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HLA and HPA typing in idiopathic thrombocytopenic purpura patients treated with Kami-kihi-to.

Matsuzaki, T; Nomura, S; Yamaoka, M; Ozaki, Y; Yoshimura, C; Xie, G L; Katsura, K; Kagawa, H; Ishida, T; Fukuhara, S.

Am J Chin Med ; 26(2): 191-8, 1998.

Artículo en Inglés | MEDLINE | ID: mdl-9799971

RESUMEN

We performed human leukocyte antigen (HLA) and human platelet antigen (HPA) in patients with Kami-kihi-to-responsive idiopathic thrombocytopenic purpura. The HLA-A2, A61 and Cw1 were significantly increased in responders compared with nonresponders, as were HLA DRB1 *0901, DRB1 *1502, and DPB1 *0501. In contrast, HLA DPB1 *0201 and DPB1 *0901 were significantly decreased in responders. The a/b genotype of HPA-2 and a/a genotype of HPA-3 were markedly increased in nonresponders, and anti-GPIb antibody was also increased. These results suggest that HLA, HPA, and anti-GP antibody studies may predict the response of idiopathic thrombocytopenic purpura to Kami-kihi-to.

Asunto(s)

Antígenos de Plaqueta Humana/clasificación , Medicamentos Herbarios Chinos/uso terapéutico , Antígenos HLA/clasificación , Púrpura Trombocitopénica Idiopática/inmunología , Antígenos de Plaqueta Humana/genética , Femenino , Antígenos HLA/genética , Antígeno HLA-A2/clasificación , Antígeno HLA-A2/genética , Antígenos HLA-B/clasificación , Antígenos HLA-B/genética , Antígenos HLA-C/clasificación , Antígenos HLA-C/genética , Antígenos HLA-DR/clasificación , Antígenos HLA-DR/genética , Cadenas HLA-DRB1 , Prueba de Histocompatibilidad , Humanos , Masculino , Púrpura Trombocitopénica Idiopática/tratamiento farmacológico

RESUMEN

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