Enfermedad venooclusiva hepática inducida por hierbas medicinales chinas / Hepatic veno-occlusive disease induced by Chinese medicinal herbs

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Evaluación preclínica de la actividad hepatoprotectora de Ocimumbasilicum L. y Allium sativum L / Preclinical Evaluation of Hepatoprotective Activity of Ocimum basilicum L. and Allium sativum L

La búsqueda de alternativas de tratamiento naturales, orientadas a proteger el hígado de los efectos nocivos de hepatotoxinas, es un tema importante dentro de las Investigaciones médico-farmacéuticas. evaluar preclínicamente la actividad hepatoprotectora de las especies Ocimum basilicum L. y Allium sativum L. en un biomodelo de toxicidad inducido por paracetamol. Métodos: se realizó un estudio farmacológico preclínico para evaluar el efecto hepatoprotector de las especies Ocimum basilicum L. y Allium sativum L. frente a la toxicidad inducida por el paracetamol. Se emplearon ratones adultos machos NMRI a los que se administró por vía oral extractos blandos de las plantas de estudio a dosisde 200mg/kg y 400mg/kg, tres días consecutivos previos a la inducción de la hepatotoxicidad. Se evaluaron los signos clínicos de toxicidad, parámetros bioquímicos hepáticos; también se realizó el análisis morfológico del hígado. Resultados: los parámetros bioquímicos analizados mostraron diferencias altamente significativas, pero solo tres grupos presentaron un comportamiento similar al grupo control no tratado. No se confirmaron alteraciones macroscópicas del hígado. Microscópicamente, predominó la ausencia de alteraciones estopatológicas en los grupos donde se administró Ocimum basilicum L. a ambas dosis yAllium sativum L. a 200mg/Kg; también se observó daño leve al administrar 400mg/Kg de Allium sativum L, con diferencias significativas respecto al grupo control no tratado. Conclusión: los extractos blandos de las especies Ocimum basilicum L. y Allium sativum L. a 200mg/kg, poseen mayor actividad hepatoprotectora frente a la acción tóxica del paracetamo(AU)

finding natural treatments designed toprotect the liver from the damaging effects of hepatotoxins is an important topic in medical and pharmaceuticalresearch. to pre-clinically evaluate the hepatoprotective activity of the species Ocimum basilicum L. and Allium sativum L. in an animal model of acetaminophen-induced toxicity. a preclinical harmacological study was conducted to evaluate the hepatoprotective effect of the species Ocimum basilicum L. and Allium sativum L. against cetaminophen-induced toxicity. Adult male NMRI micewere used. They were orally administered soft extracts ofthe plants at doses of 200mg/kg and 400mg/kg for three consecutive days before inducing hepatotoxicity. Clinicalsigns of toxicity and hepatic biochemical parameters were evaluated; in addition, the morphological analysis of theliver was performed. Results: the biochemical parameters showed highlysignificant differences, but only three groups had results similar to the untreated control group. No macroscopicchanges in the liver were confirmed. Microscopically, the absence of histopathological changes prevailed in the groups treated with Ocimum basilicum L. at both doses andAllium sativum L. at 200mg/kg; slight damage was observed by administering 400mg/kg of Allium sativum L.,with significant differences from the untreated control group.Conclusions: soft extracts of the species Ocimum basilicum L. and Allium sativum L. at a dose of 200mg/kghave greater hepatoprotective activity against the toxic action of acetaminophen(AU)

Two cases of toxic hepatitis caused by arrowroot juice / 대한간학회지

Herbal remedies and health foods are widely used, and their side effects have been reported. We describe two cases of symptomatic toxic hepatitis that developed in middle-aged women after ingesting arrowroot juice. The clinical manifestations were nausea, vomiting, and jaundice. The diagnosis of toxic hepatitis was made using the Roussel Uclaf Causality Assessment Method score on the basis of the patient's history and laboratory data. After supportive care, the patients showed rapid improvements of clinical symptoms, laboratory findings, and liver stiffness. Clinicians should be aware that the consumption of arrowroot juice can cause toxic hepatitis.