Isquemia Miocárdica/epidemiología , Isquemia Miocárdica/cirugía , Nifedipino/administración & dosificación , Proyectos Piloto , Pronóstico , Factores de Riesgo , Análisis de Supervivencia , Resultado del Tratamiento , Vasodilatadores/administración & dosificación
10.
J Health Commun ; 2(1): 43-58, 1997.
Artículo en Inglés | MEDLINE | ID: mdl-10977234

RESUMEN

Nutrition is crucial to national development; an undernourished or a malnourished population is at risk for infectious diseases that may reduce its working and productive capacities. Sub-Saharan Africa leads the world in the proportion of its population that is chronically malnourished. This article presents a symmetrical and an integrated framework of norms for nutrition communication. It uses three nutrition communication projects in Africa to illustrate the application of those norms. Based on that review, it concludes that a community-based framework should emphasize at the outset--and throughout program implementation and evaluation--the importance of folk media (e.g., Africa's "oramedia") as both formative and summative norms for planning, implementing, and evaluating nutrition communication programs in Africa.


Asunto(s)
Comunicación , Educación en Salud/organización & administración , Trastornos Nutricionales/prevención & control , Ciencias de la Nutrición/educación , Salud Pública , África del Sur del Sahara , Humanos , Comunicación Persuasiva
11.
Am J Cardiol ; 77(15): 1302-9, 1996 Jun 15.
Artículo en Inglés | MEDLINE | ID: mdl-8677870

RESUMEN

This report focuses on the subset of 235 patients from the Asymptomatic Cardiac Ischemia Pilot (ACIP) study receiving randomly assigned medical therapy to treat angina and suppress ischemia detected on ambulatory electrocardiography: 121 patients received the sequence of atenolol and nifedipine, and 114 diltiazem and isosorbide dinitrate. After 12 weeks of therapy, the primary end point (absence of ambulatory electrocardiographic (ECG) ischemia and no clinical events) was reached in 47% of atenolol/nifedipine- versus 31% of diltiazem/isosorbide dinitrate-treated patients (adjusted p = 0.03). A trend to increased exercise time to ST depression was seen in the atenolol and nifedipine versus diltiazem and isosorbide dinitrate regimens (median treadmill duration 5.8 vs 4.8 minutes; p = 0.04). However, when adjusted for baseline imbalances in ambulatory ECG ischemia, the 2 medical combinations were similar in suppression of ambulatory ECG ischemia. In both medication regimens, an association between mean heart rate and ischemia on ambulatory electrocardiography after 12 weeks of treatment was observed so that patients on either regimen with a mean heart rate > 80 beats/min had ischemia detectable almost twice as often as those with a mean heart rate < 70 beats/min (p < 0.001).


Asunto(s)
Atenolol/uso terapéutico , Diltiazem/uso terapéutico , Dinitrato de Isosorbide/uso terapéutico , Isquemia Miocárdica/tratamiento farmacológico , Nifedipino/uso terapéutico , Angina de Pecho/diagnóstico , Angina de Pecho/tratamiento farmacológico , Estudios de Casos y Controles , Preparaciones de Acción Retardada , Quimioterapia Combinada , Electrocardiografía Ambulatoria , Prueba de Esfuerzo , Tolerancia al Ejercicio/efectos de los fármacos , Femenino , Frecuencia Cardíaca/efectos de los fármacos , Humanos , Masculino , Persona de Mediana Edad , Isquemia Miocárdica/diagnóstico , Proyectos Piloto , Estudios Prospectivos , Factores de Tiempo
12.
South Med J ; 88(5): 514-23, 1995 May.
Artículo en Inglés | MEDLINE | ID: mdl-7732439

RESUMEN

To determine patterns of medication use based on clinical variables in patients with heart failure, we analyzed data from 5,999 patients participating in the Registry of Studies of Left Ventricular Dysfunction (SOLVD). The Registry comprised a broad spectrum of patients with heart failure, including some with predominantly diastolic dysfunction. Drug use was determined in a population cross-sectional manner at the time of identification (74% hospitalized). The median number of drugs per patient was four, with diuretics taken by 62%, digitalis by 45%, angiotensin-converting enzyme inhibitors (ACE-I) by 32%, calcium channel blockers by 36%, antiarrhythmics by 22%, and beta-blockers by 18%. Only 18% were on the combination of ACE-I, diuretic, and digitalis. Stratification for diagnosis, heart failure symptoms, and ejection fractions demonstrated that triple-drug therapy (digitalis, diuretic, and ACE-I) was common only in those with ejection fractions less than .20 and several signs or symptoms of heart failure. Older patients were taking diuretics frequently (73% of patients older than 70 years of age), and our European center used fewer drugs overall, while prescribing digitalis about half as frequently as North American clinics. These data serve as the baseline for analysis of evolving therapeutic practice in patients with heart failure.


Asunto(s)
Revisión de la Utilización de Medicamentos , Insuficiencia Cardíaca/tratamiento farmacológico , Pautas de la Práctica en Medicina , Sistema de Registros , Disfunción Ventricular Izquierda/tratamiento farmacológico , Anciano , Bélgica , Bloqueadores de los Canales de Calcio/uso terapéutico , Canadá , Estudios Transversales , Digitalis , Diuréticos/uso terapéutico , Método Doble Ciego , Quimioterapia Combinada , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Multicéntricos como Asunto , Peptidil-Dipeptidasa A/uso terapéutico , Plantas Medicinales , Plantas Tóxicas , Ensayos Clínicos Controlados Aleatorios como Asunto , Volumen Sistólico , Estados Unidos
13.
J Am Coll Cardiol ; 24(1): 11-20, 1994 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-8006252

RESUMEN

OBJECTIVES: The Asymptomatic Cardiac Ischemia Pilot (ACIP) study was initiated to determine the feasibility of a large trial in evaluating the effects of treatment of ischemia on outcome (mortality and myocardial infarction). The study was designed to examine the effects of medical treatment to control angina compared with treatment strategies guided by ambulatory electrocardiographic (ECG) ischemia or coronary anatomy. BACKGROUND: Treatments to suppress ischemia (asymptomatic and symptomatic) have not been evaluated in a large prospective, randomized trial. Before undertaking such a trial, issues about recruitment and treatment strategies must be addressed. METHODS: The 618 enrolled patients had coronary artery disease suitable for revascularization, ischemia on stress test and asymptomatic ischemia on ambulatory ECG. Patients were assigned randomly to one of three treatment strategies: 1) angina-guided medical strategy with titration of anti-ischemic medication to relieve angina (angina-guided strategy); 2) angina-guided plus ambulatory ECG ischemia-guided medical strategy with titration of anti-ischemic medication to eliminate both angina and ambulatory ECG ischemia (ischemia-guided strategy); and 3) revascularization by angioplasty or bypass surgery (revascularization strategy). RESULTS: Ambulatory ECG ischemia was no longer present at the week 12 visit in 39% of patients assigned to the angina-guided strategy, 41% of patients assigned to the ischemia-guided strategy and 55% of patients assigned to the revascularization strategy. All strategies reduced the median number of episodes and total duration of ST segment depression during follow-up ambulatory ECG monitoring. Revascularization was the most effective strategy. Treadmill test results were concordant with those of ambulatory ECG monitoring. For most patients in the two medical strategies, angina was controlled with low to moderate doses of anti-ischemic medication, and the majority of patients (65%) in the revascularization strategy did not require medication for angina. CONCLUSIONS: This pilot study demonstrated that cardiac ischemia can be suppressed in 40% to 55% of patients with either low or moderate doses of medication or revascularization and that a large trial is feasible.


Asunto(s)
Enfermedad Coronaria/terapia , Isquemia Miocárdica/terapia , Anciano , Atenolol/administración & dosificación , Enfermedad Coronaria/diagnóstico , Diltiazem/administración & dosificación , Quimioterapia Combinada , Femenino , Humanos , Dinitrato de Isosorbide/administración & dosificación , Masculino , Persona de Mediana Edad , Isquemia Miocárdica/diagnóstico , Revascularización Miocárdica , Nifedipino/administración & dosificación , Proyectos Piloto , Factores de Tiempo , Resultado del Tratamiento , Estados Unidos
15.
Cancer Chemother Pharmacol ; 19(1): 57-60, 1987.
Artículo en Inglés | MEDLINE | ID: mdl-2880677

RESUMEN

We compared the acute tubular nephrotoxicity of three platinum compounds in children and adults with solid tumors by monitoring the urinary excretion of alanine aminopeptidase, N-acetyl-beta-D-glucosaminidase, and total protein. Cisplatin (100 mg/m2) was administered with mannitol, or at a twofold larger total dosage (50 mg/m2 per day for 4 days) in a 3% saline infusion. Carboplatin (300 mg/m2) was administered in combination with 5-fluorouracil, and iproplatin was administered in dosages ranging from 216 to 388 mg/m2. Enzymuria and proteinuria induced by cisplatin at a total dosage of 200 mg/m2 on a divided schedule did not significantly differ from that observed for the single 100 mg/m2 dose. Enzymuria and proteinuria induced by carboplatin and iproplatin were significantly less than that for cisplatin; however, one patient developed chronic tubular damage after three courses of carboplatin, and the acute tubular toxicity of iproplatin in one of 15 patients was exceptional. Our findings support the value of administering cisplatin in hypertonic saline on a divided schedule as a strategy to reduce acute tubular damage. Although carboplatin and iproplatin are less nephrotoxic than cisplatin, occasionally patients experience subclinical acute or chronic tubular damage that may lead to overt nephrotoxicity with continued therapy.


Asunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos , Enfermedades Renales/inducido químicamente , Túbulos Renales/efectos de los fármacos , Compuestos Organoplatinos/efectos adversos , Acetilglucosaminidasa/orina , Enfermedad Aguda , Adulto , Aminopeptidasas/orina , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Antígenos CD13 , Carboplatino , Niño , Fluorouracilo/administración & dosificación , Neoplasias de Cabeza y Cuello/complicaciones , Neoplasias de Cabeza y Cuello/tratamiento farmacológico , Humanos , Enfermedades Renales/orina , Neoplasias/complicaciones , Neoplasias/tratamiento farmacológico , Compuestos Organoplatinos/administración & dosificación , Compuestos Organoplatinos/uso terapéutico , Proteinuria/inducido químicamente , Solución Salina Hipertónica/administración & dosificación
16.
Cancer ; 47(7): 1762-5, 1981 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-6971702

RESUMEN

Eighteen patients with osteosarcoma, most of whom were adolescents, were examined for abnormalities of the brain by use of computed axial tomography. These studies were performed at 15-60 months (median 47 months) after the completion of adjuvant chemotherapy, which included high-dose methotrexate, cyclophosphamide, and Adriamycin. No abnormalities were found. The results of this study, together with the absence of brain lesions in published reports in children receiving high-dose methotrexate but no cranial irradiation, indicate that delayed neurotoxicity is not a major complication of this form of therapy in older children.


Asunto(s)
Encéfalo/efectos de los fármacos , Metotrexato/efectos adversos , Osteosarcoma/tratamiento farmacológico , Tomografía Computarizada por Rayos X , Adolescente , Adulto , Encéfalo/diagnóstico por imagen , Encéfalo/patología , Niño , Femenino , Humanos , Leucovorina/uso terapéutico , Masculino , Osteosarcoma/diagnóstico por imagen , Estudios Retrospectivos , Factores de Tiempo
18.
Cancer Treat Rep ; 65 Suppl 1: 107-11, 1981.
Artículo en Inglés | MEDLINE | ID: mdl-6976828

RESUMEN

Review of the reported use of high-dose methotrexate (HDMTX) with citrovorum factor rescue (CF) for treatment of primary and metastatic osteosarcoma indicates the rarity of responses in clinical situations other than treatment of the primary tumor or isolated pulmonary metastases with doses of 7.5 g/m2 or greater delivered on a weekly basis for 4 to 6 weeks. Adjuvant chemotherapy using HDMTX-CF at triweekly intervals has led to 2-year disease-free survival rates that are inferior to those obtained with combinations of agents including HDMTX-CF Adriamycin (Adria), with or without vincristine, cyclophosphamide, phenylalanine mustard, bleomycin, and dactinomycin. We concluded that although HDMTX-CF has a role in the treatment of primary and metastatic osteosarcoma, its use in combination with other active agents offers greater potential advantage to affected patients.


Asunto(s)
Antineoplásicos/administración & dosificación , Neoplasias Óseas/tratamiento farmacológico , Metotrexato/administración & dosificación , Osteosarcoma/tratamiento farmacológico , Neoplasias Óseas/patología , Neoplasias Óseas/secundario , Ciclofosfamida/administración & dosificación , Doxorrubicina/administración & dosificación , Quimioterapia Combinada , Humanos , Leucovorina/administración & dosificación , Neoplasias Pulmonares/tratamiento farmacológico , Neoplasias Pulmonares/secundario , Osteosarcoma/patología , Pronóstico , Vincristina/administración & dosificación
19.
Cancer Treat Rep ; 64(1): 11-20, 1980 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-6966535

RESUMEN

High-dose methotrexate with leucovorin rescue was used alone or in combination with Adriamycin and cyclophosphamide for the treatment of 27 osteosarcoma patients with measurable indicators of disease. Three patients developed complete responses of measurable lesions, two had partial responses, two had static disease, one had symptomatic improvement, and one had return to normal of physical findings following treatment of a flat bone primary osteosarcoma. While the doses and frequency of administration of high-dose methotrexate differed from those used by previous investigators, these results suggest that aggressive treatment with high-dose methotrexate must be attempted to further evaluate its efficacy as single-agent therapy for osteosarcoma patients not eligible for adjuvant chemotherapy trials.


Asunto(s)
Metotrexato/uso terapéutico , Osteosarcoma/tratamiento farmacológico , Antineoplásicos/administración & dosificación , Niño , Ciclofosfamida/administración & dosificación , Doxorrubicina/administración & dosificación , Combinación de Medicamentos , Quimioterapia Combinada , Humanos , Leucovorina/administración & dosificación , Masculino , Metotrexato/sangre , Metástasis de la Neoplasia , Osteosarcoma/secundario
20.
Cancer ; 44(3): 881-90, 1979 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-314328

RESUMEN

The method of Arons et al. (Cancer Res. 35:2033-2038, 1975) for assaying methotrexate (MTX) was used to monitor serum levels of the drug attained in 18 patients with osteosarcomas. The patients received either 100 mg or 200 mg of MTX/kg via a 6-hour infusion. With one fatal exception, unacceptable toxicity to MTX was prevented by leucovorin. Serum levels of the drug were assayed routinely at 6, 12, and 18 hours after termination of the infusion. Although significantly higher serum levels of MTX were observed at 6 hours after the infusion of 200 mg MTX/kg than after 100 mg/kg, the variation in rate of clearance of individual patients masked any subsequent dosage-related differences. The mean half-time for clearance of MTX was similar irrespective of the dosage of MTX and was 2.91 +/- 1.51 hr for 53 treatments. The single incidence of toxicity, requiring hospitalization, was accompanied with markedly higher serum levels of MTX at 18 hours, but not at either 6 or 12 hours after termination of the drug infusion, and by a slightly slower rate of clearance, 6.2 hours. Certain minor adaptations were incorporated in the original assay to simplify the analysis of data.


Asunto(s)
Metotrexato/sangre , Osteosarcoma/sangre , Quimioterapia Combinada , Humanos , Leucovorina/administración & dosificación , Tasa de Depuración Metabólica , Metotrexato/administración & dosificación , Metotrexato/efectos adversos , Osteosarcoma/tratamiento farmacológico , Tetrahidrofolato Deshidrogenasa
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