RESUMEN
BACKGROUND: Primary localized cutaneous amyloidosis (PLCA) is defined by the deposition of amyloid protein in the skin without systemic involvement. There are four subtypes of PLCA: lichen amyloidosis (LA), macular amyloidosis (MA), biphasic amyloidosis (BA), and nodular amyloidosis (NA). PLCA occurs most frequently in Latin Americans and Asians. Treatment is not standardized. OBJECTIVES: To identify subtypes, demographic and clinical features and treatment efficacy in patients with histopathologically confirmed PLCA. MATERIALS AND METHODS: Data of PLCA patients were extracted from the electronic hospital database and included if diagnosis of PLCA was histopathologically confirmed and if sufficient information regarding treatment and follow-up was available. The evaluation of the treatment efficacy was based on a novel score to assess the reduction of itch and skin lesions. RESULTS: In this retrospective, monocentric study, 37 cases of PLCA diagnosed between 2000 and 2020 were included (21 females) with a mean age of 52 years. LA was the most frequent subtype found in 21 patients (56.8%), followed by MA in 10 patients (28%) and BA in 6 patients (16.2%). No cases of NA were included. 22 patients (59.4%) had skin phototype II or III. Regarding treatment, a combination of UVA1 phototherapy with high-potency topical corticosteroids seemed to show the highest efficacy with complete clearance of symptoms in 4 patients (10.8%). A substantial improvement of symptoms was found in 5 patients (12.7%) treated with high-potency topical corticosteroids alone or in combination either with UVA1 or bath PUVA or monotherapy with UVA1 phototherapy or capsaicin (0.075%) cream. Low-/medium-potency topical corticosteroids alone or in combination with UVBnb (311 nm) phototherapy showed a lower efficacy. CONCLUSION: Our data show that PCLA is a rare disease in central Europe but can also be expected in a predominantly Caucasian population. The best treatment response was achieved with a combination of UVA1 phototherapy and high-potency topical corticosteroids.
Asunto(s)
Amiloidosis , Fármacos Dermatológicos , Enfermedades Cutáneas Genéticas , Corticoesteroides/uso terapéutico , Amiloidosis/patología , Amiloidosis Familiar , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Enfermedades Cutáneas Genéticas/diagnóstico , Enfermedades Cutáneas Genéticas/patología , Enfermedades Cutáneas Genéticas/terapia , Suiza , Centros de Atención TerciariaRESUMEN
Type 1 plasminogen deficiency is a rare genetic disorder. Type 1 plasminogen deficiency is characterized by fibrin-rich pseudomembrane formation on mucosal surfaces, particularly the conjunctiva. Tracheobronchial tree involvement is a less common reported manifestation of type 1 plasminogen deficiency. Pseudomembranes in the tracheobronchial tree may result in respiratory compromise and ultimately fail if not recognized and treated. Currently, there is no specific replacement therapy approved for the treatment of congenital plasminogen deficiency. In the present paper, we report that type 1 plasminogen deficiency with novel frameshift mutation and pulmonary involvement was treated initially with systemic fresh frozen plasma followed by pulmonary lavage with fresh frozen plasma and tissue plasminogen activator.
Asunto(s)
Conjuntivitis/genética , Mutación del Sistema de Lectura , Plasminógeno/deficiencia , Plasminógeno/genética , Enfermedades Cutáneas Genéticas/genética , Transfusión de Componentes Sanguíneos , Conjuntivitis/patología , Conjuntivitis/terapia , Humanos , Lactante , Pulmón/patología , Masculino , Enfermedades Cutáneas Genéticas/patología , Enfermedades Cutáneas Genéticas/terapia , Activador de Tejido Plasminógeno/uso terapéuticoRESUMEN
INTRODUCTION: Capnocytophagacanimorsus (C. canimorsus), a commensal Gram-negative bacillus found in the oral cavity of dogs and cats, is pathogenic for humans, with the most common clinical manifestations being septicemia, meningitis and endocarditis. Herein we report a case of CC bacteremia manifesting as multiple plaques of erythema annulare centrifugum associated with monoarthritis of the knee. PATIENTS AND METHODS: A 66-year-old man consulted for a skin rash and monoarthritis of the right knee with fever following an insect bite on his right hallux. Cutaneous examination revealed numerous erythematous annular plaques on the trunk and limbs with centrifugal extension. Analysis of synovial fluid from the right knee showed an inflammatory liquid with a sterile bacteriological culture and PCR was negative for Borrelia. C. canimorsus bacteria were isolated from blood cultures. 16S RNA PCR performed on the synovial fluid was positive for the same organism. The patient's history revealed that his hallux wound had been licked by his dog. DISCUSSION: C. canimorsus most frequently affects immunosuppressed subjects. Cutaneous signs are seen in half of all cases, most frequently presenting as cellulitis, pathological livedo or thrombotic purpura. We report herein a case of CC bacteremia in an immunocompetent patient manifesting as multiple plaques of erythema annulare centrifugum, an unusual sign, and monoarthritis of one knee.
Asunto(s)
Artritis/microbiología , Bacteriemia/complicaciones , Capnocytophaga , Eritema/microbiología , Infecciones por Bacterias Gramnegativas/complicaciones , Articulación de la Rodilla , Enfermedades Cutáneas Genéticas/microbiología , Anciano , Animales , Enfermedades de los Perros/microbiología , Enfermedades de los Perros/transmisión , Perros , Eritema/patología , Humanos , Masculino , Enfermedades Cutáneas Genéticas/patologíaRESUMEN
Lichen amyloidosis is a subtype of primary localized cutaneous amyloidosis characterized by deposition of amyloid protein in the skin without visceral involvement. Although it is usually limited to localized areas of the body, it rarely can present in a generalized fashion and is severely pruritic. The limited form is treated with skin directed therapies such as topical or intralesional corticosteroids or topical tacrolimus but the generalized type is more difficult to treat. We present a patient with generalized primary cutaneous lichen amyloidosis successfully treated with dupilumab.
Asunto(s)
Amiloidosis Familiar/tratamiento farmacológico , Anticuerpos Monoclonales Humanizados/uso terapéutico , Enfermedades Cutáneas Genéticas/tratamiento farmacológico , Anciano , Amiloidosis Familiar/complicaciones , Amiloidosis Familiar/patología , Humanos , Inyecciones Subcutáneas , Masculino , Prurito/etiología , Piel/patología , Enfermedades Cutáneas Genéticas/complicaciones , Enfermedades Cutáneas Genéticas/patologíaAsunto(s)
Enfermedades Óseas Metabólicas/patología , Calcitriol/administración & dosificación , Suplementos Dietéticos , Predisposición Genética a la Enfermedad , Osificación Heterotópica/patología , Seudohipoparatiroidismo/patología , Enfermedades Cutáneas Genéticas/patología , Adolescente , Biopsia con Aguja , Enfermedades Óseas Metabólicas/complicaciones , Enfermedades Óseas Metabólicas/diagnóstico , Enfermedades Óseas Metabólicas/genética , Estudios de Seguimiento , Humanos , Inmunohistoquímica , Masculino , Osificación Heterotópica/complicaciones , Osificación Heterotópica/diagnóstico , Osificación Heterotópica/genética , Dolor/diagnóstico , Dolor/etiología , Seudohipoparatiroidismo/complicaciones , Seudohipoparatiroidismo/diagnóstico , Seudohipoparatiroidismo/genética , Enfermedades Raras , Medición de Riesgo , Índice de Severidad de la Enfermedad , Piel/patología , Enfermedades Cutáneas Genéticas/complicaciones , Enfermedades Cutáneas Genéticas/diagnóstico , Enfermedades Cutáneas Genéticas/genéticaRESUMEN
Ligneous conjunctivitis is a rare form of chronic and recurrent bilateral conjunctivitis, in which thick membranes develop on the tarsal conjunctiva and on other mucosae. We report the case of a 55-year old female patient with bilateral ligneous conjunctivitis who was successfully treated with 50% heterologous serum. There was no recurrence or side effects after one-year follow-up. We suggest the use of 50% heterologous serum should be further studied to better determine its efficacy as a treatment option for ligneous conjunctivitis.
Asunto(s)
Plasminógeno/deficiencia , Suero , Conjuntivitis/patología , Femenino , Humanos , Persona de Mediana Edad , Plasminógeno/uso terapéutico , Enfermedades Cutáneas Genéticas/patología , Resultado del TratamientoAsunto(s)
Hiperpigmentación/radioterapia , Hiperpigmentación/cirugía , Terapia por Láser/métodos , Enfermedades Cutáneas Genéticas/radioterapia , Enfermedades Cutáneas Genéticas/cirugía , Enfermedades Cutáneas Papuloescamosas/radioterapia , Enfermedades Cutáneas Papuloescamosas/cirugía , Adulto , Biopsia con Aguja , Erbio/uso terapéutico , Estética , Femenino , Estudios de Seguimiento , Humanos , Hiperpigmentación/patología , Inmunohistoquímica , Coagulación con Láser/métodos , Láseres de Estado Sólido/uso terapéutico , Terapia por Luz de Baja Intensidad/métodos , Medición de Riesgo , Índice de Severidad de la Enfermedad , Enfermedades Cutáneas Genéticas/patología , Enfermedades Cutáneas Papuloescamosas/patología , Resultado del TratamientoRESUMEN
ABSTRACT Ligneous conjunctivitis is a rare form of chronic and recurrent bilateral conjunctivitis, in which thick membranes develop on the tarsal conjunctiva and on other mucosae. We report the case of a 55-year old female patient with bilateral ligneous conjunctivitis who was successfully treated with 50% heterologous serum. There was no recurrence or side effects after one-year follow-up. We suggest the use of 50% heterologous serum should be further studied to better determine its efficacy as a treatment option for ligneous conjunctivitis.
RESUMO A conjuntivite lenhosa é uma forma rara de conjuntivite bilateral crônica e recorrente, na qual há formação de membranas espessas na conjuntiva tarsal e em outras mucosas. Relatamos o caso de uma paciente de 55 anos com conjuntivite lenhosa bilateral, que obteve sucesso no tratamento com soro heterólogo em concentração de 50%. Não houve recorrência após um ano de seguimento e nem efeitos colaterais ao tratamento. Dessa forma, o uso de soro heterólogo a 50% poderia ser mais estudado para melhor avaliação de sua eficácia como opção de tratamento para a conjuntivite lenhosa.
Asunto(s)
Humanos , Femenino , Plasminógeno/deficiencia , Suero , Plasminógeno/uso terapéutico , Enfermedades Cutáneas Genéticas/patología , Resultado del Tratamiento , Conjuntivitis/patología , Persona de Mediana EdadRESUMEN
Ligneous conjunctivitis is a rare and poorly understood pathology. Infections and repeated microtraumas are often involved in acute disease flare-ups. This masquerade may lead to misdiagnosis and delayed treatment. We report two cases of ligneous conjunctivitis, describing various presentations of its natural history and focusing on the treatment of this rare disease.
Asunto(s)
Conjuntivitis/diagnóstico , Conjuntivitis/etiología , Conjuntivitis/terapia , Plasminógeno/deficiencia , Enfermedades Cutáneas Genéticas/diagnóstico , Enfermedades Cutáneas Genéticas/etiología , Enfermedades Cutáneas Genéticas/terapia , Adulto , Niño , Conjuntivitis/patología , Diagnóstico Diferencial , Errores Diagnósticos , Femenino , Humanos , Masculino , Enfermedades Cutáneas Genéticas/patología , Tiempo de TratamientoRESUMEN
Lichen amyloidosis (LA) is a form of primary localized cutaneous amyloidosis (PLCA) characterized by bilateral intensely itchy domed scaly hyperkeratotic papules. Lichen amyloidosis is rare and affects men more than women. It is uncommonly seen in the western world but more prevalent in Asia. These papules most typically affect the shins and occasionally the arms and torso. Lichen amyloidosis has been reported in association with autoimmune disorders and after prolonged exfoliation and friction of affected skin. We present a 40-year-old woman with LA. In LA, the characteristic histological finding is apple-green birefringence of Congo red-stained preparations observed under polarized light. However, this is not always strongly positive, as in our patient. Other findings may include eosinophilia, periodic acid-Schiff positivity, staining with thioflavin T, and metachromasia after staining with crystal violet or methyl violet. Treatment of LA is difficult and complete clinical remission is seldom achieved. Recent trials revealed beneficial outcomes with topical calcipotriol, phototherapy, acitretin, cyclophosphamide, and laser treatments. A combination of acitretin, antihistamines, topical steroids, and hydrocolloid dressings have been beneficial in our patient with LA.
Asunto(s)
Amiloidosis Familiar/patología , Enfermedades Cutáneas Genéticas/patología , Piel/patología , Adulto , Amiloidosis Familiar/complicaciones , Amiloidosis Familiar/diagnóstico , Femenino , Humanos , Prurito/etiología , Enfermedades Cutáneas Genéticas/complicaciones , Enfermedades Cutáneas Genéticas/diagnósticoRESUMEN
BACKGROUND: Primary localized cutaneous amyloidosis (PLCA) is characterized by extracellular deposition of heterogenic amyloid proteins in the skin without systemic involvement. Lichen amyloidosis, macular amyloidosis, and (primary localized cutaneous) nodular amyloidosis are different subtypes of PLCA. OBJECTIVE: The aim of this study was to review the current reported treatment options for PLCA. METHODS: This systematic review was based on a search in the PubMed database for English and German articles from 1985 to 2016. RESULTS: Reports on the treatment of PLCA were limited predominantly to case reports or small case series. There were a few clinical trials but these lacked control groups. A variety of treatment options for PLCA were reported including retinoids, corticosteroids, cyclophosphamide, cyclosporine, amitriptyline, colchicine, cepharanthin, tacrolimus, dimethyl sulfoxide, vitamin D3 analogs, capsaicin, menthol, hydrocolloid dressings, surgical modalities, laser treatment, and phototherapy. CONCLUSION: No definitive recommendation of preferable treatment procedures can be made based on the analyzed literature. Randomized controlled trials are needed to offer patients an evidence-based therapy with high-quality standardized treatment regimens for PLCA.
Asunto(s)
Amiloidosis Familiar/terapia , Fármacos Dermatológicos/uso terapéutico , Procedimientos Quirúrgicos Dermatologicos/métodos , Terapia por Láser/métodos , Fototerapia/métodos , Enfermedades Cutáneas Genéticas/terapia , Amiloidosis Familiar/patología , Vendas Hidrocoloidales , Procedimientos Quirúrgicos Dermatologicos/normas , Europa (Continente) , Humanos , Terapia por Láser/normas , Fototerapia/normas , Guías de Práctica Clínica como Asunto , Piel/patología , Enfermedades Cutáneas Genéticas/patologíaRESUMEN
BACKGROUND: Although zinc responsive dermatosis is typically a disorder of Arctic breed dogs, this study identifies similar cutaneous lesions on the face and pressure points of Boston terrier dogs. HYPOTHESIS/OBJECTIVES: To document the clinical and histological features of localized parakeratotic hyperkeratosis of Boston terrier dogs, to determine if the lesions respond to zinc supplementation and to determine whether tissue zinc levels were decreased in affected versus unaffected dogs. MATERIAL AND METHODS: Sixteen Boston terrier dogs with similar gross and histological findings were identified retrospectively from two institutions. Follow-up information for nine dogs from one institution was obtained from referring veterinarians using a questionnaire. Tissue zinc levels were measured from formalin-fixed paraffin-embedded skin biopsy samples of affected and unaffected dogs using inductively coupled plasma mass spectrometry. RESULTS: Mild to severe parakeratotic hyperkeratosis with follicular involvement was present in all 16 cases. Of the nine dogs for which follow-up information was available, five dogs received oral zinc supplementation and four dogs had documented clinical improvement or resolution of dermatological lesions. The median skin zinc levels were not significantly different between affected and unaffected dogs. CONCLUSIONS AND CLINICAL IMPORTANCE: To the best of the authors' knowledge this is the first report of localized parakeratotic hyperkeratosis in Boston terrier dogs, some of which improved with oral zinc supplementation. Prospective studies in Boston terrier dogs are warranted to document potential zinc deficiency (serum and/or tissue levels, pre- and post-treatment) and to objectively assess response to zinc supplementation and other therapies.
Asunto(s)
Enfermedades de los Perros/patología , Paraqueratosis/veterinaria , Enfermedades Cutáneas Genéticas/veterinaria , Administración Oral , Animales , Enfermedades de los Perros/tratamiento farmacológico , Enfermedades de los Perros/genética , Perros , Femenino , Masculino , Paraqueratosis/genética , Paraqueratosis/patología , Estudios Retrospectivos , Enfermedades de la Piel/veterinaria , Enfermedades Cutáneas Genéticas/patología , Zinc/administración & dosificación , Zinc/uso terapéuticoRESUMEN
BACKGROUND: We describe a male with functionally impairing radial deviation of the thumb who presented to us at 24 years of age. Two sclerotic skin lesions had been excised 7 years before because of consecutive skin contracture. Latest radiological examination showed a spotted pattern consistent with osteopoikilosis. CASE PRESENTATION: A corrective osteotomy of the thumb was carried out due to the patients discomfort. Facing the simultaneous osteo-cutaneous malformation we postulated a Buschke-Ollendorff syndrome. Buschke-Ollendorff syndrome is a rare autosomal-dominant hereditary disorder of connective tissue with typical osteo-cutaneous manifestations. To explore our hypothesis, biopsies were taken from the affected bone lesions and surrounding skin and soft tissue for histological investigation and genetic testing of the LEMD3 gene was performed on blood of the patient. The histology showed typical changes of the bone architecture and a fibrotic collagenous nodule of the skin. The genetic testing on DNA extracted from peripheral blood leucocytes confirmed a heterozygous loss of function mutation in the LEM domain-containing protein 3 (LEMD3) gene coding for the inner nuclear membrane protein MAN1, which causes osteopoikilosis by antagonizing transforming growth factor ß (TGF-ß) and bone morphogenetic protein (BMP) signalling. CONCLUSIONS: In atypical cases of simultaneous occurrence of fibrotic skin lesions and a spotted pattern in the X-ray we recommend the genetic screening of the LEMD3 gene. A correct diagnosis of Buschke-Ollendorff syndrome is necessary to spare patients from expensive investigations and to provide reassurance about the benign nature of the disease.
Asunto(s)
Anomalías Múltiples/patología , Osteopoiquilosis/patología , Anomalías Cutáneas , Enfermedades Cutáneas Genéticas/patología , Pulgar/anomalías , Anomalías Múltiples/genética , Secuencia de Bases , Análisis Mutacional de ADN/métodos , Proteínas de Unión al ADN , Humanos , Masculino , Proteínas de la Membrana/genética , Mutación , Proteínas Nucleares/genética , Osteopoiquilosis/genética , Homología de Secuencia de Ácido Nucleico , Enfermedades Cutáneas Genéticas/genética , Pulgar/cirugía , Adulto JovenRESUMEN
A 6-month-old female infant presented to our clinic with bilateral eyelid swelling, yellowish-white membranes under both lids, and mucoid ocular discharge. Her aunt had similar ocular problems that were undiagnosed. The conjunctival membranes were excised and histopathological investigation of these membranes showed ligneous conjunctivitis. Further, laboratory examination revealed plasminogen deficiency. A good response was observed to topical fresh frozen plasma (FFP) treatment without systemic therapy, and the membranes did not recur during the treatment. Topical FFP treatment may facilitate rapid rehabilitation and prevent recurrence in patients with ligneous conjunctivitis.
Asunto(s)
Administración Oftálmica , Conjuntivitis/terapia , Soluciones Oftálmicas/administración & dosificación , Plasma , Plasminógeno/deficiencia , Enfermedades Cutáneas Genéticas/terapia , Conjuntivitis/patología , Femenino , Humanos , Lactante , Enfermedades Cutáneas Genéticas/patología , Resultado del TratamientoRESUMEN
ABSTRACTA 6-month-old female infant presented to our clinic with bilateral eyelid swelling, yellowish-white membranes under both lids, and mucoid ocular discharge. Her aunt had similar ocular problems that were undiagnosed. The conjunctival membranes were excised and histopathological investigation of these membranes showed ligneous conjunctivitis. Further, laboratory examination revealed plasminogen deficiency. A good response was observed to topical fresh frozen plasma (FFP) treatment without systemic therapy, and the membranes did not recur during the treatment. Topical FFP treatment may facilitate rapid rehabilitation and prevent recurrence in patients with ligneous conjunctivitis.
RESUMOUma criança feminina com seis meses de idade se apresentou à nossa clínica com edema palpebral bilateral, membranas brancas amareladas sob as pálpebras de ambos os olhos e descarga mucosa. Sua tia já havia apresentado problemas oculares semelhantes que não foram diagnosticados. As membranas conjuntivais foram excisadas e a investigação histopatológica das membranas demonstraram conjuntivite lenhosa. O diagnóstico de deficiência de plasminogênio foi obtido a partir de um exame laboratorial. Tratamento tópico com plasma fresco congelado (FFP) sem qualquer terapia sistêmica mostrou boa resposta. Não foram observadas recorrências das membranas. O tratamento tópico com FFP pode ajudar a reabilitação rápida e prevenir a recorrência em pacientes com conjuntivite lenhosa.
Asunto(s)
Femenino , Humanos , Lactante , Administración Oftálmica , Conjuntivitis/terapia , Soluciones Oftálmicas/administración & dosificación , Plasma , Plasminógeno/deficiencia , Enfermedades Cutáneas Genéticas/terapia , Conjuntivitis/patología , Enfermedades Cutáneas Genéticas/patología , Resultado del TratamientoRESUMEN
The pathogenesis of polymorphic light eruption (PLE) has been linked to a lack of UV-induced immune suppression. To determine the role of Langerhans cells (LC), mast cells and regulatory T cells, biopsies from PLE patients were taken from exposed sites in spring before and after photohardening with 311 nm or PUVA as well as again in summer. Skin sections were assessed for the presence of Langerin/CD1a+ LC and CD3+, CD4+, CD25+ or FoxP3+ T cells and mast cells. Photohardening transiently decreased the density of epidermal LC and significantly increased a low baseline mast cell density in the papillary dermis of PLE patients. Baseline T cell numbers in the skin were low, and there was no difference in PLE patients among any time point. This suggests that LC suppression together with recruitment of mast cells into photohardened skin may be a key cellular event underlying the mechanism by which phototherapy protects from PLE.
Asunto(s)
Dermis/patología , Células de Langerhans/patología , Mastocitos/patología , Trastornos por Fotosensibilidad/patología , Trastornos por Fotosensibilidad/terapia , Fototerapia , Enfermedades Cutáneas Genéticas/patología , Enfermedades Cutáneas Genéticas/terapia , Rayos Ultravioleta , Adulto , Biopsia , Estudios de Casos y Controles , Recuento de Células , Dermis/efectos de la radiación , Femenino , Humanos , Células de Langerhans/efectos de la radiación , Mastocitos/efectos de la radiación , Persona de Mediana Edad , Terapia PUVA , Linfocitos T Reguladores/patología , Linfocitos T Reguladores/efectos de la radiación , Resultado del TratamientoAsunto(s)
Enfermedades Óseas Metabólicas/diagnóstico , Displasia Fibrosa Poliostótica/complicaciones , Osificación Heterotópica/diagnóstico , Enfermedades Cutáneas Genéticas/diagnóstico , Enfermedades Óseas Metabólicas/patología , Calcio/metabolismo , Femenino , Displasia Fibrosa Poliostótica/fisiopatología , Humanos , Persona de Mediana Edad , Osificación Heterotópica/patología , Fósforo/metabolismo , Seudohipoparatiroidismo , Enfermedades Cutáneas Genéticas/patologíaRESUMEN
The term retinoid includes both natural and synthetic derivatives of vitamin A. Retinoid-containing treatments have been used since ~1550BC by the early Egyptians. Treatment of ichthyosiform disorders with retinoids dates back at least to the 1930s. Early use of high-dose vitamin A demonstrated efficacy, but because vitamin A is stored in the liver, toxicity limited usefulness. Interest turned to synthetic retinoids in an effort to enhance efficacy and limit toxicity. Acetretin, isotretinoin and, in the past etretinate, have provided the most effective therapy for ichthyosiform conditions. They have been used for a variety of ages, including in newborns with severe ichthyosis and for decades in some patients. Careful surveillance and management of mucous membrane, laboratory, skeletal, and teratogenic side effects has made systemic retinoids the mainstay of therapy for ichthyosis and related skin types.
Asunto(s)
Fármacos Dermatológicos/administración & dosificación , Ictiosis/tratamiento farmacológico , Retinoides/administración & dosificación , Acitretina/administración & dosificación , Acitretina/efectos adversos , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Niño , Preescolar , Fármacos Dermatológicos/efectos adversos , Etretinato/administración & dosificación , Etretinato/efectos adversos , Humanos , Ictiosis/patología , Lactante , Recién Nacido , Isotretinoína/administración & dosificación , Isotretinoína/efectos adversos , Hígado/efectos de los fármacos , Persona de Mediana Edad , Cooperación del Paciente/psicología , Educación del Paciente como Asunto , Retinoides/efectos adversos , Factores de Riesgo , Enfermedades Cutáneas Genéticas/tratamiento farmacológico , Enfermedades Cutáneas Genéticas/patología , Adulto JovenRESUMEN
A peculiar observation published in 1971 by Chernosky et al. is revisited in this paper. An African American mother and three of her four children (two girls and one boy) had hyperpigmented skin areas arranged along Blaschko's lines. According to the current knowledge of formal genetics, a mendelian mode of transmission can be excluded, and paradominant inheritance is likewise highly unlikely. The unusual family constellation of pigmentary mosaicism can be best explained as an example of monoallelic autosomal expression, a concept that is now well established in the genetics of plants and animals but so far unexplored in human skin disorders. Either the paternal or the maternal allele is randomly inactivated, therefore this mechanism can be taken as an autosomal counterpart of X-chromosome inactivation. Recent studies suggest that 5-10% of autosomal human genes are monoallelically expressed. This theory opens a new field of research in dermatology. Clinicians should consider this new aetiological concept when observing cases of hereditary cutaneous mosaicism that cannot be explained by X-linkage.