RESUMEN
Teguest Guerma talks to Gary Humphreys about her career in public health, and her commitment to training midwives in Ethiopia.
Asunto(s)
Infecciones por VIH , Partería , África , Antirretrovirales , Burundi , Enfermedades Transmisibles , Etiopía , Infecciones por VIH/tratamiento farmacológico , Infecciones por VIH/historia , Historia del Siglo XXI , Humanos , Partería/educación , Salud PúblicaRESUMEN
It is generally accepted that human immunodeficiency virus (HIV) is the etiological agent of acquired immune deficiency syndrome. According to this claim, HIV was transferred to humans from contact with monkeys around 35-50 years ago. However, this claim has not been sufficiently confirmed epidemiologically. The spread and incubation period of the plague epidemic has led to the theory that the Black Death was caused by hemorrhagic viruses. Having examined detailed historical data, we have concluded that the bacterium Yersenia pestis was an infectious agent in the epidemic, together with another agent which we suggest was HIV. Our considerations were mainly based on the existence of the CCR5 delta 32 mutation, which protects against HIV infection and has been present in the Caucasian population for over 2000 years. The combination of two infectious agents led to the devastation of the Black Death, the removal of HIV carriers, and an increase in the number of CCR5Δ32 mutations in the Caucasian population. In sub-Saharan Africa, this epidemic and subsequent sanitation process did not occur, which explains the much higher level of HIV genetic information in this part of the world.
Asunto(s)
Epidemias/estadística & datos numéricos , Infecciones por VIH , Receptores CCR5/genética , Síndrome de Inmunodeficiencia Adquirida/epidemiología , Síndrome de Inmunodeficiencia Adquirida/genética , Síndrome de Inmunodeficiencia Adquirida/historia , África del Sur del Sahara/epidemiología , Asia/epidemiología , Evolución Biológica , Población Negra/genética , Epidemias/historia , Europa (Continente)/epidemiología , Evolución Molecular , Infecciones por VIH/epidemiología , Infecciones por VIH/genética , Infecciones por VIH/historia , Fiebres Hemorrágicas Virales/epidemiología , Fiebres Hemorrágicas Virales/genética , Fiebres Hemorrágicas Virales/historia , Heterocigoto , Historia del Siglo XV , Historia del Siglo XVI , Historia del Siglo XVII , Historia del Siglo XX , Historia del Siglo XXI , Historia Antigua , Historia Medieval , Humanos , Peste/epidemiología , Peste/genética , Peste/historia , Viruela/epidemiología , Viruela/genética , Viruela/historia , Población Blanca/genéticaAsunto(s)
Infecciones por VIH/historia , Sobrevivientes de VIH a Largo Plazo/psicología , Salud Holística/historia , Salud Mental , Leucemia-Linfoma Linfoblástico de Células Precursoras/historia , Adaptación Psicológica , Niño , Terapia Combinada , Infecciones por VIH/mortalidad , Infecciones por VIH/psicología , Infecciones por VIH/terapia , Historia del Siglo XX , Humanos , Leucemia-Linfoma Linfoblástico de Células Precursoras/mortalidad , Leucemia-Linfoma Linfoblástico de Células Precursoras/psicología , Leucemia-Linfoma Linfoblástico de Células Precursoras/terapia , Medio Social , Estados UnidosRESUMEN
We present a systematic review of historical, political, and epidemiologic aspects of AIDS in Brazilian children. Over 25 years, Brazil has developed different strategies to control AIDS in children. Three revisions of criteria for defining AIDS cases in children and nine national guidelines on antiretroviral therapy administration for management of HIV infection were published. These guidelines represent important progress, including aspects of HIV/AIDS surveillance, antiretroviral treatment, opportunistic conditions, prophylaxis, and laboratory testing. Brazil has significantly expanded access to free therapy with different classes of antiretroviral drugs. Initially focusing on treatment for HIV and opportunistic conditions, the scope of treatment guidelines gradually expanded to comprehensive health care for children and adolescents. From 1996 to 2008, the number of AIDS cases and deaths in children has been reduced by 67% and 65%, respectively, as a result of different strategies to prevent mother-to-child transmission of HIV and highly active antiretroviral therapy administration to infected children. Improved morbidity, mortality, and survival of Brazilian children with AIDS demonstrate clear benefits of adopting a policy of free and universal access to antiretroviral drugs associated with comprehensive care. However, important issues remain to be resolved, mainly concerning social, operational, and regional inequalities in coverage and quality of care, and epidemiological surveillance in different regions of the country. This broad review shows that the overall situation of pediatric AIDS in Brazil represents an incomplete process of epidemiologic and demographic transition, with the coexistence of old and new clinical and epidemiologic challenges.
Asunto(s)
Síndrome de Inmunodeficiencia Adquirida , Fármacos Anti-VIH/uso terapéutico , Infecciones por VIH , Transmisión Vertical de Enfermedad Infecciosa/estadística & datos numéricos , Vigilancia de la Población , Síndrome de Inmunodeficiencia Adquirida/diagnóstico , Síndrome de Inmunodeficiencia Adquirida/tratamiento farmacológico , Síndrome de Inmunodeficiencia Adquirida/historia , Síndrome de Inmunodeficiencia Adquirida/mortalidad , Síndrome de Inmunodeficiencia Adquirida/transmisión , Terapia Antirretroviral Altamente Activa , Brasil/epidemiología , Niño , Preescolar , Femenino , Infecciones por VIH/diagnóstico , Infecciones por VIH/tratamiento farmacológico , Infecciones por VIH/historia , Infecciones por VIH/mortalidad , Infecciones por VIH/transmisión , Historia del Siglo XX , Humanos , Incidencia , Lactante , Recién Nacido , Transmisión Vertical de Enfermedad Infecciosa/prevención & control , Masculino , Morbilidad , Tasa de SupervivenciaAsunto(s)
Internado y Residencia , Aprendizaje , Relaciones Médico-Paciente , Enseñanza , Adulto , Argentina , Catolicismo/historia , Comunicación , Empatía , Curación por la Fe , Femenino , Infecciones por VIH/historia , Historia del Siglo XXI , Humanos , Internado y Residencia/historia , Medicina en la Literatura , EspiritualidadRESUMEN
A historical and comparative study of the origins and emergence of syphilis and AIDS show that both result from human intrusions. Treponema probably existed in primates before human infection, and nonvenereal treponemal infection existed in prehistoric tropical Africa. When humans began wearing clothes, the disappearance of endemic infection ended immunity and led to receptivity to venereal infection. It was long thought that syphilis was first introduced in Europe by the conquistadors, but lesions typical of treponematosis dating from before the Common Era have been found in Europe. It is possible that the first navigators transferred treponemal infections to Latin America. AIDS seems to have appeared throughout the Congo River basin around 1950, and genetic studies attest to its long history in primates. It may have resulted from the Bantu migration and its strong human intrusion into the forest. After the initial human infection, new epidemiological factors in a transformed environment and behavioral changes led at 500-year intervals (1480-1490 for syphilis and 1940-1950 for AIDS) to the widespread emergence and subsequent pandemic of each disease.
Asunto(s)
Síndrome de Inmunodeficiencia Adquirida/historia , Brotes de Enfermedades/historia , Sífilis/historia , Síndrome de Inmunodeficiencia Adquirida/epidemiología , África Central , Reservorios de Enfermedades , Europa (Continente) , Infecciones por VIH/historia , Historia del Siglo XV , Historia del Siglo XX , Historia Antigua , Historia Medieval , Humanos , América Latina , Sífilis/epidemiologíaRESUMEN
Objective. To describe the demographic profile, social and family characteristics, and life-style traits of HIV-infected childbearing women in the Caribbean nation of Barbados in comparison to a control group of HIV-negative women. Methods. Data for this report were drawn from the Pediatrics HIV Surveillance Program of the Queen Elizabeth Hospital in Barbados. The data covered all HIV-infected women in the country who delivered between 1986-2000, with similiar data coming from a control group of HIV-negative childbearing women ... Additional data were collected from interviews with the women. Results. There were 182 HIV-infected women who delivered during the study period, and a group of 202 childbearing women served as controls. In comparison to the control group, the HIV-infected women were younger, more often multiparous, and more likely to have been unemployed at the time of their pregnancy. The HIV-infected women also had had an earlier onset of sexual activity, had had more sexual partners during their lifetime, and were more likely to be involved with an older sexual partner. At the time of giving birth most of the HIV-infected women were asymptomatic for AIDS and were living with either their parents (mother or father or both) or the baby's father. In addition, at the time of their six-weeks-postnatal visit, the large majority of the HIV-infected women who were diagnosed prior to childbirth, increased significantly over the study period, rising from 25 percent during 1986-1990 to 82 percent during 1996-2000. Slightly over one-fifth of the HIV-infected women had had one or more subsequent pregnancies after they had learned that they were infected. Conclusions. The early age of sexual activity as well as repeated pregnancies, especially from different and older partners, may have contributed significantly to both vertical and horizontal HIV transmission in Barbados. Future studies of HIV incidence and its trend among childbearing women could be important for monitoring the HIV epidemic in this country. Many of the HIV-infected childbearing women in our study were unemployed, sick, and had multiple children. Therefore, to help them to plan for and cope with the disease and also the care of their children beyond the perinatal period, there is a need to provide the women with repeated counseling with continued follow-up and, where necessary, additional economic, social, and medical support (AU)