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1.
Am J Clin Nutr ; 60(1): 129-35, 1994 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-8017327

RESUMEN

In a double-blind controlled trial, 91 middle-aged and elderly women with mild to moderate hypertension who were not on antihypertensive medication were randomly assigned to treatment with magnesium aspartate-HCl (20 mmol Mg/d) or placebo for 6 mo. Magnesium aspartate-HCl in the given dose was well-tolerated and was not associated with an increased frequency of diarrhea compared with placebo. At the end of the study, systolic blood pressure had fallen by 2.7 mm Hg (95% CI -1.2, 6.7; P = 0.18) and diastolic blood pressure by 3.4 mm Hg (1.3, 5.6; P = 0.003) more in the magnesium group than in the placebo group. Blood pressure response was not associated with baseline magnesium status, as measured by dietary magnesium intake and urinary magnesium excretion. Urinary magnesium excretion in the magnesium group increased by 50% during the intervention period. No changes were seen in other biochemical indexes, including serum concentrations of total and high-density-lipoprotein cholesterol. The findings suggest that oral supplementation with magnesium aspartate-HCl may lower blood pressure in subjects with mild to moderate hypertension.


Asunto(s)
Ácido Aspártico/uso terapéutico , Hipertensión/tratamiento farmacológico , Administración Oral , Adulto , Anciano , Ácido Aspártico/administración & dosificación , Ácido Aspártico/efectos adversos , Presión Sanguínea/efectos de los fármacos , Peso Corporal , Diarrea/inducido químicamente , Método Doble Ciego , Femenino , Estudios de Seguimiento , Humanos , Magnesio/sangre , Magnesio/orina , Persona de Mediana Edad , Cooperación del Paciente , Renina/sangre
2.
J Am Coll Nutr ; 9(2): 128-35, 1990 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-2187027

RESUMEN

To provide further insight into the possible role of selenium in cardiovascular disease, we examined the relationship between cardiovascular risk factors, some nutritional parameters, and short- and long-term selenium status. A total of 82 healthy Dutch volunteers, 59 men and 23 women, aged 40-75 years, were studied. Means and standard deviations of selenium parameters were: plasma selenium 106.4 +/- 23.7 micrograms/L, erythrocyte selenium 0.59 +/- 0.19 microgram/g Hb, toenail selenium 0.78 +/- 0.17 ppm, and erythrocyte glutathione peroxidase activity 28.0 +/- 8.1 U/g Hb. No association was found between selenium status and gender, age, serum total-, LDL-, and HDL-cholesterol, systolic and diastolic blood pressure, alcohol intake, and body mass index. A significantly lower plasma selenium level was observed among smokers compared to nonsmokers (101.0 micrograms/L, SE = 3.9 vs 112.0 micrograms/L, SE = 3.6, p = 0.04). A significant negative association was found between erythrocyte selenium and serum levels of vitamin A and ferritin. No relevant relationship was observed between selenium status and serum fatty acid composition, vitamin E, vitamin B6, and iron. Apart from an association between smoking and short-term selenium status, we found no indications that a possible effect of selenium on cardiovascular disease may operate through the known risk factors.


Asunto(s)
Enfermedad Coronaria/etiología , Estado Nutricional/fisiología , Selenio/fisiología , Anciano , Estudios de Casos y Controles , Femenino , Humanos , Masculino , Persona de Mediana Edad , Factores de Riesgo
3.
JAMA ; 261(8): 1161-4, 1989 Feb 24.
Artículo en Inglés | MEDLINE | ID: mdl-2915438

RESUMEN

To study the association between selenium status and the risk of myocardial infarction, we compared plasma, erythrocyte, and toenail selenium levels and the activity of erythrocyte glutathione peroxidase among 84 patients with acute myocardial infarction and 84 population controls. Mean concentrations of all selenium measurements were lower in cases than controls. The differences were statistically significant, except for the plasma selenium level. A positive trend in the risk of acute myocardial infarction from high to low toenail selenium levels was observed, which persisted after adjustment for other risk factors for myocardial infarction. In contrast, erythrocyte glutathione peroxidase activity was significantly higher in cases than controls (31.3 +/- 8.4 U/g of hemoglobin and 28.0 +/- 8.1 U/g of hemoglobin, respectively). Because the toenail selenium level reflects blood levels up to one year before sampling, these findings suggest that a low selenium status was present before the infarction and, thus, may be of etiologic relevance. The higher glutathione peroxidase activity in the cases may be interpreted as a defense against increased oxidant stress either preceding or following the acute event.


Asunto(s)
Infarto del Miocardio/etiología , Selenio/deficiencia , Anciano , Eritrocitos/metabolismo , Femenino , Glutatión Peroxidasa/sangre , Humanos , Masculino , Persona de Mediana Edad , Infarto del Miocardio/metabolismo , Uñas/análisis , Factores de Riesgo , Selenio/sangre
4.
Int J Epidemiol ; 16(2): 329-32, 1987 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-3610463

RESUMEN

This paper summarizes Dutch epidemiological findings on the impact of a low selenium (Se) status on mortality from cardiovascular disease (CVD) and cancer. Se status parameters of Dutch subjects are compared to those from Finland and the USA, and the concept of a threshold effect for Se on disease risk is discussed. Case-control analyses of prospective data suggest that low serum Se (below 105 micrograms/l) is not clearly associated with an excess risk of CVD death (relative risk RR = 1.6, 90% confidence interval Cl = 0.9-2.9). Se cancer findings indicate a possible gender difference in risk (in males RR = 2.7, 90% Cl = 1.2-6.2; in females RR = 1.5, 90% Cl = 0.5-4.5). Larger studies, monitoring a combination of Se status parameters are recommended.


Asunto(s)
Enfermedades Cardiovasculares/mortalidad , Neoplasias/mortalidad , Selenio/sangre , Enfermedades Cardiovasculares/sangre , Enfermedad Crónica , Femenino , Glutatión Peroxidasa/sangre , Humanos , Masculino , Neoplasias/sangre , Países Bajos , Riesgo , Selenio/deficiencia
6.
Am J Clin Nutr ; 45(2): 462-8, 1987 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-3812345

RESUMEN

The association between low serum selenium, vitamin A, and vitamin E levels and mortality from cardiovascular disease (CVD) was investigated in a case-control study nested in a 9-yr prospective study in the Netherlands. For 10,532 persons aged greater than or equal to 5 yr who participated in a 1975-1978 medical survey, serum was stored at -20 degrees C. For the 84 of 106 subjects aged 37-87 yr who died of CVD after the baseline exam, 168 cohort members alive at the end of 1983 and matched for age and gender were selected as controls. No significant associations between serum selenium. vitamin A, vitamin E, and CVD mortality were observed before and after multivariate analyses. The adjusted risk of death from CVD for subjects in the lowest selenium quintile (less than 105.0 micrograms/L) was 1.6 (95% CI, 0.8-3.2). For coronary and stroke death risk, estimates were 1.1 (95% CI, 0.5-2.6) and 3.2 (95% CI, 0.8-12.1). Our findings do not show a clear CVD risk from low selenium and vitamin levels. Although some of the risk estimates were strong, larger studies are required for definitive conclusions.


Asunto(s)
Enfermedades Cardiovasculares/mortalidad , Selenio/sangre , Vitamina A/sangre , Vitamina E/sangre , Adulto , Anciano , Anciano de 80 o más Años , Antioxidantes/sangre , Enfermedades Cardiovasculares/sangre , Femenino , Humanos , Masculino , Persona de Mediana Edad , Países Bajos , Estudios Prospectivos , Riesgo
7.
Am J Epidemiol ; 125(1): 12-6, 1987 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-3788940

RESUMEN

The association of serum selenium with the subsequent risk of death from cancer was investigated in a case-control study that was nested in a prospective nine-year follow-up study in the Netherlands. In 1975-1978, 10,532 persons in the Dutch town of Zoetermeer who were aged five years or more participated in a medical survey. Serum samples were collected and stored at -20 C. For the 82 persons who died of cancer since the baseline examination, 164 cohort members still alive by the end of 1983 were selected as controls and matched for age, sex, and smoking. Cancer deaths that occurred in the first year of follow-up were excluded, leaving 69 cases for statistical analyses. The mean serum selenium level of 116.7 +/- 4.0 micrograms/liter among male cancer deaths (n = 40) was significantly different (p = 0.04) from that in the control subjects (126.4 +/- 3.1 micrograms/liter). In females, selenium levels were similar among cases and controls. The adjusted risk of death from cancer for men in the lowest quintile of serum selenium (below 100.8 micrograms/liter) was more than twice that of subjects with higher levels (relative risk = 2.7,90% confidence interval = 1.2-6.2). These data support recent findings of an increased cancer risk associated with low serum selenium levels in men but not in women.


Asunto(s)
Neoplasias/sangre , Selenio/sangre , Métodos Epidemiológicos , Femenino , Humanos , Estudios Longitudinales , Masculino , Neoplasias/mortalidad , Factores Sexuales
8.
Prev Med ; 14(2): 169-80, 1985 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-4048079

RESUMEN

Serum total cholesterol and its putative determinants were measured in 5,089 subjects, ages 5-30 years, comprising 76% of the total population of two districts of the Dutch town of Zoetermeer. From this group, 596 subjects, ages 5-19 years, were randomly selected, and distributions and determinants of high-density lipoprotein (HDL) cholesterol were studied in 458 of them. The variables studied included body weight; Quetelet index; menarche; parental cholesterol; physical activity; consumption of coffee, alcohol, and tobacco; and use of oral contraceptives. Mean total cholesterol levels showed a decrease in both boys and girls between the ages of 10 and 16 years. Mean HDL cholesterol levels remained the same until the age of 17, after which they showed an increase for females and a decrease for males. Total cholesterol was associated with age, body weight (in those older than 15 years), and parental cholesterol concentrations. For HDL cholesterol, the most important determinants were gender, age, and body weight (the latter only for males 15 years and older). These findings suggest that during growth and maturation the determinants of serum cholesterol differ from those later on in life.


Asunto(s)
HDL-Colesterol/sangre , Colesterol/sangre , Adolescente , Adulto , Factores de Edad , Consumo de Bebidas Alcohólicas , Constitución Corporal , Niño , Preescolar , Café , Anticonceptivos Orales/efectos adversos , Femenino , Humanos , Masculino , Países Bajos , Esfuerzo Físico , Factores Sexuales , Fumar
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