Mucormicosis asociada a COVID-19: revisión de la literatura para odontólogos / COVID-19 associated mucormycosis: a literature review for dentists

La mucormicosis es una infección fúngica rara, con alta morbilidad y mortalidad. Se presenta principalmente en pa- cientes con diabetes mellitus no controlada, inmunocompro- metidos, con tratamiento crónicos con esteroides, entre otros. Actualmente, se cree que la pandemia de COVID-19 y los tratamientos con corticosteroides podrían estar implicados en el aumento de casos de esta micosis. Este hongo invade el sistema vascular, ocluyendo el flujo sanguíneo arterial y generando una rápida trombosis e isque- mia, lo que provoca la necrosis de los tejidos duros y blandos, con invasión rápida a los tejidos circundantes. Hay varias formas clínicas. En la cavidad bucal se presenta la variante rino-orbito-cerebral, que afecta el paladar en forma de lesión eritematosa o grisácea que puede progresar hacia la formación de una masa necrótica o ulceración con muy escaso sangrado de mucosa. Se manifiesta con síntomas típicos de una rinosinusitis con fiebre y dolor en las piezas dentarias superiores. El tratamiento consta de tres pilares fundamentales: el diagnóstico, un manejo adecuado de las comorbilidades y la combinación de las terapias antifúngica y quirúrgica. Desde el año 2020, la mucormicosis asociada a COVID-19 pasó a ser un evento de notificación obligatoria inmediata al Sistema Nacional de Vigilancia de la Salud (SNVS2.0) me- diante el Sistema Integrado de Información Sanitaria Argen- tina (SISA). Es importante destacar que se han reportado casos de mu- cormicosis luego de extracciones dentales; lo que impulsa a afianzar los conocimientos sobre esta enfermedad, extremar las medidas preventivas e incentivar el diagnóstico precoz en la atención odontológica, debido a la rapidez en la evolución de la patología (AU))

Mucormycosis is a rare fungal infection, with high mor- bidity and mortality. It occurs mainly in patients with uncon- trolled diabetes mellitus, immunocompromised, on chronic treatment with steroids, among others. Currently, it is believed that the COVID-19 pandemic and the corticosteroid treatments could be one of the causes of increased cases. This fungus invades the vascular system, occluding arteri- al blood flow and generating rapid thrombosis and ischemia, which causes necrosis of hard and soft tissues, with rapid in- vasion to the surrounding tissues. There are several clinical forms. In the oral cavity, the rhino-orbito-cerebral variant presents itself affecting the pal- ate in the form of an erythematous or grayish lesion that can progress towards the formation of a necrotic mass or ulcera- tion with very little mucosal bleeding. It manifests itself with typical symptoms of rhinosinusitis, with fever and pain in the upper teeth. The treatment consists of three fundamental pillars: diag- nosis, proper management of comorbidities and the combina- tion of antifungal and surgical therapies. Since 2020, COVID-19 associated mucormycosis became an event of mandatory immediate notification to the National Health Surveillance System (SNVS2.0,) through the Argentina Integrated Health Information System (SISA). It is important to emphasize that mucormycosis cases had been reported following tooth extractions, which drives to strengthen knowledge about this disease, extreme preventive measures and encourage early diagnosis in dental care, due to the speed of the evolution of the pathology (AU))

Manejo de la salud oral en el paciente pediátrico infectado por VIH / Oral health management in the HIV-infected pediatric patient

El síndrome de inmunodeficiencia adquirida (SIDA) se caracteriza por una infección adquirida ocasionada por el virus de la inmunodeficiencia humana (VIH), que afecta a la población linfocitaria CD4+ y que predispone al paciente a un estado de inmunodefi ciencia que lo hace susceptible a infecciones oportunistas severas y/o neoplasias inusuales. La infección por el VIH es un problema grave de salud pública, ya que hay alrededor de 34 millones de personas infectadas según el Centro Nacional de Prevención de Enfermedades de Atlanta; de esta población seropositiva para VIH 68 por ciento vive en África Subsahariana. El VIH se transmite a través de la contaminación con sangre, semen, fluidos vaginales y leche materna. Muchos de los portadores de este virus son asintomáticos lo que complica la situación en virtud de que si no se toman las precauciones de bioseguridad adecuadas, esta situación representa un riesgo para el profesional de la salud oral. Los odontólogos deben brindar un tratamiento adecuado a este tipo de pacientes e identifi car oportunamente cualquier riesgo de infección y complicaciones asociadas

cquired immunodeficiency syndrome (AIDS) is characterized by a seemingly irreversible impairment acquired in CD4 + lymphocyte population that predisposes the host to severe opportunistic infections and/or neoplastic unusual. Infection produced by human immunode-fi ciency virus (HIV) is a serious public health problem, as there are about 34 million people infected reported by the National Center for Disease Prevention Atlanta, this 68% HIV-positive population lives in Sub-Saharan Africa. HIV is transmitted through blood contamination, semen, vaginal fl uids and breast milk. Many patients infected with this virus are asymptomatic complicating the situation under if appropriate biosecurity measures are not taken; this situation represents a risk for oral health professional. Dentists should provide adequate treatment to these patients and promptly identify any risk of infection and as-sociated complications.

Diabetes mellitus tipo 1: características y tratamiento en un paciente periodontal. Caso clínico seguido por 16 años / Type 1 diabetes mellitus: features and treatment in a periodontal patient. A clinical case followed over 16 years

En este trabajo presentaremos el tratamiento periodontal de una paciente diabética tipo 1 insulino-dependiente y el enfoque interdisciplinario a través de ortodoncia, operatoria dental y prótesis, su seguimiento y terapia de mantenimiento durante 16 años. Explicaremos las características clínicas de la diabetes tipo 1 y el tratamiento médico concomitante.

The concentration of IL-1B in saliva of children with oral lesions associated to histiocytosis / Concentracion de il-1β en saliva de niños con lesiones bucales asociadas a histiocitosis

La Histiocitosis de células de Langerhans(HCL) es una enfermedad de etiología y patogenia aún desconocidas. Afecta diferentes órganos y tejidos en los que produce lesiones de distinta gravedad. La histopatología de las lesiones y la clínica sugieren la participación de citoquinas en su patogenia. La IL-1β podría tener un rol importante en el desarrollo de la enfermedad. El objetivo de este estudio fue determinar las concentracionesde IL-1β de las salivas de pacientes pediátricos con diagnóstico de Histiocitosis de Célula de Langerhans con y sin manifestaciones bucales (grupos 1 y 2 respectivamente), en relación a un grupo control (grupo 3), de pacientes pediátricos que no presentaron antecedentes médicos ni lesiones bucales. Fueron estudiadas las salivas de 20 pacientes con la enfer -medad de HCL, en relación a un grupo control de 11 pacientes pediátricos que no presentaron antecedentes médicos. Los niños con Histiocitosis cuyas edades oscilaban entre 4 meses y 16 años fueron derivados del servicio de Oncohematología del Hospital Garrahan y Hospital de Clínicas, a la Cátedra de Odontología Integral Niños de la Facultad de Odontología de la Universidad de Buenos Aires. Se determinaron las concentraciones de IL-1β en los diferentes grupos, y se utilizó el Enzyme Inmune Assay Kit (Cayman, MI, USA), se expresó en pg/ml. El análisis de los resultados se realizó según el test de Kruskall Wallis, se obtuvieron diferencias significativas entre los tres grupos (H = 20,36; P<0,001). Luego se realizó el análisis de comparaciones múltiples de Dunn que mostró diferencias estadísticamente significativas entre los grupos 1 y 2 y entre los grupos 1 y 3 (p < 0,05). Se observaron valores más elevados de IL-1β en los pacientes con Histiocitosis con manifestaciones bucales (grupo 1), en relación con el grupo sin manifestaciones bucales (grupo 2) y con el grupo control (grupo 3).

Langerhans Cell Histiocytosis (LCH) is a disease whosetiology and pathogenesis are still unknown. It affects several organs and tissues, producing lesions of different severity. Its histopathology and clinical picture suggest the participation of cytokines in its pathogenesis. IL-1β might have an important role in its development. The purpose of this study was to determine the concentrations of IL-1β in saliva of pediatric patients diagnosed with LCH, with and without oral manifestations (Groups 1 and 2respectively) compared to a Control Group (Group 3) of pediatric patients without medical antecedents or oral lesions.The saliva of twenty patients with LCH was studied and compared to a Control Group consisting of eleven pediatric patients without medical antecedents. The children with histiocytosis, aged four months to sixteen years, were referred by the Onco haematology Service at Garrahan Hospital and Hospital de Clínicas, to the Department of Comprehensive Children’s Dentistry, School of Dentistry, University of BuenosAires (UBA).The concentrations of IL-1β in the different groups were determined using the Enzyme Immune Assay Kit (Cayman MI,USA) and expressed in pg/ml. Results were analyzed by the Kruskall Wallis test. Significant differences between the three cohorts were found, (H = 20.36, P< 0.001). Dunn ́s multiple comparison analysis was performed, which showed significant differences between Groups 1 and 2, and between Groups 1 and 3 (P < 0.05). Higher values of IL-1βwere found in the patients with histiocytosis with oral manifestations (Group 1) than in patients without manifestations (Group 2) and patients in the Control Group (Group 3).

Adjuncts to traditional local anesthesia techniques in instance of hypomineralized teeth.

Molar incisor hypomineralization (MIH) is a defect in the enamel of permanent and/or primary molars and incisors. This disorder allows for rapid breakdown of the teeth and often calls for extensive restorative procedures. Due to the chronic pulpitis condition that is often associated with hypomineralized teeth, local anesthesia complications can result. This paper is a systematic review of the literature for the purpose of investigating adjuncts to traditional local anesthesia techniques in the case of hyper-responsive, hypomineralized-involved teeth during restorative procedures.

Dental and anaesthetic management of children with dystrophic epidermolysis bullosa.

BACKGROUND: Epidermolysis bullosa (EB) is a genetic disease associated with fragility and bullous lesions of the skin and mucous membranes. There are various patterns of inheritance and histopathology. The disease is associated with systemic and oral manifestations, among which may be dental decay necessitating oral rehabilitation. General anaesthesia is frequently required for oral rehabilitation in children with dystrophic EB. Paediatric dentists should be aware of the implications of dystrophic EB for dental and anaesthetic management. CASE REPORT: Two siblings with moderate to severe systemic and oral manifestations of dystrophic EB requiring extensive oral rehabilitation for rampant decay are described, including special anaesthetic techniques required for airway management and maintenance of skin integrity. CONCLUSION: Dystrophic EB is a rare genetic disorder in which vesiculobullous lesions occur with erosions and scarring of cutaneous and extracutaneous surfaces in the oral cavity. Poor oral hygiene results from efforts to avoid mucosal trauma, resulting in decay. The comprehensive care of children with dystrophic EB impacts not only dental management but anaesthesia administration as well.

Epilepsy and the dental management of the epileptic patient.

AIM: The aim of this article is to educate oral healthcare providers on the diagnosis and treatment of epilepsy and seizure disorders. It also shows the impact of epilepsy on the oral cavity and provides suggestions on the dental management of epileptic patients. REVIEW: Epilepsy and seizure disorders affect 1.5 million Americans. The disease is caused by a number of genetic, physiologic, and infectious disorders as well as trauma. Treatment is primarily pharmaceutical but can also be surgical. The disease itself and the pharmaceutical management often have an impact on the oral cavity. Primary management considerations are the provision of good periodontal care and the restoration of the teeth with stable, strong restorations. CONCLUSIONS: With proper understanding of patients with epilepsy and seizure disorders and their medical treatment, the dental care team can safely and effectively render dental care that will benefit the patient and minimize the risk of oral health problems in the future.

Orthodontic treatment of a patient with a renal transplant and drug-induced gingival overgrowth: a case report.

The treatment of transplant patients is becoming an ever-increasing part of modern-day orthodontic practice. This report details the successful orthodontic management of a paediatric renal transplant patient with significant drug-induced gingival overgrowth. The problems that such patients present with are discussed before considering the specific orthodontic techniques employed. Recommendations are made for practitioners managing such cases.

Oculocerebrorenal Lowe syndrome: a literature review and two case reports.

The present paper reviews the dental findings in oculocerebrorenal Lowe syndrome and presents two case histories. Reports of different patients are useful in order to enhance knowledge about the syndrome, because there are so many different oral manifestations.

Cardiovascular effects of local anesthesia with vasoconstrictor during dental extraction in coronary patients.

OBJECTIVE: To evaluate the occurrence of variables detecting myocardial ischemia during or after dental treatment under anesthesia with vasoconstrictor (epinephrine). METHODS: A total of 54 coronary patients undergoing dental extraction under local anesthesia with or without vasoconstrictor were included. They were divided into two groups (by drawing envelopes): group I (27 patients) using anesthetics with vasoconstrictor, and group II (27 cases) without vasoconstrictor. 24-hour Holter monitoring, Doppler-echocardiogram before and after dental intervention, and determination of biochemical markers (CK-MB mass, CK-MB activity, and troponin T) before and 24 hours after dental extraction were performed in all patients. Heart rate and blood pressure were also measured in the pre, post-anesthesia and post-dental extraction phases. Doppler echocardiography assessed left ventricular segmental contractility and the occasional occurrence of mitral regurgitation. The usual pharmaceutical treatment prescribed by the cardiologist was maintained in all cases. RESULTS: Three patients in group I presented ST-segment depression (1.0 mm) during administration of anesthesia; two other patients in group I had CK-MB mass elevation, and ischemia was not observed in any other case, as assessed by the other methods. No chest pain, arrhythmias, occurrence or worsening of left ventricular segmental hypocontractility or mitral regurgitation were observed in the study. CONCLUSION: Dental extraction performed under anesthesia with 1:100,000 epinephrine does not imply additional ischemic risks, as long as performed with good anesthetic technique and maintenance of the pharmacological treatment prescribed by the cardiologist.

Efeitos cardiovasculares da anestesia local com vasoconstritor durante exodontia em coronariopatas / Cardiovascular effects of local anesthesia with vasoconstrictor during dental extraction in coronary patients

OBJETIVO: Avaliar a ocorrência de variáveis detectoras de isquemia miocárdica, durante ou após o tratamento odontológico, sob anestesia com vasoconstritor (adrenalina). MÉTODOS: Foram incluídos 54 pacientes coronariopatas submetidos a exodontia sob anestesia local com ou sem vasoconstritor, divididos em dois grupos (sorteio por envelope): grupo I, composto por 27 que receberam anestésico com vasoconstritor; e grupo II, composto por 27 que receberam anestésico sem vasoconstritor. Todos os pacientes foram submetidos a monitoração eletrocardiográfica com Holter por 24 horas, a Doppler-ecocardiografia realizada antes e após intervenção odontológica, e a dosagem dos marcadores bioquímicos antes e 24 horas após a exodontia (creatina cinase fração MB [CK-MB] massa, CK-MB atividade e troponina T). A freqüência cardíaca e a pressão arterial nas fases pré-anestesia, pós-anestesia e pós-exodontia também foram aferidas. A Doppler-ecocardiografia teve como objetivo avaliar a contratilidade segmentar do ventrículo esquerdo e a eventual ocorrência de insuficiência mitral. Em todos os casos foi mantido o protocolo farmacológico habitual prescrito pelo cardiologista. RESULTADOS: Três pacientes do grupo I apresentaram depressão do segmento ST (1,0 mm) durante a aplicação da anestesia, dois outros pacientes do mesmo grupo tiveram elevação da CK-MB massa, e em nenhum caso foi verificada presença de isquemia avaliada pelos demais métodos. Não houve registro, neste estudo, de precordialgia, arritmias e ocorrência ou agravamento de hipocontratilidade segmentar do ventrículo esquerdo ou insuficiência mitral. CONCLUSÃO: A exodontia praticada sob uso de anestesia com adrenalina 1:100.000 não implica riscos isquêmicos adicionais quando realizada com boa técnica anestésica e manutenção do tratamento farmacológico prescrito pelo cardiologista.

OBJECTIVE: To evaluate the occurrence of variables detecting myocardial ischemia during or after dental treatment under anesthesia with vasoconstrictor (epinephrine). METHODS: A total of 54 coronary patients undergoing dental extraction under local anesthesia with or without vasoconstrictor were included. They were divided into two groups (by drawing envelopes): group I (27 patients) using anesthetics with vasoconstrictor, and group II (27 cases) without vasoconstrictor. 24-hour Holter monitoring, Doppler-echocardiogram before and after dental intervention, and determination of biochemical markers (CK-MB mass, CK-MB activity, and troponin T) before and 24 hours after dental extraction were performed in all patients. Heart rate and blood pressure were also measured in the pre, post-anesthesia and post-dental extraction phases. Doppler echocardiography assessed left ventricular segmental contractility and the occasional occurrence of mitral regurgitation. The usual pharmaceutical treatment prescribed by the cardiologist was maintained in all cases. RESULTS: Three patients in group I presented ST-segment depression (1.0 mm) during administration of anesthesia; two other patients in group I had CK-MB mass elevation, and ischemia was not observed in any other case, as assessed by the other methods. No chest pain, arrhythmias, occurrence or worsening of left ventricular segmental hypocontractility or mitral regurgitation were observed in the study. CONCLUSION: Dental extraction performed under anesthesia with 1:100,000 epinephrine does not imply additional ischemic risks, as long as performed with good anesthetic technique and maintenance of the pharmacological treatment prescribed by the cardiologist.

Comprehensive dental care of pediatric patients treated under general anesthesia in a hospital setting in Saudi Arabia.

The aims of this study were to determine the characteristics of patients and type of dental treatment carried out using dental general anesthesia (DGA) during two years in a following three year period. A total of 182 patients received treatment between 1999 and 2001. The mean age was 4.9 years. The main indication for DGA was behavior management problems. Complete oral rehabilitation including complex restorative treatment and extractions was provided under DGA at a single visit. Failure to return for recalls was common; 83% of patients returned for the post-operative recall but only 26% after a three year period. Most of the patients requiring further treatment accepted it in the dental chair. Only one patient received a second DGA during the three years following treatment.

Effects of functional training of dysphagia to prevent pneumonia for patients on tube feeding.

OBJECTIVE: The purpose of this study was to evaluate the effects of functional training on outbreak frequency of pneumonia for the elderly dysphagia patients who were being tube fed. METHODS: Subjects were divided into two groups; one group (n = 10) received oral care (i.e. non-training group) and the other group (n = 11) received functional training of dysphagia in addition to oral care (i.e. training group). The dental health team treated subjects once a week for 3 years (1999-2001). The frequency of pneumonia outbreaks and changes in activities of daily living scale (ADL) were evaluated for each year. RESULT: It was recognised that the frequency of pneumonia in the training group decreased year by year (p < 0.05). Cognitive items in ADL improved in two subjects of the training group. No statistical differences were recognised in the non-training group. CONCLUSION: It was suggested that once-a-week functional training of dysphagia with professional oral care might be effective in preventing pneumonia for elderly people who were being tube fed.

[Dental extraction in patients with bleeding disorders. Proposal of a protocol based on the type of anesthesia used]. / Extractions dentaires chez les patients porteurs d'un trouble de l'hémostase. Proposition d'un protocole basé sur le type d'anesthésie nécessaire.

INTRODUCTION: The authors propose a protocol to avoid bleeding complications in patients with bleeding disorders. MATERIAL AND METHOD: When a general anesthesia or trunk nerve infiltration is indicated, clotting factor concentrates are to be used in patients with severe bleeding disorders. Desmopressin is to be used in patients with mild bleeding disorders but who are good responders and in patients with thrombopathy. An antifibrinolytic treatment and a fibrin glue are also used. Ninety-six patients underwent 107 extractions with this protocol. RESULTS: Only two patients had bleeding complications requiring an additional treatment. DISCUSSION: In case of bleeding disorders, the treatment depends on disease severity and type of anesthesia. A general treatment (clotting factor concentrates or desmopressin) is indicated with general anesthesia and with local anesthesia in severe bleeding disorders, but not absolutely necessary with local anesthesia in mild bleeding disorders. However, desmopressin can used in all good responders.

Tratamiento odontopediatrico de un paciente VIH(+) bajo anestesia general: primer caso en el Posgrado de Odontologia Infantil en la Facultad de Odontologia de la UCV / Pediatric dental treatment of a HIV+ patient under general anesthesia: first case at the Postgraduate of Pediatric Dentistry in the School of Dentistry, UCV

El sÝndrome de inmunodeficiencia adquirida es una enfermedad de alta mortalidad causada por el virus de la inmunodeficiencia humana (VIH), el cual se caracteriza por un defecto adquirido aparentemente irreversible en la inmunidad celular, que predispone al huÚsped a infecciones oportunistas severas y/o neoplasias inusuales. Se estima que el VIH infecta a 1000 niños cada dÝa en el mundo, el 90 por ciento se han contaminado durante el embarazo, parto o lactancia, a partir de una madre infectada. La infección perinatal por el VIH deberÝa ser considerada como una enfermedad familiar que requiere el manejo mÚdico multidisciplinario y servicios de atención social. En este trabajo presentamos el caso de un paciente de 3 años de edad infectado por el VIH, cuyos padres tambiÚn estaban infectados. Este niño presentaba una problemßtica bucal de caries rampante. Vale la pena destacar que Úste es el primer caso VIH(+) de nuestro postgrado, el cual se trata bajo anestesia general y fue atendido por un equipo multidisciplinario conformado por mÚdicos, odontólogos y un auxiliar de la Facultad de OdontologÝa de la U.C.V. y de los hospitales J. M. de los RÝos y Universitario de Caracas

A practical guide for patients undergoing exodontia following radiotherapy to the oral cavity.

Dental extractions or minor oral surgery in patients who have undergone radiation therapy for cancer in the head and neck carry the risk of one of the most serious and devastating complications of head and neck radiotherapy, that of osteoradionecrosis (ORN). A totally unified approach to dental extractions following radiotherapy is lacking. The role of the general dental practitioner in management of patients following radiotherapy is crucial. Contrary to clinical impression, the risk of ORN does not decrease with time. When contemplating exodontia or minor oral surgery in the irradiated patient, special consideration should be given to issues such as radiotherapy history, surgical assessment, surgical procedure and the role of antibiotics and hyperbaric oxygen.

Tratamiento odontopediátrico integral de un caso de hipotiroidismo congénito. Reporte de un caso / Comprehensive pediatric dental treatment of congenital hypothyroidism. Report of a case

Se reporta el caso de una niña de 9 años y 7 meses de edad con hipotiroidismo congénito, quien fue referida del Hospital Cayetano Heredia al Servicio de Odontología Pediátrica Post-Grado para su tratamiento integral. La niña fue evaluada en forma integral trabajando en forma multidisciplinaria con las diferentes áreas médicas y especialidades estomatológicas. Se realizó un diagnóstico minucioso y presciso, estableciendo un plan de tratamiento integral teniendo en cuenta la edad de la paciente y el nivel de cooperación que presentaba, dando énfasis tanto al aspecto recuperativo como al aspecto preventivo. El presente reporte muestra una vez más el importante rol del odontopediatra en el tratamiento de alteraciones sistémicas que tienen repercusión en la cavidad bucal y la necesidad de su identificación oportuna

Atención dental médicamente necesaria / Medically necessary dental care

En los últimos años ha vuelto a tomar auge el concepto de la atención integral del paciente. Desligar la atención dental y su impacto en la salud general del individuo, de la atención integral, equivale a enfocar en forma aislada, no realista y no funcional al sistema estomatognático. Este artículo tiene por objeto la atención dental médicamente necesaria, resaltar su importancia y defender el sitial de la estomatología en el tercer nivel de atención

Atención dental médicamente necesaria / Medically necessary dental care

En los últimos años ha vuelto a tomar auge el concepto de la atención integral del paciente. Desligar la atención dental y su impacto en la salud general del individuo, de la atención integral, equivale a enfocar en forma aislada, no realista y no funcional al sistema estomatognático. Este artículo tiene por objeto la atención dental médicamente necesaria, resaltar su importancia y defender el sitial de la estomatología en el tercer nivel de atención (AU)