[Should a doctor take into consideration the influence of climatic factors? Deliberations on the occasion of the publication of a new monograph (the book of essays of arid medicine by Z.R. Zununov, I.H. Nurov, and S.Z. Zununova)].

The authors analyze the monograph of the Uzbek scientists professor Z.R. Zununov, I.H. Nurov, and S.Z. Zununova «Essays of arid medicine¼ (Tashkent: «KAMALAK-PRESS¼ publishing house, 2016;540). The book presents the results of the comprehensive bioclimatic assessment of the arid zones of Uzbekistan, their extreme climatic conditions (such as high intensity and solar radiation and the considerable duration of its period, dry air and summer heat, sandstorms (the so-called «Afghans¼), and the great variety of the natural health-improving factors including mineral waters, microclimate of the speleotherapeutic cave, the desert dune sand, etc. The work is based on the authors' conceptual theory of «arid/meteorological stress syndrome¼, underlain by the hypothesis of the predominant role of hyperthermal weather hypoxia. A wide range of issues id discussed related to weather and climate adaptation of the healthy subjects (both indigenous and non-indigenous residents) and the patients suffering from ischemic heart disease, chronic obstructive pulmonary disease, and rheumatoid arthritis. Of special interest are the methods proposed for the correction of dysadaptive changes including the application of the natural balneotherapeutic factors existing in the arid zone (hydrogen sulphide and iodine-bromine balneotherapy, climatic therapy, speleotherapy, and psammotherapy (arenation). An important definitive conclusion at which the authors arrive is the necessity of the experimental observations in agreement with the requirements of the medico-biological ethics.

Effect of environmental factors on the germination and emergence of Salvia verbenaca L. cultivars (verbenaca and vernalis): An invasive species in semi-arid and arid rangeland regions.

Salvia verbenaca (wild sage) is a commonly cultivated herbal medicine plant, which is native to the Mediterranean climate regions of Europe, Africa, Asia and the Middle East. However, it has become an invasive species in semi-arid and arid regions of southern Australia. Two varieties are present in this region, var. verbenaca and var. vernalis, each of which can be distinguished by differences in morphology and flowering period. Following trials to determine the optimum temperate regime for germination and response to light and dark, seeds of both varieties were tested for their response to variations in pH, moisture stress, salinity, and burial depth. The temperature and light trial was carried out using three different temperature regimes; 30/20°C, 25/15°C and 20/12°C, and two light regimes; 12 hours light/12 hours dark and 24 hours dark, with var. vernalis responding to relatively higher temperatures than var. verbenaca. The germination rate of neither species was significantly inhibited by complete darkness when compared to rates under periodic light exposure. Both varieties germinated at near optimum rates strongly to very strongly in all pH buffer solutions, from pH 5 to pH 10, but they responded most strongly at neutral pH. Var. vernalis showed slightly more tolerance to reduced moisture availability, moderate to strong salinity, and burial depth, compared to var. verbenaca. However, even a fairly shallow burial depth of 2 cm completely inhibited germination of both varieties. Thus, in circumstances where both varieties are present in a soil seedbank, var. vernalis could be expected to establish in more challenging conditions, where moisture is limited and salinity is 'moderate to high', implying that it is a more serious threat for invasive weed in conditions where crop plants are already challenged.

Dietary nitrate reduces the O2 cost of desert marching but elevates the rise in core temperature.

PURPOSE: Dietary nitrate (NO3 (-)) supplementation reduces the O2 cost of fixed-workload tasks performed in temperate environments but has not been examined in the heat. If this effect were retained it could reduce heatstroke risk in military personnel that are deployed for desert combat. METHODS: Nine men completed three 45 min loaded battle marches at a standard cadence (4.83 km h(-1)/1.5 % grade) while wearing full combat gear [BDU, boots, body armor (8 kg), NBC suit] and carrying a loaded rucksack (16 kg). The 1st March (FAM) commenced in a temperate environment. The 2nd and 3rd commenced in simulated dry desert conditions (41 °C/20 % RH) and required subjects to ingest the beetroot juice equivalent of 8.4 mmol NO3 (-) (BRJ) or a NO3 (-) depleted placebo (PLA) for 6 days prior. VO2, VCO2, V E, core (T re), skin (T sk), and mean body (T b) temperatures, HR, and physiological strain index (PSI) were measured continuously. Thermal sensation, generalized discomfort, and perceived exertion (RPE) were measured at 5 min intervals. Heat storage (HS) was calculated. Blood markers of gastrointestinal permeability (TNF, Il-6, HO-1) were measured before and after exercise. RESULTS: VO2 in BRJ was lower than PLA from 1 to 12; 16 to 26; and 29 to 45 min of exercise (p < 0.05). VCO2 in BRJ was lower than PLA from 1 to 12 min (p < 0.05). V E in BRJ was lower than PLA from 1 to 20 min of exercise (p < 0.05). T re and T b in BRJ exceeded PLA from 16 to 45 min (p < 0.05). TNF, Il-6, and HO-1 were reduced in BRJ (p < 0.05) while HR, PSI, Tsk, and HS were not altered (p > 0.05). Thermal sensation, generalized discomfort, and RPE were elevated in BRJ from 40 to 45, 25 to 45, and 10 to 45 min, respectively (p < 0.01). CONCLUSION: Metabolic efficiency was improved in BRJ. Paradoxically, body temperatures rose more. This was not due to gut permeability. Therefore, we speculate that based on elimination of other possibilities, blood redistribution from skin to skeletal muscle may have contributed to impaired heat exchange.

Pollen augments the influence of desert dust on symptoms of adult asthma patients.

BACKGROUND: East Asian desert dust storms that occur during mainly spring are called Asian dust storms (ADS). Our objective was to study the association of pollen and ADS with symptoms of adult asthma patients in Japan. METHODS: We designed a telephone survey to investigate the upper and lower respiratory, ocular, and skin symptoms of asthma patients during ADS in February, March, and December on 2009. Peak expiratory flow (PEF) was also measured from February to May. RESULTS: We surveyed 106 patients in February, 101 patients in March, and 103 patients in December. In February and March, Japanese cedar and/or cypress pollen was also in the atmosphere during ADS, but no pollen was identified during December survey. Worsening of upper or lower respiratory, ocular, or skin symptoms was noted by 20.8% of patients in February, 33.7% in March, and 16.5% in December. Worsening of symptoms was significantly more common in March than in February or December. Two patients needed emergency treatment for exacerbation during ADS in March, but no patient needed hospitalization in any period. There was no significant difference of the daily morning PEF/personal best PEF ratio between ADS days and control days. However, in patients with worsening of upper and/or lower respiratory tract symptoms, the daily morning PEF/personal best ratio was significantly associated with the atmospheric level of particulate matter, but not with levels of pollen or other air pollutants. CONCLUSIONS: Pollen augmented symptoms in adult asthma patients, but ADS on its own also were able to aggravate symptoms and pulmonary function.

[Spatial variability of soil moisture, nutrients, and productivity on slopeland in loessial semiarid region].

For the sustainable development and ecological construction in the loessial semiarid region, it is important to describe the variability of slopeland soil properties and the affecting factors of slopeland productivity. In this study, soil samples were taken from eroded steep slopeland, and leaf area index (LAI) and above-ground biomass (AGB) were measured at the sampling locations. The soil water content (WC) of 2 m depth at 20 cm intervals, and the soil organic matter (OM), total nitrogen (TN), total phosphorus (TP), available nitrogen (AN) and available phosphorus (AP) contents of 0-20 and 20-40 cm soil layers were determined in the laboratory. The results showed that the majority of the properties was normally distributed, and the nutrient contents were higher in 0-20 cm than in 20-40 cm layer, but the variations of soil nutrients were much smaller in 0-20 cm than in 20-40 cm layer. Soil nutrients had a significantly larger variation than soil moisture. Soil nutrient contents in 20-40 cm layer kept increasing from upslope to downslope, while those in 0-20 cm layer varied slightly. Slope topography had more obvious impact on soil organic matter, total nitrogen and available phosphorus than other affecting factors. Soil water and nutrient contents on the shallow gully trough were notably higher than those on the upslope, but above-ground biomass was less than that on the upslope. Though longitudinal slope (35 degrees-45 degrees) was obviously larger than the horizontal one (5 degrees-10 degrees), horizontal slope position had a greater influence on soil nutrients, but much weaker effect on soil moisture than longitudinal direction. There were significant correlations between 0-120 cm soil moisture and 20-40 cm soil nutrients, and among soil nutrients except 0-20 cm soil available phosphorus. Slopeland position had a great impact on soil moisture and nutrients, but soil moisture and/or nutrients had no significant impact on above-ground biomass.