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Immunol Allergy Clin North Am ; 37(3): 585-595, 2017 08.
Artículo en Inglés | MEDLINE | ID: mdl-28687111

RESUMEN

Remarkable progress has been made in the treatment of bradykinin-mediated angioedema with the advent of multiple new therapies. Patients now have effective medications available for prophylaxis and treatment of acute attacks. However, hereditary angioedema is a burdensome disease that can lead to debilitating and dangerous angioedema episodes associated with significant costs for individuals and society. The burden of treatment must be addressed regarding medication administration difficulties, treatment complications, and adverse side effects. New therapies are being investigated and may offer solutions to these challenges. This article reviews the emerging therapeutic options for the treatment of HAE.


Asunto(s)
Angioedemas Hereditarios/terapia , Angioedemas Hereditarios/diagnóstico , Angioedemas Hereditarios/etiología , Angioedemas Hereditarios/metabolismo , Animales , Bradiquinina/metabolismo , Ensayos Clínicos como Asunto , Terapia Combinada , Proteína Inhibidora del Complemento C1/uso terapéutico , Descubrimiento de Drogas , Evaluación Preclínica de Medicamentos , Factor XII/antagonistas & inhibidores , Factor XII/metabolismo , Histamina/metabolismo , Humanos , Transducción de Señal , Resultado del Tratamiento
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