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1.
Medicine (Baltimore) ; 103(5): e37110, 2024 Feb 02.
Artículo en Inglés | MEDLINE | ID: mdl-38306555

RESUMEN

RATIONALE: Castleman disease (CD) was first included in the CSCO lymphoma diagnosis and treatment guidelines in 2021. Its diagnosis relies on lymph node pathological examination. Observation, surgical resection of the lesion, radiotherapy, chemotherapy, and medical therapy (e.g., rituximab, siltuximab, steroids) can be used. Due to the traumatic, incurable, and recurrent nature of surgical treatment, drug therapy has many side effects and is expensive. Exploring effective traditional Chinese medicine (TCM) comprehensive treatment methods for this disease is important and necessary. PATIENT CONCERNS: The main symptom was recurrent lymphadenopathy, which had been surgically removed 5 times in the past. This time, lymph node enlargement occurred again, and the local hospital recommended surgical resection again. The patient could not tolerate another surgical treatment. Other targeted treatments are not available due to financial constraints. DIAGNOSES: The case was diagnosed as CD by pathological examination, which is an important basis for the diagnosis of this disease. INTERVENTIONS: The patient was treated with surgery in the early stage several times, later came to our hospital for the trinity of TCM integrated treatment program, which combines oral TCM with external application of TCM and intravenous drip of TCM as a syndrome of positive deficiency and phlegm-toxin internalization, and the therapeutic principle. OUTCOMES: After nearly 3 years of comprehensive treatment with TCM, the enlarged lymph nodes could not be touched, and there was no fatigue, fever, or weight loss. During this period, the patient did not undergo surgery, chemotherapy and other western medicine treatment, and lived a normal life. It not only met the patient's expectation but also confirmed that the TCM treatment was indeed effective. LESSONS: This case report confirms that TCM is safe and effective in the treatment of CD, which is worthy of promotion. In clinical practice, the individualized treatment for the patient, the duration of treatment, and the different disease states also affect the treatment outcome.


Asunto(s)
Enfermedad de Castleman , Linfadenopatía , Humanos , Enfermedad de Castleman/diagnóstico , Enfermedad de Castleman/terapia , Medicina Tradicional China , Resultado del Tratamiento
4.
JAMA Dermatol ; 153(5): 449-452, 2017 05 01.
Artículo en Inglés | MEDLINE | ID: mdl-28241173

RESUMEN

Importance: Castleman disease (CD) is an ultrarare, interleukin-6 (IL-6)-driven lymphoproliferative disorder whose underlying molecular alterations are unknown. Siltuximab (anti-IL-6 antibody) is approved for treatment of this disease. To our knowledge, genomic sequencing of CD has not been reported. Objective: To investigate and identify molecular aberration(s) that help explain the exceptional response to siltuximab in a patient with cutaneous CD. Design, Setting, and Participants: This case study examines data from comprehensive genomic profiling (using targeted next-generation sequencing) of tissue from a patient with cutaneous CD who demonstrated an exceptional response to siltuximab treated at a National Cancer Institute-designated Comprehensive Cancer Center. Interventions: Intravenous siltuximab 12 mg/kg every 3 weeks. Tissue from the patient was interrogated by next-generation sequencing (405 genes). Serum was evaluated for IL-6 levels by enzyme-linked immunoassay. Main Outcomes and Measures: Identification of pretreatment serum IL-6 levels and somatic variants that may explain the exceptional response to siltuximab in this patient with cutaneous CD. Results: Patient pretreatment serum IL-6 levels were normal. Treatment with siltuximab resulted in a complete response lasting 7 years. Next-generation sequencing demonstrated a JAK1V310I missense mutation. Janus Kinase 1 (JAK1) is a crucial signaling component of the IL-6/IL-6 receptor/gp130 machinery. JAK1V310I may induce a conformation change with functional activation effect leading to enhanced sensitivity to the IL-6 ligand. Conclusions and Relevance: Our observations suggest that a JAK1 alteration may explain the underlying biology of a patient's cutaneous CD, as well as the patient's exceptional response to siltuximab.


Asunto(s)
Anticuerpos Monoclonales/uso terapéutico , Enfermedad de Castleman/tratamiento farmacológico , Interleucina-6/inmunología , Janus Quinasa 1/genética , Antineoplásicos/uso terapéutico , Enfermedad de Castleman/genética , Enfermedad de Castleman/patología , Ensayo de Inmunoadsorción Enzimática , Femenino , Genómica , Humanos , Interleucina-6/sangre , Persona de Mediana Edad , Mutación Missense , Factores de Tiempo , Resultado del Tratamiento
5.
Curr Oncol Rep ; 17(7): 29, 2015 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-25986720

RESUMEN

Siltuximab is a chimeric monoclonal antibody targeting interleukin-6 (IL-6), which in the fall of 2014 became the first FDA-approved treatment of the rare disease idiopathic multicentric Castleman's disease (MCD). MCD is a non-clonal lymphoproliferative disorder in which common symptoms include fever, night sweats, weight loss, and fatigue. Symptoms are driven by an overall hypercytokinemia, predominantly IL-6. While under clinical development, siltuximab was studied in several other disease states including multiple myeloma, non-Hodgkin lymphomas, and several solid tumors in which it did not demonstrate significant benefit. The efficacy of siltuximab in MCD is mainly confined to systemic symptomatic response and quality of life benefits with minimal complete responses and approximately 30 % partial responses, by radiographic criteria. Siltuximab treatment therefore is important in the overall treatment of this rare disease state. This review focuses on the clinical development and pharmaceutical approval of siltuximab.


Asunto(s)
Anticuerpos Monoclonales/farmacología , Anticuerpos Monoclonales/farmacocinética , Antineoplásicos/farmacología , Antineoplásicos/farmacocinética , Enfermedad de Castleman/tratamiento farmacológico , Interleucina-6/antagonistas & inhibidores , Mieloma Múltiple/tratamiento farmacológico , Animales , Anticuerpos Monoclonales/administración & dosificación , Antineoplásicos/administración & dosificación , Ensayos Clínicos Fase I como Asunto , Ensayos Clínicos Fase II como Asunto , Aprobación de Drogas , Evaluación Preclínica de Medicamentos , Humanos , Resultado del Tratamiento
6.
Clin Cancer Res ; 21(5): 950-4, 2015 Mar 01.
Artículo en Inglés | MEDLINE | ID: mdl-25601959

RESUMEN

On April 22, 2014, the FDA granted full approval to siltuximab (SYLVANT for injection; Janssen Biotech, Inc.), a chimeric human-mouse monoclonal antibody to IL6, for the treatment of patients with multicentric Castleman disease (MCD) who are human immunodeficiency virus (HIV) negative and human herpesvirus-8 (HHV-8) negative. The approval was primarily based on the results of a randomized, double-blind trial in which 79 symptomatic patients with MCD were allocated (2:1) to siltuximab plus best supportive care (BSC) or to placebo plus BSC. The primary efficacy endpoint was the proportion of patients in each arm achieving a durable tumor and symptomatic response that persisted for a minimum of 18 weeks without treatment failure. Tumor response was based on independent review of CT scans using the revised Response Criteria for Malignant Lymphoma, and symptomatic response was defined as complete resolution or stabilization of 34 MCD-related signs and symptoms as reported by the investigator. Thirty-four percent of patients in the siltuximab arm and no patients in the placebo arm met the primary endpoint (P = 0.0012). The most common adverse reactions (>10% compared with placebo) during treatment with siltuximab were pruritus, increased weight, rash, hyperuricemia, and upper respiratory tract infection.


Asunto(s)
Anticuerpos Monoclonales/uso terapéutico , Antineoplásicos/uso terapéutico , Enfermedad de Castleman/tratamiento farmacológico , Aprobación de Drogas , United States Food and Drug Administration , Adulto , Anciano , Animales , Anticuerpos Monoclonales/química , Anticuerpos Monoclonales/farmacología , Antineoplásicos/química , Antineoplásicos/farmacología , Enfermedad de Castleman/diagnóstico , Ensayos Clínicos como Asunto , Evaluación Preclínica de Medicamentos , Humanos , Persona de Mediana Edad , Resultado del Tratamiento , Estados Unidos
7.
Int J Surg ; 12(10): 1088-92, 2014 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-25150021

RESUMEN

INTRODUCTION: Diversion colitis is a non-specific inflammation of a de-functioned segment of intestine after diversion of the faecal stream. AIM: The aim of this study was to review the current level of knowledge about diversion colitis. METHODS: A literature search of relevant literature in the English language was carried out on PUBMED, MEDLINE and EMBASE. The following keywords were used: diversion colitis; disuse colitis; proctitis; colonic bacterial flora; stoma; de-functioned colon; faecal diversion; short chain fatty acids and lymphoid follicular hyperplasia. RESULTS: In total 35 articles met the inclusion criteria. 22 were case series, 9 were case reports, 2 were retrospective analysis and 2 were prospective randomized controlled studies. Diversion colitis is invariably present in all diverted segments of the colon. It is usually asymptomatic but can present with tenesmus, rectal discharge, bleeding per rectum and abdominal pain. Major macroscopic changes include mucosal nodularity, erythema and friability. Microscopic features are predominantly those of lymphoid follicular hyperplasia, apthous ulceration and chronic inflammatory changes, mostly limited to sub mucosa. Treatment modalities include surveillance for asymptomatic patients, restoration of bowel continuity for severely symptomatic cases and the use of short chain fatty acid (SCFA) enemas in selected cases. CONCLUSION: The clinical presentation of diversion colitis varies significantly. In symptomatic patients short chain fatty acid enema may help. Further prospective studies are required for evaluation.


Asunto(s)
Colitis/diagnóstico , Colitis/terapia , Complicaciones Posoperatorias , Dolor Abdominal/etiología , Enfermedad de Castleman/etiología , Colitis/etiología , Colitis/fisiopatología , Enema , Eritema/etiología , Ácidos Grasos Volátiles/uso terapéutico , Hemorragia Gastrointestinal/etiología , Humanos , Inflamación/etiología , Mucosa Intestinal/patología , Recto/cirugía
9.
Ir Med J ; 102(9): 294-5, 2009 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-19902650

RESUMEN

We report the case of a 35 year patient from Nigeria who presented with fever and splenomegaly. The initial diagnosis was Salmonellosis. However, relapsing symptoms lead to a re-evaluation and ultimately a diagnosis of Multicentric Castleman's Disease (MCD). There is no gold standard treatment but our patient responded to Rituximab and Highly active anti-retroviral therapy. MCD is a rare, aggressive disease that should be considered in a HIV positive patient presenting with fever and significant lymphadenopathy.


Asunto(s)
Anticuerpos Monoclonales/uso terapéutico , Terapia Antirretroviral Altamente Activa , Enfermedad de Castleman/diagnóstico , Herpesvirus Humano 8 , Factores Inmunológicos/uso terapéutico , Adulto , Antiinfecciosos/uso terapéutico , Anticuerpos Monoclonales de Origen Murino , Enfermedad de Castleman/tratamiento farmacológico , Enfermedad de Castleman/patología , Enfermedad de Castleman/cirugía , Ciprofloxacina/uso terapéutico , Humanos , Masculino , Rituximab , Esplenomegalia
10.
Can J Neurol Sci ; 34(3): 380-5, 2007 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-17803044
11.
Fukuoka Igaku Zasshi ; 97(11): 322-50, 2006 Nov.
Artículo en Japonés | MEDLINE | ID: mdl-17228786

RESUMEN

Multiple cases with various types of pediatric malabsorption syndromes were evaluated. The clinical manifestations, laboratory findings, pathophysiology, and histopathological descriptions of each patient were analyzed in an effort to clear the pathogenesis of the malabsorption syndromes and the treatments were undertaken. The cases studied, included one patient with cystic fibrosis, two with lactose intolerance with lactosuria (Durand type), one with primary intestinal lymphangiectasia, two with familial hypobetalipoproteinemia, one with Hartnup disease, one with congenital chroride diarrhea, one with acrodermatitis enteropathica, one with intestinal nodular lymphoid hyperplasia (NLH), five with intractable diarrhea of early infancy and four with glycogenosis type Ia. Each case description and outcome is described below: 1. A 15-year-old Japanese boy with cystic fibrosis presented with severe symptoms, including pancreatic insufficiency, bronchiectasis, pneumothorax and hemoptysis. His prognosis was poor. Analysis of the CFTR genes of this patient revealed a homozygous large deletion from intron 16 to 17b. 2. In the sibling case of Durand type lactose intolerance, the subjects'disaccaridase activity of the small bowel, including lactase, were within normal limits. The results of per oral and per intraduodenal lactose tolerance tests confirmed lactosuria in both. These observations suggested, not only an abnormal gastric condition, but also duodenal and intestinal mucosal abnormal permeability of lactose. 3. In the case of primary intestinal lymphangiectasia, the subject had a lymphedematous right arm and hand, a grossly coarsened mucosal pattern of the upper gastrointestinal tract (identified via radiologic examination) and the presence of lymphangiectasia (confirmed via duodenal mucosal biopsy). The major laboratory findings were hypoalbuminemia, decreased immunoglobulin levels and lymphopenia resulting from loss of lymph fluid and protein into the gastro-intestinal tract. 4. In two cases of heterozygous familial hypobetalipoproteinemia, serum total cholesterol and betalipoprotein levels were very low. The subjects presented with symptoms and signs of acanthocytosis and fat malabsorption. Further, one subject had neurological abnormalities such as mental retardation and severe convulsions. Treatment with MCT formula diet corrected the lipid malabsorption. 5. A 5-year-old girl presented with pellagra-like rashes, mental retardation and cerebellar ataxia. An oral tryptophan (Trp) and dipeptide (Trp-Phe) loading test were conducted and the renal clearance of amino acids was also evaluated in this patient and in controls. Following the oral Trp loading test, plasma levels of Trp indicated a lower peak in the case, reaching a maximum at 60 minutes. On the other hand, the oral dipeptide (Trp-Phe) loading test in the Hartnup patient showed the peak Trp plasma level was the same as the control subjects. The renal clearance of neutral amino acids in this case increased to levels 5 to 35 times normal. 6. In the case of congenital chloride diarrhea, the subject had secondary lactose intolerance, dehydration, hyponatremia, hypokalemia, hypochloremia, hyperreninemia and metabolic alkalosis. The chloride content of her fecal fluid was very high. The concentrations were 89-103 mEq/l. In contrast, her urine was chloride-free. The subject's growth and development improved after treatment with lactose free formura and oral replacement of the fecal loses of water, NaCl and KCl. Unfortunately, the patient died of a small bowel intussusception. The kidney histopathological finding was juxtaglomerular hyperplasia by a necropsy. 7. In the case of acrodermatitis enteropathica, the subject had characteristic skin lesions, low serum zinc levels and ALPase activity. An oral ZnSO4 loading test and intestinal mucosal histology by a peroral biopsy were conducted. The serum zinc peak level was 2 hours after the oral ZnSO4 loading test. Infant formula alone could not maintain normal serum zinc ranges. Light microscopic studies of the intestinal villous architecture showed a normal pattern. However, ultrastructual examination of several epithelial cells revealed numerous intracellular vesicles. After zinc therapy, these changes were decreased. The lesions were postulated as the secondary result of zinc deficiency. 8. A 12-year-old girl presented with hypogammaglobulinemia, recurrent infections, chronic diarrhea and intestinal NLH. A barium meal and follow-through examination showed multiple nodules throughout the stomach and intestine. The nodules, all uniform in size, were 2 mm diameter. The barium enema did not show NLH in the colon. Mucosal biopsy of the stomach and jejunum revealed the typical histology of NLH in the lamina propria. Also, achlorhydria was present in this patient and her serum gastrin levels were very high; 315-775 pg/ml. 9. In 4 cases of intractable diarrhea in early infancy (by Avery G B), a jejunal biopsy showed shortening villi and nonspecific enterocolitis. Some patients were found with only low lactase or low lactase and sucrase levels. An electron microscope analysis of the small bowel in 2 cases showed alterations: increased pinocytosis in microvillus membranes and lysosomes by endocytosis of undigested macromolecular substances. I postulated that the stated evidence was causative of this clinical profile. 10. I frequently observed diarrhea as a clinical manifestation in glycogenosis type Ia and lipid malabsorption in one case. The light and electron photomicrographs showed intestinal absorption cells with the glycogen deposits in the inferior devision of nuclei.


Asunto(s)
Síndromes de Malabsorción/etiología , Síndromes de Malabsorción/terapia , Acrodermatitis/complicaciones , Acrodermatitis/diagnóstico , Acrodermatitis/terapia , Adolescente , Enfermedad de Castleman/complicaciones , Enfermedad de Castleman/diagnóstico , Enfermedad de Castleman/terapia , Niño , Preescolar , Fibrosis Quística/complicaciones , Fibrosis Quística/diagnóstico , Fibrosis Quística/terapia , Diarrea/complicaciones , Diarrea/congénito , Diarrea/diagnóstico , Diarrea/terapia , Diarrea Infantil/complicaciones , Diarrea Infantil/diagnóstico , Diarrea Infantil/terapia , Femenino , Enfermedad del Almacenamiento de Glucógeno Tipo I/complicaciones , Enfermedad del Almacenamiento de Glucógeno Tipo I/diagnóstico , Enfermedad del Almacenamiento de Glucógeno Tipo I/terapia , Enfermedad de Hartnup/complicaciones , Enfermedad de Hartnup/diagnóstico , Enfermedad de Hartnup/terapia , Humanos , Hipobetalipoproteinemia Familiar por Apolipoproteína B/complicaciones , Hipobetalipoproteinemia Familiar por Apolipoproteína B/diagnóstico , Hipobetalipoproteinemia Familiar por Apolipoproteína B/terapia , Lactante , Recién Nacido , Intolerancia a la Lactosa/complicaciones , Intolerancia a la Lactosa/diagnóstico , Intolerancia a la Lactosa/terapia , Linfangiectasia Intestinal/complicaciones , Linfangiectasia Intestinal/diagnóstico , Linfangiectasia Intestinal/terapia , Masculino
13.
Radiología (Madr., Ed. impr.) ; 43(1): 31-33, ene. 2001. ilus
Artículo en Es | IBECS | ID: ibc-761

RESUMEN

Describimos un caso de hiperplasia nodular linfoide en el contexto de un cuadro de inmunodeficiencia combinada grave. La paciente refería estreñimiento y crisis de dolor abdominal, presentando en la exploración una voluminosa masa abdominal. Los exámenes radiológicos iniciales hicieron sospechar el diagnóstico, pero fue necesaria la realización de una biopsia intestinal con el fin de descartar una afectación linfomatosa. Queremos llamar la atención sobre la semiología radiológica de esta entidad, que si bien en principio puede ser un hallazgo casual sin significado patológico, requiere una especial atención especialmente en sujetos inmunodeficientes (AU)


Asunto(s)
Femenino , Niño , Humanos , Enfermedad de Castleman , Hiperplasia/diagnóstico , Hiperplasia/terapia , Hiperplasia , Tomografía Computarizada de Emisión/métodos , Tomografía Computarizada de Emisión , Inmunodeficiencia Combinada Grave/complicaciones , Inmunodeficiencia Combinada Grave/diagnóstico , Inmunodeficiencia Combinada Grave/terapia , Inmunodeficiencia Combinada Grave , Dolor Abdominal/complicaciones , Dolor Abdominal/diagnóstico , Dolor Abdominal , Intestinos/cirugía , Intestinos/patología , Intestinos , Seudolinfoma , Tejido Linfoide/patología , Tejido Linfoide , Tejido Linfoide/fisiopatología , Intestino Delgado/cirugía , Intestino Delgado/patología , Intestino Delgado , Linfopenia/complicaciones , Linfopenia/diagnóstico , Linfopenia/terapia , Linfopenia , Abdomen/cirugía , Abdomen/patología , Abdomen , Biopsia/métodos , Colonoscopía , Antagonistas de los Receptores Histamínicos H1/uso terapéutico , Antagonistas de los Receptores H2 de la Histamina/uso terapéutico , Estreñimiento/complicaciones , Estreñimiento/diagnóstico , Estreñimiento/terapia , Tórax/patología , Tórax , Bronquiolitis Obliterante/complicaciones , Bronquiolitis Obliterante/diagnóstico , Bronquiolitis Obliterante , Bronquiolitis Obliterante/terapia , Enema
14.
Surg Today ; 26(6): 431-4, 1996.
Artículo en Inglés | MEDLINE | ID: mdl-8782302

RESUMEN

The immunological and immunohistochemical characteristics of a patient with nodular lymphoid hyperplasia (NLH) of the terminal ileum were investigated pre- and post-operatively. The patient presented with diarrhea, lower abdominal pain, and weight loss, and an abdominal X-ray following barium enema revealed multiple small nodules in the terminal ileum which were subsequently confirmed to be NLH by histological examination. Preoperatively, although the serum immunoglobulin levels were normal, the T-cell responses in the peripheral blood, including the phytohemagglutinin (PHA)-blastogenesis and the T4/T8 ratio, were impaired. However, following an ileocecal resection, the PHA-blastogenesis became augmented and the T4/T8 ratio recovered to within the normal range. The immunohistochemical findings revealed a more marked accumulation of T cells in the interstitium around the hyperplastic follicles than in the interstitium of the normal intestine.


Asunto(s)
Enfermedad de Castleman/inmunología , Enfermedades del Íleon/inmunología , Relación CD4-CD8 , Enfermedad de Castleman/cirugía , Humanos , Enfermedades del Íleon/cirugía , Inmunohistoquímica , Activación de Linfocitos , Masculino , Persona de Mediana Edad , Linfocitos T/inmunología
15.
Rev. gastroenterol. Méx ; 58(3): 225-8, jul.-sept. 1993. ilus, tab
Artículo en Español | LILACS | ID: lil-196101

RESUMEN

La asociación entre hiperplasia nodular linfoide del instestino (HNLI) con disgamaglobulinemia fue descrita por Hermans y cols en 1966. A pesar de ser una entidad rara, una de las series con más casos, informada en la literatura, es mexicana. En este trabajo describimos las características clínicas de un hombre joven con diarrea, esteatorrea e historia de infecciones de vías aéreas superiores, en quien se estableció el diagnóstico clínico, radiológico, endoscópico e histopatológico de HNLI. El aspirado del líquido yeyunal mostró infección por E. Coli, C. Freundii y Candida albicans, así como quistes de Giardia lamblia. Los niveles séricos de IgA e IgM se encontraron bajos, al igual que hubo disminución importante en el número de linfocitos B en sangre periférica. El paciente recibió tratamiento con base en itraconazol, ciprofloxacina y furazolidona con excelente respuesta. Actualmente se encuentra asintómatico con ciclos mensuales de antibióticos y administración parenteral de gamaglobulina.


Asunto(s)
Humanos , Masculino , Adulto , Antibacterianos/uso terapéutico , Ciprofloxacina/uso terapéutico , Diarrea/fisiopatología , Enfermedad Celíaca/diagnóstico , Furazolidona/uso terapéutico , Enfermedad de Castleman/fisiopatología , Parasitosis Intestinales/transmisión , Metronidazol/uso terapéutico , Infecciones del Sistema Respiratorio/complicaciones , Tetraciclina/uso terapéutico
16.
J Postgrad Med ; 37(3): 176B, 177-8, 1991 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-1784034

RESUMEN

An unusual case of extensive benign lymphoid hyperplasia of the ileo-caecal region causing ileo-caeco-colic intussusception is presented here, with a review of relevant literature. The diagnosis of intussusception was reached with the help of an abdominal ultrasound and barium enema. Histopathology of the resected specimen, revealed lymphoid hyperplasia.


Asunto(s)
Enfermedad de Castleman/complicaciones , Enfermedades del Ciego/etiología , Enfermedades del Íleon/etiología , Intususcepción/etiología , Adolescente , Enfermedad de Castleman/patología , Humanos , Masculino
17.
J Comput Assist Tomogr ; 11(6): 990-3, 1987.
Artículo en Inglés | MEDLINE | ID: mdl-2824581

RESUMEN

The CT scans of 132 patients with mediastinal masses and CT scans from our teaching file were retrospectively reviewed to evaluate the role of contrast enhancement in limiting the differential diagnosis of a mediastinal mass. Ten patients with an enhancing mediastinal mass were found. Coupled with mass enhancement, location and hypertension were helpful in limiting the differential diagnosis. Four masses were of thyroid origin, and all were contiguous with neck thyroid. All patients with functioning paragangliomas were hypertensive and all intrapericardial enhancing masses were functioning paragangliomas. A normotensive patient had a nonfunctioning aortic body paraganglioma superiolateral to the aortic arch. An enhancing mass in a similar location in a hypertensive patient was a functioning paraganglioma. Castleman disease occurred posterior to the heart.


Asunto(s)
Neoplasias del Mediastino/diagnóstico por imagen , Tomografía Computarizada por Rayos X , Enfermedad de Castleman/diagnóstico por imagen , Diagnóstico Diferencial , Bocio/diagnóstico por imagen , Humanos , Aceite Yodado , Neoplasias del Mediastino/etiología , Mediastino/diagnóstico por imagen , Paraganglioma/diagnóstico por imagen , Feocromocitoma/diagnóstico por imagen , Estudios Retrospectivos
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