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1.
Phytomedicine ; 9(1): 56-61, 2002 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-11924765

RESUMEN

Forty-two ethanolic extracts of thirty-six Rwandan medicinal plants were investigated for their influence on complement-mediated hemolysis. The plants were selected on the base of their ethnomedicinal use in infections and autoimmune diseases. Eight plant extracts showed an inhibitory activity against the classical pathway of the complement system and ten plant extracts against the alternative pathway. Three plant extracts exhibited an interesting activity against both pathways, i.e. Aspilia pluriseta, Coleus kilimandschari, and Macaranga kilimandscharica (leaves and stem). Further study indicated that the complement inhibitory activity was not caused by chelation of bivalent cations or by direct action on the target erythrocytes.


Asunto(s)
Activación de Complemento , Eritrocitos/efectos de los fármacos , Hemólisis/efectos de los fármacos , Medicina Tradicional Africana , Fitoterapia , Extractos Vegetales/farmacología , Humanos , Concentración 50 Inhibidora , Estructuras de las Plantas , Rwanda
2.
J Ethnopharmacol ; 70(3): 213-7, 2000 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-10837985

RESUMEN

Polar fractions and flavones isolated from methanolic extracts of the leaves of Ligustrum vulgare and Phillyrea latifolia (Oleaceae), whose popular use as an anti-inflammatory is well-known in Mediterranean historical medicine and ethnobotany, showed significant in vitro complement inhibiting effect on the classical pathway of the complement system. Among the isolated flavonoidic structures, apigenin-7-O-glucoside, apigenin-7-O-rutinoside, luteolin-4'-O-glucoside, luteolin-7-O-glucoside and ligustroflavone presented remarkable activity.


Asunto(s)
Proteínas Inactivadoras de Complemento/farmacología , Flavonoides/farmacología , Plantas Medicinales/química , Apigenina , Vía Clásica del Complemento/efectos de los fármacos , Flavonoides/química , Glicósidos/química , Glicósidos/farmacología , Hemólisis/efectos de los fármacos , Humanos , Técnicas In Vitro , Luteolina , Región Mediterránea , Extractos Vegetales/química , Extractos Vegetales/farmacología , Hojas de la Planta/química
3.
Phytomedicine ; 6(1): 45-9, 1999 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-10228611

RESUMEN

Spathodea campanulata stem bark decoction (SCD) has shown hypoglycemic activity in mice. It was separated by column chromatography into different fractions, which were evaluated for their hypoglycemic, anticomplement and anti-HIV activities. The most polar fraction exerted by far the most prominent effect in different biological models.


Asunto(s)
Fármacos Anti-VIH/farmacología , Proteínas Inactivadoras de Complemento/farmacología , Hipoglucemiantes/farmacología , Plantas Medicinales/química , Animales , Fármacos Anti-VIH/aislamiento & purificación , Glucemia/metabolismo , Proteínas Inactivadoras de Complemento/aislamiento & purificación , Femenino , Gabón , Prueba de Tolerancia a la Glucosa , Humanos , Hipoglucemiantes/aislamiento & purificación , Técnicas In Vitro , Ratones , Epidermis de la Planta/química , Extractos Vegetales/farmacología
4.
Planta Med ; 63(3): 220-3, 1997 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-9265193

RESUMEN

A kaempferol 7-O-rhamnosylsophoroside isolated from the leaves of Morinda morindoides showed dose-dependent complement-modulating properties towards both the classical (inhibiting effect) and alternative (activating effect) pathways of the complement system. Its structure was elucidated by chemical and spectroscopic methods as kaempferol 7-O-[alpha-L-rhamnopyranosyl-(1-->6)]-[beta-D-glucopyranosyl-(1-->2)]-be ta-D-glucopyranoside, a new natural product which was named morindaoside.


Asunto(s)
Activación de Complemento/efectos de los fármacos , Flavonoides , Glicósidos/química , Quempferoles , Plantas Medicinales , Quercetina/análogos & derivados , Secuencia de Carbohidratos , Glicósidos/aislamiento & purificación , Glicósidos/farmacología , Medicina Tradicional , Datos de Secuencia Molecular , Estructura Molecular , Hojas de la Planta , Quercetina/química , Quercetina/aislamiento & purificación , Quercetina/farmacología
5.
Pharmazie ; 51(10): 765-8, 1996 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-8941947

RESUMEN

From extracts of olive (Olea europaea L., Oleaceae) leaves showing anti-complementary activity, the flavonoids apigenin, apigenin-4'-O-rhamnosylglucoside, apigenin-7-O-glucoside, luteolin, luteolin-4'-O-glucoside, luteolin-7-O-glucoside, chrysoeriol, chrysoeriol-7-O-glucoside and quercetin-3-O-rhamnoside were isolated. Major isolated constituents strongly inhibited the classical pathway of the complement system.


Asunto(s)
Proteínas Inactivadoras de Complemento/farmacología , Flavonoides/farmacología , Hojas de la Planta/química , Plantas Medicinales/química , Vía Alternativa del Complemento/efectos de los fármacos , Vía Clásica del Complemento/efectos de los fármacos , Hemólisis/efectos de los fármacos , Humanos , Técnicas In Vitro , Espectroscopía de Resonancia Magnética , Extractos Vegetales/química , Espectrometría de Masa Bombardeada por Átomos Veloces , Espectrofotometría Ultravioleta
6.
Planta Med ; 62(1): 10-3, 1996 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-8720380

RESUMEN

The 80% and 70% acetone extracts from fruits and leaves of Crataegus sinaica Boiss (Rosaceae) and the ethyl acetate-, butanol-, and water-fractions obtained from these initial extracts as well as the isolated compounds, quercetin (1) (1), hyperoside (quercetin 3-O-galactoside) (2) (2), rutin (quercetin 3-O-rutinoside) (3) (2), vitexin (4) (1), rhamnosylvitexin (5) (3), monoacetylrhamnosylvitexin (6) (3), epicatechin (7) (4), procyanidin B-5 (8) (4), proanthocyanidin A-2 (9) (5), procyanidin B-2 (10) (4), and procyanidin C-1 (11) (4), were tested for their influence on the classical (CP) and alternative (AP) pathways of complement-mediated hemolysis. All extracts and fractions showed a strong anti-complementary effect in a dose-dependent way which was more pronounced on the CP than on the AP. The results indicated that the pure proanthocyanidins were active on the CP. Procyanidin C-1 and proanthocyanidin A-2 were the most active on the CP and also showed activity on AP, whereas the flavonoids isolated were generally less active. However, rutin, showed a strong activity, quercetin and rhamnosylvitexin a moderate activity on the CP. This is the first report on the chemical constituents and complement-modulating activity of C. sinaica and on the occurrence of proanthocyanidin A-2 (9) in hawthorn.


Asunto(s)
Biflavonoides , Catequina , Proteínas Inactivadoras de Complemento/farmacología , Frutas/química , Extractos Vegetales/farmacología , Hojas de la Planta/química , Proantocianidinas , Proteínas Inactivadoras de Complemento/química , Proteínas Inactivadoras de Complemento/aislamiento & purificación , Hemólisis/efectos de los fármacos , Humanos , Espectroscopía de Resonancia Magnética , Extractos Vegetales/química , Extractos Vegetales/aislamiento & purificación , Espectrometría de Masa Bombardeada por Átomos Veloces , Espectrofotometría Ultravioleta
7.
Planta Med ; 62(1): 22-7, 1996 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-8720383

RESUMEN

In our biological screening of higher plants, an aqueous and an 80% EtOH extract from the root bark of Cryptolepis sanguinolenta showed potent antibacterial, anticomplementary, and moderate antiviral activities, but no antifungal effect could be detected. Bioassay-guided fractionation of the 80% EtOH extract led to the isolation of three alkaloids: quindoline (1), hydroxycryptolepine (2), cryptolepine.HCl (3), and the corresponding base cryptolepine (4). All compounds strongly inhibited the growth of Gram-positive bacteria (MIC < or = 100 micrograms/ml) and showed a moderate (MIC = 125 or 250 micrograms/ml), a weak (MIC = 500 micrograms/ml), or no activity (MIC > 500 micrograms/ml) against selected Gram-negative bacteria. They also possessed a bactericidal effect depending on the bacterial strain. Compounds 1, 2 and 3 displayed a dose-dependent inhibitory effect on the classical pathway of the complement system while compounds 2 and 3 activated the alternative pathway, except for compound 1. Compound 3 was found to possess an antiherpetic activity. Compounds 1 and 4 showed no antiviral effect, but were quite cytotoxic in the antiviral test system down to a concentration of 1 microgram/ml.


Asunto(s)
Alcaloides/farmacología , Antibacterianos/farmacología , Proteínas Inactivadoras de Complemento/farmacología , Raíces de Plantas/química , Plantas Medicinales/química , Alcaloides/química , Antibacterianos/química , Proteínas Inactivadoras de Complemento/química , Pruebas de Sensibilidad Microbiana , Análisis Espectral
8.
J Ethnopharmacol ; 49(1): 23-32, 1995 Nov 17.
Artículo en Inglés | MEDLINE | ID: mdl-8786654

RESUMEN

Selected plants having a history of use in Polynesian traditional medicine for the treatment of infectious disease were investigated for anti-viral, anti-fungal and anti-bacterial activity in vitro. Extracts from Scaevola sericea, Psychotria hawaiiensis, Pipturus albidus and Eugenia malaccensis showed selective anti-viral activity against Herpes Simplex Virus-1 and 2 and Vesicular Stomatitis Virus. Aleurites moluccana extracts showed anti-bacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa, while Pipturus albidus and Eugenia malaccensis extracts showed growth inhibition of Staphylococcus aureus and Streptococcus pyogenes. Psychotria hawaiiensis and Solanum niger inhibited growth of the fungi Microsporum canis, Trichophyton rubrum and Epidermophyton floccosum, while Ipomoea sp., Pipturus albidus, Scaevola sericea, Eugenia malaccensis, Piper methysticum, Barringtonia asiatica and Adansonia digitata extracts showed anti-fungal activity to a lesser extent. Eugenia malaccensis was also found to inhibit the classical pathway of complement suggesting that an immunological basis for its in vivo activity was identified. This study has confirmed some of the ethnobotanical reports of Hawaiian medicinal plants having curative properties against infections using biological assays in vitro.


Asunto(s)
Antibacterianos/farmacología , Medicina Tradicional , Extractos Vegetales/farmacología , Infecciones Bacterianas/tratamiento farmacológico , Hawaii
9.
J Nat Prod ; 58(3): 372-8, 1995 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-7775983

RESUMEN

In a screening program for complement classical pathway modulation, an 80% MeOH extract of the leaves of Morinda morindoides showed potent dose-dependent anticomplementary activity. Bioassay-guided chromatographic separation of the active constituents led to the isolation of ten flavonoids of which two were aglycones. The compounds were tested in vitro for their putative complement-inhibiting properties on the classical (CP) and the alternative (AP) pathways of the complement system. The results indicated that quercetin [1], quercetin 3-O-rhamnoside (quercitrin) [5], and quercetin 3-O-rutinoside (rutin) [7] showed similar anticomplementary activities (inhibition) on the CP of complement. A mixture of two kaempferol triglycosides isolated and denoted as M(015), also had a good inhibitory effect. The effects of these compounds were dose-dependent for this pathway. On the AP of complement, quercetin [1] and M(015) had, respectively, more pronounced inhibitory and activatory effects than the other tested flavonoids, but their effects were not dose-dependent for this pathway. The other isolated flavonoids showed weak effects or were inactive for both pathways.


Asunto(s)
Proteínas Inactivadoras de Complemento/farmacología , Plantas Medicinales/química , Animales , Vía Alternativa del Complemento/efectos de los fármacos , Vía Clásica del Complemento/efectos de los fármacos , Flavonoides/aislamiento & purificación , Flavonoides/farmacología , Cobayas , Hemólisis/efectos de los fármacos , Humanos , Técnicas In Vitro , Extractos Vegetales/farmacología , Hojas de la Planta/química , Conejos , Ovinos
10.
Phytomedicine ; 1(4): 303-7, 1995 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-23196019

RESUMEN

Plants from Rwanda used in traditional medicine have been investigated for their influence on lymphocyte proliferation with and without the presence of the mitogen phytohemagglutinin. Phytolacca dodecandra displayed a significant mitogenic effect. Several plants inhibited the lymphocyte proliferation after prestimulation with the mitogen.

11.
Phytomedicine ; 2(1): 17-22, 1995 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-23196095

RESUMEN

The wound healing activity of dragon'sblood (Croton spp.), in Spanish 'sangre de drago? or 'sangre de grado?, a traditional South American drug, and some of its constituents, including the alkaloid taspine (1), the dihydrobenzufuran lignan 3',4-O-dimethylcedrusin (2) and proantho-cyanidins, was evaluated in vivo on rats, and compared with the wound healing actitivy of synthetic proanthocyanidins. The beneficial effect of dragon's blood on wound healing was confirmed. Dragon's blood stimulated contraction of the wound, formation of a crust, formation of new collagen, and regeneration of the epithelial layer. 3',4-O-Dimethylcedrusin also improved wound healing in vivo by stimulating the formation of fibroblasts and collagen, but crude dragon's blood was more effective. This was due to the proanthocyanidins, present in dragon's blood, which stimulate contraction of the wound and precipitate with proteins forming a dark crust covering the wound, but which delay wound repair by a decreased formation of new fibroblasts.

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