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1.
Midwifery ; 131: 103948, 2024 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-38335692

RESUMEN

OBJECTIVE: We sought to explore and describe midwives' attitudes and practices relating to their provision of postpartum contraception counselling. DESIGN: We used an exploratory cross-sectional design. Recruitment used an anonymous online survey using electronic communication platforms of professional, and special-interest organisations, over six months . Descriptive and quantitative analysis was used. SETTING AND PARTICIPANTS: Australian Midwives who provide postpartum care. MEANING AND FINDINGS: A total of 289 complete responses were included. Findings from this national survey of midwives showed that almost 75% of Australian midwives reported providing some contraceptive advice to women. Those working in continuity of care models were significantly more likely to fulfil this responsibility. More than half (67%) indicated they had not received any formal contraception education or training. Those working in private obstetric-led settings were significantly less likely to have received education compared to midwives in community settings. Systems barriers preventing the provision of contraceptive counselling included: clinical workload; lack of management support; lack of education; and models of care. KEY CONCLUSIONS: Most midwives (82%) wanted to provide postpartum contraception counselling as part of their role. They cited barriers from within the health system, ambiguity about roles and responsibilities and offered solutions to improve the provision of postnatal contraception counselling. IMPLICATIONS FOR PRACTICE: Recommendations include the development of education programs for midwives. Continuity of care models provided the time, autonomy and opportunity for midwives to undertake contraceptive counselling and fulfil this part of their professional scope. Consideration should be given to expanding access and provision of continuity of midwifery care. An urgent investment in the education and skills of midwives is recommended to ensure all women across acute and community services benefit from improved outcomes associated with pregnancy spacing.


Asunto(s)
Partería , Embarazo , Femenino , Humanos , Estudios Transversales , Atención Posnatal , Australia , Anticonceptivos , Consejo
2.
PLoS One ; 19(1): e0295796, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38165872

RESUMEN

BACKGROUND: Male involvement in maternal health care has proven to be beneficial for improving maternal and child health and is often crucial in areas of family planning and contraceptive use. However, compared to male involvement in maternal health care, male involvement in contraceptive counselling is complex and controversial and thus faces certain challenges. Immigrant men in Sweden are often accompanying their partner for contraceptive counselling. Little is known about their presence and role. AIM: To explore how immigrant men from the Middle East and Afghanistan perceive and experience accompanying their partner for contraceptive counselling provided by midwives in Sweden. METHODS: Inductive qualitative content analysis guided the interpretation of data based on 21 individual in-depth interviews. FINDINGS: Balancing conflicting values and norms about sexual and reproductive health and rights including family planning was challenging and confusing when living in Sweden. Contraceptive counselling was perceived as a joint visit, and men were often acting as decision makers. The midwife's role as a contraceptive counsellor was perceived as trusted, but knowledge was lacking about the Swedish midwifery model and the Swedish healthcare system. Providers' ways of communicating sensitive information were crucial. Without marriage contraceptive counselling was unthinkable. CONCLUSION: Highlighting male engagement and including men's sexual and reproductive health at policy levels are necessary for improving women's sexual and reproductive health and rights. Additional and new ways of contraceptive counselling and midwifery services, such as outreach work and joint visits, are needed in order to reach both men and women.


Asunto(s)
Emigrantes e Inmigrantes , Partería , Embarazo , Niño , Humanos , Masculino , Femenino , Suecia , Servicios de Planificación Familiar , Investigación Cualitativa , Consejo , Anticonceptivos
3.
BMC Public Health ; 23(1): 1833, 2023 09 20.
Artículo en Inglés | MEDLINE | ID: mdl-37730599

RESUMEN

BACKGROUND: Contraceptive methods have been used to space births, but also to limit a couple's desired number of children. Efforts of family planning programmes have mainly concentrated on females, even though males tend to have large say on the desired number of children a couple should have. In our study, we sought to determine linkages between contraceptive use and desired number of children, as well as associated demographic and socio-economic characteristics, among sexually active males in Zambia. METHODS: The main outcome variable of interest was desired number of children as measured by ideal number of children which is a count variable. Data for this paper was the male dataset from the 2018 Zambia Demographic and Health Survey, a cross-sectional national survey. Binary logistic regression was performed to determine odds ratios of contraceptive use by selected characteristics of sexually active males. Multivariate Poisson Regression Model was used to establish factors associated with desired number of children. RESULTS: Age of men (20-29, 30-39 and 40-49 years), residence in rural areas, wealth quintile, Protestant or Muslim religious affiliation, media exposure, and having discussed family planning with a health worker in the last few months prior to the survey were associated with contraceptive use. Sexually active males who reported using any contraception method reported 3% less desired number of children compared to those who were not using any method. Older males (age group 30-49 years), resident in rural areas, with primary education, married, employed, Protestant religion, and those labelling women who use contraceptives "as promiscuous" had more desired number of children. CONCLUSIONS: There were minimal differences in the desired number of children among males who reported using and not using any contraceptive method. Strategies aimed at encouraging contraception use should cover all categories of males to achieve universal involvement of men in family planning in Zambia. Future research may consider combining both qualitative and quantitative methods to look holistically at the demographic, socio-economic and cultural factors associated with non-contraception use and desired number of children among sexually active men in Zambia.


Asunto(s)
Anticoncepción , Anticonceptivos , Niño , Femenino , Masculino , Humanos , Adulto Joven , Adulto , Persona de Mediana Edad , Estudios Transversales , Zambia , Servicios de Planificación Familiar
4.
Bull Menninger Clin ; 87(2): 189-208, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37260327

RESUMEN

The medical community has begun to focus on factors that impact not only health but also wellness for both mainstream and disadvantaged communities. Public health initiatives have evaluated nonmedical factors to determine whether they have a broader influence on physical health than traditional medicine, especially in reproductive care. These factors, referred to as social determinants of health (SDOH), affect a variety of medical conditions, have an impact on medical strategies, and suggest that traditional medicine may be more limited than commonly thought. The purpose of this article, therefore, is threefold: First, it will offer a general review of selected components of current SDOH that act as nonmedical factors in health and behavioral wellness. Second, it will present specific SODH and their impact on contraceptive and prenatal care. Finally, it will highlight SODH policies that either enhance or impede the ability of health systems to deliver innovative reproductive services to underserved populations.


Asunto(s)
Reproducción , Determinantes Sociales de la Salud , Embarazo , Femenino , Humanos , Anticonceptivos , Atención Prenatal , Dispositivos Anticonceptivos
5.
PLoS One ; 18(3): e0282996, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-36930610

RESUMEN

Progress has been made to improve access to family planning services and contraceptive methods, yet many women still struggle to access contraception, increasing their risk for unintended pregnancy. This is also true for South Africa, where over fifty per cent of pregnancies are reported as unintended, even though contraception is freely available. There is also stagnation in the fertility rate indicators and contraceptive use data, indicating that there may be challenges to accessing contraception. This paper explores the evaluation of access to contraception from community and health care provider perspectives. This qualitative study explored factors affecting the uptake and use of contraception through focus group discussions (n = 14), in-depth interviews (n = 8), and drawings. Participants included male and female community members (n = 103) between 15 and 49 years of age, health care providers (n = 16), and key stakeholder informants (n = 8), with a total number of 127 participants. Thematic content analysis was used to explore the data using NVivo 10. Emergent themes were elucidated and thematically categorised. The results were categorised according to a priori access components. Overall, the results showed that the greatest obstacle to accessing contraception was the accommodation component. This included the effects of integrated care, long waiting times, and limited operational hours-all of which contributed to the discontinuation of contraception. Community members reported being satisfied with the accessibility and affordability components but less satisfied with the availability of trained providers and a variety of contraceptive methods. The accessibility and affordability themes also revealed the important role that individual agency and choice in service provider plays in accessing contraception. Data from the illustrations showed that adolescent males experienced the most geographic barriers. This study illustrated the importance of examining access as a holistic concept and to assess each component's influence on contraceptive uptake and use.


Asunto(s)
Servicios de Planificación Familiar , Sector Público , Embarazo , Adolescente , Humanos , Masculino , Femenino , Sudáfrica , Anticoncepción/métodos , Anticonceptivos , Personal de Salud , Conducta Anticonceptiva , Accesibilidad a los Servicios de Salud
6.
Artículo en Inglés | MEDLINE | ID: mdl-36768107

RESUMEN

This scoping review mapped and synthesised existing evidence on the influence of individual, parental, peer, and societal-related factors on adolescents' decisions to use contraception in sub-Saharan Africa (SSA). Peer-reviewed and review articles published before May 2022, targeting adolescents aged 10-19 years were searched in PubMed, MEDLINE with Full Text via EBSCOhost, PsychINFO via EBSCOhost, CINAHL with Full Text via EBSCOhost, Google Scholar, Science Direct, and Scopus databases. Seven studies were included and analysed using thematic analysis based on the social-ecological model (SEM) and reported using the preferred reporting items for systematic reviews and meta-analyses (PRISMA). Individual (fear of side effects, fear of infertility), parental (parental disappointment and disapproval), peer (social stigma), partner (association with promiscuity and multiple sexual partners), societal and community (contraceptive use disapproval and stigma), and institutional and environmental factors (lack of privacy and confidentiality) influence contraceptive decisions among adolescents. These also include a lack of accurate information, social exclusion, negative health provider attitudes, and a lack of infrastructure that provides privacy and safe spaces. Identifying and addressing core issues within the context of local cultural practices that restrict contraceptive use is important. Holistic, inclusive approaches that promote the well-being of adolescents must be utilised to provide a conducive environment that ensures privacy, confidentiality, safety, and easy access to contraceptive services.


Asunto(s)
Anticoncepción , Anticonceptivos , Humanos , Adolescente , Confidencialidad , África del Sur del Sahara , Privacidad
7.
Contraception ; 118: 109907, 2023 02.
Artículo en Inglés | MEDLINE | ID: mdl-36328094

RESUMEN

OBJECTIVES: The CHARM2 (Counseling Husbands and wives to Achieve Reproductive Health and Marital Equity) intervention engages health care providers to deliver gender-equity and family planning sessions to couples using a person-centered shared decision-making approach for contraception counseling. We previously showed that the intervention improved contraceptive use at 9-month follow-up. We sought to assess whether the intervention was further associated with the quality of care reported by participants and whether the quality of care reported mediated the effect of the intervention on contraceptive use. STUDY DESIGN: This is a planned secondary analysis of the effect of the CHARM2 intervention on 1201 married couples in rural Maharashtra, India in a cluster randomized controlled trial completed between 2018 and 2020. We assessed the effect of CHARM2 on perceived quality of care as measured by the Interpersonal Quality of Family Planning (IQFP) scale using a difference-in-differences linear regression approach including a mixed-effects model with nested random effects to account for clustering. We assessed whether the association between CHARM2 and modern contraceptive use was mediated by quality of family planning care. RESULTS: Intervention participants had higher mean IQFP scores than control participants at 9-month follow-up (intervention 3.2, SD 0.6 vs. control 2.3 mean, SD 0.9, p < 0.001). The quality of care reported mediated the effect of the intervention on contraceptive use (indirect effect coefficient 0.29, 95% CI 0.07-0.50). CONCLUSION: Family planning interventions such as CHARM2, which utilize person-centered shared decision-making contraceptive counseling approaches improve women's perceived quality of care. Effects on quality of care mediate observed effects of the intervention on contraceptive use. IMPLICATIONS: Contraceptive interventions should focus on improving person-centered outcomes, such as quality of care, rather than contraceptive use targets. By focusing on improving person-centered care, interventions will improve contraceptive use among those who desire a method while meeting the holistic reproductive health needs of clients and couples.


Asunto(s)
Anticoncepción , Servicios de Planificación Familiar , Humanos , Femenino , India , Anticoncepción/psicología , Anticonceptivos , Consejo , Conducta Anticonceptiva
8.
Gates Open Res ; 7: 105, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-38605912

RESUMEN

Background: Launched in 2014, Indonesia's national health insurance system (JKN) aimed to provide universal health coverage, including contraceptive services, to its population. We aim to evaluate the contribution of JKN to the overall spending for the family planning program in Indonesia. Methods: Data from the Indonesian Demographic Health Survey, Survey on Financial Flows for Family Planning, Indonesia Motion Tracker Matrix, World Population Prospect, and Indonesian ministries' budget accountability reports were entered into the CastCost Contraceptive Projection Tool to define budgetary allocation and spending for the family planning program at the national level in 2019. Results: Indonesia's family planning program in 2019 was financed mostly by the national budget (64.0%) and out-of-pocket payments (34.6%). There were three main ministries responsible for family planning financing: the National Population and Family Planning Board (BKKBN) (35.8%), the Ministry of Finance (26.2%), and the Ministry of Health (2.0%). Overall, JKN contributed less than 0.4% of the funding for family planning services in Indonesia in 2019. The majority of family planning spending was by public facilities (57.3%) as opposed to private facilities (28.6%). Conclusion: JKN's contribution to funding Indonesia's family planning programs in 2019 was low and highlights a huge opportunity to expand these contributions. A coordinated effort should be conducted to identify possible opportunities to realign BKKBN and JKN roles in the family planning programs and lift barriers to accessing family planning services in public and private facilities. This includes a concerted effort to improve integration of private family planning providers into the JKN program.


Asunto(s)
Servicios de Planificación Familiar , Administración Financiera , Humanos , Indonesia , Planificación en Salud , Programas Nacionales de Salud , Anticonceptivos
9.
Nurse Educ Today ; 119: 105605, 2022 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-36265211

RESUMEN

BACKGROUND: Effective contraceptives used correctly offer many benefits to both women's and children's health. However, public data reports that the rate at which women use an effective contraceptive method is still insufficient. Midwives, including the students, have an essential role in contraceptive counselling so there is a need to determine midwives' knowledge level on contraceptives. OBJECTIVE: To evaluate midwifery students' knowledge levels of contraceptive methods. DESIGN: Cross-sectional and descriptive study. SETTINGS: Online survey. PARTICIPANTS: 290 midwifery students who met the inclusion criteria. METHODS: The study was conducted between December 2020-March 2021 through Sociodemographic Form and Contraceptive Methods Information Form. RESULTS: The mean age of the participants was 20.93 ± 1.97. There were 7.72 ± 3.21 correct answers to 15 questions measuring knowledge level of contraceptive methods. The most known modern contraceptive method was the condom, and the most known traditional method was the calendar method. 59.7 % of the participants considered the post-coital contraceptive method as a family planning method. The knowledge level on contraceptives of students who had not received prior training before was lower; and the knowledge level of students who received information about contraceptives through their courses in the curriculum was higher than those who learned from other sources. The level of knowledge increased as age and grade increased. CONCLUSIONS: Midwifery students had insufficient level of knowledge about contraceptives. Since midwifery students play an active role in family planning, interventions are necessary to deliver more detailed and accurate information about contraceptive methods.


Asunto(s)
Partería , Embarazo , Niño , Femenino , Humanos , Estudios Transversales , Salud Infantil , Salud de la Mujer , Anticoncepción/métodos , Estudiantes , Anticonceptivos , Conocimientos, Actitudes y Práctica en Salud
10.
Glob Health Action ; 15(1): 2112395, 2022 12 31.
Artículo en Inglés | MEDLINE | ID: mdl-36161863

RESUMEN

BACKGROUND: Preconception care (PCC) is necessary to identify and deal with all the risk factors before conception. Some aspects of PCC, like folic acid supplementation, would be relevant to people desiring a pregnancy. Alternatively, PCC could provide contraceptive support to those with no pregnancy intention. In South Africa, primary healthcare nurses provide a comprehensive package of essential services in public health facilities to about 90% of the population at no cost. Therefore, they are the key providers of promotive, preventive, and curative services, including PCC. OBJECTIVE: This study aimed to determine the level of PCC practice among primary healthcare nurses and identify determinants of effective practice. METHODS: This cross-sectional descriptive survey was conducted among 196 nurses undertaking a specialisation Primary HealthCare program in a selected higher education institution. A pretested questionnaire was used to collect data that were analysed with SPSS version 27 software. RESULTS: The overall practice of PCC was 87.8%. Older participants were significantly less likely to exhibit good PCC practice than their younger counterparts. Female participants were also less likely to have good PCC practices than their male counterparts. Married participants were significantly more likely to practice PCC than their unmarried counterparts. Participants practicing in rural areas were also less likely to have good PCC practices than their urban counterparts. CONCLUSION: The PCC practice of most primary healthcare nurses in the study is relatively high. The study also identified the determinants of good PCC practice that can enhance its practice. There is a need to revisit the PCC training of healthcare workers, as most indicated the need for further training.


Asunto(s)
Atención Preconceptiva , Atención Primaria de Salud , Anticonceptivos , Estudios Transversales , Femenino , Ácido Fólico , Instituciones de Salud , Humanos , Masculino , Embarazo , Sudáfrica
11.
Sex Reprod Health Matters ; 30(1): 2111796, 2022 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-36129725

RESUMEN

Immigrant women in Sweden often have unmet sexual and reproductive health (SRH) needs. Successful contraceptive counselling may improve their sexual and reproductive health and rights. The unique Swedish model, with midwives as the main providers of contraceptive counselling, is important for immigrant women's health at both individual and societal levels. This study explored immigrant women's perspectives on receiving contraceptive counselling from midwives in Sweden, in order to obtain deeper knowledge about the factors they perceive as important in the counselling situation. Nineteen in-depth individual interviews were conducted from December 2018 to February 2019, followed by qualitative manifest and latent content analysis. Trust emerged as the overall important factor in the contraceptive counselling meeting. Knowledge was lacking about the midwife's professional role as a contraceptive counsellor. Contraceptive counselling was seen as a private matter not easily shared with unfamiliar midwives or interpreters. Previous experiences of contraceptives and preconceptions were important considerations for contraceptive choice, but communicating these needs required trust. Women also wanted more knowledge about contraceptives and SRH care and rights. Cultural and social norms concerning when and why to use contraceptives needed to be acknowledged in the midwife encounter. Although immigrant women want more knowledge about contraception, a trustful relationship with the midwife is needed to be able to make informed contraceptive choices. Midwives may need increased awareness of the many factors influencing immigrant women's choices to ensure their contraceptive autonomy. Policy changes that promote new ways of counselling and ability to provide continuous care are needed.


Asunto(s)
Emigrantes e Inmigrantes , Partería , Anticonceptivos , Consejo , Femenino , Humanos , Embarazo , Suecia
12.
Rev Bras Ginecol Obstet ; 44(9): 884-890, 2022 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-35793692

RESUMEN

Although almost 0.7% of the Brazilian population identifies as transgender, there is currently no training for healthcare professionals to provide comprehensive care to these patients, including the discussion of reproductive planning. The use of testosterone promotes amenorrhea in the first months of use; however, this effect does not guarantee contraceptive efficacy, and, consequently, increases the risks of unplanned pregnancy. The present article is an integrative review with the objective of evaluating and organizing the approach of contraceptive counseling for the transgender population who were assigned female at birth. We used the PubMed and Embase databases for our search, as well as international guidelines on care for the transgender population. Of 88 articles, 7 were used to develop the contraceptive counseling model. The model follows the following steps: 1. Addressing the information related to the need for contraception; 2. Evaluation of contraindications to the use of contraceptive methods (hormonal and nonhormonal); and 3. Side effects and possible discomfort associated with the use of contraception. The contraceptive counseling model is composed of 18 questions that address the indications and contraindications to the use of these methods, and a flowchart to assist patients in choosing a method that suits their needs.


Apesar de 0,7% da população brasileira se identificar como transgênera, não existe treinamento para que o profissional de saúde realize um acolhimento de maneira integral a estes pacientes, incluindo a discussão do planejamento reprodutivo. O uso de testosterona promove a amenorreia nos primeiros 6 meses de uso; entretanto, este efeito não garante eficácia contraceptiva, e, consequentemente, aumenta os riscos de uma gravidez não planejada. O presente artigo é uma revisão integrativa com o objetivo de avaliar e organizar uma abordagem do aconselhamento contraceptivo na população transgênera que foi designada mulher ao nascimento. Para a estratégia de busca, foram pesquisados os bancos de dados PubMed e Embase, incluindo diretrizes internacionais sobre cuidados à população transgênera. De 88 artigos, 7 foram utilizados para desenvolver o modelo de aconselhamento contraceptivo. O modelo segue as seguintes etapas: 1. Abordagem das informações relacionadas à necessidade de contracepção; 2. Avaliação das contraindicações ao uso dos métodos contraceptivos (hormonais e não hormonais); 3. Efeitos colaterais e possíveis desconfortos associados ao uso do contraceptivo. O modelo de aconselhamento contraceptivo é composto por 18 questões que abordam as indicações e contraindicações ao uso destes métodos e um fluxograma que auxilia na escolha dentre os métodos permitidos ao paciente de acordo com a sua necessidade.


Asunto(s)
Personas Transgénero , Anticoncepción/métodos , Anticonceptivos , Consejo , Servicios de Planificación Familiar , Femenino , Humanos , Recién Nacido , Embarazo , Testosterona
14.
Clin Obstet Gynecol ; 65(4): 753-767, 2022 12 01.
Artículo en Inglés | MEDLINE | ID: mdl-35467570

RESUMEN

A growing number of adolescents in the United States identify as transgender and gender nonbinary, and many will seek medical management of menstruation. In this evidence-based review, we recommend a model of gender-affirming care grounded in the tenants of reproductive justice, emphasizing patient autonomy and the development of holistic management plans centered around the patient's unique goals for affirming their gender identity. We then review strategies for achieving menstruation suppression for transgender and gender nonbinary adolescents, including dosing considerations, menstruation, ovulation, contraceptive effects, and metabolic considerations specific to the adolescent population.


Asunto(s)
Personas Transgénero , Transexualidad , Adolescente , Femenino , Humanos , Masculino , Estados Unidos , Identidad de Género , Menstruación , Transexualidad/terapia , Anticonceptivos
15.
Reprod Biomed Online ; 44(6): 1143-1157, 2022 06.
Artículo en Inglés | MEDLINE | ID: mdl-35461762

RESUMEN

The aim of this systematic review and meta-analysis was to evaluate the effectiveness of different hormone therapies, including hormonal contraceptives, in women with premature ovarian insufficiency (POI). Thirty reports of 28 studies were included, with a total of 4004 participants with POI from diverse aetiologies, of whom 3785 received hormone therapies and 219 received calcium supplementation, vitamin D, placebo or no treatment. Hormone therapy was superior to non-treatment, placebo, calcitriol or calcium in preserving bone mineral density (BMD) in women with POI. Hormone therapy was associated with up to 80% reduction in the prevalence of hot flushes and with stability or improvement in the quality of life scores. Hormone therapy induced significant increases in uterine volume and endometrial thickness in women with POI. The studies yielded convergent results and were of good quality, although some lacked blinding or had incomplete outcome data. Moderate to high quality evidence was found that hormone therapy with oestrogen and progesterone or progestin (including contraceptives) is beneficial to women with POI, not only to mitigate hypoestrogenic symptoms but also to preserve BMD and avoid uterine atrophy. More studies are needed to confirm the long-term safety of this therapy and to assess its possible impact on the risk of hard outcomes such as bone fractures and cardiovascular events.


Asunto(s)
Menopausia Prematura , Insuficiencia Ovárica Primaria , Calcio , Anticonceptivos/uso terapéutico , Estrógenos/farmacología , Femenino , Humanos , Insuficiencia Ovárica Primaria/tratamiento farmacológico , Calidad de Vida
16.
Proc Natl Acad Sci U S A ; 119(15): e2122512119, 2022 04 12.
Artículo en Inglés | MEDLINE | ID: mdl-35380904

RESUMEN

We identified the anti-Mullerian hormone (also known as Müllerian inhibiting substance or MIS) as an inhibitory hormone that induces long-term contraception in mammals. The type II receptor to this hormone, AMHR2 (also known as MISR2), represents a promising druggable target for the modulation of female reproduction with a mechanism of action distinct from steroidal contraceptives. We designed an in vitro platform to screen and validate small molecules that can activate MISR2 signaling and suppress ovarian folliculogenesis. Using a bone morphogenesis protein (BMP)­response element luciferase reporter cell­based assay, we screened 5,440 compounds from a repurposed drug library. Positive hits in this screen were tested for specificity and potency in luciferase dose­response assays, and biological activity was tested in ex vivo Mullerian duct regression bioassays. Selected candidates were further evaluated in ex vivo follicle/ovary culture assays and in vivo in mice and rats. Here, we report that SP600125, CYC-116, gandotinib, and ruxolitinib can specifically inhibit primordial follicle activation and repress folliculogenesis by stimulating the MISR2 pathway.


Asunto(s)
Anticonceptivos , Reposicionamiento de Medicamentos , Folículo Ovárico , Receptores de Péptidos , Receptores de Factores de Crecimiento Transformadores beta , Bibliotecas de Moléculas Pequeñas , Animales , Antracenos/química , Antracenos/farmacología , Anticonceptivos/química , Anticonceptivos/farmacología , Evaluación Preclínica de Medicamentos , Femenino , Humanos , Ratones , Nitrilos/química , Nitrilos/farmacología , Folículo Ovárico/efectos de los fármacos , Folículo Ovárico/crecimiento & desarrollo , Pirazoles/química , Pirazoles/farmacología , Pirimidinas/química , Pirimidinas/farmacología , Ratas , Receptores de Péptidos/agonistas , Receptores de Factores de Crecimiento Transformadores beta/agonistas , Bibliotecas de Moléculas Pequeñas/química , Bibliotecas de Moléculas Pequeñas/farmacología , Tiazoles/química , Tiazoles/farmacología
18.
N C Med J ; 83(1): 58-66, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-34980657

RESUMEN

BACKGROUND Although use of contraceptives has increased among young women in the United States, more than half of pregnancies remain unplanned. The goal of this study was to examine the association between insurance status and receipt of contraceptives among young women receiving care within a large integrated health care system in the Southeastern United States to better inform strategies for increasing access to contraception.METHODS This retrospective study used electronic medical record data from an integrated health care system based in Charlotte, North Carolina. Data were analyzed for 51,900 women aged 18-29 who lived in Mecklenburg County and had at least 1 primary care visit between 2014 and 2016. Contraceptive orders were identified by service and procedure codes and grouped into long-acting reversible contraceptives (LARC) and non-LARC categories. Adjusted multinomial logistic regression models were used to assess the association between receipt of contraceptives and insurance status.RESULTS Compared to non-Hispanic White women with commercial insurance, non-Hispanic Black (OR = 1.25; 95% CI, 1.13-1.38) and Hispanic (OR = 2.25; 95% CI, 1.93-2.61) women with Medicaid had higher odds of receiving LARC. Similar variations by insurance and race/ethnicity were observed for the non-LARC group.LIMITATIONS Data were limited to a single health care system and did not capture contraceptive orders by unaffiliated providers. Analyses used the most frequent payor and did not account for changes in insurance status.CONCLUSION Findings indicate an important role of race/ethnicity and insurance coverage in contraceptive care. Higher receipt of LARC among Black and Hispanic women also suggests that implicit biases may influence contraception counseling and promotion practices. Future study is warranted to further delineate these relationships.


Asunto(s)
Anticonceptivos , Etnicidad , Femenino , Humanos , Cobertura del Seguro , North Carolina , Embarazo , Estudios Retrospectivos , Estados Unidos
19.
Afr J Reprod Health ; 26(5): 107-119, 2022 May.
Artículo en Inglés | MEDLINE | ID: mdl-37585103

RESUMEN

In recent years, contraceptive medication has been widely used for birth control. It is worth noting that contraceptive medication from botanical source has great potential for clinical use. Yunnan is the province with the most species of plants in China and is known as the "plant kingdom". This study aims to archive herbal remedies traditionally used as antifertility remedies in Dali District, Yunnan Province, P. R. China. The survey was conducted from February 2011 to September 2016 in the population distributed in Dali and the surrounding counties. The data were collected from three groups of practitioners within the study area: therapists using traditional medicines (n = 104), aboriginal families (n = 37), and herbalists in commercial stalls (n = 12), and a total number of 117 plant species were recorded. Among the 117 plant species, 104 of which have been authenticated by a plant taxonomist from the Dali Herbarium. These plants were classified into 98 genera and 54 families, including Leguminosae (12 species), Liliaceae (7 species), Cucurbitaceae, Rosaceae and Rutaceae (5 species, respectively), Malvaceae, Compositae and Euphorbiaceae (4 species, respectively). Our data provides an in-depth delineation of the contraceptive plants used in Dali, which serve as valuable information for the practitioners of traditional Chinese medicine in contraceptive use. In addition, these data also hint that plants from different genus contain contraceptive components, which should be avoided by pregnant women. Future studies are required to identify the active contraceptive components, assess the toxicology, and elucidate the pharmacological mechanism of action.


Asunto(s)
Plantas Medicinales , Embarazo , Femenino , Humanos , Fitoterapia , China , Etnobotánica , Anticonceptivos
20.
Cult Health Sex ; 24(3): 315-329, 2022 03.
Artículo en Inglés | MEDLINE | ID: mdl-33170110

RESUMEN

A growing body of literature suggests that contraceptives' impact on sexual experiences influences willingness to initiate and continue with a method. Little is known, however, about how clinicians engage with clients on this topic during contraceptive consultations. Fifteen clinicians in South Eastern Australia participated in semi-structured interviews between April and June 2019. Interviews were analysed using inductive, semantic thematic analysis. Participants varied in their evaluation and management of contraceptives' sexual side effects and the legitimacy given to women's bodily experience versus their own understanding of the evidence in the medical literature. We identified two distinct groups of clinicians: those who prioritised sexual wellbeing as a primary issue in contraceptive consultations and those who perceived sexual wellbeing as a secondary concern. The difference in practices was influenced by whether participants considered sexual wellbeing to be part of holistic care provision and their views on the clinician's role in raising the topic. Strategies to equip clinicians to integrate sexual wellbeing into contraceptive consultations include interactive clinical training and incorporating information about sexual side effects into contraceptive guidelines and client resources. Benefits gained from normalising sexual wellbeing could extend beyond contraceptive care to help clinicians address clients' sexual wellbeing in other contexts.


Asunto(s)
Anticoncepción , Anticonceptivos , Anticoncepción/métodos , Conducta Anticonceptiva , Dispositivos Anticonceptivos , Femenino , Humanos , Conducta Sexual
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