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Colloids Surf B Biointerfaces ; 188: 110739, 2020 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-31901623

RESUMEN

This study aims to develop in situ microemulsion-gel (ME-Gel) obtained from hydroxypropyl methylcellulose (HPMC) films for transdermal administration of Zidovudine (AZT). Firstly, HPMC films containing propylene glycol (PG) and eucalyptus oil (EO) were obtained and characterized. Later, a pseudo-ternary phase diagram composed of water, EO, tween 80 and PG was obtained and one microemulsion (ME) with a similar proportion of the film components was obtained. ME was transformed in ME-Gel by the incorporation of HPMC. Finally, HPMC films were hydrated with Tween 80 solution to yield in situ ME-Gel and its effect on AZT skin permeation was compared with HPMC film hydrated with water (F5hyd). The results showed that the ME and ME-Gel presented a droplet size of 16.79 and 122.13 µm, respectively, polydispersity index (PDI) < 0.39 and pH between 5.10 and 5.40. The incorporation of HPMC resulted in viscosity about 2 times higher than the use of ME. The presence of AZT did not alter the formulation properties. The in situ ME-Gel promoted a two-fold increase in the permeated amount of AZT compared to F5hyd. The results suggest that it was possible to obtain an ME-Gel in situ from HPMC films and that its effect on transdermal permeation of AZT was significant.


Asunto(s)
Metilcelulosa/química , Profármacos/química , Zidovudina/química , Administración Cutánea , Animales , Emulsiones/administración & dosificación , Emulsiones/química , Emulsiones/metabolismo , Aceite de Eucalipto/administración & dosificación , Aceite de Eucalipto/química , Aceite de Eucalipto/metabolismo , Geles/administración & dosificación , Geles/química , Geles/metabolismo , Masculino , Metilcelulosa/administración & dosificación , Metilcelulosa/metabolismo , Tamaño de la Partícula , Profármacos/administración & dosificación , Profármacos/metabolismo , Propilenglicol/administración & dosificación , Propilenglicol/química , Propilenglicol/metabolismo , Ratas , Ratas Wistar , Piel/química , Piel/metabolismo , Absorción Cutánea , Propiedades de Superficie , Zidovudina/administración & dosificación , Zidovudina/metabolismo
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