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1.
Mar Drugs ; 18(1)2020 Jan 17.
Artículo en Inglés | MEDLINE | ID: mdl-31963560

RESUMEN

The Asian coastal communities have used the brown seaweeds Fucus vesiculosus and Ascophyllum nodosum since ancient times. Recently, some in vitro and in vivo studies have demonstrated their abilities in reducing risk factors for metabolic syndrome. Here, we analyzed the protective effect of a phytocomplex extracted from these seaweeds on the deposition of fat in the liver after the administration of a high-fat diet (HFD) to rats for five weeks. The administration of F. vesiculosus and A. nodosum led to significant reductions in microvescicular steatosis and plasma biochemical and lipid parameters, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total and conjugated bilirubin, and triglycerides. Furthermore, the postprandial glycemic peak was delayed and significantly reduced (p < 0.01) by the algal extract administration. In conclusion, this extract is effective in reducing microvescicular steatosis and improving glycemic control, thereby lowering the risk of nonalcoholic fatty liver disease, obesity, and diabetes, diseases related to the consumption of fat and sugar-enriched diets.


Asunto(s)
Ascophyllum/química , Dieta Reductora/efectos adversos , Fucus/química , Hígado/efectos de los fármacos , Enfermedad del Hígado Graso no Alcohólico/inducido químicamente , Enfermedad del Hígado Graso no Alcohólico/tratamiento farmacológico , Extractos Vegetales/farmacología , Alanina Transaminasa/metabolismo , Animales , Aspartato Aminotransferasas/metabolismo , Glucemia/efectos de los fármacos , Dieta Alta en Grasa/efectos adversos , Hígado/metabolismo , Masculino , Enfermedad del Hígado Graso no Alcohólico/metabolismo , Periodo Posprandial/efectos de los fármacos , Ratas , Ratas Wistar , Algas Marinas/química , Triglicéridos/metabolismo
2.
Int J Sport Nutr Exerc Metab ; 29(3): 331-338, 2019 May 01.
Artículo en Inglés | MEDLINE | ID: mdl-29989458

RESUMEN

The aim of the present case study was to quantify the physiological and metabolic impact of extreme weight cutting by an elite male mixed martial arts athlete. Throughout an 8-week period, we obtained regular assessments of body composition, resting metabolic rate, peak oxygen uptake, and blood clinical chemistry to assess endocrine status, lipid profiles, hydration, and kidney function. The athlete adhered to a "phased" weight loss plan consisting of 7 weeks of reduced energy (ranging from 1,300 to 1,900 kcal/day) intake (Phase 1), 5 days of water loading with 8 L/day for 4 days followed by 250 ml on Day 5 (Phase 2), 20 hr of fasting and dehydration (Phase 3), and 32 hr of rehydration and refueling prior to competition (Phase 4). Body mass declined by 18.1% (80.2 to 65.7 kg) corresponding to changes of 4.4, 2.8, and 7.3 kg in Phases 1, 2, and 3, respectively. We observed clear indices of relative energy deficiency, as evidenced by reduced resting metabolic rate (-331 kcal), inability to complete performance tests, alterations to endocrine hormones (testosterone: <3 nmol/L), and hypercholesterolemia (>6 mmol/L). Moreover, severe dehydration (reducing body mass by 9.3%) in the final 24 hr prior to weigh-in-induced hypernatremia (plasma sodium: 148 mmol/L) and acute kidney injury (serum creatinine: 177 µmol/L). These data, therefore, support publicized reports of the harmful (and potentially fatal) effects of extreme weight cutting in mixed martial arts athletes and represent a call for action to governing bodies to safeguard the welfare of mixed martial arts athletes.


Asunto(s)
Lesión Renal Aguda/etiología , Deshidratación/etiología , Dieta Reductora/efectos adversos , Artes Marciales , Pérdida de Peso , Atletas , Metabolismo Basal , Composición Corporal , Peso Corporal , Creatinina/sangre , Ayuno , Humanos , Hipernatremia/etiología , Masculino , Adulto Joven
3.
Curr Opin Clin Nutr Metab Care ; 21(1): 58-63, 2018 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-29035973

RESUMEN

PURPOSE OF REVIEW: The growing obesity epidemic is associated with an increased demand for bariatric surgery with Roux-en-Y Gastric Bypass and Sleeve Gastrectomy as the most widely performed procedures. Despite beneficial consequences, nutritional complications may arise because of anatomical and physiological changes of the gastrointestinal tract. The purpose of this review is to provide an update of the recent additions to our understanding of the impact of bariatric surgery on the intake, digestion and absorption of dietary protein. RECENT FINDINGS: After bariatric surgery, protein intake is compromised because of reduced gastric capacity and aversion for certain foods. A minority of patients reaches the recommended protein intake of minimal 60 g per day, which results in the loss of fat-free mass rather than the desired loss of fat mass. Despite inadequate protein intake, protein digestion and absorption do not seem to be impaired suggesting that other mechanisms could counteract the reduced secretion of digestive enzymes and their delayed inlet. SUMMARY: After bariatric surgery, protein supplementation or diet enrichment could attribute to achieve the minimal recommended protein intake and benefit the amount and composition of postoperative weight loss.


Asunto(s)
Cirugía Bariátrica/efectos adversos , Proteínas en la Dieta/uso terapéutico , Medicina Basada en la Evidencia , Obesidad Mórbida/dietoterapia , Obesidad Mórbida/cirugía , Complicaciones Posoperatorias/prevención & control , Deficiencia de Proteína/prevención & control , Terapia Combinada/efectos adversos , Dieta Rica en Proteínas , Dieta Reductora/efectos adversos , Suplementos Dietéticos , Humanos , Complicaciones Posoperatorias/epidemiología , Complicaciones Posoperatorias/etiología , Guías de Práctica Clínica como Asunto , Deficiencia de Proteína/epidemiología , Deficiencia de Proteína/etiología , Riesgo , Pérdida de Peso
4.
Nutrients ; 9(3)2017 Mar 01.
Artículo en Inglés | MEDLINE | ID: mdl-28257040

RESUMEN

Many Americans are attempting to lose weight with the help of healthcare professionals. Clinicians can improve weight loss results by using technology. Accurate dietary assessment is crucial to effective weight loss. The aim of this study was to validate a computer-led dietary assessment method in overweight/obese women. Known dietary intake was compared to Automated Self-Administered 24-h recall (ASA24) reported intake in women (n = 45), 19-50 years, with body mass index of 27-39.9 kg/m². Participants received nutrition education and reduced body weight by 4%-10%. Participants completed one unannounced dietary recall and their responses were compared to actual intake. Accuracy of the recall and characteristics of respondent error were measured using linear and logistic regression. Energy was underreported by 5% with no difference for most nutrients except carbohydrates, vitamin B12, vitamin C, selenium, calcium and vitamin D (p = 0.002, p < 0.0001, p = 0.022, p = 0.010, p = 0.008 and p = 0.001 respectively). Overall, ASA24 is a valid dietary assessment tool in overweight/obese women participating in a weight loss program. The automated features eliminate the need for clinicians to be trained, to administer, or to analyze dietary intake. Computer-led dietary assessment tools should be considered as part of clinician-supervised weight loss programs.


Asunto(s)
Enfermedades Carenciales/diagnóstico , Dieta Reductora/efectos adversos , Suplementos Dietéticos/efectos adversos , Evaluación Nutricional , Obesidad/dietoterapia , Sobrepeso/dietoterapia , Cooperación del Paciente , Adulto , Índice de Masa Corporal , California , Enfermedades Carenciales/etiología , Diagnóstico por Computador , Diagnóstico Precoz , Ingestión de Energía , Femenino , Humanos , Persona de Mediana Edad , Ciencias de la Nutrición/educación , Educación del Paciente como Asunto , Medicina de Precisión , Pérdida de Peso , Adulto Joven
5.
Osteoporos Int ; 28(1): 377-388, 2017 01.
Artículo en Inglés | MEDLINE | ID: mdl-27535752

RESUMEN

The effects of higher than recommended vitamin D doses on bone mineral density (BMD) and quality are not known. In this study, higher intakes, in postmenopausal women undergoing weight control over 1 year, had no effect on areal or volumetric BMD but prevented the deterioration in cortical bone geometry. INTRODUCTION: Studies examining how bone responds to a standard dose of vitamin D supplementation have been inconsistent. In addition, the effects of higher doses on BMD and quality are not known. Postmenopausal women undergoing weight control to improve health outcomes are particularly at risk for bone loss and might benefit from supplemental vitamin D intake above the recommended allowance. METHODS: This 1-year-long, randomized, double-blind controlled study addresses whether vitamin D supplementation, in healthy overweight/obese older women, affects BMD and bone structural parameters. In addition, bone turnover and serum total, free, and bioavailable 25-hydroxyvitamin D (25OHD) responses to one of three daily levels of vitamin D3 (600, 2000, 4000 IU) with 1.2 Ca g/day during weight control were examined. RESULTS: Fifty-eight women (age, 58 ± 6 years; body mass index, 30.2 ± 3.8 kg/m2, serum 25OHD, 27.3 ± 4.4 ng/mL) were randomized to treatment. After 1 year, serum 25OHD concentrations increased to 26.5 ± 4.4, 35.9 ± 4.5, and 41.5 ± 6.9 ng/mL, in groups 600, 2000, and 4000 IU, respectively, and differed between groups (p < 0.01). Weight change was similar between groups (-3.0 ± 4.1 %). Cortical (Ct) thickness of the tibia changed by -1.5 ± 5.1 %, +0.6 ± 3.2 %, and +2.0 ± 4.5 % in groups 600, 2000, and 4000 IU, respectively, and each group was significantly different from each other (p < 0.05). CONCLUSION: The decline in Ct thickness was prevented with higher vitamin D3 supplementation, but there were no other significant changes due to treatment over 1 year. Whether these findings translate to changes in biomechanical properties leading to reduced fracture risk should be addressed in future studies.


Asunto(s)
Conservadores de la Densidad Ósea/administración & dosificación , Densidad Ósea/efectos de los fármacos , Colecalciferol/administración & dosificación , Obesidad/terapia , Osteoporosis Posmenopáusica/prevención & control , Anciano , Antropometría/métodos , Composición Corporal/fisiología , Peso Corporal/fisiología , Densidad Ósea/fisiología , Conservadores de la Densidad Ósea/farmacología , Colecalciferol/farmacología , Dieta Reductora/efectos adversos , Suplementos Dietéticos , Relación Dosis-Respuesta a Droga , Método Doble Ciego , Ejercicio Físico/fisiología , Femenino , Humanos , Persona de Mediana Edad , Obesidad/fisiopatología , Osteoporosis Posmenopáusica/etiología , Posmenopausia/fisiología , Pérdida de Peso/fisiología
6.
Clin Nutr ; 36(4): 1175-1181, 2017 08.
Artículo en Inglés | MEDLINE | ID: mdl-27591033

RESUMEN

BACKGROUND & AIMS: Roux-en-Y gastric bypass (RYGB) is associated with an increased risk for micronutrient deficiencies. This study aimed to assess total (dietary and supplement) intake and association with iron (including hepcidin), vitamin B12, vitamin C and zinc status markers before and after Roux-en-Y gastric bypass (RYGB). METHODS: This prospective study included patients with a planned RYGB in University Hospitals Leuven, Belgium; who were followed until 12 months post-RYGB. Patients completed an estimated dietary record of two non-consecutive days before and 1, 3, 6 and 12 months post-RYGB and supplement/drug use was registered. Associations between total micronutrient intake and status markers were analyzed. RESULTS: Fifty-four patients (21 males; mean age: 48.0 [95%CI 46.6; 49.3] years; mean preoperative BMI: 40.4 [95%CI 39.4; 41.4] kg/m2) were included. One month post-RYGB, usual dietary intake of the studied micronutrients was significantly decreased compared to pre-RYGB, but gradually increased until 12 months post-RYGB, remaining below baseline values. By including micronutrient supplement intake, 12 months post-RYGB values were higher than baseline, except for zinc. Hemoglobin, ferritin, vitamin B12 and C-reactive protein serum concentrations were significantly decreased and transferrin saturation and mean corpuscular volume were significantly increased 12 months post-RYGB. Serum hepcidin concentration was significantly decreased 6 months post-RYGB. CONCLUSIONS: Medical nutritional therapy is essential following RYGB as dietary intake of iron, vitamin B12, vitamin C, copper and zinc was markedly decreased postoperatively and some patients still had an inadequate total intake one year post-RYGB.


Asunto(s)
Enfermedades Carenciales/etiología , Dieta Reductora/efectos adversos , Suplementos Dietéticos , Derivación Gástrica/efectos adversos , Micronutrientes/administración & dosificación , Obesidad Mórbida/cirugía , Complicaciones Posoperatorias/etiología , Bélgica/epidemiología , Biomarcadores/sangre , Terapia Combinada/efectos adversos , Enfermedades Carenciales/sangre , Enfermedades Carenciales/epidemiología , Enfermedades Carenciales/prevención & control , Registros de Dieta , Femenino , Estudios de Seguimiento , Hospitales Universitarios , Humanos , Masculino , Micronutrientes/deficiencia , Micronutrientes/uso terapéutico , Persona de Mediana Edad , Estado Nutricional , Obesidad Mórbida/sangre , Obesidad Mórbida/dietoterapia , Pacientes Desistentes del Tratamiento , Complicaciones Posoperatorias/sangre , Complicaciones Posoperatorias/epidemiología , Complicaciones Posoperatorias/prevención & control , Prevalencia , Estudios Prospectivos , Riesgo
8.
Nutrients ; 8(12)2016 Dec 09.
Artículo en Inglés | MEDLINE | ID: mdl-27941661

RESUMEN

Diet-induced thermogenesis (DIT) is believed to be largely related to ATP production, which is dependent on phosphorus (P) availability. We aimed to test the effect of P addition on DIT of lean and overweight/obese healthy subjects. DIT was measured with or without P in 10 lean and 13 overweight/obese adults in a double-blind randomized cross-over pilot study with one week washout period. After 10 h overnight fast, resting metabolic rate, respiratory quotient, and substrate utilization were measured at fasting and every 30 min for 3 h after subjects drank a standardized glucose solution, with P (500 mg) or placebo pills. Subjective ratings of hunger and satiety were assessed before and after the end of each experiment using validated visual analogue scale (VAS) questionnaires. Overweight/obese subjects had a blunted DIT with placebo, while P supplementation induced a 23% increase in their DIT area under the curve (p < 0.05), which was associated with a significant increase in carbohydrate oxidation. Subjects had lower appetite following P supplementation, which was expressed as a significantly (p = 0.02) lower desire to eat a meal (4.0 ± 0.7 cm) compared with placebo (5.8 ± 0.9 cm). P supplementation recovers the blunted diet-induced thermogenesis in overweight and obese subjects and enhances their postprandial satiety.


Asunto(s)
Dieta Reductora/efectos adversos , Suplementos Dietéticos , Obesidad/metabolismo , Fósforo/farmacología , Termogénesis/efectos de los fármacos , Metabolismo de los Hidratos de Carbono , Femenino , Humanos , Masculino , Fósforo/administración & dosificación , Proyectos Piloto , Adulto Joven
9.
Food Funct ; 6(6): 2041-8, 2015 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-26029855

RESUMEN

Obesity is typically associated with increased risk factors of cardiovascular diseases (CVDs). Therefore, a therapeutic approach that aims to control body weight and metabolic profile might be effective in preventing CVDs. We aimed to determine the effects of Nigella Sativa (NS) oil with a low-calorie diet on cardiometabolic risk factors in obese women. In this double-blind randomized controlled clinical trial, 90 obese women were recruited. Participants were females aged 25-50 years old with body mass index (BMI) between 30 and 35 kg m(-2). They were randomly assigned to receive a low-calorie diet with 3 g per day (1 g before each meal) NS oil or placebo for 8 weeks. Anthropometric indices, dietary intake and biochemical parameters were measured at the baseline and after the intervention. Eighty-four females completed the trial (intervention n = 43, placebo n = 41). Two groups were similar in the baseline characteristics. After the intervention, dietary intake was changed in both groups compared to the baseline, but the differences were not significant between the two groups. In the NS group, weight (-6.0 vs. -3.6%; p < 0.01) and waist circumference (-6.9 vs. -3.4%; p < 0.01) decreased significantly compared with the placebo group at the end of the trial. Comparison of biochemical parameters presented a significant decline in triglyceride (-14.0 vs. 1.4%; p = 0.02) and very low density lipoprotein (-14.0 vs. 7%; p < 0.01) levels in the NS group compared to the placebo group. NS oil concurrent with a low-calorie diet can reduce cardiometabolic risk factors in obese women. However, more clinical trials are needed to elucidate efficacy of NS as a complementary therapy in obese subjects.


Asunto(s)
Fármacos Antiobesidad/uso terapéutico , Enfermedades Cardiovasculares/prevención & control , Dieta Reductora , Suplementos Dietéticos , Nigella sativa/química , Obesidad/dietoterapia , Aceites de Plantas/uso terapéutico , Adulto , Fármacos Antiobesidad/efectos adversos , Índice de Masa Corporal , Enfermedades Cardiovasculares/sangre , Enfermedades Cardiovasculares/epidemiología , Enfermedades Cardiovasculares/etiología , Dieta Reductora/efectos adversos , Grasas Insaturadas en la Dieta/efectos adversos , Grasas Insaturadas en la Dieta/uso terapéutico , Suplementos Dietéticos/efectos adversos , Método Doble Ciego , Femenino , Humanos , Hiperlipidemias/etiología , Hiperlipidemias/prevención & control , Irán/epidemiología , Perdida de Seguimiento , Síndrome Metabólico/epidemiología , Síndrome Metabólico/etiología , Síndrome Metabólico/prevención & control , Persona de Mediana Edad , Obesidad/fisiopatología , Pacientes Desistentes del Tratamiento , Aceites de Plantas/efectos adversos , Factores de Riesgo , Circunferencia de la Cintura , Pérdida de Peso
10.
J Nutr Gerontol Geriatr ; 34(1): 50-65, 2015.
Artículo en Inglés | MEDLINE | ID: mdl-25803604

RESUMEN

This study employed a quasi-experimental design in a community-based study translating the results of our recent findings on the combined effects of Tai Chi and weight loss on physical function and coronary heart disease (CHD) risk factors. A 16-week intervention was conducted to assess the impact of Tai Chi plus a behavioral weight loss program (TCWL, n = 29) on obese (body mass index [BMI] = 35.4 ± 0.8 kg/m²) older (68.2 ± 1.5 yr.) women compared to a control group (CON, n = 9, BMI = 38.0 ± 1.5 kg/m², 65.6 ± 2.7 yr.), which was asked to maintain their normal lifestyle. The TCWL group lost weight (1.6 ± 2.9 kg, P = 0.006) while the CON group did not (1.2 ± 1.9 kg, P = 0.106). Physical functioning as measured by the short physical performance battery improved in TCWL when compared to the CON group (ß = 1.94, 95% Confidence Interval [CI]: 1.12, 2.76, P < 0.001). TCWL also improved in sit-and-reach flexibility (ß = -2.27, 95% CI: -4.09, -0.46, P = 0.016), body fat mass (BMI, ß = -0.65, 95% CI: -1.03, -0.26, P = 0.002), waist circumference (ß = -1.78, 95% CI: -2.83, -0.72, P = 0.002), systolic blood pressure (ß = -16.41, 95% CI: -21.35, -11.48, P < 0.001), and diastolic blood pressure (ß = -9.52, 95% CI: -12.65, -6.39, P < 0.001). Thus, TCWL intervention may represent an effective strategy to improve physical function and ameliorate CHD risk in the older adult population.


Asunto(s)
Terapia Conductista , Enfermedad Coronaria/prevención & control , Dieta Reductora , Dieta Hiposódica , Fenómenos Fisiológicos Nutricionales del Anciano , Obesidad/terapia , Taichi Chuan , Anciano , Índice de Masa Corporal , Terapia Combinada/efectos adversos , Enfermedad Coronaria/epidemiología , Enfermedad Coronaria/etiología , Dieta Reductora/efectos adversos , Dieta Hiposódica/efectos adversos , Estudios de Factibilidad , Femenino , Humanos , Persona de Mediana Edad , Sistema Musculoesquelético/fisiopatología , Obesidad/dietoterapia , Obesidad/fisiopatología , Pacientes Desistentes del Tratamiento , Rhode Island/epidemiología , Factores de Riesgo , Taichi Chuan/efectos adversos , Pérdida de Peso
11.
Eur J Nutr ; 54(1): 101-7, 2015 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-24687684

RESUMEN

PURPOSE: Recent data suggest that chronic low-grade inflammation, a characteristic of obesity, is associated with altered tryptophan (Trp) and tyrosine (Tyr) metabolism and plays a role in neuropsychiatric symptoms. The present study assessed the effect of an extreme short-term diet on Trp breakdown and inflammatory biomarkers in overweight adults. METHODS: Thirty-eight overweight participants (16 women, 22 men; average body mass index: 29 kg/m², mean age 52.8 years) were randomized into two diet groups: a very low kcal diet group (VLCD; Ø 600 kcal/day, n = 21) and a low kcal diet group (LCD; Ø 1,200 kcal/day, n = 17). Assays included the measurement of Trp, kynurenine (Kyn), and their ratio, neopterin, phenylalanine (Phe), Tyr, as biologic markers; leptin, plasma insulin, glucose, and homeostatic model assessment-insulin resistance; and interleukin 6, tumor necrosis factor alpha, and C-reactive protein, as biochemical and inflammatory markers at baseline and after 2 weeks of treatment. RESULTS: Weight loss diet lowered leptin levels in both groups by 46%, although not reaching significance. Trp and Kyn decreased significantly by 21 and 16% for VLCD and by 15 and 17% for the LCD group, respectively. A significant reduction in Phe was only seen after VLCD. Inflammatory biomarkers, neopterin, and Tyr were not significantly altered during the study period. Leptin was significantly correlated with Trp breakdown before and after the intervention (P < 0.02). CONCLUSIONS: Since disturbed metabolism of Trp affects biosynthesis of serotonin and might be associated with increased susceptibility for mood disturbances and carbohydrate craving, strategies to supplement Trp while dieting could be highly useful in treating uncontrolled weight gain or in preventing neuropsychiatric symptoms.


Asunto(s)
Restricción Calórica/efectos adversos , Dieta Reductora/efectos adversos , Mediadores de Inflamación/sangre , Trastornos del Humor/etiología , Sobrepeso/dietoterapia , Triptófano/metabolismo , Austria/epidemiología , Biomarcadores/sangre , Índice de Masa Corporal , Femenino , Humanos , Quinurenina/sangre , Quinurenina/metabolismo , Leptina/sangre , Masculino , Persona de Mediana Edad , Trastornos del Humor/epidemiología , Trastornos del Humor/prevención & control , Neopterin/sangre , Neopterin/metabolismo , Sobrepeso/inmunología , Sobrepeso/metabolismo , Sobrepeso/psicología , Fenilalanina/sangre , Fenilalanina/metabolismo , Riesgo , Triptófano/sangre , Tirosina/sangre , Tirosina/metabolismo , Pérdida de Peso
12.
Nutr Clin Pract ; 29(6): 740-6, 2014 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-25332015

RESUMEN

The prevalence of obesity in adolescents has dramatically increased over the past 3 decades in the United States. Weight loss surgery is becoming a viable treatment option for obese adolescents. The number of surgeries being performed yearly is rising, and this trend is likely to continue. Adolescent patients present a unique challenge to clinicians. There are currently best-practice recommendations and evidence-based nutrition guidelines for the treatment of the adolescent bariatric patient. A review of the current literature was performed to discuss bariatric surgery and nutrition for the adolescent patient. Studies show that most adolescents with obesity will become obese adults, thus increasing their risk of developing serious and debilitating health conditions. It is recommended that the candidates for surgery be referred to a practice that has a multidisciplinary team experienced in meeting the distinct physical and psychological needs of adolescents. Specific nutrition concerns for the adolescent bariatric patient include preoperative educational pathway, postoperative dietary progression, female reproduction, compliance with vitamin/supplementation recommendations, laboratory tests, and long-term monitoring. The medical literature has reported positive outcomes of bariatric surgery in adolescents with severe obesity. Before surgery is offered as an option, unique factors to adolescents must be addressed. The multidisciplinary clinical team must consider the adolescents' cognitive, social, and emotional development when considering their candidacy for surgery. As the number of adolescent bariatric surgery programs increases, continued research and long-term outcome data need to be collected and shared to base future treatment decisions.


Asunto(s)
Cirugía Bariátrica/efectos adversos , Dieta Reductora , Medicina Basada en la Evidencia , Obesidad Mórbida/dietoterapia , Obesidad/dietoterapia , Complicaciones Posoperatorias/prevención & control , Guías de Práctica Clínica como Asunto , Adolescente , Medicina del Adolescente/tendencias , Fenómenos Fisiológicos Nutricionales de los Adolescentes , Terapia Combinada , Comorbilidad , Dieta Reductora/efectos adversos , Dietética/tendencias , Tracto Gastrointestinal/fisiopatología , Tracto Gastrointestinal/cirugía , Humanos , Obesidad/epidemiología , Obesidad/fisiopatología , Obesidad/cirugía , Obesidad Mórbida/epidemiología , Obesidad Mórbida/fisiopatología , Obesidad Mórbida/cirugía , Grupo de Atención al Paciente/tendencias , Educación del Paciente como Asunto , Grupos de Autoayuda , Estados Unidos/epidemiología , Pérdida de Peso , Recursos Humanos
13.
BMJ Case Rep ; 20142014 Oct 29.
Artículo en Inglés | MEDLINE | ID: mdl-25355748

RESUMEN

Complementary medications and herbal medicine for weight loss have become very popular. We report a case of thyroid dysfunction following the ingestion of a kelp-containing marketed diet in a 45-year-old woman with no previous thyroid disease. Signs of hyperthyroidism occurred shortly after a kelp-containing diet. Hyperthyroidism lasted 2 months and was followed by an overt hypothyroidism. The thyroid scintiscan exhibited an extremely low uptake and colour-Doppler ultrasonography revealed multiple small areas of pulsatile flow. After 3 months of levothyroxine substitutive therapy, normal thyroid function was recovered after levothyroxine discontinuation. This clinical history is compatible with a case of iodine-induced thyrotoxicosis followed by prolonged block of the sodium-iodide symporter activity as a consequence of excessive iodine consumption from kelp. Consumers of marketed diets containing kelp or other iodine-rich ingredients should be advised of the risk to develop a thyroid dysfunction also in the absence of underlying thyroid disease.


Asunto(s)
Dieta Reductora/efectos adversos , Hipertiroidismo/inducido químicamente , Hipotiroidismo/inducido químicamente , Yodo/efectos adversos , Kelp , Femenino , Humanos , Hipotiroidismo/tratamiento farmacológico , Persona de Mediana Edad , Glándula Tiroides/diagnóstico por imagen , Tirotoxicosis/inducido químicamente , Tiroxina/uso terapéutico , Ultrasonografía
14.
Nutr Clin Pract ; 29(6): 786-91, 2014 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-25049263

RESUMEN

We published the first article that addressed hypocaloric, high-protein enteral nutrition therapy for critically ill patients with obesity more than 10 years ago. This study demonstrated that it was possible to successfully achieve this mode of therapy with a commercially available high-protein enteral formula and concurrent use of protein supplements. This study was also the first to demonstrate improved clinical outcomes with the use of hypocaloric, high-protein nutrition therapy. The results of this study, its unique findings, and shortcomings are discussed. Subsequent studies have added clarity to the effective use of this therapy, including its use in home parenteral nutrition patients, patients with class III obesity, and older patients with obesity.


Asunto(s)
Cuidados Críticos , Dieta Reductora/métodos , Proteínas en la Dieta/uso terapéutico , Nutrición Enteral , Medicina Basada en la Evidencia , Alimentos Formulados , Obesidad/dietoterapia , Restricción Calórica/efectos adversos , Comorbilidad , Dieta Reductora/efectos adversos , Humanos , Obesidad/epidemiología
15.
Public Health Nutr ; 17(10): 2359-67, 2014 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-24124907

RESUMEN

OBJECTIVE: The present study examines seasonal and temporal patterns in food-related content of two UK magazines for young women focusing on food types, cooking and weight loss. DESIGN: Content analysis of magazines from three time blocks between 1999 and 2011. SETTING: Desk-based study. SUBJECTS: Ninety-seven magazines yielding 590 advertisements and 148 articles. RESULTS: Cluster analysis of type of food advertising produced three clusters of magazines, which reflected recognised food behaviours of young women: vegetarianism, convenience eating and weight control. The first cluster of magazines was associated with Christmas and Millennium time periods, with advertising of alcohol, coffee, cheese, vegetarian meat substitutes and weight-loss pills. Recipes were prominent in article content and tended to be for cakes/desserts, luxury meals and party food. The second cluster was associated with summer months and 2010 issues. There was little advertising for conventional foods in cluster 2, but strong representation of diet plans and foods for weight loss. Weight-loss messages in articles focused on short-term aesthetic goals, emphasising speedy weight loss without giving up nice foods or exercising. Cluster 3 magazines were associated with post-New Year and 2005 periods. Food advertising was for everyday foods and convenience products, with fewer weight-loss products than other clusters; conversely, article content had a greater prevalence of weight-loss messages. CONCLUSIONS: The cyclical nature of magazine content - indulgence and excess encouraged at Christmas, restraint recommended post-New Year and severe dieting advocated in the summer months - endorses yo-yo dieting behaviour and may not be conducive to public health.


Asunto(s)
Culinaria , Dieta Reductora , Alimentos , Política Nutricional , Publicaciones Periódicas como Asunto , Adolescente , Adulto , Fármacos Antiobesidad/efectos adversos , Fármacos Antiobesidad/economía , Fármacos Antiobesidad/uso terapéutico , Análisis por Conglomerados , Modas Dietéticas/efectos adversos , Dieta Reductora/efectos adversos , Dieta Vegetariana/efectos adversos , Suplementos Dietéticos/efectos adversos , Suplementos Dietéticos/economía , Inglaterra , Comida Rápida/efectos adversos , Comida Rápida/economía , Femenino , Humanos , Sobrepeso/dietoterapia , Educación del Paciente como Asunto , Publicaciones Periódicas como Asunto/economía , Pérdida de Peso , Adulto Joven
16.
Eur J Nutr ; 53(3): 723-9, 2014 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-23975326

RESUMEN

PURPOSE: Small fat droplets infused into the gut reduce food intake and hunger more than bigger ones, at levels as low as 6 g, and these effects are hypothesized to occur via satiety hormones such as cholecystokinin. It is, however, unknown whether the effect of droplet size would persist after oral consumption. It is also unknown whether an even smaller droplet size can affect hunger and food intake and at what minimum amount of fat. Therefore, the aim of the study was to test the effect of very fine fat droplets on satiety and food intake in two different quantities. METHODS: In a balanced-order 4-way crossover design, 24 volunteers consumed a fat-free meal replacement drink with either 5 or 9 g oil (rapeseed) and either 3 or 0.1 µm droplet size. Appetite scores and plasma cholecystokinin levels (in n = 12 subset) were measured for 180 min, when food intake was assessed during an ad libitum meal. Data were analyzed by ANCOVA, followed by Dunnett's test and paired t test. The behavior of the emulsions was also characterized in a simulated gastrointestinal model. RESULTS: Despite faster in vitro lipolysis of the smallest droplets, neither droplet size nor fat amount affected satiety or food intake. From t = 45-150 min, cholecystokinin response was 50% higher (P < 0.05) after the 0.1 versus 3 µm, but only with 9 g fat. CONCLUSION: When this particular fat at these amounts is delivered in a meal replacement drink, droplet size does not influence appetite or food intake. This effect is independent of the amount of fat or plasma cholecystokinin changes.


Asunto(s)
Bebidas , Desayuno , Colecistoquinina/sangre , Grasas de la Dieta/uso terapéutico , Alimentos Especializados , Sobrepeso/dietoterapia , Regulación hacia Arriba , Adulto , Bebidas/efectos adversos , Bebidas/análisis , Índice de Masa Corporal , Colecistoquinina/metabolismo , Estudios Cruzados , Dieta Reductora/efectos adversos , Dieta Reductora/métodos , Grasas de la Dieta/administración & dosificación , Grasas de la Dieta/efectos adversos , Grasas de la Dieta/metabolismo , Digestión , Método Doble Ciego , Emulsiones , Ácidos Grasos Monoinsaturados , Femenino , Alimentos Especializados/efectos adversos , Alimentos Especializados/análisis , Humanos , Masculino , Persona de Mediana Edad , Países Bajos , Sobrepeso/sangre , Aceites de Plantas/administración & dosificación , Aceites de Plantas/efectos adversos , Aceites de Plantas/metabolismo , Aceites de Plantas/uso terapéutico , Aceite de Brassica napus , Respuesta de Saciedad , Adulto Joven
17.
Can J Diet Pract Res ; 75(4): 195-201, 2014 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-26067073

RESUMEN

A Nutrition Screening Form (NSF) was designed to identify lifestyle risk factors that negatively impact fertility and to provide a descriptive profile of 300 female infertility patients in a private urban infertility clinic. The NSF was mailed to all new patients prior to the initial physician's visit and self-reported data were assessed using specific criteria to determine if a nutrition referral was warranted. This observational study revealed that 43% of the women had a body mass index (BMI) <20 or ≥25 kg/m(2), known risks for infertility. Almost half reported a history of "dieting" and unrealistic weight goals potentially limiting energy and essential nutrients. A high number reported eating disorders, vegetarianism, low fat or low cholesterol diets, and dietary supplement use. Fourteen percent appeared not to supplement with folic acid, 13% rated exercise as "extremely" or "very active", and 28% reported a "high" perceived level of stress. This preliminary research demonstrated that a NSF can be a useful tool to identify nutrition-related lifestyle factors that may negatively impact fertility and identified weight, BMI, diet, exercise, and stress as modifiable risk factors deserving future research. NSF information can help increase awareness among health professionals and patients about the important link between nutrition, fertility, and successful reproductive outcomes.


Asunto(s)
Enfermedades Carenciales/etiología , Trastornos de Alimentación y de la Ingestión de Alimentos/diagnóstico , Infertilidad Femenina/etiología , Estilo de Vida , Estado Nutricional , Sobrepeso/etiología , Delgadez/etiología , Adulto , Índice de Masa Corporal , Enfermedades Carenciales/complicaciones , Enfermedades Carenciales/psicología , Dieta Reductora/efectos adversos , Dieta Reductora/psicología , Dieta Vegetariana/efectos adversos , Dieta Vegetariana/psicología , Ejercicio Físico/psicología , Trastornos de Alimentación y de la Ingestión de Alimentos/epidemiología , Trastornos de Alimentación y de la Ingestión de Alimentos/fisiopatología , Femenino , Humanos , Infertilidad Femenina/complicaciones , Infertilidad Femenina/psicología , Evaluación Nutricional , Ontario/epidemiología , Sobrepeso/complicaciones , Sobrepeso/psicología , Factores de Riesgo , Autoinforme , Delgadez/complicaciones , Delgadez/psicología
18.
Nutr Hosp ; 31(3): 995-1002, 2014 Oct 03.
Artículo en Inglés | MEDLINE | ID: mdl-25726186

RESUMEN

INTRODUCTION: In an effort to treat obesity, health care professionals pursue, by means of dieting and exercise interventions, weight loss as a primary goal of treatment. Although in few cases these interventions induce shortterm moderate weight loss, in the long-term, the efficacy of these treatments is at least questionable. Weight-loss interventions based on restrictive diets may be associated to adverse health and well-being. In this regard, some researchers have considered shifting the focus of obesity treatment into a health-centered paradigm. Among the models derived from this new paradigm, Health at Every Size (HAES) is one of the most referenced. HAES has enhanced intuitive eating as a core component of the paradigm, which refers to the reliance on biological mechanisms to regulate food intake (i.e., internal hunger and satiety cues). Recently, intuitive eating has been winning recognition since it have been associated with numerous indices of physical and psychological well-being, and noteworthy, it have not been related to any adverse effects. OBJECTIVE: The present paper reviews the concept of intuitive eating, as well as the existing evidence that upholds this emerging approach. Also, it discusses the implication of shifting the focus of dietetic interventions into a health-centered paradigm. DESIGN: Narrative Review. CONCLUSIONS: Although it is certain there is a need to extend current research on health-centered interventions, this approach may be a more promising and realistic alternative to address overweight and obesity than the conventional weight-loss treatments.


Introducción: Con la finalidad de tratar la obesidad, los profesionales en salud buscan, por medio de intervenciones dietéticas restrictivas y ejercicio, la pérdida de peso como objetivo principal del tratamiento. Aunque en algunos casos estas intervenciones inducen pérdida de peso a corto plazo, en el largo plazo la eficacia de estos tratamientos es, al menos, cuestionable. Investigaciones recientes han sugerido que los tratamientos dirigidos a la pérdida de peso basados en dietas restrictivas no resultan eficaces a largo plazo e incluso pueden comprometer la salud y el bienestar del paciente. En este sentido, algunos investigadores han considerado cambiar el enfoque del tratamiento de la obesidad a un paradigma centrado en la salud y no en la pérdida de peso. Entre los modelos derivados de este nuevo paradigma, Salud a Cualquier Talla (HAES, por sus siglas en inglés) es uno de los más referenciados. Como componente central de este paradigma se sitúa la ingesta intuitiva, la cual se refiere a la confianza en los mecanismos biológicos para regular la ingesta de alimentos (i.e., las señales internas de hambre y saciedad). Recientemente, la ingesta intuitiva ha ganado reconocimiento, pues se ha asociado a diversos parámetros de bienestar físico y psicológico, además, no se ha observado ningún efecto adverso en pacientes que la practican. Objetivo: El presente artículo revisa el concepto de la ingesta intuitiva, así como la evidencia que sustenta este nuevo enfoque. Además, se discute la implicación de cambiar el enfoque convencional de los tratamientos dietéticos a un paradigma centrado en la salud. Diseño: Revisión Narrativa Conclusiones: A pesar de la necesidad de ampliar la investigación de las intervenciones centradas en la salud, este enfoque podría ser una alternativa más prometedora y realista para el abordaje del sobrepeso y la obesidad que los tratamientos de pérdida de peso convencionales.


Asunto(s)
Conducta Alimentaria , Promoción de la Salud/métodos , Interocepción/fisiología , Obesidad/prevención & control , Adaptación Psicológica , Actitud Frente a la Salud , Glucemia/análisis , Tamaño Corporal , Señales (Psicología) , Dieta Reductora/efectos adversos , Emociones , Femenino , Humanos , Hambre/fisiología , Masculino , Modelos Biológicos , Modelos Psicológicos , Ensayos Clínicos Controlados no Aleatorios como Asunto , Obesidad/terapia , Respuesta de Saciedad , Autoinforme
19.
Matern Child Nutr ; 9(4): 467-72, 2013 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-22288981

RESUMEN

A semi-structured, web-based questionnaire was developed to survey midwives (n = 241) employed by NHS Tayside, UK, to identify current practice and views on weight management of obese women during pregnancy and the puerperium. A total of 78 (32%) midwives submitted responses following email invitation. Most respondents (79%) reported always calculating women's body mass index (BMI) at booking, with 73% routinely explaining the BMI category. In terms of future practice for obese women, although few respondents (15%) currently offer personalised advice regarding weight management based on a woman's diet and physical activity levels, 77% of respondents thought such advice would be appropriate and 69% thought it could possibly be feasible to offer such advice. The respondents viewed weight management to be of importance and felt that universal advice is appropriate, but confidence in discussing weight management and knowledge of the subject was low. Strategies to improve midwife confidence and weight management services should include training, ongoing support and definition of the midwife's role within the multidisciplinary team to support practice in the future.


Asunto(s)
Partería/métodos , Obesidad/terapia , Educación del Paciente como Asunto , Atención Posnatal , Medicina de Precisión , Complicaciones del Embarazo/terapia , Atención Prenatal , Actitud del Personal de Salud , Índice de Masa Corporal , Terapia Combinada , Dieta Reductora/efectos adversos , Femenino , Encuestas de Atención de la Salud , Humanos , Internet , Fenómenos Fisiologicos Nutricionales Maternos , Actividad Motora , Obesidad/dietoterapia , Embarazo , Complicaciones del Embarazo/dietoterapia , Escocia , Aumento de Peso
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