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1.
BMC Urol ; 24(1): 16, 2024 Jan 16.
Artículo en Inglés | MEDLINE | ID: mdl-38229041

RESUMEN

In this critical review, we explore the study design, strengths and limitations of the paper: "Two-Year Outcomes of Sacral Neuromodulation Versus OnabotulinumtoxinA for Refractory Urgency Urinary Incontinence: A Randomized Trial." The paper reports 24 month follow-up data of the landmark ROSETTA trial. This multi-centre, open-labelled parallel randomised trial allocated females 1:1 to receive Sacral Neuromodulation (SNM) or OnabotulinumtoxinA(BTX) 200 units (U). The primary outcome was change in mean daily urinary urgency incontinence episodes (UUIE) over 24 months. The study did not demonstrate a difference between treatments (-3.88 vs. -3.50 episodes per day), however women treated with BTX were more satisfied; but reported higher rates of UTI. The two treatments provide comparable third-line treatment options for patients with refractory urgency urinary incontinence.


Asunto(s)
Toxinas Botulínicas Tipo A , Estimulación Eléctrica Transcutánea del Nervio , Vejiga Urinaria Hiperactiva , Incontinencia Urinaria , Urología , Humanos , Femenino , Toxinas Botulínicas Tipo A/uso terapéutico , Incontinencia Urinaria de Urgencia/tratamiento farmacológico , Incontinencia Urinaria de Urgencia/inducido químicamente , Incontinencia Urinaria/etiología , Resultado del Tratamiento , Vejiga Urinaria Hiperactiva/etiología , Ensayos Clínicos Controlados Aleatorios como Asunto , Estudios Multicéntricos como Asunto
2.
Zhongguo Zhong Yao Za Zhi ; 35(23): 3207-10, 2010 Dec.
Artículo en Chino | MEDLINE | ID: mdl-21355251

RESUMEN

OBJECTIVE: To discuss the influence of Suoquan capsule (SQJN) on the detrusor of D-galactose mimetic rats, and to explore the mechanism of reducing urine. METHOD: Investigate the enzymes (ATPase, SDH, SOD, MDA, Na+ -K+ -ATPase, Ca2+ - Mg2+ -ATPase) which influence the production and excretion of urine and the reactivity of urinary detrusor strips to different concentrations of ISO and ATP. RESULT: Compared with the model group, the activity of SOD, Na+ -K+ -ATPase, Ca2+ -Mg2+ -ATPase and SDH increased significantly in aging rats after administrating SQJN (P < 0.01); the complaisance and elasticity of bladder also increased (P < 0.05). The frequency of spontaneous contraction and the MDA decreased significantly (P < 0.05-0.01). The decreased relaxation response to ISO and increased contractile response to ATP were also changed after administrating SQJN. CONCLUSION: SQJN can regulate the metabolism of fluid through recovering the normal physiologic function of the detrusor of bladder.


Asunto(s)
Medicamentos Herbarios Chinos/administración & dosificación , Galactosa/efectos adversos , Incontinencia Urinaria de Urgencia/tratamiento farmacológico , Animales , Modelos Animales de Enfermedad , Femenino , Humanos , Masculino , Contracción Muscular , Músculo Liso/fisiología , Ratas , Vejiga Urinaria/efectos de los fármacos , Vejiga Urinaria/metabolismo , Vejiga Urinaria/fisiopatología , Incontinencia Urinaria de Urgencia/inducido químicamente , Incontinencia Urinaria de Urgencia/metabolismo , Incontinencia Urinaria de Urgencia/fisiopatología , Micción/efectos de los fármacos
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