RESUMEN
Calcium pantothenate (CAS no. 137-08-6) is the calcium salt of pantothenic acid (vitamin B5). It is used in cosmetics due to its anti-static and hair conditioning properties. A 53-year-old female nurse's aide presented with intermittent facial eruptions (Figure S1). Patch tests were positive to calcium pantothenate, an ingredient of two of her products (a cleansing milk and a facial tonic). To our knowledge, no previous cases of sensitization from calcium pantothenate have been reported except for one case of systemic dermatitis from a nutritional supplement in a dexpanthenol-sensitized patient.
Asunto(s)
Cosméticos/efectos adversos , Dermatitis Alérgica por Contacto/etiología , Dermatosis Facial/inducido químicamente , Ácido Pantoténico/efectos adversos , Complejo Vitamínico B/efectos adversos , Diagnóstico Tardío , Dermatitis Alérgica por Contacto/diagnóstico , Dermatosis Facial/diagnóstico , Femenino , Humanos , Persona de Mediana Edad , Pruebas del ParcheAsunto(s)
Dermatitis Alérgica por Contacto/diagnóstico , Dermatitis Profesional/diagnóstico , Dermatosis Facial/diagnóstico , Masaje , Dermatitis Alérgica por Contacto/etiología , Dermatitis Profesional/etiología , Dermatosis Facial/inducido químicamente , Femenino , Preparaciones para el Cabello/efectos adversos , Humanos , Masaje/métodos , Persona de Mediana Edad , Odorantes , Aceites Volátiles/efectos adversos , Aceite de Oliva/efectos adversosAsunto(s)
Dermatitis Alérgica por Contacto/etiología , Dermatosis Facial/inducido químicamente , Hiperpigmentación/inducido químicamente , Magnolia/efectos adversos , Corteza de la Planta/efectos adversos , Extractos Vegetales/efectos adversos , Crema para la Piel/efectos adversos , Anciano , Femenino , Humanos , Prurito/inducido químicamenteAsunto(s)
Aceite de Coco , Dermatitis Alérgica por Contacto/etiología , Dermatosis Facial/inducido químicamente , Extractos Vegetales/efectos adversos , Crema para la Piel/efectos adversos , Triglicéridos/efectos adversos , Dermatitis Alérgica por Contacto/diagnóstico , Dermatosis Facial/diagnóstico , Femenino , Humanos , Persona de Mediana Edad , Pruebas del ParcheAsunto(s)
Benzoquinonas/efectos adversos , Dermatitis Alérgica por Contacto/etiología , Aceites de Plantas/efectos adversos , Alérgenos/efectos adversos , Alopecia/tratamiento farmacológico , Benzoquinonas/inmunología , Reacciones Cruzadas/inmunología , Dermatitis Alérgica por Contacto/inmunología , Dermatosis Facial/inducido químicamente , Femenino , Humanos , Hidroquinonas/inmunología , Persona de Mediana Edad , Nigella sativa , Dermatosis del Cuero Cabelludo/inducido químicamenteAsunto(s)
Cosméticos/efectos adversos , Dermatitis Alérgica por Contacto/etiología , Eccema/inducido químicamente , Extractos Vegetales/efectos adversos , Scutellaria/química , Protectores Solares/efectos adversos , Timerosal/efectos adversos , Adulto , Dermatitis Alérgica por Contacto/prevención & control , Eccema/prevención & control , Dermatosis Facial/inducido químicamente , Dermatosis Facial/prevención & control , Femenino , Humanos , Pruebas del ParcheAsunto(s)
Dermatitis Alérgica por Contacto/etiología , Erupciones por Medicamentos/etiología , Nigella sativa , Aceites de Plantas/efectos adversos , Semillas/efectos adversos , Administración Cutánea , Eccema/inducido químicamente , Ojo , Dermatosis Facial/inducido químicamente , Femenino , Humanos , Persona de Mediana Edad , Aceites de Plantas/administración & dosificaciónAsunto(s)
Antiinfecciosos/efectos adversos , Aceite de Ricino/efectos adversos , Dermatitis Alérgica por Contacto/etiología , Dermatosis Facial/inducido químicamente , Nitrofurazona/efectos adversos , Sulfadiazina de Plata/efectos adversos , Pustulosis Exantematosa Generalizada Aguda/diagnóstico , Anciano , Quemaduras/terapia , Dermatitis Alérgica por Contacto/diagnóstico , Diagnóstico Diferencial , Humanos , MasculinoAsunto(s)
Carmín/efectos adversos , Colorantes/efectos adversos , Dermatitis Alérgica por Contacto/etiología , Dermatosis Facial/inducido químicamente , Formaldehído/efectos adversos , Conservadores Farmacéuticos/efectos adversos , Dorso , Nalgas , Cosméticos/efectos adversos , Dermatitis Alérgica por Contacto/complicaciones , Dermatomicosis/complicaciones , Dermatomicosis/tratamiento farmacológico , Dermatomicosis/microbiología , Suplementos Dietéticos/efectos adversos , Dermatosis Facial/microbiología , Femenino , Humanos , Malassezia , Persona de Mediana Edad , CuelloAsunto(s)
Cosméticos/efectos adversos , Dermatitis Alérgica por Contacto/etiología , Dermatosis Facial/inducido químicamente , Glycyrrhiza , Extractos Vegetales/efectos adversos , Anciano , Cosméticos/química , Humanos , Masculino , Persona de Mediana Edad , Pruebas del Parche , Extractos Vegetales/análisisAsunto(s)
Cosméticos/efectos adversos , Dermatitis Alérgica por Contacto/etiología , Flavonoides/efectos adversos , Glycyrrhiza/efectos adversos , Extractos Vegetales/efectos adversos , Adulto , Cromatografía Liquida , Cosméticos/química , Dermatosis Facial/inducido químicamente , Femenino , Flavonoides/análisis , Humanos , Espectrometría de Masas , Extractos Vegetales/químicaRESUMEN
BACKGROUND: More than 50% of adults report to suffer from sensitive skin. This common condition is characterized by subjective sensations such as prickling, burning, skin tightness or pruritus, and is often accompanied by objective symptoms like inflammation and erythema. OBJECTIVE: The objective of this study was to develop an active ingredient concept for the treatment of sensitive skin. We tested compounds regarding their potential to (i) decrease the release of proinflammatory mediators, which among others induce erythema and (ii) counteract the hyperresponsiveness of nerve fibres and, thus, exert effects on cutaneous neurosensory dysfunction. METHODS: 4-t-butylcyclohexanol, licochalcone A and acetyl dipeptide-1 cetyl ester were analysed in vitro regarding their potential to (i) decrease the release of PGE2 and activation of NFκB and to (ii) inhibit TRPV1 activation or the release of neuronal CGRP. To assess subjective and objective symptoms of skin sensitivity in vivo, two controlled, single-blind, randomized studies were conducted with 4-t-butylcyclohexanol and the combination with licochalcone A. RESULTS: In vitro, 4-t-butylcyclohexanol significantly reduced TRPV1 activation, while acetyl dipeptide-1 cetyl ester had no effect on receptor activation. Licochalcone A significantly decreased NFκB signalling and PGE2 secretion, at lower concentrations than acetyl dipeptide-1 cetyl ester. A formulation containing 4-t-butylcyclohexanol showed a significant immediate anti-stinging/anti-burning effect in vivo, and a cream base containing a combination of 4-t-butylcyclohexanol and a licochalcone A-rich licorice extract reduced shaving-induced erythema. CONCLUSION: In vitro and in vivo data indicate that the combination of the TRPV1 antagonist 4-t-butylcyclohexanol and the potent anti-inflammatory licochalcone A provide an effective active ingredient concept for the treatment of sensitive skin, as the topical application resulted in an immediate relief from symptoms such as erythema and stinging.
Asunto(s)
Antiinflamatorios no Esteroideos/uso terapéutico , Chalconas/uso terapéutico , Ciclohexanoles/uso terapéutico , Dermatosis Facial/tratamiento farmacológico , Dolor/tratamiento farmacológico , Trastornos de la Sensación/tratamiento farmacológico , Canales Catiónicos TRPV/antagonistas & inhibidores , Adulto , Animales , Antiinflamatorios no Esteroideos/farmacología , Péptido Relacionado con Gen de Calcitonina/metabolismo , Capsaicina/farmacología , Línea Celular , Chalconas/farmacología , Ciclohexanoles/farmacología , Dinoprostona/metabolismo , Dipéptidos/farmacología , Relación Dosis-Respuesta a Droga , Combinación de Medicamentos , Eritema/inducido químicamente , Eritema/tratamiento farmacológico , Dermatosis Facial/inducido químicamente , Femenino , Humanos , Masculino , Persona de Mediana Edad , FN-kappa B/efectos de los fármacos , FN-kappa B/metabolismo , Neuronas/efectos de los fármacos , Neuronas/metabolismo , Dolor/inducido químicamente , Trastornos de la Sensación/inducido químicamente , Transducción de Señal/efectos de los fármacos , Método Simple Ciego , Crema para la Piel/uso terapéutico , Porcinos , Canales Catiónicos TRPV/metabolismo , Adulto JovenRESUMEN
OBJECTIVE: To assess and compare the skin calming effect of cosmetic products containing 4-t-butylcyclohexanol (Eucerin(®) UltraSensitive Soothing Care Dry Skin) or acetyl dipeptide-1 cetyl ester (La Roche-Posay Toleriane(®) Ultra Intense Soothing Care) on subjective symptoms of skin sensitivity, a controlled, single-blind, randomized split-face capsaicin-induced stinging test was conducted. METHODS: Thirty-one female test subjects, ranging from 19 to 65 years of age, with self-perceived sensitive to very sensitive skin were enrolled. After a 3-day preconditioning period with no application of facial products and positive reaction to stimulation with a 40 ppm capsaicin cream, the test products were randomly applied to either the right or left nasolabial fold. Burning severity was assessed immediately after capsaicin application, and 1, 2, 5, 10 and 15 min after application of the test products. RESULTS: All 31 subjects reported a stinging/burning sensation on both nasolabial folds after application of capsaicin. Treatment with the 4-t-butylcyclohexanol containing product resulted in significant lower values for burning/stinging after one, and two minutes post-application in comparison to the values for the acetyl dipeptide-1 cetyl ester containing product. No significant difference was determined between the two test products for the point in time with most intense burning sensation, the severity of burning and the duration of burning after capsaicin application and subsequent application of the test products. CONCLUSION: Both products alleviated capsaicin-induced burning during the first 15 min after application. A faster and more pronounced soothing effect in vivo was demonstrated for the 4-t-butylcyclohexanol containing cosmetic product in comparison to the acetyl dipeptide-1 cetyl ester containing cosmetic formulation.
Asunto(s)
Cosméticos/uso terapéutico , Ciclohexanoles/uso terapéutico , Dipéptidos/uso terapéutico , Dermatosis Facial/tratamiento farmacológico , Dolor/tratamiento farmacológico , Trastornos de la Sensación/tratamiento farmacológico , Adulto , Anciano , Capsaicina , Dermatosis Facial/inducido químicamente , Femenino , Humanos , Persona de Mediana Edad , Dolor/inducido químicamente , Trastornos de la Sensación/inducido químicamente , Índice de Severidad de la Enfermedad , Método Simple Ciego , Factores de Tiempo , Adulto JovenAsunto(s)
Echinacea/efectos adversos , Edema/inducido químicamente , Dermatosis Facial/inducido químicamente , Preparaciones de Plantas/efectos adversos , Eritema/inducido químicamente , Humanos , Lactonas/efectos adversos , Masculino , Persona de Mediana Edad , Parestesia/inducido químicamente , Recurrencia , Sesquiterpenos/efectos adversosAsunto(s)
Dermatitis por Contacto/etiología , Aceites de Plantas/efectos adversos , Semecarpus , Tobillo , Dermatitis por Contacto/tratamiento farmacológico , Dermatosis Facial/inducido químicamente , Femenino , Humanos , Pierna , Persona de Mediana Edad , Dolor Musculoesquelético/tratamiento farmacológico , CuelloRESUMEN
BACKGROUND: Exogenous ochronosis (EO), a disfiguring cutaneous complication of topical hydroquinone use, is difficult to treat. There are few reports of successful outcomes following treatment with different modalities. OBJECTIVE: We assessed the results of treatment of EO with the Q-switched Nd:YAG laser. MATERIAL AND METHODS: Patients with histologically-confirmed EO were treated with the Q-switched Nd:YAG laser. RESULTS AND CONCLUSION: Q-switched Nd:YAG laser treatment appears to be effective in reducing the dyschromia of EO.