Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations.

Multiple sclerosis (MS) is a neuro-inflammatory and neurodegenerative disease that is most prevalent in Northern Europe. Although it is known that inherited risk for MS is located within or in close proximity to immune-related genes, it is unknown when, where and how this genetic risk originated1. Here, by using a large ancient genome dataset from the Mesolithic period to the Bronze Age2, along with new Medieval and post-Medieval genomes, we show that the genetic risk for MS rose among pastoralists from the Pontic steppe and was brought into Europe by the Yamnaya-related migration approximately 5,000 years ago. We further show that these MS-associated immunogenetic variants underwent positive selection both within the steppe population and later in Europe, probably driven by pathogenic challenges coinciding with changes in diet, lifestyle and population density. This study highlights the critical importance of the Neolithic period and Bronze Age as determinants of modern immune responses and their subsequent effect on the risk of developing MS in a changing environment.

Pastoralism and Emergent Complex Settlement in the Middle Bronze Age, Azerbaijan: isotopic analyses of mobility strategies in transformation.

OBJECTIVES: This article explores the scale and seasonal patterns of mobility at the complex settlement site of Qizqala during the Middle Bronze Age (2400-1,500 BCE). By integrating human bone, teeth, and environmental samples this research tests the hypothesis of the persistent importance of community-wide seasonal pastoral transhumance during the early formation of complex settlement systems of the South Caucasus. METHODS: This research applies stable oxygen and radiogenic strontium isotope analyses on incremental samples of human tooth enamel, bulk tooth enamel, and bone to resolve mobility patterns. Sequential and bulk sampling techniques elucidate seasonal and residential mobility behaviors. Extensive environmental isotope samples of plant and water were collected through regional survey and establish local and regional isotopic baselines, which are compared to human isotope analysis results. RESULTS: Qizqala individuals exhibit low isotopic variability compared to regional contemporaries. 87 Sr/86 Sr ratios from human remains indicate seasonal and residential isotopic variability within the baseline ranges of local landscapes. δ18 O values display erratic patterns, but correspond to seasonal variability with fluctuations between highland and lowland altitudinal zone baseline values. CONCLUSIONS: Results suggest that isotopic analysis of multiple elements and sequential enamel samples offers finer resolution on the complexities of human mobility strategies and elucidate the daily lives of often overlooked mobile populations. Higher resolution of individual mobility reveals shared routine behaviors that underscore the importance of diverse social collaborations in forming complex polities in the South Caucasus.

Lifestyle of a Roman Imperial community: ethnobotanical evidence from dental calculus of the Ager Curensis inhabitants.

BACKGROUND: The analysis of ancient calcified dental plaque is a powerful archaeobotanical method to elucidate the key role of the plants in human history. METHODS: In this research, by applying both optic microscopy and gas chromatography mass spectrometry on this matrix, a detailed qualitative investigation for reconstructing the lifestyle of a Roman imperial community of the Ager Curensis (Sabina Tiberina, Central Italy) was performed. RESULTS: The detection of animal micro-remains and molecules (e.g., hairs, feather barbules, markers of dairy products), starch granules of several cereals and legumes, pollen (e.g., Juglans regia L., Hedera sp. L.) and other plant micro-debris (e.g., trichome of Olea sp., hemp fibers), and phytochemicals (e.g., Brassicaceae, Lamiaceae herbs, Ferula sp., Trigonella foenum-graecum L., wine, and Humulus lupulus L.) in the dental calculus sample demonstrated that plant-derived foods were regularly consumed together with animal resources. CONCLUSIONS: This nutritional plan, consistent with the information reported in ancient written texts, suggested that the studied population based its own subsistence on both agriculture and husbandry, probably also including beekeeping and hunting activities. All together, these results represent proofs for the comprehension of food habits, phytotherapeutic practices, and cultural traditions of one of the first Roman settlements in the Sabina Tiberina area.

Spondylolysis in the past: A case study of hunter-gatherers from Southern Patagonia.

Spondylolysis is a fracture of the pars interarticularis, the portion of the neural arch that lies between the superior articular facets and the inferior articular facets. Clinical evidence has suggested repetitive trauma to be the most probable cause, even though morphological weakness of the vertebra is probably also involved. Prevalence is between 3% and 8% in modern populations, while in archaeological samples it varies from 0% to 71.4%. Considering that very little data about this condition is available in past populations from the southern extreme of South America, the aim of this paper is to analyze the spondylolysis in a human skeletal sample from Southern Patagonia and, at the same time, to explore the prevalence of spondylolysis in archaeological contexts around the world to gain a better understanding of the results presented here. The Southern Patagonian skeletal series analyzed here showed a prevalence of 20%, with lower prevalence in the pre contact sample (11.1%) than in the contact period (23.1%). Skeletons from the Salesian Mission "Nuestra Señora de La Candelaria" showed a higher prevalence (25%) than the sample of skeletal remains recovered from outside the mission (20%), suggesting that changes in lifestyle of hunter-gatherers during contact could be implicated in the development of spondylolysis in this sample. A worldwide survey displays a wide range of prevalence figures in American and Asian samples and low diversity between African and European populations. Hunter-gatherers from Southern Patagonia showed similar values to those observed in other American samples.

Social reorganization and biological change: An examination of stature variation among Iron Age Samnites from Abruzzo, central Italy.

Stature is a sensitive indicator of overall environmental quality experienced during growth and development, and can provide insights on a population's 'well-being'. This study investigated changes in estimated adult stature in a large (N=568) sample of Samnite Iron Age (800-27 BCE) people from central Italy, during a period of increasing sociopolitical complexity. Stature was analyzed diachronically, between sexes, and across social strata inferred using the 'Status Index' based on funerary treatment. It was expected: 1) a decrease in stature from the Orientalizing-Archaic period (O-A) to the fifth century BC (V SEC) and the following Hellenistic period (ELL), due to population increase and urbanization; 2) social status to positively influence the attainment of the full stature potential; 3) sexual dimorphism to be higher in more stratified groups. Results revealed no significant diachronic changes in stature (females: O-A: 154.2cm,V SEC: 154.2cm, and ELL: 153.6cm; males: O-A: 165.0cm,V SEC: 165.2cm, and ELL: 165.0cm) or sexual dimorphism. High-status males were taller than low-status (p=0.021), possibly due to a better diet, but only in the Orientalizing-Archaic period. Nonsignificant changes in females suggest either differential access to resources in women, or a better buffering from environmental optima or crises. The results of this study highlight the complex interrelation between social factors and human growth, and stress the importance of understanding the specific mechanisms leading to variation in adult stature.

Los primeros pasos en la organización de la lucha contra el cáncer en la Argentina: el papel del Instituto de Medicina Experimental, 1922-1947 / The begginings of teh fight against cancer in Argentina: the role of the Instituto de Medicina Experimental, 1922-1947

El artículo analiza iniciativas para organizar la lucha contra el cáncer en la Argentina entre comienzos de la década de 1920 y mediados de la década de 1940. En particular, hace eje en las acciones del Instituto de Medicina Experimental, un hospital-instituto de investigación dependiente de la Facultad de Ciencias Médicas de la Universidad de Buenos Aires que tuvo un papel central en este proceso. Se presta atención a la organización de la atención médica en el establecimiento, a las campañas de difusión de conocimiento a la población, a los intentos por incorporar esta cuestión a la formación profesional, a la articulación de las actividades con organismos estatales para dar mayor alcance territorial a la lucha contra el cáncer y a las investigaciones científicas que apuntaron a vincular el desarrollo del cáncer con estilos de vida (AU)

This article analyses initiatives to organize the fight against cancer in Argentina between the early 1920s to mid 1940s. Specifically, it focuses on the initiatives of the Instituto de Medicina Experimental, a hospital-research institute dependent on the Facultad de Ciencias Médicas of the Universidad de Buenos Aires that played a key role in this process. This paper considers the organization of the medical attention within the establishment, knowledge awareness campaigns, and the intents to incorporate cancer as a topic in the professional curricula and scientific research linking cancer and life styles (AU)

[Living in abundance in the ancient and modern worlds from a medical and cultural-historical point of view]. / Weiterleben im Uberfluss in der antiken und modernen Welt aus medizin- und kulturhistorischer Sicht.

Comparative investigations centre on attitudes of demand and consumption in ethnic groups living in affluence, beginning with the first pre-Christian century in the Roman Empire on the one hand and in Western countries in the post-industrial age of hight-tech in times of far advanced globalization on the other. In this context medical, psycho-social and socio-economical aspects will be treated considering ideal and cultural breaks. Renowned Roman and Greek historians, physicians and philosophers are vouching as witnesses of the times for developments in the antique world with their literary works, in excerpts and verbatim. Obviously general moral decay is a side effect of any affluence. Even in the antiquitiy the "ideology of renewal" proclaimed by the Emperor Augustus died away mostly in emptiness just as do the appeals for improving one's state of health for surviving directed to all citizens in our time. With the rise of Rome as a world power general relative affluence was widespread to such an extent that diseases caused by affluence have occured as mass phenomena. The old Roman virtues of temperance and frugality turned into greed and addiction to pleasure. In this way the Roman people under the banner of affluence degenerated into a society of leisure time, consumption, fun and throwaway mentality. The decline of the Empire was predetermined. The promise of affluence which modern Europe is addicted to is demanding its price following the principle of causality. "How the pictures resemble each other!"

[From the history of studying the impact of style of life on health].

The style of life as a particular type of life activity is one of main factors of health conditionality. This problem needs further investigation. At the same time, study of impact of factors of style of life on health has its own long-standing history and dates from times of Antiquity. The philosophers and sociologists determined the structure of style of life as an aggregate of predominantly subjective behavioral factors impacting in a particular way on health. The folk medicine made a significant input into development of foundation of healthy style of life and its application in treatment. Hereinafter, studying of these issues made it possible to find further development in numerous works of philosophers, sociologists, biologists, hygienists, physicians. Nowadays, the investigation process is going on and traditionally finds its reflection in the WHO activities.

Gertrude Stein, opium queen: notes on a mistaken embrace.

Gertrude Stein was not only a fairly open lesbian but also Jewish, expatriate, and androgynous-all attributes that often retarded mass-market success. Why then was she so popular? The article offers original research highlighting how Stein was constructed as a kind of "opium queen" in the popular American press, and the ways that this decadent, bohemian celebrity persona allowed her to operate as "broadly queer" rather than "specifically gay" in the American cultural imaginary-a negotiation that accounts for the mass-market success rather than censure of The Autobiography of Alice B. Toklas despite the unparalleled visibility of its lesbian erotics.

[The contribute of the trauma analysis to reconstruct the lifestyle of Castel Malnome community (Rome, I-II cent. A.C.)]. / Il contributo dell'analisi traumatologica nella ricostruzione dello stile di vita della comunita di Castel Malnome (Roma, I-II sec. D.C.).

The relations between fractures and living conditions of a population are important to reconstruct the biological status of a population. This work is focused on the description and interpretation of trauma in the skeletal remains: the sample consist of 218 individuals, coming from Roman imperial necropolis of Castel Malnome (I-II century AD). The trauma incidence has been considered by the calculation offrequencies per individual and per bone. The examination of the pattern offractures in the skeleton for this site indicates that the individuals are characterized by high level of trauma and reveals that ulna and ribs were the mostfrequently affected bones. The evidence of trauma in this population may reflect many factors about the lifestyle of individuals,for example their occupation and environmental conditions, moreover the state of healing of the injuries may also indicate the availability of treatments.

Localizing HIV/AIDS discourse in a rural Kenyan community.

This paper examines the effectiveness of multimodal texts used in HIV/AIDS campaigns in rural western Kenya using multimodal discourse analysis (Kress and Van Leeuwen, 2006; Martin and Rose, 2004). Twenty HIV/AIDS documents (posters, billboards and brochures) are analysed together with interview data (20 unstructured one-on-one interviews and six focus groups) from the target group to explore the effectiveness of the multimodal texts in engaging the target rural audience in meaningful interaction towards behavioural change. It is concluded that in some cases the HIV/AIDS messages are misinterpreted or lost as the multimodal texts used are unfamiliar and contradictory to the everyday life experiences of the rural folk. The paper suggests localization of HIV/AIDS discourse through use of local modes of communication and resources.

The relevance of personal characteristics in health care rationing: what the Australian public thinks and why.

This article examines the preferences of the general public in Australia regarding health care resource allocation. While previous studies have revealed that the public is willing to give priority to particular groups of patients based on their personal characteristics, the present article goes beyond previous efforts in attempting to explain these results. In the present study, there was strong support among respondents for giving "equal priority" to people regardless of their personal characteristics. However, respondents did reveal a preference for married patients over single, for children over adults, for carers of children and the elderly, sole breadwinners, and good community contributors. Further, they would give a lower priority to those perceived as "self-harmers"­smokers, individuals with unhealthy diets, and those who rarely exercise. Variation in the answers according to broad economic and social beliefs across seven different categories ("factors") influenced the pattern of the public's attitudes towards rationing. The Principal Components Analysis (PCA) indicated that most of the items in our survey are associated with seven factors that explain or capture much of the variation. These relate to a patient's avoidance of self-harm behaviors (Safe Living), their Life Style (diet, exercise, etc.), their contribution to the community through caring for others (Caring), their talents (Gifted), their sexual behavior (Sexuality), their age and marital status (Family), and whether they are an Australian citizen or employed (Citizen). The strength of social preferences­e.g., how strongly respondents would "discriminate" against a recreational drug user or preference a person with a healthy diet­is related to the particular class of preferences.

Migrant remittances and household wellbeing in urban Zimbabwe.

Evidence from household surveying in December 2005 in Harare and Bulawayo, Zimbabwe, indicates that a wide network of international migrant remitters are ameliorating the economic crisis in Zimbabwe by sending monetary and in-kind transfers to over 50 per cent of urban households. The research combines quantitative measurement of scale and scope, with demographic and qualitative narrative to build a holistic picture of the typography of receiving and non-receiving households. A complex set of interrelated variables helps to explain why some households do and others do not receive income and goods from people who are away, and the economic and social extent of their subsequent benefit from them. Moreover, the mixed methods approach is designed to capture inter-household and likely macroeconomic effects of how households receive their goods and money; and of how they subsequently exchange (if applicable), store and spend it. Evidence emerges of a largely informal, international social welfare system, but one which is not without adverse inter-household effects for some. These include suffering exclusion from markets suffering from inflationary pressures, not least as a result of other people's remittances. This paper explores the role of remittances, within this internationalised informal welfare system which we can map from our household survey, in reframing vulnerability and marginalization differentially among and between our subject households.

[Health status and life style in Castel Malnome (Rome, I-II cent. A. D.)]. / Attività lavorative e condizioni di vita della comunità di Castel Malnome (Roma, I-II sec. D.C.).

The necropolis of Castel Malnome, chronologically framed between the I and II century AD, is located in the vicinity of Ponte Galeria (Rome), nearby the via Portuense. The excavation of the funerary site has allowed the collection of 292 inhumations, referred to the lower social classes and for the most part adult males. Regarding the funerary ritual, only the 42.8% of the graves had a tiles cover, while about one third provided grave goods. The field analysis shows that almost all the burials are primaries, and is not possible to highlight a main position of the inhumated individuals. The laboratory analysis, till today carried out on 100 individuals, shows a high degree of skeletal robustness and of occupational markers due to heavy work load (inflammation, muscle-skeletal trauma, fractures, osteoarthritis, enthesopathies). The recording of oral pathologies and aspecific stresses, in order to obtain information about the health status of the population, shows a very high frequency of caries mainly related to poor dental hygiene, and of enamel hypoplasia.