Suplementación de ácidos grasos omega-3 y adiponectina plasmática en mujeres con síndrome de ovarios poliquísticos / Supplementation with omega-3 fatty acids and plasma adiponectin in women with polycystic ovary syndrome

Objetivo: Estudiar las concentraciones plasmáticas de adiponectina en mujeres con diagnóstico de síndrome de ovario poliquístico (SOPQ) tratadas con suplementación de ácidos grasos omega-3. Material y métodos: Se realizó un estudio en 195 mujeres con diagnóstico de SOPQ que fueron tratadas con ácidos grasos omega-3 durante 12semanas (n=97; grupo A) y controles tratados con placebo (n=98, grupo B). Se compararon las características generales, las concentraciones hormonales, el perfil lipídico y la adiponectina. Resultados: No se encontraron diferencias significativas entre ambos grupos con relación a las características generales. Tampoco se encontraron diferencias significativas en las concentraciones hormonales, glucemia y HOMA entre los grupos. Las mujeres de los grupos A y B no mostraron diferencias estadísticamente significativas en la ingesta total, ingesta de hidratos de carbono, proteínas y grasas totales entre los valores al inicio y al final del estudio. Las mujeres del grupo A presentaron disminución en las concentraciones de colesterol total, de lipoproteínas de baja densidad y de triglicéridos (p<0,0001). Los valores promedio de adiponectina también mostraron aumento estadísticamente significativo luego del tratamiento (p<0,0001). No se encontraron diferencias estadísticamente significativas en los valores promedio de las diferentes variables en las mujeres del grupo B. Conclusión: La suplementación de ácidos grasos omega-3 durante 12semanas produce aumento significativo en las concentraciones plasmáticas de adiponectina en mujeres con SOPQ (AU)

Objective: To study plasma adiponectin levels in women diagnosed with polycystic ovary syndrome given omega-3 fatty acid supplements. Patients and methods: A study was conducted in 195 women diagnosed with polycystic ovary syndrome treated with omega-3 fatty acids for 12weeks (n=97; group A) and control women given placebo (n=98, group B). General characteristics, metabolism, lipid profile, and hormone and adiponectin levels were compared. Results: There were no significant differences between the two groups in general characteristics. No significant differences were also found in hormone, blood glucose, and HOMA levels between the groups. Women in study groups A and B showed no statistically significant differences in total calorie, carbohydrate, protein, and total fat intake between the baseline and final values. Decreased total cholesterol, low-density lipoprotein, and triglyceride levels were found in group A women (P<.0001). Mean of adiponectin levels also showed a statistically significant increase after treatment (P<.0001). There were no statistically significant differences in the mean values of the different variables in group B women. Conclusion: Omega-3 fatty acid supplementation for 12 weeks caused a significant increase in plasma adiponectin levels in women with polycystic ovary syndrome (AU)

A Case of Subclinical Hypothyroidism with Lingual and Right Pretracheal Ectopic Thyroid.

Ectopic thyroid tissue is most commonly located in a single location, this being the lingual area. Presentation with two ectopic thyroid foci is quite unusual. A girl patient aged 7 years who presented with complaints of two masses in the right anterior neck and submandibular area is reported. Her growth pattern and development were normal. The masses were detected to be dual ectopic thyroid glands by ultrasonography, computed tomography and 99m-technetium pertechnetate thyroid scan. The patient also had subclinical hypothyroidism. She was treated with oral levothyroxine and the masses slightly decreased in size. The repeated thyroid function tests were within the normal limits. Thyroid function tests and imaging studies need to be conducted in all patients with anterior neck masses.

Congenital hyperinsulinism: exclusive human milk and breastfeeding.

Congenital hyperinsulinism is a genetic condition causing dysregulation of insulin and results in persistent hypoglycemia. The most common types are sulfonylurea receptor (SUR1), potassium inward rectifying channel (Kir6.2), glutamate dehydrogenase (GDH), and glucokinase (GK), with SUR1 and Kir6.2 being the most prevalent. It is imperative that these infants undergo diagnostic testing, which includes genetic, neonatal fasting study to induce hypoglycemia, glucagon stimulation, and imaging. Once a diagnosis has been made, surgical intervention may be needed to help regulate blood glucose levels. During this diagnostic process and as the infant is undergoing treatment, there may be little concern for the mother's feeding plan. Because human milk is the preferred form of nutrition for all infants, these mothers should receive prenatal counseling regarding the initiation and maintenance of milk supply. Parenteral nutrition may be necessary to maintain blood glucose to support human milk administration and breastfeeding.