Búsqueda | BVS Medicinas Tradicionales, Complementarias, e Integrativas en las Américas

1.

Discovery of GSK3527497: A Candidate for the Inhibition of Transient Receptor Potential Vanilloid-4 (TRPV4).

Brooks, Carl A; Barton, Linda S; Behm, David J; Brnardic, Edward J; Costell, Melissa H; Holt, Dennis A; Jolivette, Larry J; Matthews, Jay M; McAtee, John J; McCleland, Brent W; Patterson, Jaclyn R; Pero, Joseph E; Rivero, Ralph A; Roethke, Theresa J; Sanchez, Robert M; Shenje, Raynold; Terrell, Lamont R; Lawhorn, Brian G.

J Med Chem ; 62(20): 9270-9280, 2019 10 24.

Artículo en Inglés | MEDLINE | ID: mdl-31532662

2.

Design and Optimization of Sulfone Pyrrolidine Sulfonamide Antagonists of Transient Receptor Potential Vanilloid-4 with in Vivo Activity in a Pulmonary Edema Model.

Pero, Joseph E; Matthews, Jay M; Behm, David J; Brnardic, Edward J; Brooks, Carl; Budzik, Brian W; Costell, Melissa H; Donatelli, Carla A; Eisennagel, Stephen H; Erhard, Karl; Fischer, Michael C; Holt, Dennis A; Jolivette, Larry J; Li, Huijie; Li, Peng; McAtee, John J; McCleland, Brent W; Pendrak, Israil; Posobiec, Lorraine M; Rivera, Katrina L K; Rivero, Ralph A; Roethke, Theresa J; Sender, Matthew R; Shu, Arthur; Terrell, Lamont R; Vaidya, Kalindi; Xu, Xiaoping; Lawhorn, Brian G.

J Med Chem ; 61(24): 11209-11220, 2018 12 27.

Artículo en Inglés | MEDLINE | ID: mdl-30500190

3.

Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening.

Woolford, Alison J-A; Pero, Joseph E; Aravapalli, Sridhar; Berdini, Valerio; Coyle, Joseph E; Day, Philip J; Dodson, Andrew M; Grondin, Pascal; Holding, Finn P; Lee, Lydia Y W; Li, Peng; Manas, Eric S; Marino, Joseph; Martin, Agnes C L; McCleland, Brent W; McMenamin, Rachel L; Murray, Christopher W; Neipp, Christopher E; Page, Lee W; Patel, Vipulkumar K; Potvain, Florent; Rich, Sharna; Rivero, Ralph A; Smith, Kirsten; Somers, Donald O; Trottet, Lionel; Velagaleti, Ranganadh; Williams, Glyn; Xie, Ren.

J Med Chem ; 59(11): 5356-67, 2016 06 09.

Artículo en Inglés | MEDLINE | ID: mdl-27167608

4.

Discovery of biphenyl piperazines as novel and long acting muscarinic acetylcholine receptor antagonists.

Jin, Jian; Budzik, Brian; Wang, Yonghui; Shi, Dongchuan; Wang, Feng; Xie, Haibo; Wan, Zehong; Zhu, Chongye; Foley, James J; Webb, Edward F; Berlanga, Manuela; Burman, Miriam; Sarau, Henry M; Morrow, Dwight M; Moore, Michael L; Rivero, Ralph A; Palovich, Michael; Salmon, Michael; Belmonte, Kristen E; Lainé, Dramane I.

J Med Chem ; 51(19): 5915-8, 2008 Oct 09.

Artículo en Inglés | MEDLINE | ID: mdl-18798607

5.

Discovery of novel and long acting muscarinic acetylcholine receptor antagonists.

Jin, Jian; Wang, Yonghui; Shi, Dongchuan; Wang, Feng; Davis, Roderick S; Jin, Qi; Fu, Wei; Foley, James J; Webb, Edward F; Dehaas, Chris J; Berlanga, Manuela; Burman, Miriam; Sarau, Henry M; Morrow, Dwight M; Rao, Parvathi; Kallal, Lorena A; Moore, Michael L; Rivero, Ralph A; Palovich, Michael; Salmon, Michael; Belmonte, Kristen E; Busch-Petersen, Jakob.

J Med Chem ; 51(16): 4866-9, 2008 Aug 28.

Artículo en Inglés | MEDLINE | ID: mdl-18680280

6.

Oxazolidinones as novel human CCR8 antagonists.

Jin, Jian; Wang, Yonghui; Wang, Feng; Kerns, Jeffery K; Vinader, Victoria M; Hancock, Ashley P; Lindon, Matthew J; Stevenson, Graeme I; Morrow, Dwight M; Rao, Parvathi; Nguyen, Cuc; Barrett, Victoria J; Browning, Chris; Hartmann, Guido; Andrew, David P; Sarau, Henry M; Foley, James J; Jurewicz, Anthony J; Fornwald, James A; Harker, Andy J; Moore, Michael L; Rivero, Ralph A; Belmonte, Kristen E; Connor, Helen E.

Bioorg Med Chem Lett ; 17(6): 1722-5, 2007 Mar 15.

Artículo en Inglés | MEDLINE | ID: mdl-17267215

7.

Synthesis and SAR of 1,3-disubstituted cyclohexylmethyl urea and amide derivatives as non-peptidic motilin receptor antagonists.

Johnson, Sigmond G; Gunnet, Joseph W; Moore, John B; Miller, William; Wines, Pam; Rivero, Ralph A; Combs, Don; Demarest, Keith T.

Bioorg Med Chem Lett ; 16(13): 3362-6, 2006 Jul 01.

Artículo en Inglés | MEDLINE | ID: mdl-16650762

8.

Aminoalkoxybenzyl pyrrolidines as novel human urotensin-II receptor antagonists.

Jin, Jian; Dhanak, Dashyant; Knight, Steven D; Widdowson, Katherine; Aiyar, Nambi; Naselsky, Diane; Sarau, Henry M; Foley, James J; Schmidt, Dulcie B; Bennett, Carl D; Wang, Bing; Warren, Gregory L; Moore, Michael L; Keenan, Richard M; Rivero, Ralph A; Douglas, Stephen A.

Bioorg Med Chem Lett ; 15(13): 3229-32, 2005 Jul 01.

Artículo en Inglés | MEDLINE | ID: mdl-15936190

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