Rosuvastatin as a Supplemental Treatment for the Clinical Symptoms of Nephropathia Epidemica: A Pilot Clinical Study.

Nephropathis epidemica (NE), a mild form of hemorrhagic fever with renal syndrome (HFRS), is an acute zoonotic disease endemic in the Republic of Tatarstan. This study aimed to assess the impact of rosuvastatin on the clinical and laboratory results of NE. A total of 61 NE patients and 30 controls were included in this study; 22 NE patients and 7 controls received a daily dose of rosuvastatin (10 mg) for ten consecutive days. Serum samples were collected on days 1, 5, and 10 after admission to the hospital. These samples were analyzed to determine the levels of lipids, cytokines, and kidney toxicity markers. Our findings indicate that rosuvastatin reduced the duration of the second wave of fever and alleviated back pain and headache symptoms. Additionally, low-density lipoprotein cholesterol (LDL-C) serum levels were significantly decreased on days 5 and 10 upon rosuvastatin treatment. Furthermore, rosuvastatin decreased the levels of cytokines in the serum, particularly proinflammatory cytokines IL-1ß and IL-8. NE patients had significantly altered levels of the kidney toxicity markers albumin and osteopontin. The data from our study provide evidence supporting the therapeutic potential of rosuvastatin in NE cases.

[Changes in hypothalamus-pituitary-adrenal (HPA) axis and the deficiency-excess syndrome differentiation on epidemic hemorrhagic fever patients].

UNLABELLED: In order to understand the relationship between the functional changes of hypothalamus-pituitary-adrenal (HPA) axis and the Deficiency-Excess Syndrome Differentiation of traditional Chinese medicine (TCM), the levels of serum cortisol and urinary 17-hydroxy-corticosteroid (U 17-OH) per 24 hours were studied. 171 serum samples and 139 urinary samples were obtained from 87 patients suffering from epidemic hemorrhagic fever (EHF) in various stage. RESULT: The Syndrome displayed as Excess-Heat type accompanied with Blood Stasis in febrile phase of EHF, both the level of serum cortisol and the U 17-OH increased to meet the stress. But the Syndrome converted from the Excess-Heat type to the Cold-Deficiency type in hypotensive and shock phase and the secretion of HPA axis began to reduce. However, in oliguric phase, the Syndrome was Kidney Deficiency complicated with Blood-Heat and Blood Stasis, their U 17-OH lowered significantly (7.53 +/- 3.82 mg/24 h.) in comparing with normal control (P < 0.01), but the level of serum cortisol, on the contrary, raised significantly (1517.96 +/- 421.96 mol/L) in comparing with control (P < 0.01). And in diuretic phase, the Syndrome was the Cold-Deficiency type, the HPA excretion tended to restore gradually but 17-OH maintain at a lower level in serious case. Therefore the change of serum cortisol was closely related with the HPA excretion in all phases of EHF, as well as to the Deficiency-Excess Syndrome Differentiation.(ABSTRACT TRUNCATED AT 250 WORDS)