Effects of Pilates method on quality of life, fatigue and sleep quality among breast cancer women receiving hormone therapy - Two-arm randomized clinical trial.

OBJECTIVE: To analyze the effect of the Pilates method on the quality of life, fatigue, and sleep quality of patients undergoing adjuvant clinical treatment with hormone therapy for breast cancer. METHODS: A randomized two-arm clinical trial with 34 breast cancer women that were randomized into two groups: a) Intervention group, who performed 16 weeks of mat Pilates; b) Control group, who maintained their daily routine activities and received three educational sessions. The questionnaires for each variable were applied before the intervention, after the intervention, and six months after the end of the intervention. Quality of life was assessed by The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQ-C30), fatigue by the Functional Assessment of Cancer Therapy-Fatigue (FACT-F), and sleep quality by the Pittsburgh Sleep Quality Index. RESULTS: The fatigue variable presented a time effect (p = 0.034) regardless of the analyzed group, in which a difference was found between baseline and the post-intervention period (p = 0.037). The variable sleep showed an effect of time (p = 0.025), presenting a difference between the baseline period and six months, with improvement for all participants (p = 0.004). Global health also showed a positive change also for all participants, with an isolated effect of time (p = 0.024). CONCLUSION: Interventions based on the Pilates method may bring positive results in quality of life, fatigue, and sleep quality in patients undergoing adjuvant treatment for breast cancer, but further studies on the subject are needed to prove the results in a larger number of patients.

Curative potential of Populus ciliata Wall ex. Royle extract against adjuvant-induced arthritis and peripheral neuropathy in Wistar rats.

Populus ciliata (PCCR) is traditionally used to treat muscular swelling, inflammation, pain, and fever. The current study was designed to validate the potential of aqueous ethanolic extract of the plant against inflammation, peripheral neuropathy, and pain in arthritic rats. The PCCR was chemically characterized by gas chromatography-mass spectroscopy and high-performance liquid chromatography. In vitro antioxidant, and in vitro anti-inflammatory assays were carried out on PCCR. For anti-arthritic potential, Wistar rats' rear paws were injected with 0.1 ml Complete Freund's Adjuvant using methotrexate (3 mg/kg/week) as standard control. PCCR at 100, 200, and 400 mg/kg was given orally to arthritic rats for 21 days. The PCCR exhibited significant inhibition of bovine serum albumin denaturation (IC-50: 202.1 µg/ml), egg albumin denaturation (IC-50:553.5 mg/ml) and RBC membrane stabilization (IC-50: 122.5 µg/ml) and antioxidant (IC-50 = 49.43 µg/ml) activities. The PCCR notably decreased the paw diameter and increased body weight of treated arthritic animals as equated to diseased control. The treatment notably (p < 0.05-0.0001) decreased malondialdehyde, and increased superoxide dismutase, reduced glutathione, and catalase in the liver and sciatic nerve homogenate in compared to diseased rats. The PCCR treatment remarkably (p < 0.05-0.0001) regulated the levels of nor-adrenaline and serotonin in sciatic nerve in contrast to diseased rats. Treatment with PCCR improved the motor activity, pain, ligament degeneration, and synovial hyperplasia in arthritic rats. Moreover, PCCR significantly (p < 0.01-0.0001) decreased the IL-6 and TNF-α. It is evident from the current study that PCCR had ameliorated polyarthritis and peripheral neuropathy through reduction of inflammatory markers, and improvement of oxidative stress might be due to presence of phenolic acids, flavonoids, phytosterols, and other fatty acids.

Changes in sensorimotor cortex oscillatory activity by orexin-A in the ventrolateral preoptic area of the hypothalamus reflect increased muscle tone.

Orexin-A (OXA) is a hypothalamic neuropeptide implicated in the regulation of wakefulness, appetite, reward processing, muscle tone, motor activity, and other physiological processes. The broad range of systems affected stems from the widespread projections of orexin neurons toward multiple brain regions regulating numerous physiological processes. Orexin neurons integrate nutritional, energetic, and behavioral cues and modulate the functions of target structures. Orexin promotes spontaneous physical activity (SPA), and we recently showed that orexin injected into the ventrolateral preoptic area (VLPO) of the hypothalamus increases behavioral arousal and SPA in rats. However, the specific mechanisms underlying the role of orexin in physical activity are unknown. Here we tested the hypothesis that OXA injected into the VLPO alters the oscillatory activity in the electroencephalogram (EEG) to reflect an increased excitability of the sensorimotor cortex, which may explain the associated increase in SPA. The results showed that OXA increased wakefulness following injections into the VLPO. In addition, OXA altered the power spectrum of the EEG during the awake state by decreasing the power of 5-19 Hz oscillations and increasing the power of >35 Hz oscillations, which are markers of increased sensorimotor excitability. Consistently, we found that OXA induced greater muscle activity. Furthermore, we found a similar change in power spectrum during slow-wave sleep, which suggests that OXA altered the EEG activity in a fundamental way, even in the absence of physical activity. These results support the idea that OXA increases the excitability of the sensorimotor system, which may explain the corresponding increase in awake time, muscle tone, and SPA.

Dance therapy and free dance with a focus on the psychological aspects of patients in adjuvant treatment of breast cancer - study protocol for randomized clinical trial

Abstract Aim: To propose a dance therapy and free dance protocol for women undergoing adjuvant treatment of breast cancer and to compare its effectiveness with the control group and the healthy group. Method: Protocol for a 12-week randomized clinical trial with a frequency of 2 times at progressive intensity, in which the participants will be allocated into 4 groups: (a) dance therapy intervention; (b) free dance intervention; (c) control group and (d) healthy group. Information related to personal and clinical characteristics as well as psychological aspects will be collected. The primary outcome will be analyzed through depressive symptoms while secondary outcomes include the variables: body image, anxiety, mood, perceived stress, and optimism. Assessments will be carried out in the pre-intervention period (baseline) and after 12 weeks of intervention in all groups. Discussion: As a hypothesis, there are improvements in psychological aspects after dance therapy interventions and free dance, reaching the level of healthy women, given the benefits of that protocol.

Rehabilitación propioceptiva del síndrome de hombro doloroso / Proprioceptive rehabilitation of painful shoulder syndrome / Reabilitação proprioceptiva da síndrome do ombro doloroso

El hombro es una de las regiones anatómicas de mayor movilidad en la vida cotidiana, siendo una de las causas de consulta más frecuentes en el área de fisioterapia para su rehabilitación, pues la primera línea de acción es el tratamiento conservador del hombro; por ello, es de suma importancia conocer y evaluar el complejo articular del hombro, así como también de la región cervicotorácica, con los resultados de la valoración establecer una estrategia de tratamiento que pueden ir desde la terapia manual, el masaje terapéutico, cambios de temperatura hasta el empleo de otros agentes físicos. Paciente femenino de 42 años, con ocupación de asistente odontológica; no reporta discapacidad previa. Como antecedente médico se presenta accidente de tránsito en motocicleta sin producir fractura de hueso ni luxación, ocurrido ocho años antes de la consulta en fisiatría, la paciente tiene afectado el desarrollo de las actividades de la vida cotidiana. Recibió serie de tratamientos durante 10 sesiones, en las cuales se aplican agentes físicos, dado que anteriormente recibió tratamiento farmacológico sin resultados favorables. Se aplica protocolo de rehabilitación fundamentado en las técnicas de propiocepción y al finalizar la terapia la paciente reporta dolor leve, y mejora en la realización de actividades de la vida diaria.

The shoulder is one of the anatomical regions of greater mobility in daily life, being one of the most frequent causes of consultation in the area of physiotherapy for rehabilitation, since the first line of action is the conservative treatment of the shoulder; therefore, it is of utmost importance to know and evaluate the articular complex of the shoulder, as well as the cervicothoracic region, with the results of the assessment to establish a treatment strategy that can range from manual therapy, therapeutic massage, temperature changes to the use of other physical agents. Female patient, 42 years old, with occupation as a dental assistant; she reports no previous disability. As medical history, she had a traffic accident on a motorcycle without bone fracture or dislocation, which occurred eight years before the physiatry consultation, the patient has affected the development of activities of daily living. She received a series of treatments during 10 sessions, in which physical agents are applied, since she had previously received pharmacological treatment without favorable results. Rehabilitation protocol based on proprioception techniques is applied and at the end of therapy the patient reports mild pain and improvement in the performance of activities of daily living.

O ombro é uma das regiões anatômicas de maior mobilidade na vida diária, sendo uma das causas mais freqüentes de consulta na área de fisioterapia para reabilitação, pois a primeira linha de ação é o tratamento conservador do ombro; portanto, é extremamente importante conhecer e avaliar o complexo articular do ombro, bem como a região cervicotorácica, com os resultados da avaliação para estabelecer uma estratégia de tratamento que pode variar desde a terapia manual, massagem terapêutica, mudanças de temperatura até o uso de outros agentes físicos. Paciente do sexo feminino, 42 anos de idade, trabalhando como assistente odontológica; nenhuma deficiência anterior foi relatada. O histórico médico inclui um acidente de trânsito em uma motocicleta sem fratura ou deslocamento ósseo, que ocorreu oito anos antes da consulta ao fisiatra; as atividades de vida diária do paciente são afetadas. Ela recebeu uma série de tratamentos durante 10 sessões, nas quais foram aplicados agentes físicos, já que ela havia recebido anteriormente tratamento farmacológico sem resultados favoráveis. Um protocolo de reabilitação baseado em técnicas de propriocepção foi aplicado e ao final da terapia o paciente relatou dor leve e melhora no desempenho das atividades da vida diária.

Conductas alimentarias y actividad física asociadas a estrés, ansiedad y depresión durante la pandemia COVID-19 / Eating Behaviors and Physical Activity Associated With Stress, Anxiety, and Depression During the COVID-19 Pandemic

Resumen Introducción. Como medida preventiva para limitar el contagio ante la pandemia por COVID-19, se implementó el confinamiento. Este evento limitó la disponibilidad de alimentos y favoreció el consumo de alimentos procesados y no perecederos, menos saludables; estas conductas que se pueden ver relacionadas con trastornos de la salud mental como estrés, ansiedad y depresión. Métodos. Estudio cuantitativo, descriptivo, transversal, con muestreo no probabilístico por conveniencia realizado entre agosto-octubre, 2020, con una participación de 1657 personas latinoamericanas de población general. Se aplicó el cuestionario Depression, Anxiety and Stress Scales-21 y el de conductas alimentarias asociadas a estrés, ansiedad y depresión-17. Se empleó regresión logística ordinal para valorar la asociación entre variables. Resultados. El 62 % presentó algún grado de depresión, 55.9 % ansiedad y 55.2 % estrés. Se encontró asociación entre estrés con actividad física (p 0.048), consumo de pescado (p 0.041), agua (p 0.003), panes/postres (p 0.005), comidas rápidas (p <0.001), bebidas azucaradas (p 0.035), té e infusiones (p 0.023) y cacao y sus derivados (p 0.018). Ansiedad con actividad física (p 0.006), ingesta de verduras (p 0.022), pescado (p 0.031), aceites (p 0.008), panes/postres (p 0.026), comidas rápidas (p <0.001), té e infusiones (p 0.018), cacao y derivados (p 0.038) y suplementos vitamínicos (p 0.016). Depresión con la actividad física (p 0.037), consumo de frutas (p 0.012), agua (p 0.012), café (p 0.045), panes/postres (p 0.003), comidas rápidas (p <0.001). Conclusiones. Se encontró asociación entre el consumo de ciertos alimentos y los elevados niveles de estrés, ansiedad y depresión.

Abstract Introduction. Confinement was implemented as a preventive measure to limit contagion in the face of the COVID-19 pandemic. This measure limited food availability and favored the consumption of less healthy processed and non-perishable foods. These behaviors can be seen as related to mental health disorders, such as stress, anxiety, and depression. Methods. It is a quantitative, descriptive, cross-sectional study with non-probabilistic convenience sampling carried out between August-October 2020, with the participation of 1657 Latin American people from the general population. The Depression, Anxiety and Stress Scales-21 questionnaire and the eating behaviors questionnaire associated with stress, anxiety, and depression-17 were applied. Ordinal logistic regression was used to assess the association between variables. Results. The 62% of participants presented some degree of depression; 55.9%, anxiety; and 55.2%, stress. An association was found between stress with physical activity (p 0.048) and consumption of fish (p 0.041), water (p 0.003), breads / desserts (p 0.005), fast foods (p <0.001), sugary drinks (p 0.035), tea and infusions (p 0.023), and cocoa and its derivatives (p 0.018). Another association was also found between anxiety with physical activity (p 0.006) and intake of vegetables (p 0.022), fish (p 0.031), oils (p 0.008), breads / desserts (p 0.026), fast foods (p <0.001), tea and infusions (p 0.018), cocoa and derivatives (p 0.038), and vitamin supplements (p 0.016). Depression was also found as associated with physical activity (p 0.037) and consumption of fruits (p 0.012), water (p 0.012), coffee (p 0.045), breads / desserts (p 0.003), and fast foods (p <0.001). Conclusions. An association was found between consuming certain foods and high levels of stress, anxiety, and depression.

Resumo Introdução. Como medida preventiva para limitar o contágio em face da pandemia COVID-19, o confinamento foi implementado. Esse evento limitou a disponibilidade de alimentos e favoreceu o consumo de alimentos industrializados menos saudáveis e não perecíveis, comportamentos que podem ser vistos relacionados a transtornos mentais como estresse, ansiedade e depressão. Métodos. Estudo quantitativo, descritivo, transversal, com amostragem não probabilística por conveniência, realizado no período de agosto a outubro de 2020 com a participação de 1.657 latino-americanos da população geral. Foram aplicados o questionário Depression, Anxiety and Stress Scales-21 e o questionário de comportamentos alimentares associados ao estresse, ansiedade e depressão-17. A regressão logística ordinal foi utilizada para avaliar a associação entre as variáveis. Resultados. 62% apresentavam algum grau de depressão, 55,9% ansiedade e 55,2% estresse. Foi encontrada associação entre estresse com atividade física (p 0,048), consumo de peixe (p 0,041), água (p 0,003), pães / sobremesas (p 0,005), fast food (p <0,001), bebidas açucaradas (p 0,035), chá e infusões (p 0,023) e cacau e seus derivados (p 0,018); ansiedade com atividade física (p 0,006), ingestão de vegetais (p 0,022), peixes (p 0,031), óleos (p 0,008), pães / sobremesas (p 0,026), fast food (p <0,001), chá e infusões (p 0,018), cacau e derivados (p 0,038) e suplementos vitamínicos (p 0,016); depressão com atividade física (p 0,037), consumo de frutas (p 0,012), água (p 0,012), café (p 0,045), pães / sobremesas (p 0,003), fast food (p <0,001). Conclusões. Foi encontrada associação entre o consumo de determinados alimentos e altos níveis de estresse, ansiedade e depressão.

Multicomponent exercise training is effective in improving health and behavior indicators in Brazilian elderly women: A non-randomized trial.

OBJECTIVE: The aim was to evaluate the effects of a supervised 12-week Multicomponent exercise training on elderly women health and behavior indicators. METHODS: Anthropometric characteristics and body composition, functional capacity, sedentary behavior, physical activity level and biochemical profile were evaluated in the control group (67.2 ± 5.2 years, n = 14) and in the experimental group (67.4 ± 6.1 years, n = 41). The experimental group were composed by 41 elderly women who performed 12 weeks of Multicomponent exercise training involving strength, aerobic, flexibility and balance exercises. The inclusion criteria for the study were women aged 60 years or more and presentation of a medical certificate authorizing the practice of physical exercise. RESULTS: Maintenance of anthropometric characteristics and body composition was observed in both groups (p > 0.05). There was an improvement in aerobic capacity, lower and upper limb strength in the experimental group (p < 0.01), while the control group showed a reduction in aerobic capacity, lower limb strength, agility and dynamic balance (p < 0.01), as shown in Fi.gure 3. There was a reduction in sedentary behavior and an increase in physical activity level in experimental group (p < 0.05), but not in control group. Experimental group showed an improvement in glucose levels and lipid profile (p < 0.01). CONCLUSION: Multicomponent exercise training was efficient to improve health and behavior indicators of the elderly women.

Efeitos do uso de vestes terapêuticas em programas de reabilitação de crianças com paralisia cerebral: uma revisão integrativa da literatura / Effects of suit therapy rehabilitation programs of children with cerebral palsy: an integrative literature review

A Paralisia Cerebral (PC) engloba um grupo de desordens do movimento e da postura resultantes de uma lesão não progressiva no sistema nervoso. Diversas abordagens fisioterapêuticas vêm sendo propostas para o tratamento de indivíduos com PC, dentre elas o uso de vestes terapêuticas. Sendo assim, a presente revisão teve como objetivo avaliar os efeitos das vestes terapêuticas na reabilitação de crianças com PC, destacando seus benefícios e possíveis limitações. Tratou-se de uma revisão integrativa da literatura realizada nas bases SciELO, Lilacs, Pubmed, Science Direct e PEDro, por meio do descritor "Paralisia Cerebral" e das palavras-chave "AdeliSuit", "PediaSuit", "TheraSuit". Após o levantamento bibliográfico, foram selecionados 11 estudos envolvendo crianças com idade entre um e 15 anos, os quais descreveram o uso das vestes terapêuticas AdeliSuit, TheraSuit e PediaSuit. Todos os estudos apresentaram efeitos favoráveis ao uso das vestes para função motora das crianças avaliadas. Também houveram relatos de melhora na funcionalidade, velocidade e qualidade da marcha e equilíbrio. Apenas quatro estudos compararam programas de reabilitação envolvendo vestes terapêuticas e outras abordagens, os quais apresentaram resultados controversos. Os achados demonstraram resultados favoráveis ao uso das vestes terapêuticas em indivíduos com diagnóstico de PC, apesar de poucas evidências quanto a sua superioridade sobre outras abordagens. (AU)

Cerebral Palsy (CP) is a group of movement and posture disorders resulting from nervous system non-progressive injury. Several physiotherapy approaches have been proposed to individuals with CP treatment, including the use of therapeutic suits. Thus, the present review aimed to assess the effects of therapeutic suits on children with CP rehabilitation, highlighting their benefits and possible limitations. It was an integrative literature review carried out on SciELO, Lilacs, Pubmed, Science Direct and PEDro databases, using tdescriptor "Cerebral Palsy" and keywords "AdeliSuit", "PediaSuit", "TheraSuit". After bibliographic search, 11 studies were selected involving children aged between one and 15 years old, which described the use of therapeutic suits: AdeliSuit, TheraSuit and PediaSuit. All studies showed positive effects therapeutic suits use during rehabilitation for motor function. Improvements in functionality, speed and quality of gait and balance were also reported. Only four studies compared rehabilitation programs involving therapeutic suits and other therapeutic approaches, which showed controversial results. Those findings demonstrated favorable results for the use of therapeutic suits during rehabilitation programs in individuals with CP, despite little evidence regarding their superiority over other approaches. (AU)

Effect of music therapy on motor function recovery in patients with stroke / 国际脑血管病杂志

As a new therapeutic method, music therapy has a good clinical effect on improving the motor dysfunction of patients with stroke. This article reviews the concept, main forms of music therapy and its role in motor function recovery of patients with stroke.

Personalized protocol and scoring scale for functional electrical stimulation of the hand: A pilot feasibility study.

BACKGROUND: Complex personalized Functional Electrical Stimulation (FES) protocols for calibrating parameters and electrode positioning have been proposed, most being time-consuming or technically cumbersome for clinical settings. Therefore, there is a need for new personalized FES protocols that generate comfortable, functional hand movements, while being feasible for clinical translation. OBJECTIVE: To develop a personalized FES protocol, comprising electrode placement and parameter selection, to generate hand opening (HO), power grasp (PW) and precision grip (PG) movements, and compare in a pilot feasibility study its performance to a non-personalized protocol based on standard FES guidelines. METHODS: Two FES protocols, one personalized (P1) and one non-personalized (P2), were used to produce hand movements in twenty-three healthy participants. FES-induced movements were assessed with a new scoring scale which comprises items for selectivity, functionality, and comfort. RESULTS: Higher FES-HSS scores were obtained with P1 for all movements: HO (p= 0.00013), PW (p= 0.00007), PG (p= 0.00460). Electrode placement time was significantly shorter for P2 (p= 0.00003). Comfort scores were similar for both protocols. CONCLUSIONS: The personalized protocol for electrode placement and parameter selection enabled functional FES-induced hand movements and presented advantages over a non-personalized protocol. This protocol warrants further investigation to confirm its suitability for developing upper-limb rehabilitation interventions with clinical translational potential.

Karate Training Improves Metabolic Health in Overweight and Obese Adolescents: A Randomized Clinical Trial.

PURPOSE: This study evaluated the effects of 12 weeks of karate training on cardiometabolic parameters, oxidative stress, and inflammation in adolescents with overweight and obesity. METHOD: Seventy adolescents were randomized into 2 groups: control received nutritional and psychological interventions once a week for 12 weeks, and treatment received nutritional and psychological interventions once a week, plus 3 karate sessions per week, for 12 weeks. The main outcome measure was improvement in cardiometabolic parameters, oxidative stress, and inflammation. RESULTS: After the intervention period, the treatment group showed a reduction in resting heart rate (77.86 [10.89]), high-density lipoprotein cholesterol (40.86 [8.31]), and triglycerides (75.18 [32.29]) and an increase in low-density lipoprotein cholesterol (95.64 [42.53]) in relation to pretraining. Regarding oxidative stress markers, there was a reduction in protein carbonylation (0.07 [0.06]) and nitric oxide (1.39 [1.11]) and an increase in superoxide dismutase (0.68 [0.31]) and glutathione (0.11 [0.08]) compared with pretraining. With respect to inflammation, adiponectin increased (14.54 [5.36]) after the intervention when compared with preintervention. CONCLUSION: The study concluded that the intervention may improve cardiometabolic parameters, oxidative stress, and inflammation in adolescents with overweight and obesity. Long-term effects need to be evaluated.

Can belly dance and mat Pilates be effective for range of motion, self-esteem, and depressive symptoms of breast cancer women?

OBJECTIVE: This study aims to analyse the effect of an intervention with belly dance or mat Pilates on range of motion, self-esteem and depressive symptoms in women with breast cancer receiving hormone therapy. METHOD: A randomized clinical trial of 52 participants, diagnosed with breast cancer and undergoing adjuvant hormone therapy that were randomized and divided into three groups (1): Belly dance group, which received 16 weeks of Belly Dance classes 2) Mat Pilates group, that performed 16 weeks of Pilates intervention and (3) Control group, that received educational activities in the form of lectures and was invited to maintain its routine activities. The participants answered a questionnaire in which they contained the clinical and personal characteristics; quantification of the range of motion of the upper limbs using the Absolute Axis 360° digital goniometer; self-esteem by the Self-Esteem Scale (EAR) and depressive symptoms by the Beck Depression Inventory (BDI). All data was collected at two moments in the study, in the pre-intervention period (baseline) and at the end of the 16 weeks of intervention. RESULTS: Only the variable range of motion variable showed significant results in all study groups (p = 0.025), with the Mat Pilates group having the best scores. Although not significant, the other study variables also improved after the intervention period. CONCLUSION: Belly dance and the Mat Pilates can bring positive results in the range of movement of women undergoing adjuvant treatment of breast cancer, with the Pilates method being the one that most contributed to improvements in this variable.

Characteristics Associated With People With Chronic Low Back Pain Meeting Physical Activity Guidelines and Recommendations for Sedentary Behavior: A Cross-Sectional Study.

OBJECTIVE: The purpose of this study was to identify factors associated with meeting physical activity guidelines and sedentary recommendations in people with chronic low back pain (LBP). METHODS: This was a cross-sectional study including 171 people with chronic LBP. Trained assessors collected information regarding demographic, anthropometric, and clinical data. Physical activity levels and sedentary time were objectively measured using a tri-axial accelerometer. Participants were classified as being physically active (ie, performing at least 150 minutes of moderate or 75 minutes of vigorous physical activity per week) and sedentary (ie, more than 8 hours of time spent in sedentary activities per day). Multivariable logistic regression analyses were used to determine the association of being physically active or sedentary with the range of demographic, anthropometric and clinical variables. RESULTS: Our results showed that although lower body mass index (odds ratio [OR] = 0.91; 95% CI: 0.85-0.98) and higher self-reported levels of leisure time physical activity (OR = 3.46; 95% CI: 1.94-6.15) were associated with being physically active, lower self-reported levels of physical activity at work (OR = 0.56; 95% CI: 0.39-0.81) was associated with being sedentary. CONCLUSION: Our findings showed that, in people with LBP, lower body mass index and higher levels of leisure time physical activity may be important factors for identifying those physically active. In contrast, lower levels of physical activity at work may be considered when identifying sedentary people with LBP. Future studies should consider these factors when designing interventions aiming to promote physical activity and decrease sedentary behavior in this population.

As possibilidades do espaço urbano para as práticas de atividades físicas: a Academia a Céu Aberto de Belo Horizonte, Minas Gerais / The possibilities of urban space for physical activities practices: the Open Sky Academy of Belo Horizonte, Minas Gerais

Objetivo: analisar a Academia a Céu Aberto (AaCA) sob a perspectiva dos seus frequentadores. Metodologia: estudo de abordagem qualitativa, a partir de entrevistas subsidiadas por roteiro semiestruturado com questões versando sobre: o espaço para a prática de atividades físicas, as condições e o estilo de vida. Foram entrevistados 18 frequentadores de uma AaCA no município de Belo Horizonte. O material empírico foi integralmente transcrito e a discussão se deu sob orientação da Análise Crítica do Discurso de Fairclough, buscando a compreensão entre texto, prática discursiva e prática social. Resultados e discussão: a mudança da paisagem urbana com a implantação da AaCA é percebida pelos participantes como uma iniciativa boa e aprazível. Os frequentadores reconhecem que o uso do espaço público para a instalação de aparelhagem de academia concretiza-se como uma alternativa ao sedentarismo para aqueles que não podem pagar por uma academia de ginástica privada. Conclusão: os participantes indicam que a AaCA é um espaço favorável à prática de atividades físicas na cidade. O estudo evidencia que a interferência municipal por intermédio da AaCA exerce um papel importante no estímulo à adoção do estilo de vida ativo.

Objective: to investigate the Open Sky Academies (public academy) as spaces for physical activities practices from its visitors perspective. Methodology: a qualitative study, held from interviews based on the space for physical activities practice, life conditions and lifestyle. 18 visitors of an academy located at Belo Horizonte were interviewed. The empirical material was fully transcribed and the discussion was guided by Fairclough's Critical Discourse Analysis seeking to understand text, discursive practice and social practice. Results and discussion: the change in the urban landscape with the implementation of a public academy is perceived by the participants as a good and pleasant initiative. The visitors recognize that the use of the public space for the installation of gym equipment becomes an alternative to a sedentary lifestyle for those who cannot afford a private gym. Conclusion: the participants indicate that the public academy is a favorable space for the practice of physical activities in the city. The study shows that the municipal interference through the public academy plays an important role in stimulating the adoption of an active lifestyle.

The influence of 12-week dance intervention on sleep quality and pain among women with breast cancer - Pilot study of a non-randomized clinical trial.

BACKGROUND: Analyze the effects of a 12-week dance intervention on the sleep quality and the level of pain among women with breast cancer. METHODS: Non-randomized clinical trial including 21 breast cancer survivors allocated in intervention group (n = 11) or control group (n = 10). Intervention group received a 12-week mix dance intervention and the control group maintained their routine activities. Data collection was realized through the application of a questionnaire before and after 12 weeks, involving pain (VAS) and sleep quality (Pittsburgh Sleep Quality Index). The Two-way ANOVA with repeated measures and Sidák correction, and multiple linear regression was used. RESULTS: No significant effects were found on sleep quality and pain after the 12-week intervention with a mix dance protocol. Also, no significant difference was found between intervention and control group during post-intervention. The multiple linear regression analysis, controlled by stage of treatment, did not present a significant relationship between sleep quality and pain. Additionally, some spontaneous reports provided by the participants demonstrated a subjective improvement in their social life and general well-being. CONCLUSION: The 12-week mix dance intervention did not seem to directly influence the sleep quality and pain of breast cancer survivors in this study; however, no adverse events were reported. Perhaps, a dance protocol focusing only in one modality of dance may be more effective for breast cancer survivors on sleep quality and pain.

Impact of Acute and Persistent Excitation of Prelimbic Pyramidal Neurons on Motor Activity and Trace Fear Learning.

Drug-induced neuroadaptations in the mPFC have been implicated in addictive behaviors. Repeated cocaine exposure has been shown to increase pyramidal neuron excitability in the prelimbic (PL) region of the mouse mPFC, an adaptation attributable to a suppression of G protein-gated inwardly rectifying K+ (GIRK) channel activity. After establishing that this neuroadaptation is not seen in adjacent GABA neurons, we used viral GIRK channel ablation and complementary chemogenetic approaches to selectively enhance PL pyramidal neuron excitability in adult mice, to evaluate the impact of this form of plasticity on PL-dependent behaviors. GIRK channel ablation decreased somatodendritic GABAB receptor-dependent signaling and rheobase in PL pyramidal neurons. This manipulation also enhanced the motor-stimulatory effect of cocaine but did not impact baseline activity or trace fear learning. In contrast, selective chemogenetic excitation of PL pyramidal neurons, or chemogenetic inhibition of PL GABA neurons, increased baseline and cocaine-induced activity and disrupted trace fear learning. These effects were mirrored in male mice by selective excitation of PL pyramidal neurons projecting to the VTA, but not NAc or BLA. Collectively, these data show that manipulations enhancing the excitability of PL pyramidal neurons, and specifically those projecting to the VTA, recapitulate behavioral hallmarks of repeated cocaine exposure in mice.SIGNIFICANCE STATEMENT Prolonged exposure to drugs of abuse triggers neuroadaptations that promote core features of addiction. Understanding these neuroadaptations and their implications may suggest interventions capable of preventing or treating addiction. While previous work showed that repeated cocaine exposure increased the excitability of pyramidal neurons in the prelimbic cortex (PL), the behavioral implications of this neuroadaptation remained unclear. Here, we used neuron-specific manipulations to evaluate the impact of increased PL pyramidal neuron excitability on PL-dependent behaviors. Acute or persistent excitation of PL pyramidal neurons potentiated cocaine-induced motor activity and disrupted trace fear conditioning, effects replicated by selective excitation of the PL projection to the VTA. Our work suggests that hyperexcitability of this projection drives key behavioral hallmarks of addiction.

Therapeutic Instrumental Music Training and Motor Imagery in Post-Stroke Upper-Extremity Rehabilitation: A Randomized-Controlled Pilot Study.

OBJECTIVE: To investigate the potential benefits of 3 therapeutic instrumental music performance (TIMP)-based interventions in rehabilitation of the affected upper-extremity (UE) for adults with chronic poststroke hemiparesis. DESIGN: Randomized-controlled pilot study. SETTING: University research facility. PARTICIPANTS: Community-dwelling volunteers (N=30; 16 men, 14 women; age range, 33-76 years; mean age, 55.9 years) began and completed the protocol. All participants had sustained a unilateral stroke more than 6 months before enrollment (mean time poststroke, 66.9 months). INTERVENTION: Two baseline assessments, a minimum of 1 week apart; 9 intervention sessions (3 times/week for 3 weeks), in which rhythmically cued, functional arm movements were mapped onto musical instruments; and 1 post-test following the final intervention. Participants were block-randomized to 1 of 3 conditions: group 1 (45 minutes TIMP), group 2 (30 minutes TIMP, 15 minutes metronome-cued motor imagery [TIMP+cMI]), and group 3 (30 minutes TIMP, 15 minutes motor imagery without cues [TIMP+MI]). Assessors and investigators were blinded to group assignment. MAIN OUTCOME MEASURES: Fugl-Meyer Upper-Extremity (FM-UE) and Wolf Motor Function Test- Functional Ability Scale (WMFT-FAS). Secondary measures were motor activity log (MAL)-amount of use scale and trunk impairment scale. RESULTS: All groups made statistically significant gains on the FM-UE (TIMP, P=.005, r=.63; TIMP+cMI, P=.007, r=.63; TIMP+MI, P=.007, r=.61) and the WMFT-FAS (TIMP, P=.024, r=.53; TIMP+cMI, P=.008, r=.60; TIMP+MI, P=.008, r=.63). Comparing between-group percent change differences, on the FM-UE, TIMP scored significantly higher than TIMP+cMI (P=.032, r=.57), but not TIMP+MI. There were no differences in improvement on WMFT-FAS across conditions. On the MAL, gains were significant for TIMP (P=.030, r=.54) and TIMP+MI (P=.007, r=.63). CONCLUSION: TIMP-based techniques, with and without MI, led to significant improvements in paretic arm control on primary outcomes. Replacing a physical training segment with imagery-based training resulted in similar improvements; however, synchronizing internal and external cues during auditory-cMI may pose additional sensorimotor integration challenges.

Does a Live Performance Impact Synchronization to Musical Rhythm in Cognitively Impaired Elderly?

BACKGROUND: Music-based interventions appear to be efficient approaches to improve emotional, social, and cognitive functioning of patients with neurodegenerative diseases. OBJECTIVE: Because benefits seem to increase with patient's motor involvement, we studied sensorimotor synchronization (SMS) abilities of patients with cognitive impairments (Alzheimer's disease, vascular and mixed dementia) and of patients with no evidence of cognitive impairments. More specifically, we compared the impact of a live performance by a musician to a video recording on SMS. METHODS: SMS to a metronomic or a musical stimulus was assessed while patients watched a live musician or his pre-recorded video. RESULTS: SMS to a metronome was better than to music but this effect was modulated by the social context. While SMS to a metronome was better when facing a video than a live performance, there was no impact of social context on SMS to music. No group differences of SMS were found. CONCLUSION: The decrease in SMS to a metronome in a live performance may be due to social pressure. Such a pressure might be removed in pleasant social activities, like moving with music in a group, explaining the lack of effect on SMS to music. We found no performance differences in groups, suggesting relatively spared SMS in cognitively impaired patients. By showing that it is possible to encourage patients to synchronize with others, even when facing a video, our results indicate that SMS can be used as a relevant predictor in clinical trials and open up promising therapeutic options for isolated patients.

The Pathopharmacological Interplay between Vanadium and Iron in Parkinson's Disease Models.

Parkinson's disease (PD) pathology is characterised by distinct types of cellular defects, notably associated with oxidative damage and mitochondria dysfunction, leading to the selective loss of dopaminergic neurons in the brain's substantia nigra pars compacta (SNpc). Exposure to some environmental toxicants and heavy metals has been associated with PD pathogenesis. Raised iron levels have also been consistently observed in the nigrostriatal pathway of PD cases. This study explored, for the first time, the effects of an exogenous environmental heavy metal (vanadium) and its interaction with iron, focusing on the subtoxic effects of these metals on PD-like oxidative stress phenotypes in Catecholaminergic a-differentiated (CAD) cells and PTEN-induced kinase 1 (PINK-1)B9Drosophila melanogaster models of PD. We found that undifferentiated CAD cells were more susceptible to vanadium exposure than differentiated cells, and this susceptibility was modulated by iron. In PINK-1 flies, the exposure to chronic low doses of vanadium exacerbated the existing motor deficits, reduced survival, and increased the production of reactive oxygen species (ROS). Both Aloysia citrodora Paláu, a natural iron chelator, and Deferoxamine Mesylate (DFO), a synthetic iron chelator, significantly protected against the PD-like phenotypes in both models. These results favour the case for iron-chelation therapy as a viable option for the symptomatic treatment of PD.

Condición física saludable y su relación con habilidades básicas para la independencia del adulto mayor / Healthy physical condition and its relationship with basic skills for the independence of the senior citizen / Condição física saúdavel e sua relação com habilidades básicas para a independência do idoso

Resumen Introducción: se estudia la relación entre la condición física saludable y algunas habilidades básicas para la independencia de las personas mayores del municipio de La Plata, Argentina, desde el año 2015 al 2018. Hipótesis: Las personas adultas mayores que tienen mejor condición física tienen mayor independencia para las actividades de la vida diaria básicas. Métodos: se aplicó el test de Barthel para medir las habilidades para la vida diaria en adultos mayores. Se midió la fuerza máxima de prensión con dinamómetro, y se tomaron las pruebas "velocidad de la marcha" y "time up and go", para evaluar condición física. Se calculó correlación, coeficiente de determinación. Resultados: 91 adultos mayores, 25 hombres, 64 mujeres. Edad: 74,81±9,38, peso: 69,99±19,09, talla: 155±13,06. A medida que aumentó la edad, la fuerza máxima disminuyó significativamente (r-0,40 R2 0,16, p<0,05). La fuerza muscular es significativamente mayor en personas que son independientes que en aquellas que tienen algún grado de dependencia (dependientes Fmax 17,47 kg ± 6,58 P<0,05 con IC 95% 14,1-20, 85 vs independientes Fmax 23,76 kg ± 6,3 P<0,05 con IC 95% 22,27-25,25). Conclusiones: la fuerza máxima de prensión de la mano está relacionada con la independencia para las actividades de la vida diaria. El componente de fuerza muscular puede ser relevante en programas de salud y calidad de vida en esta población.

Abstract Introduction: The relationship between healthy physical condition and some basic skills for the independence of the senior citizen in the Municipality of La Plata, Argentina, from 2015 to 2018 is studied. Hypothesis: senior citizens who are in better physical condition have greater independence for basic activities of daily living. Methods: the Barthel test was applied to measure daily living skills on senior citizens. The maximum grip strength was measured with dynamometer, and the "walking speed" and "time up and go" tests were applied to assess physical condition. Correlation, coefficient of determination was calculated. Results: A total of 91 senior citizens, 25 men, 64 women with an average age of 74.81 ± 9.38, average weight 69.99 ± 19.09, and average height 155 ± 13.06 were evaluated. As age increased, the maximum strength decreased significantly (r-0.40, R2 0.16, p <0.05). Maximum strength is significantly greater in people who are independent than in those who have some degree of dependence (dependent Fmax 17,47kg ± 6,58 with IC 95% 14,1-20,85 vs independent 23,76 kg ± 6,3 P <0.05 with IC 95% 22.27-25.25). Conclusions: the maximum grip strength of the hand is related to the independence for activities of daily living. The component of muscular strength may be relevant in health and quality of life programs in this population.

Resumo Introdução: A escola é um espaço privilegiado de promoção da saúde, em Colômbia se desenvolve a estratégia escola saudável como uma ferramenta integradora de políticas em saúde no âmbito escolar. Objetivo: o estudo busca avaliar a execução da estratégia escola saudável no contexto rural do município de Ibagué. Materiais e métodos: a avaliação da execução se realizou mediante a construção de um modelo lógico e a definição de critérios avaliativos em relação com os ambientes saudáveis, as políticas públicas e planos para a escola saudável, a participação social, o empoeiramento e a educação para a saúde. Avaliaram se um total de 93 escolas rurais, a informação foi levantada mediante questionários aos responsáveis das escolas e a través de entrevistas aos gestores de saúde. Resultados: se identificaram problemáticas sanitárias e ambientais nas escolas associadas às carências da ruralidade, falta de articulação do setor saúde e educação, baixa participação social, a educação enfocada à prevenção da doença. Conclusão: promover os entornos escolares saudáveis na ruralidade requer de um marco legal nacional e local que garante à atuação estadual, a intersetorial, a participação efetiva do setor educativo, a renovação da saúde e que promova interesses e vontades político, sociais e administrativas.