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Appl Biochem Biotechnol ; 194(1): 291-301, 2022 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-34988845

RESUMEN

Corona virus pandemic outbreak also known as COVID-19 has created an imbalance in this world. Scientists have adopted the use of natural or alternative medicines which are consumed mostly as dietary supplements to boost the immune system as herbal remedies. India is famous for traditional medicinal formulations which includes 'Trikadu'-a combination of three acrids, namely Zingiber officinale, Piper nigrum and Piper longum which have antioxidant properties that boost our immune system hence acting as a strong preventive measure. In this study, AutoDock 4.0 was used to study interaction between the phytocompounds of Trikadu with RNA-dependent polymerase protein and enveloped protein of the SARS-CoV-2 virus. Analysis of the results showed that coumarin, coumaperine and bisdemethoxycurcumin showed strong bonding interactions with both the proteins. We can conclude that Trikadu has the potential molecules; hence, it can be incorporated in the diet to boost the immune system as a preventive measure against the virus.


Asunto(s)
Tratamiento Farmacológico de COVID-19 , COVID-19/inmunología , Fitoterapia , Preparaciones de Plantas/uso terapéutico , SARS-CoV-2 , Antioxidantes/aislamiento & purificación , Antioxidantes/uso terapéutico , COVID-19/virología , Simulación por Computador , ARN Polimerasa Dependiente de ARN de Coronavirus/química , ARN Polimerasa Dependiente de ARN de Coronavirus/efectos de los fármacos , Suplementos Dietéticos , Zingiber officinale/química , Humanos , Sistema Inmunológico/efectos de los fármacos , India , Ligandos , Medicina Tradicional , Simulación del Acoplamiento Molecular , Fitoquímicos/química , Fitoquímicos/uso terapéutico , Piper/química , Piper nigrum/química , Preparaciones de Plantas/aislamiento & purificación , Plantas Medicinales/química , SARS-CoV-2/química , SARS-CoV-2/efectos de los fármacos , SARS-CoV-2/inmunología , Glicoproteína de la Espiga del Coronavirus/química , Glicoproteína de la Espiga del Coronavirus/efectos de los fármacos
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