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Métodos Terapéuticos y Terapias MTCI
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1.
J Environ Manage ; 312: 114912, 2022 Jun 15.
Artículo en Inglés | MEDLINE | ID: mdl-35306420

RESUMEN

Solving the problem of rural sewage is considered an essential task in China's rural revitalization strategy. Based on the yearbook data of sewage treatment in rural areas between 2014 and 2019, although the rate of sewage treatment in rural areas of China showed an upward trend, it was still below 35%, mainly due to the lack of suitable sewage treatment technologies. Here, we discuss the multi-soil-layering (MSL) system, which is an emerging technology suitable for rural sewage treatment. It was deemed to overcome the shortcomings of current biological and ecological treatment technologies, such as complex operation, large area, and high operating costs. We used system dynamics to evaluate the advancing and limiting factors of MSL application for rural sewage treatment from the social, environmental, and economic dimensions. The results illustrated a complete causal loop diagram in which essential variables and relationships were concentrated in the technology, operation and maintenance, and satisfaction of farmers. The efficiency of MSL is the key variable affecting the final decision of the MSL application. Overall, using MSL to treat rural sewage could be an option to improve the rural environment in China. However, the scientific technological model for MSL should be further explored. This review provides guidance on how to promote MSL systems in rural areas.


Asunto(s)
Aguas del Alcantarillado , Suelo , China
2.
Mol Ther ; 30(2): 644-661, 2022 02 02.
Artículo en Inglés | MEDLINE | ID: mdl-34547462

RESUMEN

Preclinical and clinical studies have validated the antitumor effects of several oncolytic viruses (OVs). However, the efficacy of OVs is limited when they are administered as monotherapies. Combination therapy is a promising direction for oncolytic virotherapy in the future. A high dose of vitamin C (VitC) exerts anticancer effects by triggering the accretion of substantial amounts of reactive oxygen species (ROS). OVs can induce immunogenic tumor cell death and elicit an antitumor immune response. ROS play an important role in immunogenic cell death (ICD). This study aimed to explore whether high-dose VitC in combination with oncolytic adenoviruses (oAds) exhibited a synergistic antitumor effect. High-dose VitC synergized with oAds against tumor by enhancing immunogenic tumor cell death. Combination therapy with high-dose VitC and oAds significantly increased the number of T cells in the tumor microenvironment (TME) and promoted the activation of T cells. Furthermore, the antitumor effect of the combination therapy was CD8+ T cell dependent. In addition, combination therapy with high-dose VitC and oAds reprogramed the immunosuppressive TME. Our study provides a new strategy for combination therapy of OVs.


Asunto(s)
Neoplasias , Viroterapia Oncolítica , Virus Oncolíticos , Adenoviridae/genética , Humanos , Muerte Celular Inmunogénica , Neoplasias/terapia , Virus Oncolíticos/fisiología , Microambiente Tumoral
3.
Sci Rep ; 10(1): 8351, 2020 05 20.
Artículo en Inglés | MEDLINE | ID: mdl-32433494

RESUMEN

Mercury (Hg) exposure poses serious health risks to humans, resulting in extensive investigations examining Hg accumulation, biotransformation and uptake in crops. In this investigation, Hg accumulation in potato tubers due to bioaccumulation processes was determined and bioconcentration factors affecting bioaccumulation were identified using a greenhouse experiment. Our results showed that the percentage of available Hg concentrations from total Hg in soil samples were less than 1.2%, indicating that soils used in our experiment exhibited a high binding strength for Hg, with alkaline soil recording the lowest available Hg/total Hg ratio. Results indicated that soil type and Hg treatment, as well as their interactions, significantly affected Hg accumulation in potato tubers (P < 0.01). Importantly, our results also indicated that potatoes grown in soil with a Hg concentration two times higher than the Chinese Environmental Quality Standard exhibited no obvious toxic effects on humans; Bioconcentration factors (BCF) values (<0.04) suggested that potatoes can be considered as a low Hg accumulating species and suitable for human consumption. Potato yields in acidic soil were lower than those in neutral or alkaline soils, making this medium unsuitable for growth.


Asunto(s)
Bioacumulación , Contaminación Ambiental/efectos adversos , Mercurio/análisis , Contaminantes del Suelo/análisis , Solanum tuberosum/química , China , Producción de Cultivos/normas , Productos Agrícolas/química , Productos Agrícolas/crecimiento & desarrollo , Productos Agrícolas/metabolismo , Productos Agrícolas/normas , Enfermedades Transmitidas por los Alimentos/etiología , Enfermedades Transmitidas por los Alimentos/prevención & control , Humanos , Mercurio/metabolismo , Mercurio/normas , Mercurio/toxicidad , Tubérculos de la Planta/química , Tubérculos de la Planta/crecimiento & desarrollo , Tubérculos de la Planta/metabolismo , Tubérculos de la Planta/toxicidad , Suelo/química , Contaminantes del Suelo/metabolismo , Contaminantes del Suelo/normas , Contaminantes del Suelo/toxicidad , Solanum tuberosum/crecimiento & desarrollo , Solanum tuberosum/metabolismo , Solanum tuberosum/normas
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