Optimizing drug regimens and supplementation in orthognathic surgery: A comprehensive and practical guide.

OBJECTIVE: This study aimed to comprehensively review the literature and provide a practical guide for optimizing drug regimens and supplementation related to orthognathic surgery. METHODS: The authors conducted a thorough review of the existing literature, following the PRISMA-ScR guidelines. Various types of studies except case reports and reviews were included. The study applied specific inclusion criteria, focusing on perioperative and/or postoperative drugs, medications, or supplementation related to orthognathic surgery. RESULTS: This guide included 78 studies on various medications in orthognathic surgery. It encompasses clinical trials, cohort studies, cross-sectional studies, prospective and retrospective studies. The topics covered include antibiotics, analgesics, corticosteroids, antiemetics, hemostatic agents, local anesthetics, herbal medicine, and botulinum toxin. Pain and edema control involved specific medications, while local anesthesia utilized ropivacaine and bupivacaine. The guide also discusses mineral and vitamin supplementation. The effectiveness of hemostatic agents and antiemetics was highlighted. CONCLUSION: Pain management, reduced swelling, enhanced wound healing, and faster recovery are among the advantages. In addition to the standard drugs and medications, the inclusion of vitamin and mineral supplements, tranexamic acid, postoperative anesthetic blocks, and preemptive antiemetics is anticipated to offer various benefits in orthognathic surgery, despite the limited available evidence.

Photobiomodulation using 940-nm laser as an adjuvant therapy on orthognathic surgery: A randomized clinical trial.

This study aimed to evaluate the effectiveness of photobiomodulation (PBM) therapy using 940-nm laser in patients undergoing orthognathic surgery. Twenty individuals were randomly distributed into laser (n = 10) and control (n = 10) groups. The PBM was conducted immediately after surgery, after 24 h, 48 h, and weekly for up to 4 weeks. All participants were evaluated for pain, edema, trismus and paresthesia. Data were compared by Fisher's and Mann-Whitney or chi-square tests (5%). The pain decreased from 24 h to 4 weeks, with the laser group reaching any pain after 3 weeks (p < 0.001). A significant difference was noticed for trismus on days 14 and 30 (p = 0.002; p = 0.019), without difference in paresthesia (p = 0.198). Edema was lower on the laser group compared to control, without a significant difference for most measurements. Data indicate that 940-nm PBM therapy decreased the occurrence of postoperative pain and significantly improved trismus.

Characteristics of Adults Undergoing Soft Tissue and Orthognathic Surgery for Obstructive Sleep Apnea.

OBJECTIVE: To identify clinical and demographic characteristics of adults with obstructive sleep apnea (OSA) undergoing soft tissue and orthognathic sleep surgery, assess temporal trends in surgery type and proportion of women undergoing surgery, and provide clinical perspective before wide-spread implementation of hypoglossal nerve stimulation (HGNS). METHODS: In a retrospective cohort study, adults diagnosed with OSA from 2009 to 2016 were identified in a large integrated healthcare system. Characteristics between cohort members who did and did not undergo sleep surgeries were compared. Multivariable logistic regression models examined associations of different characteristics with whether surgery was performed. RESULTS: Of 172,216 adults with OSA, 2,262 (1.3%) underwent sleep surgery during 2009-2017. The most common sleep surgery was palate surgery (56.9%), which decreased proportionately over time. In multivariable analysis, older age and obesity were associated with lower odds of undergoing surgery. Those who underwent tonsillectomy and adenoidectomy were more likely to have larger tonsils and not require additional surgery, whereas tongue reduction recipients were more likely to have severe OSA and require multiple surgery types. The proportion of women undergoing surgery increased over time (p < 0.001 from trend test). CONCLUSION: Clinical and demographic characteristics associated with soft tissue and orthognathic sleep surgery were identified in a large adult cohort prior to widespread implementation of HGNS. An increase in sleep surgery among women and a decrease in palate surgery over time were observed. The findings provide clinical perspective on sleep surgery performed prior to implementation of HGNS and may inform future studies examining its associations with patient characteristics. LEVEL OF EVIDENCE: 3 Laryngoscope, 133:1262-1270, 2023.

Perioperative therapies to reduce edema after orthognathic surgery: a systematic review and meta-analysis.

Objective To systematically review the literature and assess the effectiveness of perioperative systemic and nonsystemic therapies in reducing edema after orthognathic surgery. Study Design Four databases (PubMed, Web of Science, Bireme, and Scopus) were searched. Only randomized clinical trials were included and assessed using the RoB 2.0 software (Cochrane Collaboration, London, UK). Studies were grouped into time of assessment and systemic/nonsystemic therapy. Results Eighteen studies were included in this review (8 in the meta-analysis, n = 349). The qualitative assessment of systemic (enzyme therapy, dexamethasone, betamethasone, and Venoplant) and nonsystemic therapies (thermotherapy and K-Taping) appear to reduce edema. Manual lymphatic drainage (MLD) after 72 hours (CI: -1.03 to 2.31; P = .45), and 30 days (CI: -1.53 to 0.49; P = .49), and laser after 24 hours (CI: -1.36 to 1.48; P = .93), 72 hours (CI: -4.81 to 2.92; P = .63), 30 days (CI: -3.44 to 0.99; P = .28), and 90 days (CI: -1.83 to 0.96; P = .54) showed no significance. Thermotherapy reduced edema after 48 hours (CI: -48.47 to -13.31; P = .0006) and 30 days (CI: -14.73 to -1.98; P = .01). Conclusion The Grading of Recommendations, Assessment, Development and Evaluations tool showed moderate evidence for thermotherapy (significant reduction of edema), whereas the MLD and laser results were rated as high certainty of evidence (no reduction of edema).

Quality-of-life improvement, psychosocial benefits, and patient satisfaction of patients undergoing orthognathic surgery: a summary of systematic reviews.

BACKGROUND: Function, aesthetics, and social and psychological well-being are all important aspects for patients undergoing orthognathic surgery. OBJECTIVE: To evaluate the impact of orthognathic surgery on patient perception and quality of life before, during and after treatment. SEARCH METHODS: All relevant systematic reviews published up to 31st July 2020 have been searched via MEDLINE via OVID, Scopus, EMBASE, Web of Science, Cochrane Database of Systematic Reviews, PsycINFO, AMED (Allied and Complementary Medicine Database), and PubMed.Ongoing systematic reviews and grey literature were eliminated. A manual search was also undertaken, and no restrictions were applied to language or publication date. SELECTION CRITERIA: Systematic reviews involving dentofacial deformities related to systemic disorders, cleft lip and palate, facial trauma, and syndromes affecting cranial and dentofacial structures were excluded. DATA COLLECTION AND ANALYSIS: Identification, screening, eligibility, and quality assessment [using the AMSTAR 2 tool (A Measurement Tool to Assess Systematic Reviews)] were performed by two authors independently. Data were synthesized qualitatively using thematic analysis. RESULTS: A total of 662 eligible studies were obtained of which 24 studies were selected for full-text evaluation, resulting in 12 eligible systematic reviews. LIMITATIONS: Due to heterogeneity of data, quantitative analysis was not possible. CONCLUSIONS AND IMPLICATIONS: Aesthetics and function are the main motives for seeking orthognathic surgery. Patient assessment before, during, and after orthognathic surgery is necessary for a thorough evaluation of self-perception and satisfaction throughout treatment. While psychological and social domains improved after orthognathic surgery treatment, the quality of life can deteriorate transiently during the pre-surgical orthodontic phase of treatment. A standardized assessment tool needs to be developed to assess quality-of-life changes consistently and provide comparable results. REGISTRATION: CRD42020199091.

Predictors of Blood Loss During Orthognathic Surgery and the Need for Pre-Deposit Autologous Blood Donation.

ABSTRACT: The aim of this study was to identify the clinicolaboratory predictors of relative blood loss (RBL) during orthognathic surgery and determine the need for predeposit autologous blood donation (PABD) for the surgery. Using a retrospective study design, 297 patients who underwent bimaxillary orthognathic surgery between 2016 and 2020 were enrolled. To investigate patient-specific risk factors, we calculated the allowable blood loss (ABL) for each patient and RBL as the ratio of estimated intraoperative blood loss (EiBL) to ABL. The correlations between the clinico-laboratory variables and EiBL and RBL were analyzed using stepwise multivariate regression analysis, and independent t test and one-way ANOVA were performed.There was no significant difference in transfusion rate between the PABD group (N = 202/279) and non-PABD group (N = 77/279) ( P   =  0.052). Sex ( P   <  0.001), body mass index class ( P   =  0.001), operative time ( P  < 0.001), and baseline hematocrit ( P  < 0.001) were significant predictors of EIBL and RBL. EIBL exceeded ABL in only 2 patients. The significant factors of RBL in orthognathic surgery were hematocrit, body mass index, and operative time. Clinicians should be more careful about bleeding in patients with low baseline hematocrit level or high body mass index, or those expected to undergo prolonged surgeries owing to a complicated surgical plan. The need for PABD before orthognathic surgery is low.

Does the use of low-level light therapy postoperatively reduce pain, oedema, and neurosensory disorders following orthognathic surgery? A systematic review.

The aim of this study was to evaluate the efficacy of low-level light therapy (LLLT) in improving pain, oedema, and neurosensory disorders of the inferior alveolar nerve (IAN) after orthognathic surgery. This systematic review was performed in compliance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Searches were conducted in the PubMed, Embase, and Web of Science databases for randomized clinical trials (RCTs) published up to September 2020. After evaluating eligibility, 15 RCTs were selected. None of the studies reported an evaluation of all of the outcomes within the same publication. It was possible to determine the effect of LLLT in controlling pain following orthognathic surgery. Of the three studies evaluating this outcome, all observed a positive effect. Of the four studies that evaluated oedema, two found a positive effect. Of the 11 studies that evaluated neurosensory disorders of the IAN, all of them observed a positive effect, at least in one of the sensory evaluation tests. A meta-analysis was not possible due to the heterogeneity across studies. Considering the limitations of this review, but given the fact that LLLT is a minimally invasive intervention, its use merits consideration in immediate postoperative orthognathic surgery.

Effects of low-level laser therapy on reducing pain, edema, and trismus after orthognathic surgery: a systematic review.

The purpose of this study was to systematically review the scientific evidence of the effect of low-level laser therapy (LLLT) on the perception of pain, edema, and trismus after orthognathic surgery. The literature was searched in 11 databases (MedLine via PubMed, Scopus, LILACS, SciELO, Embase, Web of Science, Cochrane Library, and LIVIVO, OpenGrey, OADT, and OpenThesis), without restriction of publication year or language. This search aimed to identify randomized clinical trials comparing low-level laser therapy and placebo for controlling pain, edema, and trismus after orthognathic surgeries. Two reviewers extracted the data and assessed the individual risk of bias of the eligible studies using the Cochrane Collaboration Risk of Bias Tool (RoB, version 2.0). The initial search resulted in 808 articles, from which only five (total of 190 participants) were included in the qualitative synthesis. The studies were published from 2014 to 2020. Two presented a low risk of bias + in the mean mouth opening of all patients subjected to bimaxillary surgery who received LLLT. However, the other study found a significant difference in maximum mouth opening in the LLLT group at 14, 30, and 60 days after surgery. Based on limited evidence, LLLT was presented as an auxiliary tool for reducing pain and trismus after surgery. However, the reduction of edema is controversial due to the absence of measuring standardization.

RETRACTED: Does Low-Level Laser Photobiomodulation Improve Neurosensory Recovery After Orthognathic Surgery? A Clinical Trial With Blink Reflex.

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief. The article includes material that had already appeared in de Oliveira RF, da Silva AC, Simoes A, Youssef MN, de Freitas PM. Laser Therapy in the Treatment of Paresthesia: A Retrospective Study of 125 Clinical Cases. Photomed Laser Surg. 2015 Aug; 33(8)415-23. doi: 10.1089/pho.2015.38888. PMID:26226172 in the journal Photomedicine and Laser Surgery by Mary Ann Liebert Publishing. Any re-use of any material should be appropriately cited and published with permission of any relevant copyright owner. As such this article represents a misuse of the scientific publishing system. Apologies are offered to readers of the journal that this was not detected during the submission process.

Análise fonoaudiológica na cirurgia ortognática: estudo de caso uma década após procedimento / Speech-Language and Hearing Sciences Analysis in orthognathic surgery: a case study with a ten-year follow up / Análisis fonoaudiológica en la cirugía ortognática: estudio de caso una década de evolución posquirúrgica

Introdução: desproporções esqueléticas são consideradas casos extremos de variação da tipologia facial, caracterizadas por grandes alterações da oclusão associadas a modificações funcionais. O tratamento é orto-cirúrgico, com reconstrução das bases ósseas por meio de cirurgia ortognática. Após essa cirurgia, o acompanhamento fonoaudiológico auxilia o paciente no reconhecimento da nova face e nas readaptações das funcões de respiração, fala, mastigação e deglutição. Objetivo: apresentar relato de caso clínico de cirurgia ortognática, em seguimento longitudinal de 10 anos, por meio de análise das avaliações fonoaudiológicas. Relato do caso: mulher, 26 anos, portadora de deformidade craniofacial do tipo Classe III, prognata, com queixa estética e de mastigação, com indicação de cirurgia ortognática. Foram realizadas cinco avaliações fonoaudiológicas, sendo: a primeira na fase pré-operatória, segunda no 19º dia de pós-operatório, terceira após três meses de reabilitação fonoaudiológica, quarta após quatro meses de manutenção dos resultados obtidos e a quinta após 10 anos da intervenção cirúrgica. Em avaliação pré-cirúrgica foi registrada alteração no padrão miofuncional relacionado às funções de mastigação, deglutição, fala e respiração. Após terapia fonoaudiológica observou-se melhora da musculatura de lábios, bochecha, masseter e postura de língua, bem como na amplitude dos movimentos mandibulares. Em 10 anos observa-se estabilidade nos padrões funcionais de respiração, posicionamento de língua em repouso, organização do padrão da fala, articulação, deglutição, assim como na autoestima da paciente. Considerações finais: o tratamento fonoaudiológico associado à cirurgia ortognática e à ortodontia mostrou evoluções e eficácia, para nesse caso, atingir satisfação da paciente aos novos ajustes do padrão miofuncional.

Introduction: dentofacial deformities are seen as extreme cases of facial typology variation, characterized by major changes in occlusion associated with functional modifications. It requires an ortho-surgical treatment, in which the bone bases are reconstructed through orthognathic surgery. Treatment and monitoring are required after surgery with a Speech-language Pathologist (SLP) in order to assist patients in the recognition of their new faces and in the adjustments of orofacial functional patterns, avoiding negative interferences. Purpose: to report an orthognathic surgery clinical case in a 10-year longitudinal follow-up through the analysis of the SLP assessments. Case report: a prognathous 26-year-old woman with Class III craniofacial deformity, presenting aesthetic and chewing complaints with indication for orthognathic surgery. Five SLP ́s assessments were conducted, as follows: the first one, in the preoperative stage; the second, 19 days after the surgery; the third, after three months of SLP rehabilitation; the fourth, after four months of follow-up as maintenance of the results obtained; and the fifth, ten years after the surgical intervention. In the preoperative assessment, changes were recorded in the myofunctional pattern related to chewing, swallowing, speech and breathing functions. Improvements in the lip, cheek and masseter muscles were reported after SLP therapy, as well as in tongue posture and mandibular range of motion. After 10 years, favorable changes were observed in breathing pattern and tongue posture at rest, organization and stability of speech, articulation, and swallowing patterns, as well as in the patient's self-esteem. Final considerations: the SLP approach associated with orthognathic surgery and orthodontics procedure achieved evolutions and proved to be effective, leading this patient to satisfactory new adjustments of the myofunctional pattern.

Introducción: Desproporciones esqueléticas son consideradas casos extremos de variaciones de la tipología facial, caracterizadas por grandes alteraciones de la oclusión asociadas a las modificaciones funcionales. El tratamiento es echo con ortodoncia y cirugía ortognática, con reconstrucción de las bases óseas y estabilización oclusal. Después de esa cirugía, acompañamiento fonoaudiólogo auxilia el paciente en el reconocimiento facial y en las readaptaciones de las funciones estomatognáticas. Objetivo: Presentar relato de caso clínico de cirugía ortognática, en seguimiento longitudinal de 10 años, por medio de análisis de las evaluaciones fonoaudiológicas. Relato del caso: Mujer, 26 años portadora de deformidad cráneo facial del tipo clase III, prognata, con queja estética y de masticación, con indicación de cirugía ortognática. Fueron realizadas cinco evaluaciones fonoaudiológicas, siendo: la primera en la fase pre-operatorio, segunda en el 19º día de post operatorio, tercera después de tres meses de rehabilitación fonoaudiológica, cuarta después de cuatro meses de manutención de los resultados obtenidos y la quinta después de 10 años de la intervención de cirugía. En la evaluación preoperatorio fue registrada alteración en el patrón miofuncional relacionado a las funciones de masticación, deglución, habla y respiración. Después terapia fonoaudiológica se observó mejora en la musculatura de labios, mejillas, masseter (musculo masetero) y postura de la lengua, bien como en el patrón de oclusión. En 10 años se observa el cambio favorable en el patrón de respiración y posicionamiento de la lengua en reposo, organización y estabilidad del patrón de habla, articulación, deglución, así como en el auto estima de la paciente. Consideraciones Finales:El tratamiento fonoaudiológico asociado a la cirugía ortognática y la ortodoncia mostro evoluciones y eficacia, para en ese caso, alcanzar satisfacción de la paciente a los nuevos ajustes del patrón miofuncional.

Assessment of pre- and post-operative nutritional status in patients undergoing orthognathic surgery / Avaliação do estado nutricional pré e pós-operatório em pacientes submetidos à cirurgia ortognática

ABSTRACT: Introduction: The maxillofacial procedures for skeletal deformities are characterized by structural-morphological changes derived from unfavorable genetics with diagnosis performed during craniofacial growth. Orthognathic surgery requires a total restriction on chewing for 60 days, leading to loss of body weight in overweight and obese individuals, as well as in well-nourished patients. Objective: Evaluating the pre- and post-operative nutritional status of patients undergoing orthognathic surgery. Material and methods: This is an interventional study. The study group received supplementation with whey protein, L-arginine, L-glutamine, and fatty acid Omega-3, and both groups were assessed in terms of anthropometric and biochemical measurements. The evaluation of soft tissue healing was conducted after surgery. Results: It is possible to infer that the percentage of skeletal muscle mass tends to increase in the intervention group, however, the weight loss was greater (-4.88%). Uric acid increased post-operative in the control group (+37.64%). Conclusion: Oral nutritional supplementation used in the study seems promising for reducing the loss of skeletal muscle mass, but further studies involving a larger number of patients are needed to confirm the results. (AU)

RESUMO: Introdução: Os procedimentos maxilofaciais para deformidades esqueléticas são caracterizados por intervenções morfológicas estruturais, necessários por conta de genética desfavorável com diagnóstico feito durante o cresci-mento craniofacial. A cirurgia ortognática requer uma restrição total na mastigação por 60 dias, levando à perda de peso corporal em indivíduos com sobrepeso e obesos, bem como em pacientes bem nutridos. Objetivo: Avaliar o estado nutricional pré e pós-operatório dos pacientes submetidos à cirurgia ortognática. Material e métodos: Trata-se de um estudo de intervenção. O grupo de estudo recebeu suplementação com proteína de soro de leite, L-arginina, L-glutamina e ácido graxo ômega-3 e ambos os grupos foram avaliados em termos de medidas antropo-métricas e bioquímicas. A avaliação da cicatrização de tecidos moles foi realizada após a cirurgia. Resultados: É possível inferir que o percentual de massa muscular esquelética tendeu a aumentar no grupo de intervenção, porém a perda de peso foi maior (-4,88%). O ácido úrico aumentou no pós-operatório no grupo controle (+37,64%). Conclusão: A suplementação nutricional oral utilizada no estudo parece promissora para reduzir a perda de massa muscular esquelética, mas estudos adicionais envolvendo um número maior de pacientes são necessários para confirmar os resultados. (AU)

The effect of manual lymphatic drainage on patient recovery after orthognathic surgery-A qualitative and 3-dimensional facial analysis.

OBJECTIVE: The aim of this study was to investigate the effect of manual lymphatic drainage (MLD) on postoperative facial swelling and pain. STUDY DESIGN: A randomized, single-center, prospective, 2-arm clinical trial with blinded endpoint assessment was set up. Patients were enrolled from the Maxillofacial Department of the Ghent University Hospital (Belgium) between January 2015 and March 2018. Both the intervention group (n = 13) and the control group (n = 13) received the same postoperative care; in addition, the intervention group underwent 6 sessions of MLD after orthognathic surgery. Three-dimensional facial scans were performed and questionnaires administered on postoperative days 3, 7, 14, 30, 90, and 180. A linear mixed model was performed, and statistical significance was assumed at the 5% level. RESULTS: In total, 26 patients (mean age 29 years; range 16-57 years) were included for statistical analysis. A faster decrease in swelling in the intervention group was observed on 3-dimensional scans. Furthermore, patients receiving MLD reported reduction in swelling and pain within the first month after surgery. However, no statistically significant difference could be detected in these observations (P > .05). CONCLUSIONS: Within the limitations of this study, no statistically significant difference could be found between patients treated with or without MLD after orthognathic surgery with regard to swelling and pain.

La ortodoncia y la cirugía ortognática como aliadas en el tratamiento / Orthodontics and orthognathic surgery as treatment allied

¿Qué es la estética? Es más que un concepto frívolo. Tiene que ver con la armonía facial, la autoestima, la autoimagen, la percepción de belleza. Es un concepto que involucra al individuo en su totalidad, en su ser, que va más allá de frivolidad estética. Muchos pacientes que vienen a la consulta no expresan inicialmente su real demanda. Expresan problemas funcionales, pero su real preocupación, en la mayor parte de los casos, es estética. Pueden manifestar que no pueden comer bien, masticar un alimento o que no respiran bien o sesean, pero su motivación principal es estética y tiene que ver con su propia autoestima. Las funciones de respiración, deglución, fonación, masticación, oclusión deben estar entre los objetivos a conservarse o restituirse por parte del especialista, pero el tratamiento sería un fracaso si no atendemos la demanda, a veces no bien explicitada, por el paciente y que responde a su profunda necesidad real. Para la OMS, la salud puede definirse como el estado completo de bienestar físico, mental y social. Nuestro objetivo, como agentes de salud, será poder satisfacer la demanda explícita o encubierta con la mayor estética y la mayor funcionalidad (AU)

What is aesthetics? It is more than a frivolous concept. It has to do with facial harmony, self-esteem, self-image, the perception of beauty. It is a concept, which involves the individual as a whole, in his being, which goes beyond aesthetic frivolity. Many patients who come to the office do not initially express their real demand. They express functional problems, but their real concern, in most cases, is aesthetic. They may state that they cannot eat well, chew a food or that they do not breathe well or sedate, but their main motivation is aesthetic and has to do with their own self-esteem. The functions of breathing, swallowing, phonation, chewing, occlusion should be among the objectives to be retained or restored by the specialist, but the treatment would be a failure if we do not meet the demand sometimes not well explained by the patient and responding to their Deep real need. For WHO, health can be defined as the complete state of physical, mental and social well-being. Our goal, as health agents, will be to be able to meet the explicit or covert demand with the greatest aesthetics and functionality (AU)

Effect of Lavender Oil Inhalation on Reducing Presurgical Anxiety in Orthognathic Surgery Patients.

PURPOSE: We hypothesized that lavender oil inhalation, before orthognathic surgery, would have an anxiolytic effect on patients. MATERIALS AND METHODS: We executed a single-blinded, randomized, prospective study. The study comprised 90 patients (43 men and 47 women) scheduled to undergo orthognathic surgery (bilateral sagittal split, Le Fort I, and bimaxillary osteotomies). The patients were exposed to different concentrations of lavender oil diffusions in 120 mL of water during a 1-hour period before surgery (group 1, 0.1-mL oil diffusion; group 2, 0.3-mL oil diffusion; and group 3, no oil). The predictor variable was the State-Trait Anxiety Inventory (STAI). The STAI-2 was used to assess trait anxiety scores, and the STAI-1 was used to assess state anxiety scores at the time of admittance (STAI-1-A) and after 1 hour, before operating room transfer (STAI-1-OR). We performed a χ2 analysis for categorical variables, 1-way analysis of variance for continuous variables, and paired-samples t test for patients' state and trait anxiety levels. The P value was set at .05. RESULTS: No significant differences were found between groups concerning gender, age, working status, educational background, and surgical operation to be performed. When the demographic data and STAI scores were compared, the STAI-2 scores of patients in group 3 aged between 18 and 30 years and high school graduates were significantly higher. The mean trait anxiety scores were significantly higher in group 2 than in group 1. The STAI-1-OR scores in all 3 groups were significantly higher than the STAI-1-A scores. However, no statistically significant difference was found between the groups. CONCLUSIONS: The results of this study suggested that 1 hour of presurgical inhalation of 0.1-mL and 0.3-mL lavender oil diffusions in 120 mL of water did not have an anxiolytic effect on patients undergoing orthognathic surgery. Future studies will focus on different concentrations, different inhalation times, and higher study samples.

Efficacy of orthodontic and orthognathic treatment for oral and maxillofacial deformities.

BACKGROUND: This study aims to assess the efficacy and safety of orthodontic and orthognathic treatment (OOT) for patients with oral and maxillofacial deformities (OMDF) systematically. METHODS: This study will comprehensively search Cochrane Library, PubMed, EMBASE, Scopus, Web of Science, PsycINFO, Index to Nursing and Allied Health Literature, Allied and Complementary Medicine Database, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure from their inceptions to the July 1, 2019. Grey literature will be explored via searching dissertations, Google scholar and conference abstracts. Two team members will independently perform all citations, data extraction, and methodological quality. We will also utilize RevMan 5.3 Software for statistical analysis. RESULTS: This study will provide high quality evidence of OOT for OMDF. The primary outcomes consist of number of patients cured; proportion of patients healed; and time to complete healing within trial period. Secondary outcomes include quality of life (often assessed as any relevant scales, such as 36-Item Short Form Survey), costs, and complications. CONCLUSION: This study will provide evidence for judging whether OOT is effective treatment for OMDF. SYSTEMATIC REVIEW REGISTRATION: CRD42019144610.

Incidence of Pneumothorax Experienced After Orthognathic Surgery.

The purpose of this study is to evaluate the frequency of pneumothorax following orthognathic surgery and describe its clinical presentation. A retrospective analysis of a hospital database was carried out on consecutive patients with normal presurgical clinical assessment, laboratory findings, and chest X-ray who underwent orthognathic surgery from January 2007 to September 2018 in the Department of Oral and Craniomaxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine. Two patients (0.038%), 1 male (age 20 years) and 1 female (age 32 years), complained of respiratory difficulty and chest pain and were clearly diagnosed with postoperative pneumothorax by radiographic chest X-rays from a sample of 5229 consecutive patients during the study period. Intercostal drainage under local anesthesia was performed immediately and the treatment effects for both patients were satisfactory. The present study findings indicate that although orthognathic surgeries can be safely performed in patients with craniofacial anomalies, some unexpected complications such as pneumothorax may occur. Therefore, accurate postoperative follow-up must be done in every patient to monitor possible clinical complications. Patients who experience respiratory difficulty and postoperative chest pain may have pneumothorax, and once it is diagnosed, treatment should be promptly carried out to eliminate further severe sequelae.

Longitudinal evaluation of the effects of low-power laser phototherapy on mandibular movements, pain, and edema after orthognathic surgery.

The aim of this study was to longitudinally evaluate mandibular movements, pain, and edema in patients who underwent low-power laser (LPL) phototherapy after bimaxillary orthognathic surgery. A double-blind, randomized, controlled clinical trial was conducted using 30 patients, who were divided into a study group (n = 15) and control group (n = 15). The former group received postoperative LPL (3 J/cm2, 808 nm, and 100 mW) and the latter group received placebo LPL phototherapy. Over a period of 60 days, these groups were evaluated for: mandibular movements - opening, laterality, and protrusion; pain - visual analogue scale; and edema - measured between cephalometric points. The study group showed significantly better jaw opening (p = 0.009), laterality (p = 0.036), and protrusion (p = 0.029) after 2 weeks in most comparisons. The study group showed significantly less postoperative pain (p < 0.001) in most comparisons, and they recovered from pain earlier than the control group. There was a reduction in edema, with no statistically significant difference for most measurements. As observed in most analyses, there were increases in values for all mandibular movements, no significant differences in the occurrence of edema, and decreases in the occurrence of pain.

[Systemic toxicity of local anesthetics]. / Sistemnaia toksichnost' mestnykh anestetikov.

The paper presents characteristics of local anesthetics used in dentistry and maxillofacial surgery taking into account their effectiveness and toxicity. We described the main clinical symptoms of manifestation of systemic toxicity and measures for prevention of local anesthesia complications, as well as the detailed protocol of 'lipid rescue' and resuscitation at manifestation of systemic toxic reaction of local anesthetics with the mechanism of the fatty emulsion action.