RESUMEN
The investigation of the prevention and treatment action of some immunomodulators (ridostin, reaferon and polyribonate) used alone and in combinations was conducted on laboratory animals infected aerogenically by Venezuelan equine encephalitis (VEE) virus. A lower death rate of the aerogenically infected mice (10-30 respiratory LD50) was observed after intramuscular injection of ridostin. The preventive affect of ridostin and ridostin + reaferon administered intranasally and intramuscularly was achieved in the aerogenically infected guinea pigs (10 respiratory LD50). The results of the study on the early virus reproduction in the animals were used for the choice of the treatment scheme. The immunomodulators had no effect when the treatment was started 1 day after the VEE virus infection.
Asunto(s)
Adyuvantes Inmunológicos/uso terapéutico , Encefalomielitis Equina Venezolana/tratamiento farmacológico , Encefalomielitis Equina Venezolana/prevención & control , Aerosoles , Animales , Evaluación Preclínica de Medicamentos , Quimioterapia Combinada , Encefalomielitis Equina Venezolana/mortalidad , Encefalomielitis Equina Venezolana/transmisión , Cobayas , Interferón Tipo I/uso terapéutico , Interferón alfa-2 , Interferón-alfa , Ratones , Compuestos Orgánicos , ARN Bicatenario/uso terapéutico , ARN de Hongos/uso terapéutico , Proteínas Recombinantes , Factores de TiempoRESUMEN
The prophylactic and therapeutic effects of ADP-ribosylation inhibitors, 3,N-acetylaminobenzamide and 3,N-butyrylaminobenzamide, were studied in mice inoculated with an alphavirus or a bunyavirus. Both drugs were shown to have high levels of antiviral activity when given as a single subcutaneous injection in a dose of 10 mg/kg while increasing the number of injections did not increase their efficacy or might even decrease it.
Asunto(s)
Adenosina Difosfato Ribosa/antagonistas & inhibidores , Antivirales/uso terapéutico , Benzamidas/uso terapéutico , Virus de la Encefalitis Equina del Este , Encefalomielitis Equina/tratamiento farmacológico , Encefalomielitis Equina Venezolana/tratamiento farmacológico , Fiebre del Valle del Rift/tratamiento farmacológico , Animales , Evaluación Preclínica de Medicamentos , Encefalomielitis Equina/mortalidad , Encefalomielitis Equina Venezolana/mortalidad , Ratones , Ribavirina/uso terapéutico , Fiebre del Valle del Rift/mortalidad , Factores de TiempoRESUMEN
A relationship between ribamydil concentration and the intensity of accumulation of peroxidation products was found while storing ribamydil-containing liposomes which indicated a significant pro-oxidant activity of ribamydil. Increasing lethality of guinea pigs and white mice infected with Venezuelan equine encephalomyelitis virus was shown while using liposomal ribamydil containing from 4.78 to 6.82 nmol. ml-1 malonic dialdehyde which appeared to be associated with disordered function of the antioxidant system of the experimental animals.
Asunto(s)
Encefalomielitis Equina Venezolana/tratamiento farmacológico , Peroxidación de Lípido/efectos de los fármacos , Ribavirina/farmacocinética , Fiebre del Valle del Rift/tratamiento farmacológico , Animales , Relación Dosis-Respuesta a Droga , Portadores de Fármacos , Evaluación Preclínica de Medicamentos , Encefalomielitis Equina Venezolana/metabolismo , Encefalomielitis Equina Venezolana/mortalidad , Radicales Libres , Cobayas , Liposomas , Malondialdehído/metabolismo , Ratones , Ratas , Ribavirina/administración & dosificación , Fiebre del Valle del Rift/metabolismo , Fiebre del Valle del Rift/mortalidadRESUMEN
Considerable differences in antiviral efficacy of ribamydil were demonstrated in various animals experimentally infected with Venezuelan equine encephalomyelitis virus. The infection in baboons was quite similar to the manifestations of this disease in man as reported in the literature. With ribamydil used prophylactically, manifestations of the infection in monkeys were less marked.