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Métodos Terapéuticos y Terapias MTCI
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Int Immunopharmacol ; 90: 107242, 2021 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-33307514

RESUMEN

Colonic patches, the counterparts of Peyer's patches in the small intestine, are dynamically regulated lymphoid tissues in the colon that have an important role in defensing against microbial infections. Berberine is an isoquinoline alkaloid extracted from medicinal herbs including Rhizoma coptidis and has long been used for the treatment of infectious gastroenteritis, but its impact on the colonic lymphoid tissues (such as colonic patches) is unknown. In this study, we aimed to investigate whether berberine had any influences on the colonic patches in mice with bacterial infection. The results showed that oral berberine administration in bacterial infected mice substantially enhanced the hypertrophy of colonic patches, which usually possessed the features of two large B-cell follicles with a separate T-cell area. Moreover, the colonic patches displayed follicular dendritic cell networks within the B-cell follicles, indicative of mature colonic patches containing germinal centers. Concomitant with enlarged colonic patches, the cultured colon of infected mice treated with berberine secreted significantly higher levels of interleukin-1ß (IL-1ß), IL-6, TNF-α, and CCL-2, while NLRP3 inhibitor MMC950 or knockout of NLRP3 gene abrogated berberine-induced hypertrophy of colonic patches, suggesting the involvement of the NLRP3 signaling pathway in this process. Functionally, oral administration of berberine ameliorated liver inflammation and improved formed feces in the colon. Altogether, these results indicated that berberine was able to augment the hypertrophy of colonic patches in mice with bacterial infection probably through enhancing local inflammatory responses in the colon.


Asunto(s)
Infecciones Bacterianas/patología , Berberina/uso terapéutico , Colon/efectos de los fármacos , Tejido Linfoide/efectos de los fármacos , Enfermedades Peritoneales/patología , Animales , Linfocitos B/efectos de los fármacos , Infecciones Bacterianas/tratamiento farmacológico , Infecciones Bacterianas/metabolismo , Colon/crecimiento & desarrollo , Colon/patología , Citocinas/metabolismo , Células Dendríticas/efectos de los fármacos , Femenino , Gastroenteritis/tratamiento farmacológico , Tejido Linfoide/crecimiento & desarrollo , Tejido Linfoide/patología , Ratones , Ratones Endogámicos C57BL , Ratones Noqueados , Proteína con Dominio Pirina 3 de la Familia NLR/antagonistas & inhibidores , Proteína con Dominio Pirina 3 de la Familia NLR/genética , Enfermedades Peritoneales/tratamiento farmacológico , Enfermedades Peritoneales/metabolismo , Linfocitos T/efectos de los fármacos
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