[Resources and utilization of medicinal plants in countries and regions involved in "the Belt and Road" Initiative].

The protection, development, and utilization of medicinal plant resources are important cornerstones of maintaining human health. However, due to factors such as the reduction of high-quality land resources, deterioration of ecological environments, and excessive and disorderly resource development, medicinal plant resources are becoming scarce, and some of them are insufficiently supplied. With the proposal of "the Belt and Road" Initiative, the cooperation between China and "the Belt and Road" partners(the countries and regions involved in "the Belt and Road" Initiative)is increasingly close, which provides a new opportunity for carrying out trade of medicinal plant resources and alleviating the problem of imbalance and relative inadequacy of medicinal plant resources in countries. This study first determined the distribution and species information of plant resources in countries and regions involved in "the Belt and Road" Initiative by investigating the database of plant distribution and that of medicinal plant resources. Then, according to the published data from the International Union for Conservation of Nature(IUCN) and the Convention on International Trade in Endangered Species of Wild Fauna and Flora(CITES), this study identified the rare and endangered medicinal plants and the medicinal plants under trade control in countries and regions involved in "the Belt and Road" Initiative and finally sorted out the list of potential medicinal plant resources in countries and regions involved in "the Belt and Road" Initiative that can be used by China. This data resource can not only be used for the overall protection of important endangered species but also scientifically guide the development and utilization of medicinal resources, providing guidance and a theoretical basis for the sustainable development of medicinal plant resources in countries and regions involved in "the Belt and Road" Initiative.

Harmony in nature: understanding the cultural and ecological aspects of plant use in Ladakh.

BACKGROUND: Traditional knowledge (TK) in Ladakh encapsulates a repository of experimental wisdom cultivated over millennia. Despite this cultural wealth, dwindling interest among the younger generations in the region's age-old practices underscores the urgency to document TK. The current study investigates the diverse usage of plants in Surru, Wakha and Lower Indus valleys of Western Ladakh exploring the influence of socioeconomic and ecological factors. METHODS: A stratified random sample approach was adopted to select 540 respondents for gathering information of useful plants through interviews and questionnaires. Participant observation, questionnaires, open-ended and semi-structured interviews were conducted for data collection. Free listing was done to create an extensive list of plants and their uses. Ethnobotanical metrics such as relative frequency of citation (RFC), relative importance index (RI), cultural value (CV) index and cultural importance (CI) index were computed to assess species applicability. Additionally, one-way analysis of variance (ANOVA) was utilized to discern significant differences in knowledge levels based on valleys, gender, education and religion using TK as a response variable. RESULTS: Altogether, we recorded 246 plant species under various ethnobotanical uses from Western Ladakh. These include medicinal (126), fodder (124), wild ornamentals (86), food (81), fuel wood (54), dye (20), religious (31) and others (34). Novel plant reports include Berberis brandisiana Ahrendt and Dactylorhiza kafiriana Renz. The dominant plant family is Asteraceae with 35 species. Suru valley exhibits the highest number of cited plants followed by Wakha-chu and Lower Indus valleys (192, 168 and 152 species, respectively). CONCLUSION: Disparities in plant use understanding are evident among different groups, prompting further investigation through intercultural comparisons. Plants such as Arnebia euchroma, Juniperus semiglobosa, and Artemisia species emerge with cultural importance. Gender, valley affiliation, religious background and the remoteness of a village all influence local plant knowledge. These variations are linked to socioeconomic disparities among communities.

Carbon and phosphorus exchange rates in arbuscular mycorrhizas depend on environmental context and differ among co-occurring plants.

Phosphorus (P) for carbon (C) exchange is the pivotal function of arbuscular mycorrhiza (AM), but how this exchange varies with soil P availability and among co-occurring plants in complex communities is still largely unknown. We collected intact plant communities in two regions differing c. 10-fold in labile inorganic P. After a 2-month glasshouse incubation, we measured 32P transfer from AM fungi (AMF) to shoots and 13C transfer from shoots to AMF using an AMF-specific fatty acid. AMF communities were assessed using molecular methods. AMF delivered a larger proportion of total shoot P in communities from high-P soils despite similar 13C allocation to AMF in roots and soil. Within communities, 13C concentration in AMF was consistently higher in grass than in blanketflower (Gaillardia aristata Pursh) roots, that is P appeared more costly for grasses. This coincided with differences in AMF taxa composition and a trend of more vesicles (storage structures) but fewer arbuscules (exchange structures) in grass roots. Additionally, 32P-for-13C exchange ratios increased with soil P for blanketflower but not grasses. Contrary to predictions, AMF transferred proportionally more P to plants in communities from high-P soils. However, the 32P-for-13C exchange differed among co-occurring plants, suggesting differential regulation of the AM symbiosis.

Ecospirituality and Health: A Systematic Review.

Environmental changes are affecting human health. A renewal of the way we understand and relate to the planet is needed. Ecospirituality brings together the terms spirituality and environment and is born as a means of solution to this dilemma. This systematic review aimed to find out the influence of ecospirituality on global health. A search of scientific literature was carried out in the main health science databases. A review was conducted to critically evaluate the studies that identified relevant ecospiritual aspects regarding health care for communities. After a systematic search and screening, and following specified methodological criteria, a total of 14 articles were selected in the review. The findings of the review suggest that a new perspective in our worldview such as ecospirituality will provide us with the necessary keys to improve health. To understand ecospirituality, we must keep in mind the indigenous way of life, which is the clear example to follow to achieve environmental health and global health. Ecospirituality leads to a healthier environment, and as this is directly related to health, there is also an improvement in global health.

Modern pollen dispersal in relation to present vegetation distribution and land use in the Baspa valley, Kinnaur, western Himalayas.

Interpretation of a fossil pollen data for the vegetation and climate reconstruction of any region needs a modern pollen-vegetation analogue for its calibration. We analyzed the surface sediments and moss polsters for the pollen and microcharcoal records to understand the modern pollen-vegetation relationship and human activities in the Baspa Valley, Kinnaur, Himachal Pradesh. Presently, valley is occupied by the arboreal and non-arboreal vegetation of temperate to subalpine habitats and land use activities. The recovered pollen assemblages showed variability in the dispersal behavior of pollen of taxa growing along the valley transect and also captured the signals of human activities over land use. The overall dominance of arboreal pollen in the recovered pollen assemblage corresponds with the dominant growth of conifers and broadleaf tree taxa and represents the valley vegetation at a regional scale. However, the profuse pollen production of a few arboreal taxa and long distance pollen transport from one vegetation zone to other by the strong upthermic valley winds could bias the pollen representation of in-situ vegetation. The high pollen frequency of non-arboreal taxa in the open meadows represents the near vicinity to their plant source. Human activities like fire burning and cultivation by the local population are evident by the recovery of microcharcoal particles and pollen of plants belonging to Cerealia Poaceae, Asteraceae, Amaranthaceae, Polygonaceae, Rosaceae, Juglandaceae, etc. The dataset taken as modern pollen-vegetation analogue is useful to assess past changes in the vegetation and land cover in relation to climate and human factors for future sustenance.

Making partners in the city: impact of urban soil P enrichment on the partnership between an invasive herb and arbuscular mycorrhizal fungi in a tropical city.

The mutualistic relationship between plants and arbuscular mycorrhizal (AM) fungi is essential for optimal plant nutrition, enabling plants to better withstand biotic and abiotic stressors and enhancing survival, reproduction, and colonization of new environments. Activities, such as soil enrichment or compaction, may decrease the benefits of AM fungi for plants, potentially reducing interactions in urban environments. Here, we examine this prediction by studying how urbanization alters AM interactions with the invasive herb Ruellia nudiflora (Acanthaceae). We collected soil and plants from deep urban sites (DUS; e.g., sidewalks), open urban sites (OUS; parks), and rural sites (RS) to analyse soil nutrient content, plant morphology, AM colonization rates, spore density, richness, and diversity. Contrary to predicted, DUS had the lowest soil nutrient concentration, except for phosphorus, reducing AM colonization. This supports the prediction of reduced AM interactions in urban environments. We also found that potassium affects the AM association. Urban plants had smaller and more compact root systems compared to their rural counterparts, but there were no discernible differences in AM fungi communities between urban and rural environments. Phosphorus enrichment in sidewalks is the main driver of reductionof R. nudiflora-AM fungi interactions in Mérida. More studies are needed to gain a better understanding of how AM fungi contribute to plant colonization in urban environments.

Facilitative and competitive interactions between mycorrhizal and nonmycorrhizal plants in an extremely phosphorus-impoverished environment: role of ectomycorrhizal fungi and native oomycete pathogens in shaping species coexistence.

Nonmycorrhizal cluster root-forming species enhance the phosphorus (P) acquisition of mycorrhizal neighbours in P-impoverished megadiverse systems. However, whether mycorrhizal plants facilitate the defence of nonmycorrhizal plants against soil-borne pathogens, in return and via their symbiosis, remains unknown. We characterised growth and defence-related compounds in Banksia menziesii (nonmycorrhizal) and Eucalyptus todtiana (ectomycorrhizal, ECM) seedlings grown either in monoculture or mixture in a multifactorial glasshouse experiment involving ECM fungi and native oomycete pathogens. Roots of B. menziesii had higher levels of phytohormones (salicylic and jasmonic acids, jasmonoyl-isoleucine and 12-oxo-phytodienoic acid) than E. todtiana which further activated a salicylic acid-mediated defence response in roots of B. menziesii, but only in the presence of ECM fungi. We also found that B. menziesii induced a shift in the defence strategy of E. todtiana, from defence-related secondary metabolites (phenolic and flavonoid) towards induced phytohormone response pathways. We conclude that ECM fungi play a vital role in the interactions between mycorrhizal and nonmycorrhizal plants in a severely P-impoverished environment, by introducing a competitive component within the facilitation interaction between the two plant species with contrasting nutrient-acquisition strategies. This study sheds light on the interplay between beneficial and detrimental soil microbes that shape plant-plant interaction in severely nutrient-impoverished ecosystems.

Evidence-Based Practice: Implementing REIS Findings in South African Aged Care Facilities.

BACKGROUND: Older adults living in Residential Aged Care Facilities (RACFs) in South Africa are often exposed to environments that fail to provide adequate occupational opportunities. Practitioners in developing economies are challenged to provide therapeutic services in environments that emphasize occupational deprivation. OBJECTIVES: This study investigated barriers and enablers to implementing recommendations derived from the findings generated by the Residential Environment Impact Scale (REIS). METHOD: A two-phased embedded mixed methodology was employed. Phase 1 was the administration of the REIS. In Phase 2, leadership staff considered factors to implementing findings of the REIS, using the nominal discussion group technique. Data were thematically analyzed. FINDINGS: Findings indicated an organizational culture characterized by top-down management and a medically dominated care approach, constrained by financial and operational concerns. CONCLUSION: Using the REIS to holistically assess, RACFs are an applicable tool that could promote collaborative approaches to enhance organizational culture change, cultivating more occupational opportunities.

Bioadsorbent nanocellulose aerogel efficiency impregnated with spent coffee grounds.

Due to growing environmental concerns for better waste management, this study proposes developing a composite aerogel using cellulose nanofibers (CNF) and spent coffee grounds (SCG) through an eco-friendly method for efficient methylene blue (MB) adsorption. Adding SCG to the CNF aerogel altered the physical properties: it increases the volume (4.14 cm3 to 5.25 cm3) and density (0.018 to 0.022 g/cm3) but decrease the water adsorption capacity (2064 % to 1635 %). FTIR spectrum showed distinct functional groups in both all aerogels, showing hydroxyl, glyosidic bonds, and aromatic compounds. Additionally, SCG improved thermal stability of the aerogels. In term of adsorption efficacy, CNF-SCG40% aerogel as exceptionally well. According to Langmuir isotherm models, the adsorption of MB happened in a monolayer, with CNF-SCG40% showing a maximum adsorption capacity of 113.64 mg/g, surpassing CNF aerogel (58.82 mg/g). The study identified that the pseudo-second-order model effectively depicted the adsorption process, indicating a chemical-like interaction. This investigation successfully produced a single-use composite aerogel composed of CNF and SCG using an eco-friendly approach, efficiently adsorbing MB. By utilizing cost-effective materials and eco-friendly methods, this approach offers a sustainable solution for waste management, contributes to an eco-friendly industrial environment, and reduces production expenses and management costs.

The interactions of plastic with tar and other petroleum derivatives in the marine environment: A general perspective.

Plastic and oil pollution are closely linked to our dependence on petroleum derivatives. Their excessive use and inefficiencies in their management, have led to negative impacts on marine ecosystems since their very introduction. Agglomerates of tar, plastic, paraffins, and other petrochemicals and oil derivatives with naturally occurring materials, are increasingly widespread in coastal environments, stalling as an iconic and readable sign of environmental degradation. Starting from a historical review of the available reports on the occurrence of similar aggregates dating back to 1971, we highlight how most of these observations are based on the morphological description of the petroleum residues with no chemical fingerprinting and are mainly related to materials stranded on the coastline, with few and unclear indications for the open sea. We discuss here a list of scientific questions and knowledge gaps, that need to be examined by future studies.

Roadside vegetated filter strips to simultaneously lower stormwater pollution loadings and improve economics of biorefinery feedstocks.

Roadside vegetated filters strips (VFSs) reduce roadway runoff pollution by intercepting stormwater and reducing pollutant loads. VFS maintenance and operating costs can be reduced by designing the VFSs to serve as sites for production of marketable biomass. This biomass can provide feedstock for the emerging bioeconomy producing renewable fuels and biobased chemicals and products. Economic evaluation is needed to quantify the benefit of combining VFS with bioenergy biomass production. This evaluation requires a place-based approach to quantify availability of land, transportation costs, and benefits to sensitive habitats. We evaluated roadside land, within the state right-of-way, in Western Washington, to determine the total area available for implementing VFSs. These data were then used to estimate the volume and cost, of biomass produced on the filter strips, and the resultant reduction in pollutants emitted through highway runoff. The analysis showed that up to 5600 ha were available for roadside VFSs that would be within transportation distance of the theoretical biorefinery location. This space could produce up to 97 dry Gg per year of poplar biomass. The resulting reduction in biorefinery feedstock cost was up to $24 per dry Mg compared to biomass from dedicated tree farms. The results showed that combining roadside poplar with traditional dedicated poplar feedstocks can reduce the feedstock cost of the biorefinery from $76 to $67 per Mg for a biorefinery processing 150 Gg biomass per year. Environmental impact analysis showed that within the study area half of urban roadways and one-third of rural roadways in highly sensitive aquatic areas were amenable to VFS. Construction of VFS in these amenable areas would reduce total loadings to sensitive aquatic areas in urban areas by 26% for TSS, copper, and zinc, and by 10% for phosphorus, and nitrogen and by 21% for lead. The impact for rural sensitive areas was even greater where the VFS had potential to reduce total loadings to sensitive aquatic areas by 38% for TSS, copper, and zinc, by 15% for phosphorus and nitrogen, and by 31% for lead. This research showed an approach combining geographic information system (GIS) mapping and economic analysis to document simultaneous evaluation of cost and environmental benefits when considering use of non-traditional land for bioenergy crop production.

Simulated upwelling and marine heatwave events promote similar growth rates but differential domoic acid toxicity in Pseudo-nitzschia australis.

Along the west coast of the United States, highly toxic Pseudo-nitzschia blooms have been associated with two contrasting regional phenomena: seasonal upwelling and marine heatwaves. While upwelling delivers cool water rich in pCO2 and an abundance of macronutrients to the upper water column, marine heatwaves instead lead to warmer surface waters, low pCO2, and reduced nutrient availability. Understanding Pseudo-nitzschia dynamics under these two conditions is important for bloom forecasting and coastal management, yet the mechanisms driving toxic bloom formation during contrasting upwelling vs. heatwave conditions remain poorly understood. To gain a better understanding of what drives Pseudo-nitzschia australis growth and toxicity during these events, multiple-driver scenario or 'cluster' experiments were conducted using temperature, pCO2, and nutrient levels reflecting conditions during upwelling (13 °C, 900 ppm pCO2, replete nutrients) and two intensities of marine heatwaves (19 °C or 20.5 °C, 250 ppm pCO2, reduced macronutrients). While P. australis grew equally well under both heatwave and upwelling conditions, similar to what has been observed in the natural environment, cells were only toxic in the upwelling treatment. We also conducted single-driver experiments to gain a mechanistic understanding of which drivers most impact P. australis growth and toxicity. These experiments indicated that nitrogen concentration and N:P ratio were likely the drivers that most influenced domoic acid production, while the impacts of temperature or pCO2 concentration were less pronounced. Together, these experiments may help to provide both mechanistic and holistic perspectives on toxic P. australis blooms in the dynamic and changing coastal ocean, where cells interact simultaneously with multiple altered environmental variables.

Biomolecular characterization of 3500-year-old ancient Egyptian mummification balms from the Valley of the Kings.

Ancient Egyptian mummification was practiced for nearly 4000 years as a key feature of some of the most complex mortuary practices documented in the archaeological record. Embalming, the preservation of the body and organs of the deceased for the afterlife, was a central component of the Egyptian mummification process. Here, we combine GC-MS, HT-GC-MS, and LC-MS/MS analyses to examine mummification balms excavated more than a century ago by Howard Carter from Tomb KV42 in the Valley of the Kings. Balm residues were scraped from now empty canopic jars that once contained the mummified organs of the noble lady Senetnay, dating to the 18th dynasty, ca. 1450 BCE. Our analysis revealed balms consisting of beeswax, plant oil, fats, bitumen, Pinaceae resins, a balsamic substance, and dammar or Pistacia tree resin. These are the richest, most complex balms yet identified for this early time period and they shed light on balm ingredients for which there is limited information in Egyptian textual sources. They highlight both the exceptional status of Senetnay and the myriad trade connections of the Egyptians in the 2nd millennium BCE. They further illustrate the excellent preservation possible even for organic remains long removed from their original archaeological context.

Nature contact and general health: Testing multiple serial mediation pathways with data from adults in 18 countries.

The role of neighbourhood nature in promoting good health is increasingly recognised in policy and practice, but consistent evidence for the underlying mechanisms is lacking. Heterogeneity in exposure methods, outcome measures, and population characteristics, little exploration of recreational use or the role of different types of green or blue space, and multiple separate mediation models in previous studies have limited our ability to synthesise findings and draw clear conclusions. We examined multiple pathways linking different types of neighbourhood nature with general health using a harmonised international sample of adults. Using cross-sectional survey data from 18 countries (n = 15,917), we developed a multigroup path model to test theorised pathways, controlling for sociodemographic variables. We tested the possibility that neighbourhood nature (e.g. greenspace, inland bluespace, and coastal bluespace) would be associated with general health through lower air pollution exposure, greater physical activity attainment, more social contact, and higher subjective well-being. However, our central prediction was that associations between different types of neighbourhood nature and general health would largely be serially mediated by recent visit frequency to corresponding environment types, and, subsequently, physical activity, social contact, and subjective well-being associated with these frequencies. Several subsidiary analyses assessed the robustness of the results to alternative model specifications as well as effect modification by sociodemographics. Consistent with this prediction, there was statistical support for eight of nine potential serial mediation pathways via visit frequency which held for a range of alternative model specifications. Effect modification by financial strain, sex, age, and urbanicity altered some associations but did not necessarily support the idea that nature reduced health inequalities. The results demonstrate that across countries, theorised nature-health linkages operate primarily through recreational contact with natural environments. This provides arguments for greater efforts to support use of local green/blue spaces for health promotion and disease prevention.

Virus-pathogen interactions improve water quality along the Middle Route of the South-to-North Water Diversion Canal.

Bacterial pathogens and viruses are the leading causes of global waterborne diseases. Here, we discovered an interesting natural paradigm of water "self-purification" through virus-pathogen interactions over a 1432 km continuum along the Middle Route of the South-to-North Water Diversion Canal (MR-SNWDC) in China, the largest water transfer project in the world. Due to the extremely low total phosphorus (TP) content (ND-0.02 mg/L) in the MR-SNWDC, the whole canal has experienced long-lasting phosphorus (P) limitation since its operation in 2015. Based on 4443 metagenome-assembled genomes (MAGs) and 40,261 nonredundant viral operational taxonomic units (vOTUs) derived from our recent monitoring campaign, we found that residential viruses experiencing extreme P constraints had to adopt special adaptive strategies by harboring smaller genomes to minimize nucleotide replication, DNA repair, and posttranslational modification costs. With the decreasing P supply downstream, bacterial pathogens showed repressed environmental fitness and growth potential, and a weakened capacity to maintain P acquisition, membrane formation, and ribonucleotide biosynthesis. Consequently, the unique viral predation effects under P limitation, characterized by enhanced viral lytic infections and an increased abundance of ribonucleotide reductase (RNR) genes linked to viral nuclear DNA replication cycles, led to unexpectedly lower health risks from waterborne bacterial pathogens in the downstream water-receiving areas. These findings highlighted the great potential of water self-purification associated with virus-pathogen dynamics for water-quality improvement and sustainable water resource management.

Unleashing the nexus among urban land use, national physical health inputs and environment: an environmental sustainability paradigm.

Nowadays, the contemporary ecological environment has a significant impact on human survival and development. Consequently, an in-depth examination of the link between humans and nature has significant practical significance and aspirational appeal. This research analyzes provincial panel data from 2011 to 2019 using an empirical model to determine the relationship between urban land use, the ecological environment, and national physical health inputs in China. The results indicate that (1) urbanization and air pollution do not have an "inverted U-shaped" traditional environmental Kuznets curve relationship, but rather a significant "positive U" relationship; (2) urbanization and environmental management do have an inverted U-shaped classical environmental Kuznets curve relationship; (3) GDP per capita and infrastructure have a negative impact on air quality and environmental quality, and strict environmental rules can improve air quality and green amenities; (4) national physical health investment has a substantial moderating effect on the relationship between urban land use and the ecological environment.

[The implications of the concepts One Health and Planetary Health for the environmental medicine of the 21st century]. / Die Bedeutung der Konzepte One Health und Planetary Health für die Umweltmedizin im 21. Jahrhundert.

In the 21st century, an accumulation of complex crises such as climate change, biodiversity loss, environmental pollution, wars, and pandemics is leading to economic, social, and health problems for people of current and future generations. These problems are essentially due to the disregard of natural regenerative capacities of ecosystems. Health approaches such as One Health and Planetary Health have gained popularity since the early 2000s and are increasingly used in politics, science, and the health professions. Environmental medicine is also influenced by the growing number of crises and environmental problems and the increasing interest in the concepts of One Health and Planetary Health.In this discussion paper, the development of the two concepts is first presented. Then, their significance for environmental medicine will be discussed. Health professionals working on environmental medicine issues must now consider both local and global causes and health effects when assessing environmental impacts, which can complicate decisions and lead to conflicting objectives.

The key to improving the beauty of the giant retaining wall in valleys: Increasing visual extension.

The retaining wall is a passive engineering measure to prevent and control unsafe factors caused by rock collapse in the valleys. Existing studies have mainly focused on its functional robustness and safety features, with few exploring its visual quality in the landscape. A multiple regression analysis was applied to evaluate the Scenic Beauty Estimation (SBE) of the giant retaining wall in Jiuzhaigou's (a world natural heritage site) Heye Village, then the factors affecting SBE were analyzed. It is found that enhancing the sense of perspective and spatial hierarchy of retaining-wall murals in narrow roads contributes to the extension of observers' sight, which is the key to improving SBE. Furthermore, the showcase of folk culture in murals can realize the beautification function of the giant retaining walls. In addition, the SBE of giant retaining walls is also linked to coordination, where the walls embellished with the natural landscape and folk culture murals have better SBE performance than those with local stones. This study provides a reference for constructing scenic beauty after fulfilling the safety function of retaining wall engineering.

Integrating the social environment with an equity perspective into the exposome paradigm: A new conceptual framework of the Social Exposome.

The importance of the social environment and social inequalities in disease etiology is well-known due to the profound research and conceptual framework on social determinants of health. For a long period, in exposome research with its classical orientation towards detrimental health effects of biological, chemical, and physical exposures, this knowledge remained underrepresented. But currently it gains great awareness and calls for innovations in rethinking the role of social environmental health determinants. To fill this gap that exists in terms of the social domain within exposome research, we propose a novel conceptual framework of the Social Exposome, to integrate the social environment in conjunction with the physical environment into the exposome concept. The iterative development process of the Social Exposome was based on a systematic compilation of social exposures in order to achieve a holistic portrayal of the human social environment - including social, psychosocial, socioeconomic, sociodemographic, local, regional, and cultural aspects, at individual and contextual levels. In order to move the Social Exposome beyond a mere compilation of exposures, three core principles are emphasized that underly the interplay of the multitude of exposures: Multidimensionality, Reciprocity, and Timing and continuity. The key focus of the conceptual framework of the Social Exposome is on understanding the underlying mechanisms that translate social exposures into health outcomes. In particular, insights from research on health equity and environmental justice have been incorporated to uncover how social inequalities in health emerge, are maintained, and systematically drive health outcomes. Three transmission pathways are presented: Embodiment, Resilience and Susceptibility or Vulnerability, and Empowerment. The Social Exposome conceptual framework may serve as a strategic map for, both, research and intervention planning, aiming to further explore the impact of the complex social environment and to alter transmission pathways to minimize health risks and health inequalities and to foster equity in health.