RESUMEN
A report is presented of Amanita phalloides poisoning in a family of 3 members admitted with acute gastrointestinal symptoms after eating a meal of various self-picked mushrooms. A latent period of 11 hours preceded the onset of symptoms, a typical feature of this form of poisoning. There was an enormous increase in liver-specific enzymes in two of the cases. The clinical picture was markedly mitigated by the early initiation of silybin therapy, in combination with penicillin and cortisone. The patients made a rapid symptomatic recovery and the liver parameters were sufficiently improved by the 12th day so that the patients could be discharged.
Asunto(s)
Flavonoides/uso terapéutico , Intoxicación por Setas/tratamiento farmacológico , Penicilina G/uso terapéutico , Prednisolona/uso terapéutico , Silimarina/uso terapéutico , Adulto , Alanina Transaminasa/sangre , Amanita , Aspartato Aminotransferasas/sangre , Quimioterapia Combinada , Femenino , Humanos , Hígado/enzimología , Masculino , Persona de Mediana Edad , Intoxicación por Setas/enzimologíaAsunto(s)
Intoxicación por Tetracloruro de Carbono/complicaciones , Enfermedad Hepática Inducida por Sustancias y Drogas/etiología , Intoxicación por Setas/complicaciones , Adulto , Amanita , Enfermedad Hepática Inducida por Sustancias y Drogas/enzimología , Niño , Humanos , Persona de Mediana Edad , Intoxicación por Setas/enzimología , Fósforo/envenenamiento , Dicromato de Potasio/envenenamientoRESUMEN
Recent experimental evidences have been produced on the protection afforded by penicillin G in rats poisoned by Amanita phalloides extracts. A therapeutic trend which combines penicillin G infusions to the classical supportive measures was applied to 33 cases of severe A. phalloides poisoning, with 100% survival rates. The possible mechanism of the protective effect of penicillin G in A. phalloides poisoning is discussed.