RESUMEN
Selenium pollution from coal ash wastewater was investigated in Lake Sutton, NC. This lake has been continuously used as a cooling pond for a coal-fired power plant since 1972. Historic and recent levels of contamination in fish tissues (14-105µg Se/g dry weight in liver, 24-127 in eggs, 4-23 in muscle, 7-38 in whole-body) exceeded toxic thresholds and teratogenic effects were observed in fish collected in 2013. A high proportion (28.9 percent) of juvenile Lepomis spp. exhibited spinal and craniofacial malformations that were consistent with selenium poisoning. Teratogenic Deformity Index values indicated population-level impacts on the fishery. The partially monetized cost of resultant fishery losses was calculated at over $US 8.6 million annually, and over $US 217 million for the entire period of damage, which dates back to 1987 when chemical and biological monitoring began.
Asunto(s)
Peces/anomalías , Lagos , Intoxicación/economía , Intoxicación/patología , Selenio/envenenamiento , Contaminantes Químicos del Agua/envenenamiento , Animales , Anomalías Craneofaciales/inducido químicamente , Masculino , North Carolina , Columna Vertebral/anomalías , TeratógenosRESUMEN
RATIONALE: Exposure to arsenic through drinking water has been linked to respiratory symptoms, obstructive lung diseases, and mortality from respiratory diseases. Limited evidence for the deleterious effects on lung function exists among individuals exposed to a high dose of arsenic. OBJECTIVES: To determine the deleterious effects on lung function that exist among individuals exposed to a high dose of arsenic. METHODS: In 950 individuals who presented with any respiratory symptom among a population-based cohort of 20,033 adults, we evaluated the association between arsenic exposure, measured by well water and urinary arsenic concentrations measured at baseline, and post-bronchodilator-administered pulmonary function assessed during follow-up. MEASUREMENTS AND MAIN RESULTS: For every one SD increase in baseline water arsenic exposure, we observed a lower level of FEV1 (-46.5 ml; P < 0.0005) and FVC (-53.1 ml; P < 0.01) in regression models adjusted for age, sex, body mass index, smoking, socioeconomic status, betel nut use, and arsenical skin lesions status. Similar inverse relationships were observed between baseline urinary arsenic and FEV1 (-48.3 ml; P < 0.005) and FVC (-55.2 ml; P < 0.01) in adjusted models. Our analyses also demonstrated a dose-related decrease in lung function with increasing levels of baseline water and urinary arsenic. This association remained significant in never-smokers and individuals without skin lesions, and was stronger in male smokers. Among male smokers and individuals with skin lesions, every one SD increase in water arsenic was related to a significant reduction of FEV1 (-74.4 ml, P < 0.01; and -116.1 ml, P < 0.05) and FVC (-72.8 ml, P = 0.02; and -146.9 ml, P = 0.004), respectively. CONCLUSIONS: This large population-based study confirms that arsenic exposure is associated with impaired lung function and the deleterious effect is evident at low- to moderate-dose range.
Asunto(s)
Intoxicación por Arsénico/complicaciones , Agua Potable/análisis , Pulmón/efectos de los fármacos , Trastornos Respiratorios/inducido químicamente , Contaminantes Químicos del Agua/envenenamiento , Adulto , Areca/efectos adversos , Arsénico/análisis , Arsénico/orina , Intoxicación por Arsénico/etiología , Intoxicación por Arsénico/orina , Bangladesh , Relación Dosis-Respuesta a Droga , Agua Potable/efectos adversos , Femenino , Humanos , Pulmón/fisiopatología , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Pruebas de Función Respiratoria , Fumar/efectos adversos , Contaminantes Químicos del Agua/análisisRESUMEN
Exposure to TEX-OE®, a patented extract of the prickly pear cactus (Opuntia ficus indica) containing chaperone-stimulating factor, was shown to protect common carp, Cyprinus carpio L., fingerlings against acute ammonia stress. Survival was enhanced twofold from 50% to 95% after exposure to 5.92 mg L(-1) NH(3) , a level determined in the ammonia challenge bioassay as the 1-h LD50 concentration for this species. Survival of TEX-OE®-pre-exposed fish was enhanced by 20% over non-exposed controls during lethal ammonia challenge (14.21 mg L(-1) NH(3) ). Increase in the levels of gill and muscle Hsp70 was evident in TEX-OE®-pre-exposed fish but not in the unexposed controls, indicating that application of TEX-OE® accelerated carp endogenous Hsp70 synthesis during ammonia perturbation. Protection against ammonia was correlated with Hsp70 accretion.
Asunto(s)
Amoníaco/envenenamiento , Carpas/fisiología , Enfermedades de los Peces/prevención & control , Regulación de la Expresión Génica , Proteínas HSP70 de Choque Térmico/genética , Proteínas HSP70 de Choque Térmico/metabolismo , Intoxicación/veterinaria , Contaminantes Químicos del Agua/envenenamiento , Animales , Regulación de la Expresión Génica/efectos de los fármacos , Branquias/metabolismo , Dosificación Letal Mediana , Músculos/metabolismo , Opuntia/química , Extractos Vegetales/farmacología , Intoxicación/prevención & controlRESUMEN
Gametes were collected from Dolly Varden char (Salvelinus malma) from waterbodies in a region exposed to mining-related selenium (Se) releases in British Columbia, Canada. Fertilized eggs were incubated in a laboratory and deformities were assessed on newly-hatched alevins using a graduated severity index. No effects were observed on egg or alevin survival or larval weight across the studied exposure range of 5.4 to 66 mg/kg dry weight in egg. Length of some larvae was reduced at the highest egg Se concentrations and a clear residue-response relationship was observed for larval deformity. The egg concentration corresponding to a 10% increase in the frequency of deformity (EC10) was 54 mg/kg dry weight, which is substantially higher than reported for other cold-water fish species.
Asunto(s)
Oncorhynchus/anomalías , Selenio/envenenamiento , Contaminantes Químicos del Agua/envenenamiento , Animales , Colombia Británica , Femenino , Minería , Oncorhynchus/embriología , Reproducción/efectos de los fármacos , Selenio/análisis , Pruebas de Toxicidad/métodos , Contaminantes Químicos del Agua/análisisRESUMEN
In November 2002, the oil tanker Prestige sank off the northwestern coast of Spain, spilling more than 50,000 tons of petroleum with disastrous ecological and economical consequences. In order to analyse the harmful consequences of the oil spill on marine microalgae, short- and long-term effects of oil samples from the Prestige spill were studied using laboratory cultures of Dunaliella tertiolecta (strain Dt1Lwt). Significant inhibition of photosynthesis (assessed by F(v)/F(m), ETR(max) and alpha estimations) was observed after only 1h of oil exposure with clear concentration dependency. Three days later, photosynthetic activity remained inhibited although cell survival was only slightly effected. In cultures exposed to the lowest oil concentration, mitotic rates and percentage of motile cells were 17-33% and 12-42% of the controls, respectively. After 1 month, neither dividing nor motile cells were observed at the highest oil concentrations. However, after further incubation, occasionally the growth of rare cells resistant to oil was found. A fluctuation analysis was carried out to distinguish between resistant cells arising from rare spontaneous mutations and resistant cells arising from physiological or other mechanisms of adaptation. The existence of rapid evolution as result of preselective mutations from petroleum sensitivity to petroleum resistance was observed. Resistant cells arose by rare spontaneous mutations prior to the addition of oil, with a mutation rate of 2.76x10(-5) oil-resistant mutants per cell division. Apparently, rare spontaneous preselective mutations are able to assure the survival of microalgae in oil-polluted environments.
Asunto(s)
Chlorophyta/efectos de los fármacos , Petróleo/envenenamiento , Contaminantes Químicos del Agua/envenenamiento , Animales , Movimiento Celular/efectos de los fármacos , Supervivencia Celular/efectos de los fármacos , Chlorophyta/genética , Chlorophyta/metabolismo , Mutación , Fotosíntesis/efectos de los fármacos , Complejo de Proteína del Fotosistema II/metabolismo , Agua de Mar , España , Estadísticas no ParamétricasAsunto(s)
Tamaño Corporal , Desastres , Monitoreo del Ambiente , Petróleo/análisis , Hidrocarburos Policíclicos Aromáticos/análisis , Guerra , Contaminantes Químicos del Agua/análisis , Animales , Tamaño Corporal/efectos de los fármacos , Peso Corporal , Recolección de Datos , Mar Mediterráneo , Músculo Esquelético/química , Ostreidae/química , Ostreidae/metabolismo , Perciformes/metabolismo , Petróleo/envenenamiento , Hidrocarburos Policíclicos Aromáticos/envenenamiento , Smegmamorpha/metabolismo , Contaminantes Químicos del Agua/envenenamientoAsunto(s)
Bioensayo/métodos , Desastres , Monitoreo del Ambiente/métodos , Petróleo/envenenamiento , Navíos , Contaminantes Químicos del Agua/envenenamiento , Animales , Copépodos/efectos de los fármacos , Diatomeas/efectos de los fármacos , Concentración de Iones de Hidrógeno , Oxígeno/análisis , Petróleo/toxicidad , Medición de Riesgo , Agua de Mar/química , Contaminantes Químicos del Agua/toxicidadRESUMEN
Largemouth bass (Micropterus salmoides) and common carp (Cyprinus carpio) were collected from 13 sites located in the Mobile (MRB), Apalachicola-Flint-Chattahoochee (ARB), Savannah (SRB), and Pee Dee (PRB) River Basins to document spatial trends in accumulative chemical contaminants, health indicators, and reproductive biomarkers. Organochlorine residues, 2,3,7,8-tetrachlorodibenzo-p-dioxin-like activity (TCDD-EQ), and elemental contaminants were measured in composite samples of whole fish, grouped by species and gender, from each site. Mercury (Hg) and polychlorinated biphenyls (PCBs) were the primary contaminants of concern. Concentrations of Hg in bass samples from all basins exceeded toxicity thresholds for piscivorous mammals (>0.1 microg/g ww), juvenile and adult fish (>0.2 microg/g ww), and piscivorous birds (>0.3 microg/g ww). Total PCB concentrations in samples from the MRB, ARB, and PRB were >480 ng/g ww and may be a risk to piscivorous wildlife. Selenium concentrations also exceeded toxicity thresholds (>0.75 microg/g ww) in MRB and ARB fish. Concentrations of other formerly used (total chlordanes, dieldrin, endrin, aldrin, mirex, and hexachlorobenzene) and currently used (pentachlorobenzene, pentachloroanisole, dacthal, endosulfan, gamma-hexachlorocyclohexane, and methoxychlor) organochlorine residues were generally low or did not exceed toxicity thresholds for fish and piscivorous wildlife. TCDD-EQs exceeded wildlife dietary guidelines (>5 pg/g ww) in MRB and PRB fish. Hepatic ethoxyresorufin O-deethylase (EROD) activity was generally greatest in MRB bass and carp. Altered fish health indicators and reproductive biomarker were noted in individual fish, but mean responses were similar among basins. The field necropsy and histopathological examination determined that MRB fish were generally in poorer health than those from the other basins, primarily due to parasitic infestations. Tumors were found in few fish (n=5; 0.01%); ovarian tumors of smooth muscle origin were found in two ARB carp from the same site. Intersex gonads were identified in 47 male bass (42%) representing 12 sites and may indicate exposure to potential endocrine disrupting compounds. Comparatively high vitellogenin concentrations (>0.35 mg/mL) in male fish from the MRB, SRB, and PRB indicate exposure to estrogenic or anti-androgenic chemicals.
Asunto(s)
Lubina , Carpas , Enfermedades de los Peces/inducido químicamente , Enfermedades de los Peces/metabolismo , Contaminantes Químicos del Agua/envenenamiento , Animales , Citocromo P-450 CYP1A1/metabolismo , Dioxinas/análisis , Estradiol/metabolismo , Femenino , Enfermedades de los Peces/patología , Gónadas/patología , Hidrocarburos Clorados/análisis , Lípidos/análisis , Masculino , Metales Pesados/análisis , Plaguicidas/análisis , Ríos , Selenio/análisis , Sudeste de Estados Unidos , Testosterona/análogos & derivados , Testosterona/metabolismo , Vitelogeninas/metabolismo , Contaminantes Químicos del Agua/análisisRESUMEN
In marine mollusks, many physiologic functions are regulated seasonally depending on such factors as the reproductive cycle or the presence of food. The synthesis of nitric oxide by hemocytes of Mytilus galloprovincialis is among the multiple physiologic actions in the immune response, and it is also affected by season. The maximal basal production of NO by hemocytes of M. galloprovincialis was detected in summer, whereas the minimum values were detected in winter. In winter, the presence of IL-2 induced an increase in NO production that was not detected in summer. Three months after the Prestige oil spill (November 2002), basal NO production by the hemocytes of mussels in the Galician coast showed a progressive decrease and stopping, both in summer and in winter. The characteristic increase of NO synthesis induced by IL-2 in winter also disappeared all through 2003 and 2004. The two different nitric oxide synthases previously identified by immunoblotting between 1999 and 2002 were undetectable in both 2003 and 2004. When comparing the data obtained during 2003 and 2004 to those obtained in previous years, an increase in the proportion of SH cells was detected. Also, these cells showed a higher sensitivity to apoptosis- and necrosis-inducing agents than in earlier years.
Asunto(s)
Apoptosis/inmunología , Hemocitos/inmunología , Mytilus/inmunología , Óxido Nítrico/biosíntesis , Petróleo/envenenamiento , Contaminantes Químicos del Agua/envenenamiento , Animales , Apoptosis/efectos de los fármacos , Cicloheximida/inmunología , Fragmentación del ADN/efectos de los fármacos , Mytilus/citología , Óxido Nítrico/inmunología , Estaciones del Año , España , Factor de Crecimiento Transformador beta/inmunología , Factor de Necrosis Tumoral alfa/inmunologíaRESUMEN
We assessed the relationship between chronic arsenic exposure through drinking water with respiratory complications and humoral immune response by measuring serum immunoglobulin profiles in the affected subjects (arsenicosis patients) living in the arsenic endemic rural villages of Bangladesh. The duration of exposure was determined through detailed history of the patients (n=125) and the levels of arsenic in the drinking water and urine samples were determined. The mean duration of exposure in the patients was 7.4+/-5.3 y, and the levels of arsenic in the drinking water and urine samples were 216+/-211 and 223+/-302 micro g/L, respectively, compared to 11+/-20 and 29+/-19 microg/L, respectively, in the unexposed subjects. There was high prevalence of respiratory complications like breathing problems including chest sound, asthma, bronchitis and cough associated with drinking water arsenic toxicity. Arsenicosis patients had significantly elevated levels of IgG (P<0.001) and IgE (P<0.001) while the levels of IgA were also significantly higher (P<0.005) but IgM were similar to that of the control subjects. Analysis of the clinical symptoms based on skin manifestations showed the levels of both IgG and IgE were significantly elevated during the initial stages while IgE were further elevated with the duration of arsenic exposure. Arsenicosis patients with respiratory complications had mean serum IgE levels of 706+/-211 IU/mL compared to 542+/-241 IU/mL in patients without apparent involvement with the respiratory system (P<0.01). The eosinophil counts in the patients did not differ significantly from the unexposed subjects indicating that elevated levels of serum IgE might not be due to allergic diseases, rather it could be due to direct effects of arsenic. We found significant linear relationships between the levels of serum IgE and inorganic phosphorus (P<0.05), and serum IgA levels with urinary excretion of arsenic (P<0.001). These observations suggested that arsenic toxicity caused respiratory complications, induced changes in the humoral as well as mucosal immune responses.
Asunto(s)
Intoxicación por Arsénico/sangre , Arsénico/análisis , Inmunoglobulinas/sangre , Trastornos Respiratorios/sangre , Abastecimiento de Agua/análisis , Intoxicación por Arsénico/etiología , Intoxicación por Arsénico/patología , Exposición a Riesgos Ambientales/efectos adversos , Humanos , Inmunoglobulina A/sangre , Inmunoglobulina E/sangre , Inmunoglobulina G/sangre , Inmunoglobulina M/sangre , Recuento de Leucocitos , Fósforo/sangre , Trastornos Respiratorios/etiología , Trastornos Respiratorios/patología , Contaminantes Químicos del Agua/análisis , Contaminantes Químicos del Agua/envenenamientoRESUMEN
This was a cross-sectional study under taken to explore the socioeconomic perspective of the arsenicosis problem, carried out in arsenic contaminated Upazillas where at least 100 arsenicosis patients had been identified. Two of the Upazillas with significant arsenic mitigation intervention and three of the Upazillas with limited interventions were selected for the study. Seven hundred fifty respondents were included in the study from 25 villages of the 5 Upazillas. Arsenicosis became a serious problem for the affected communities. Majority (71.31%) of respondents obtained their drinking water from tubewells, almost one third (29%) of the respondents still knowingly using arsenic contaminated water. Primary reason identified for this practice was distance of safe water source. Majority (58.6%) of the respondents said to face economic and 17.9% said to face social problem of varied range. Patients of lower income group were particularly more likely to face economic problems (P< .001) as well as social problem (P< .01). About half (50.7%) of the arsenicosis patients faced difficulty whilst receiving treatment, particularly female patients were more likely to face problem than male (P< .05). Several concerns also were surfaced regarding the heath care service provider particularly to the women patients, some of which are: long waiting time for receiving treatment (15%), discrimination in service delivery (10.7%) and inadequate separate facility for female patients (14.3%). Moreover the issues of financial burden raised by the respondents seem to have emerged as significant in terms of health care access. Access to Health service was particularly difficult for poor patients, as they often had to face problems associated with accessing service like, non availability of medicines in the hospitals (50.7%), traveling long distance (26.7%), purchasing medicine in most cases (32.4%) etc. Their dissatisfaction was compounded by negligent behavior of health care staff and nature of treatment provided. Furthermore length of time needed for reversal of symptoms led to loosing faith on efficacy of treatment, which cascades to negligence of patient's part in seeking health care. Women are less likely to get treatment for arsenicosis than men (P< .01). As there appear to be specific difficulties for women particularly for poor women in accessing health care, social and cultural values make it difficult for them to attend to their own health needs and to travel to service providers. Study findings suggest that a significant proportion (79.9%) of arsenicosis patient was found to access alternative health care. This includes; Homeopath, village doctors, Kabiraj and local pharmacists. Respondents in high intervention Upazillas were significantly more likely to get treatment (P< .05), to face fewer problems and to be satisfied with the facility (P< .001). Provision of safe water options, periodic screening of water source for arsenic, availability of trained doctor, regular availability of medicine, doorstep treatment, follow up on severe patients were the suggestions came from community for improvement.
Asunto(s)
Arsénico/análisis , Queratosis/epidemiología , Melanosis/epidemiología , Contaminantes Químicos del Agua/envenenamiento , Adolescente , Adulto , Anciano , Bangladesh/epidemiología , Estudios Transversales , Monitoreo del Ambiente/economía , Monitoreo del Ambiente/estadística & datos numéricos , Monitoreo Epidemiológico , Femenino , Costos de la Atención en Salud , Necesidades y Demandas de Servicios de Salud , Humanos , Queratosis/economía , Queratosis/prevención & control , Masculino , Melanosis/economía , Melanosis/prevención & control , Persona de Mediana Edad , Factores Socioeconómicos , Contaminantes Químicos del Agua/análisisRESUMEN
The molecular basis and downstream targets of oral selenium supplementation in individuals with elevated risk of cancer due to chronic exposure from environmental carcinogens has been largely unexplored. In this study, we investigated genome-wide differential gene expression in peripheral blood mononuclear cells (PBMC) from individuals with pre-malignant arsenic (As)-induced skin lesions before and after 6 months daily oral supplementation of 200 microg L-selenomethionine. The Affymetrix GeneChip Human 133A 2.0 array, containing probes for 22,277 gene transcripts, was used to assess gene expression. Three different normalization methods, RMA (robust multi-chip analysis), GC-RMA and PLIER (Probe logarithmic intensity error), were applied to explore differentially expressed genes. We identified a list of 28 biologically meaningful, significantly differentially expressed genes. Genes up-regulated by selenium supplementation included TNF, IL1B, IL8, SOD2, CXCL2 and several other immunological and oxidative stress-related genes. When mapped to a biological association network, many of the differentially expressed genes were found to regulate functional classes such as fibroblast growth factor, collagenase, matrix metalloproteinase and stromelysin-1, and thus, considered to affect cellular processes like apoptosis, proliferation and others. Many of the significantly up-regulated genes following selenium-supplementation were previously found by us to be down-regulated in a different set of individuals with As-induced skin lesions compared to those without. In conclusion, findings from this study may elucidate the biological effect of selenium supplementation in humans. Additionally, this study suggests that long-term selenium supplementation may revert some of the gene expression changes presumably induced by chronic As exposure in individuals with pre-malignant skin lesions.
Asunto(s)
Antioxidantes/administración & dosificación , Intoxicación por Arsénico/genética , Regulación Neoplásica de la Expresión Génica/efectos de los fármacos , Lesiones Precancerosas/genética , Selenometionina/administración & dosificación , Neoplasias Cutáneas/genética , Contaminantes Químicos del Agua/envenenamiento , Arsénico/orina , Intoxicación por Arsénico/metabolismo , Intoxicación por Arsénico/orina , Bangladesh , Perfilación de la Expresión Génica , Humanos , Leucocitos Mononucleares/efectos de los fármacos , Leucocitos Mononucleares/fisiología , Masculino , Persona de Mediana Edad , Análisis de Secuencia por Matrices de Oligonucleótidos , Lesiones Precancerosas/inducido químicamente , Lesiones Precancerosas/metabolismo , Lesiones Precancerosas/orina , ARN/química , ARN/genética , Neoplasias Cutáneas/inducido químicamente , Neoplasias Cutáneas/metabolismo , Neoplasias Cutáneas/orinaRESUMEN
Anthropogenic activities resulting in elevated selenium (Se) levels in aquatic ecosystems can result in teratogenic and reproductive effects in fish and waterfowl. However, relationships between observed effects and exposure concentrations or body burdens are ambiguous. Therefore, it is critical to identify factors that affect Se ecotoxicity before defining adequate protective environmental regulations. One important political debate questions if Se ecotoxicity differs between standing (lentic) and flowing (lotic) waters and, if so, how this should be incorporated into the definition of protective criteria. In the present review, we compile and discuss the scarce literature regarding Se ecotoxicity in lotic systems, and we compare it to the substantial body of evidence for lentic systems. General differences between lentic and lotic systems with respect to ecology, hydrology, and biogeochemistry are identified and related to Se ecotoxicity. The limited knowledge regarding Se speciation in the biomagnification process is reviewed and put in context. Fundamental considerations suggest that Se ecotoxicity in lotic systems should be reduced compared to lentic systems, but we conclude that this statement is not substantiated by the existing data. Additionally, we identify critical gaps of knowledge that must be resolved in future studies before the argument can be decided conclusively.
Asunto(s)
Ecosistema , Selenio/química , Selenio/envenenamiento , Contaminantes Químicos del Agua/envenenamiento , Animales , Aves , Monitoreo del Ambiente , Peces , Selenio/análisis , Selenio/metabolismo , Movimientos del Agua , Contaminantes Químicos del Agua/metabolismoRESUMEN
Coal Oil Point (COP) is a natural oil seep off the coast of Santa Barbara, California. Although most studies examining the fate and effects of petroleum have focused upon urbanized or anthropogenic sources of inputs, few have examined the effects of polyaromatic hydrocarbons (PAHs) derived from natural seeps. In order to evaluate the effects of PAHs derived from COP on marine fish populations, hatchery-reared California Halibut (Platichthys californicus) were exposed for 30 days to seven dilutions of sediments collected from COP. Hepatic cytochrome P450 1A (CYP1A), biliary fluorescent aromatic compounds (FACs), gonadal somatic indices, and plasma steroid concentrations. Sixteen USEPA priority PAHs were targeted for analysis in each sediment dilution. In general, biochemical responses were somewhat recalcitrant to dose-response relationships and were less sensitive than the literature values established for the same indicators following exposure to urbanized PAHs. Trends toward reductions in plasma 17beta-estradiol concentrations were observed, but reductions in gonadal somatic indices were not observed. FAC values for naphthalene, benzo(a)pyrene, phenanthrene-related compounds reached maximums at 33-100% COP sediment. The resulting insensitivity may be unique for exposure to "natural" petroleum due to a higher concentration of lower molecular weight PAHs or uncharacterized inhibitors.
Asunto(s)
Exposición a Riesgos Ambientales , Lenguado/fisiología , Hidrocarburos Policíclicos Aromáticos/envenenamiento , Contaminantes Químicos del Agua/envenenamiento , Adaptación Fisiológica , Animales , Estradiol/sangre , Fenómenos Geológicos , Geología , Masculino , Petróleo , Testículo/citologíaRESUMEN
In the 2000 report of the National Research Council's Committee on the Toxicological Effects of Methylmercury (MeHg), various adverse health effects potentially associated with MeHg exposure including cardiovascular effects were considered. At that time, the committee concluded that neurodevelopmental toxicity was the most sensitive endpoint but recognized emerging evidence of potential cardiovascular effects at low levels of exposure. The committee recommended that these potential effects be addressed through the uncertainty factors applied to the development of the neurodevelopmental reference dose (RfD). This approach was adopted by the US EPA in its derivation of the methylmercury RfD. Since that time, additional studies have become available. The available studies addressing the broad categories of heart disease (including myocardial infarction (MI) and ischemic heart disease), hypertension, and heart rate variability are critically reviewed here. Overall, the evidence linking realistic rates of MeHg exposure from fish consumption to cardiovascular disease suggests an association with heart disease, particularly MI. The apparent antagonistic interaction of MeHg and n-3 fatty acids contained in fish suggests a causal mechanism. As different individuals and populations characteristically consume different species of fish, the risk of cardiovascular effects may not be a simple function of MeHg exposure but its assessment may well need to take n-3 fatty acid intake into account also. The case for significant adverse effects of MeHg on blood pressure at current levels of exposure is weaker. This effect, observed in childhood, does not appear to persist into adolescence, and animal studies are difficult to interpret given the high doses employed. The decrease in heart rate variability related to fetal exposure to MeHg in the same cohort appears to persist into early adolescence and may reflect developmental neurophysiological alterations that are consistent with the developmental neuropsychological effects also observed in that cohort. However, the cardiovascular significance of this effect with regard to its direct effect on health or its ability to predict other, more direct, health effects is unclear. At present, the studies of the Finnish cohort relating MeHg exposure to acute MI and coronary heart disease appear to provide the strongest basis for a formal quantitative risk assessment of the cardiovascular effects of MeHg.
Asunto(s)
Enfermedades Cardiovasculares/inducido químicamente , Exposición a Riesgos Ambientales/efectos adversos , Compuestos de Metilmercurio/envenenamiento , Contaminantes Químicos del Agua/envenenamiento , Adolescente , Adulto , Anciano , Animales , Presión Sanguínea/efectos de los fármacos , Presión Sanguínea/fisiología , Niño , Ácidos Grasos Omega-3/metabolismo , Femenino , Peces/metabolismo , Frecuencia Cardíaca/efectos de los fármacos , Frecuencia Cardíaca/fisiología , Humanos , Masculino , Persona de Mediana Edad , Medición de Riesgo/métodosRESUMEN
An estimated 40 million people in Bangladesh have been suffering from arsenic toxicity-related diseases because of drinking water contamination with high levels of naturally occurring arsenic. To evaluate the biochemical changes in chronic arsenic exposure, a total of 115 exposed subjects diagnosed as arsenicosis patients were examined and interviewed, and 120 unexposed volunteers were enrolled in this study. Drinking water, urine and peripheral blood samples were collected from all participants and analyzed. The average levels of arsenic in the drinking water and spot urine samples of the arsenicosis patients were 218.1 microg/L and 234.6 microg/L, respectively, and duration of exposure was 7.6 +/- 5.2 yrs that ranged from 1-25 yrs. Prevalence of diabetes mellitus among chronic arsenic-exposed subjects was about 2.8 times higher than the unexposed subjects. The activities of alkaline phosphatase were significantly elevated in the patients, 197 U/L compared to 149 U/L in the controls, but alanine transaminase and aspartate transaminase were mostly normal. The patients had significantly lower levels of serum creatinine, 0.97 mg/dL compared to 1.15 mg/dL in the controls; but had significantly elevated levels of total protein, 84 g/L and 77 g/L respectively. The mean level of inorganic phosphate in the serum of arsenicosis patients was 6.4 mg/dL compared to 4.6 mg/dL in the unexposed subjects and the level was significantly higher, indicating substitution of the pentavalent arsenate for the phosphate ion causing underutilization of the latter. Evaluation of the lipid profiles showed while the levels of triacylglycerol were not much different, the patients had significantly lower levels of cholesterol, HDL-cholesterol and LDL-cholesterol compared to the unexposed subjects. These findings suggest significant changes in biochemical parameters in human arsenic toxicity.
Asunto(s)
Intoxicación por Arsénico/sangre , Arsénico , Contaminantes Químicos del Agua/envenenamiento , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Alanina Transaminasa/sangre , Fosfatasa Alcalina/sangre , Arsénico/análisis , Arsénico/orina , Intoxicación por Arsénico/epidemiología , Intoxicación por Arsénico/orina , Bangladesh/epidemiología , Glucemia/análisis , Proteínas Sanguíneas/análisis , Colesterol/sangre , Creatinina/sangre , Monitoreo del Ambiente , Monitoreo Epidemiológico , Femenino , Humanos , Masculino , Persona de Mediana Edad , Fósforo/sangre , Triglicéridos/sangre , Contaminantes Químicos del Agua/análisis , Contaminantes Químicos del Agua/orina , Abastecimiento de Agua/análisisRESUMEN
Day-old mallard (Anas platyryhnchos) ducklings received either a clean sediment (24%) supplemented control diet, Coeur d'Alene River Basin, Idaho (CDARB) sediment (3449 microg/g lead) supplemented diets at 12% or 24%, or a positive control diet (24% clean sediment with equivalent lead acetate to the 24% CDARB diet) for 6 weeks. The 12% CDARB diet resulted in a geometric mean concentration of 396 ppb (WW) brain lead with decreased brain protein and ATP concentrations but increased oxidized glutathione (GSSG) relative to the control diet. The 24% CDARB diet resulted in a concentration of 485 ppb brain lead with lower brain weight and ATP concentration than controls but higher concentrations of reduced glutathione (GSH) and calcium. Lead acetate accumulated twice as well as CDARB derived lead and resulted in histopathological lesions of the brain. With a combination of a suboptimal diet and 24% CDARB, brain lead concentration was higher (594 ppb) than with 24% CDARB in the standard diet, histopathological lesions became apparent and GSH was higher than suboptimal diet controls.
Asunto(s)
Encéfalo/efectos de los fármacos , Patos/crecimiento & desarrollo , Sedimentos Geológicos/química , Intoxicación por Plomo/veterinaria , Contaminantes Químicos del Agua/envenenamiento , Fenómenos Fisiológicos Nutricionales de los Animales , Animales , Encéfalo/crecimiento & desarrollo , Encéfalo/patología , Dieta/veterinaria , Patos/metabolismo , Intoxicación por Plomo/complicaciones , Tamaño de los Órganos/efectos de los fármacos , Distribución AleatoriaRESUMEN
Incorporation of ecologically relevant biomarkers into routine environmental management programs has been advocated as a pragmatic means of linking environmental degradation with its causes. Here, suites of biomarkers, devised to measure molecular damage, developmental abnormality and physiological impairment, were combined with chemical analysis to determine exposure to and the effects of pollution at sites within Southampton Water (UK). Test species included a filter feeder, a grazer, and an omnivore to determine the sensitivity of organisms occupying different trophic levels. Linear regression confirmed a significant association between incidence of intersex in Littorina littorea and tributyltin (TBT) concentrations (R2 = 0.954) and between PAH metabolites in Carcinus maenas urine and PAHs in sediments (R2 = 0.754). Principal component analysis revealed a gradient of detrimental impact to biota from the head to the mouth of the estuary, coincident with high sediment concentrations of heavy metals, PAHs, and biocides. Multidimensional scaling identified C. maenas as the organism most sensitive to contamination. Carboxylesterase activity, metallothionein and total haemolymph protein were the most discriminating biomarkers among sites. This holistic approach to environmental assessment is encouraged as it helps to identify the integrated impact of chemical contamination on organisms and to provide a realistic measure of environmental quality.