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AIM: To explore nurse managers' perceptions of patient-centered care (PCC), its influence on quality nursing care, nurse job satisfaction, and to provide baseline data for a context-driven PCC model. DESIGN: The study utilized a qualitative, phenomenological design, employing individual in-depth interviews to collect data on nurse managers' PCC perceptions until data saturation. METHODS: Sampling involved purposive selection of Northern Ghana, random selection of the tertiary hospital cluster with the three participating hospitals, and purposive sampling of the nine nurse managers. Data analysis employed thematic analysis based on a six-phase framework. Methodological trustworthiness was ensured through various strategies including prolonged engagement, supervisor discussions and crosschecking with interviewees. RESULTS: Three main themes emerged from the study including nurse managers' conceptualization of PCC, perceived patient-centred practices and its influence on nursing quality and job satisfaction. The findings emphasized the patient's individuality, cultural values, holistic care, the importance of strong nurse-patient relationships and a patient-centric environment. The nurse managers perceived PCC as positively influencing quality nursing care and nurse job satisfaction. The findings offer nuanced insights into nurse managers' perspectives on patient-centeredness and highlight areas for improvement.
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Enfermeras Administradoras , Humanos , Investigación Empírica , Formación de Concepto , Atención Dirigida al Paciente , Centros de Atención TerciariaRESUMEN
Background and Objective - In the field of medical image analysis, achieving high accuracy is not enough; ensuring well-calibrated predictions is also crucial. Confidence scores of a deep neural network play a pivotal role in explainability by providing insights into the model's certainty, identifying cases that require attention, and establishing trust in its predictions. Consequently, the significance of a well-calibrated model becomes paramount in the medical imaging domain, where accurate and reliable predictions are of utmost importance. While there has been a significant effort towards training modern deep neural networks to achieve high accuracy on medical imaging tasks, model calibration and factors that affect it remain under-explored. Methods - To address this, we conducted a comprehensive empirical study that explores model performance and calibration under different training regimes. We considered fully supervised training, which is the prevailing approach in the community, as well as rotation-based self-supervised method with and without transfer learning, across various datasets and architecture sizes. Multiple calibration metrics were employed to gain a holistic understanding of model calibration. Results - Our study reveals that factors such as weight distributions and the similarity of learned representations correlate with the calibration trends observed in the models. Notably, models trained using rotation-based self-supervised pretrained regime exhibit significantly better calibration while achieving comparable or even superior performance compared to fully supervised models across different medical imaging datasets. Conclusion - These findings shed light on the importance of model calibration in medical image analysis and highlight the benefits of incorporating self-supervised learning approach to improve both performance and calibration.
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Benchmarking , Redes Neurales de la Computación , Calibración , Investigación Empírica , RotaciónRESUMEN
BACKGROUND: Focusing on patients' perceived values is essential for patient-centered health care. Only by identifying the patient's preferred values can we better meet their needs and provide them with valuable medical services. This study aimed to construct and validate a research model to obtain an overall quantification of patient value during outpatient encounters. METHODS: The development of the research model was based on the reviewed literature, and an initial theoretical framework was formed by an expert panel discussion. A scale questionnaire for all the items was adapted from previous research related to patient value, verified using a presurvey, and thus used for data collection for this study. The structural equation model was used to determine and evaluate the research model of the values patients perceived during outpatient encounters. RESULTS: 572 eligible respondents who completed outpatient visits from a typical public hospital in China participated in this study from November 2020 to February 2021. We constructed the patient perceived value (PPV) model to identify core values, which includes eight dimensions and 29 items in terms of functional value (installation, efficiency, price, service quality), emotional value (interactive, control), and social value (accessibility, image) from two subgroups of patient value outside and in the outpatient visit process. Cronbach's alpha for the whole model was 0.950. The confirmatory factor analysis showed that the PPV model fits well, with a correlation of 0.83 between the two subgroups. CONCLUSION: It is essential to recognize the values based on patients' perceptions and experiences throughout the entire visit process. Our findings offer targeted insights for healthcare administrators, enabling them to holistically optimize outpatient service processes and continually enhance the quality of outpatient medical services from the patient's perspective.
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Hospitales Públicos , Pacientes Ambulatorios , Humanos , Pacientes Ambulatorios/psicología , Atención Ambulatoria , Investigación Empírica , China , Satisfacción del Paciente , Encuestas y CuestionariosRESUMEN
Active citizenship is closely related to basic human values and patriotism, but empirical studies have lacked investigating these variables holistically. Likewise, the mediating role of patriotism between basic human values and active citizenship seems neglected. In this context, the current study examined the relationships between basic human values, patriotism, and active citizenship by grounding upon basic human values, individualism, and collectivism theories. Results revealed that constructive patriotism positively predicted all dimensions of active citizenship (political literacy, participation and protest, and social responsibility) and mediated the relationships between basic human values and active citizenship. Additionally, while stimulation and self-direction individual values, including motivational goals such as challenges in life, independent thought, and autonomy, were associated with the individual aspect of active citizenship (protest and individual responsibility), the values based on equality (benevolence) were related with the collectivist aspect of active citizenship (participation and social responsibility). One of the most influential findings was that the universalism value could only associate positively with active citizenship through constructive patriotism. Another impressive culture-specific result was that the political literacy dimension of active citizenship was positively related to power, which includes the goal of achieving individual success and dominating others. It can be evaluated as Turkish culture is more of a vertical collectivist because, historically and sociologically, a way of gaining power and status has been possible with politics and its cognitive equivalent, political literacy. The study also revealed that active citizenship is promoted through individual values based upon an individual's independent choices and collectivist values that support societal interests based on equality. In summary, the research mainly revealed that active citizenship is sustained by both individualist values (stimulation, self-direction) and collectivist values (universalism, benevolence), and constructive patriotism has a critical mediating role. Implications of the results were discussed with the relevant literature.
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Ciudadanía , Motivación , Humanos , Adulto , Investigación Empírica , Responsabilidad SocialRESUMEN
AIM: This integrative review aimed to examine empirical research on resilience among nursing students in the context of nursing education. Resilience helps nursing students handle challenges, such as changing learning styles and experiencing their first clinical practice. DESIGN: An integrative review. METHODS: The search terms focused on resilience and health in nursing students and nursing education. The database used in this review were CINAHL Plus, PubMed and MEDLINE. The Mixed Methods Appraisal Tool appraised the studies' quality. RESULTS: This study explored 52 records and revealed three current research focuses related to nursing students' resilience: (1) the concept and description of resilience, (2) the characteristics affecting resilience and (3) the mediating role of resilience in maintaining holistic health. Recommendations include adding a resilience topic to the nursing curriculum, providing resilience enhancement programs, examining the relationship between resilience and holistic health and exploring the influence of resilience about global health crises. PUBLIC CONTRIBUTION: Resilience among nursing students plays a vital role in helping them to overcome adversities during their nursing education. Additionally, after graduation, nursing students can continue contributing to society as resilient Registered Nurses in the future.
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Educación en Enfermería , Estudiantes de Enfermería , Humanos , Investigación Empírica , CurriculumRESUMEN
The concept of traditional Chinese medicine has different connotations and extensions in different historical periods. This paper examines the formation and development of the concept of traditional Chinese medicine in the perspective of history, theory and empirical research, and explores the internal connection among different medical systems and between medicine and other disciplines. It attempts to re-define the connotation and extension of the concept of traditional Chinese medicine in the context of the new era, provide references for building the medical community of the Chinese nation and promote the standardization of Chinese medicine terminology, advance the cross-disciplinary construction and establishing a new medical system with the characteristics of openness and tolerance, in order to provide the solution, wisdom and power of traditional Chinese medicine for global health in the process of building a community of human health.
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Medicina Tradicional China , Investigación Empírica , HumanosRESUMEN
BACKGROUND: Progesterone has been the standard of practice for the prevention of preterm birth for decades. The drug received expedited Food and Drug Administration approval, prior to the robust demonstration of scientific efficacy. METHODS: Prospective research from the American Association of Birth Centers Perinatal Data Registry, 2007-2020. Two-tailed t tests, logistic regression, and propensity score matching were used. RESULTS: Midwifery-led care was underutilized by groups most at risk for preterm birth and was shown to be effective at maintaining low preterm birth rates. The model did not demonstrate reliable access to progesterone. People of color are most at risk of preterm birth, yet were least likely to receiving progesterone treatment. Progesterone was not demonstrated to be effective at decreasing preterm birth when comparing the childbearing people with a history of preterm birth who used the medication and those who did not within this sample. CONCLUSIONS: This study adds to the body of research that demonstrates midwifery-led care and low preterm birth rates. The ineffectiveness of progesterone in the prevention of preterm birth among people at risk was demonstrated.
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Partería , Nacimiento Prematuro , Administración Intravaginal , Investigación Empírica , Femenino , Humanos , Recién Nacido , Embarazo , Nacimiento Prematuro/prevención & control , Progesterona/uso terapéutico , Estudios Prospectivos , Racismo SistemáticoRESUMEN
PURPOSE: This paper applies systems thinking modelling to enhance the dynamic understanding of how to nurture an innovative culture in healthcare organisations to develop the innovation system in practice and speed up the innovative work. The model aims to provide a holistic view of a studied healthcare organisation's innovation processes, ranging from managerial values to its manifestation in improved results. DESIGN/METHODOLOGY/APPROACH: The study is based on empirical material from a healthcare unit that, within a few years, changed from having no innovations to repeatedly generating innovations. The study uses the modelling language of causal loop diagrams (CLDs) in the system dynamics methodology to identify the key important aspects found in the empirical material. FINDINGS: The proposed model, based on the stories of the interviewees, explores the dynamics of inertia when nurturing an innovative culture, identifying delays attributed to the internal change processes and system relationships. These findings underscored the need for perseverance when developing an innovative culture in the entrepreneurial phases. PRACTICAL IMPLICATIONS: The approach of using systems thinking to make empirical healthcare research results more tangible through the visual notations of CLDs and mental simulations is believed to support exploring complex phenomena to induce and nurture both individual and organisational learning. ORIGINALITY/VALUE: The results from this approach provide deepened analysis and provoke the systems view to explain how the nurturing of the culture can accelerate the innovation processes, which helps practitioners and researchers to further expand their understanding of their healthcare contexts.
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Instituciones de Salud , Investigación sobre Servicios de Salud , Atención a la Salud , Investigación Empírica , Análisis de SistemasRESUMEN
Smedslund (Psychol Inq 2(4):325-338, 1991) has demonstrated that much of the experimental research in psychology is pseudo-empirical-empirically testing what can be determined a priori based on the meanings of everyday psychological terminology. The present article shows how Smedslund's general perspective is consistent with certain aspects of a theoretical model of the narrative form, and how the latter provides a useful lens for making sense of pseudo-empiricism. This raises a paradox: While something along the lines of the narrative element of 'trouble' is required as a premise for research, trouble is not possible in the context of questions of the general relation between everyday psychological concepts. This paradox is resolved by showing how certain methodological and discursive characteristics of research-specifically, the reification and abstraction of psychological terminology, quantification, and the statistical analysis of group-level results function to obscure the absence (and impossibility) of trouble and/or to create the illusion of its presence.
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Narración , Proyectos de Investigación , Investigación Empírica , HumanosRESUMEN
BACKGROUND: Complementary medicine (CM) use is a ubiquitous aspect of an increasingly consumer-driven model of healthcare delivery and plays an increasingly prominent role in the Australian health sector. Yet there is limited empirical research investigating the quality and integrity of protections for consumers in Australia. The aim of this study is to help address this gap in knowledge by exploring how members of the public engage with protection mechanisms related to CM use. METHODS: This study utilised a cross-sectional online survey to recruit a sample of 1132 Australian adults aged 18 and over. Purposive convenience sampling was used to recruit participants from an existing database of Australian adults who had expressed interest in participating in research. RESULTS: The majority of the participants (64.0%) had visited a CM practitioner in their lifetime. However, a minority of participants (36.9%) indicated they would feel confident in knowing where to complain if something went wrong with the treatment they received from a CM practitioner. Most participants (74.7%) had used a CM product in their lifetime. Specifically, 32.3% had 'ever' used an herbal product and 69.9% had 'ever' used a nutritional supplement. However, a minority of participants (32.7%) indicated they would feel confident knowing where to complain if something went wrong with a herbal or nutritional supplement they used. Most participants indicated a lack of knowledge about how CM practitioners and CM products are regulated in Australia. CONCLUSION: The findings of this study clearly highlight a concerning lack of knowledge by CM patients and consumers regarding the regulation of CM in Australia. From a policy perspective, it is necessary to seek proactive approaches that target complaint-related knowledge of the CM patients and consumers through education and advocacy efforts.
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Terapias Complementarias , Adulto , Humanos , Adolescente , Australia , Estudios Transversales , Practicantes de la Medicina Tradicional , Investigación EmpíricaRESUMEN
BACKGROUND: There are hundreds of mindfulness-based interventions in the form of structured and unstructured therapies, trainings, and meditation programs, mostly utilized in a clinical rather than a well-being perspective. The number of empirical studies on positive potentials of mindfulness is comparatively less, and their known status in academia is ambiguous. Hence, the current paper aimed to review the studies where mindfulness-based interventions had integrated positive psychology variables, in order to produce positive functioning. METHODS: Data were obtained from the databases of PubMed, Scopus, and PsycNet and manual search in Google Scholar. From the 3831 articles, irrelevant or inaccessible studies were eliminated, reducing the number of final articles chosen for review to 21. Interventions that contribute to enhancement of eudaimonia, hedonia, and other positive variables are discussed. RESULTS: Findings include the potential positive qualities of MBIs in producing specific positive outcomes within limited circumstances, and ascendancy of hedonia and other positive variables over eudaimonic enhancement. CONCLUSION: In conclusion, exigency of modifications in the existing MBIs to bring about exclusively positive outcomes was identified, and observed the necessity of novel interventions for eudaimonic enhancement and elevation of hedonia in a comprehensive manner.
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Meditación , Atención Plena , Investigación Empírica , Humanos , Mamografía , Psicología PositivaRESUMEN
BACKGROUND: Despite the increasing use of osteopathy, a manipulative complementary and alternative medicine therapy, in the general population, its efficacy continues to be debated. In this era of evidence-based practice, no studies have previously reviewed the scientific literature in the field to identify published knowledge, trends and gaps in empirical research. The aims of this bibliometric analysis are to describe characteristics of articles published on the efficacy of osteopathic interventions and to provide an overall portrait of their impacts in the scientific literature. METHODS: A bibliometric analysis approach was used. Articles were identified with searches using a combination of relevant MeSH terms and indexing keywords about osteopathy and research designs in MEDLINE and CINAHL databases. The following indicators were extracted: country of primary author, year of publication, journals, impact factor of the journal, number of citations, research design, participants' age group, system/body part addressed, primary outcome, indexing keywords and types of techniques. RESULTS: A total of 389 articles met the inclusion criteria. The number of empirical studies doubled every 5 years, with the United States, Italy, Spain, and United Kingdom being the most productive countries. Twenty-three articles were cited over 100 times. Articles were published in 103 different indexed journals, but more than half (53.7%) of articles were published in one of three osteopathy-focused readership journals. Randomized control trials (n = 145; 37.3%) and case reports (n = 142; 36.5%) were the most common research designs. A total of 187 (48.1%) studies examined the effects of osteopathic interventions using a combination of techniques that belonged to two or all of the classic fields of osteopathic interventions (musculoskeletal, cranial, and visceral). CONCLUSION: The number of osteopathy empirical studies increased significantly from 1980 to 2014. The productivity appears to be very much in sync with practice development and innovations; however, the articles were mainly published in osteopathic journals targeting a limited, disciplinary-focused readership.
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Bibliometría , Investigación Empírica , Medicina OsteopáticaRESUMEN
In an effort to better utilize published evidence obtained from animal experiments, systematic reviews of preclinical studies are increasingly more common-along with the methods and tools to appraise them (e.g., SYstematic Review Center for Laboratory animal Experimentation [SYRCLE's] risk of bias tool). We performed a cross-sectional study of a sample of recent preclinical systematic reviews (2015-2018) and examined a range of epidemiological characteristics and used a 46-item checklist to assess reporting details. We identified 442 reviews published across 43 countries in 23 different disease domains that used 26 animal species. Reporting of key details to ensure transparency and reproducibility was inconsistent across reviews and within article sections. Items were most completely reported in the title, introduction, and results sections of the reviews, while least reported in the methods and discussion sections. Less than half of reviews reported that a risk of bias assessment for internal and external validity was undertaken, and none reported methods for evaluating construct validity. Our results demonstrate that a considerable number of preclinical systematic reviews investigating diverse topics have been conducted; however, their quality of reporting is inconsistent. Our study provides the justification and evidence to inform the development of guidelines for conducting and reporting preclinical systematic reviews.
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Revisión de la Investigación por Pares/métodos , Revisión de la Investigación por Pares/normas , Proyectos de Investigación/normas , Experimentación Animal/normas , Animales , Sesgo , Lista de Verificación/normas , Evaluación Preclínica de Medicamentos/métodos , Evaluación Preclínica de Medicamentos/normas , Investigación Empírica , Métodos Epidemiológicos , Epidemiología/tendencias , Humanos , Revisión de la Investigación por Pares/tendencias , Publicaciones , Reproducibilidad de los Resultados , Proyectos de Investigación/tendenciasRESUMEN
Objectives: This paper constructs a comprehensive evaluation index of the traditional Chinese medicine (TCM) medical service system and summarizes the development of TCM medical services in China. Methods: We chose 31 provinces' TCM hospitals as research objects. The data were obtained from the Health Statistics Yearbook from 2013 to 2018 and from the National Statistics of Chinese Medicine from 2012 to 2017. The approaches to factor analysis and TOPSIS are used in this paper. It is found that the comprehensive evaluation indexes of the TCM medical service system can be divided into 4 first-level indicators and 14 second-level indicators. Results: The development of the TCM medical service system in China is unbalanced and inadequate. North China and East China are generally superior to Northwest and Southwest China in terms of revenue and expenditure for TCM medical services. The per capita of medical resources in the Southwest and Northwest are stronger than those in Central and South China, but overall medical resources are weaker than those in East China and North China. TCM medical service institutions in East China, South China and Central China have achieved better service results and higher economic benefits with less resource input, which further indicates the efficient allocation of resources and the balanced operation of TCM medical service institutions. Conclusion: The development of China's TCM medical service system shows the imbalance and inadequacy of "East is strong, West is weak" and "South is superior, North is inferior."
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Gastos en Salud , Medicina Tradicional China , China , Investigación Empírica , Análisis FactorialRESUMEN
BACKGROUND: Few studies have quantitatively estimated the income elasticity of demand of voluntary private health insurance (VPHI) in countries with a universal National Health Service. Most studies to date have uses cross-sectional data. METHODS: In this paper we used a longitudinal database from the Bank of Spain to analyse the financial behaviour of approximately six thousand families per wave. We used three waves (2008, 2011 and 2014). We estimated income and wealth semi-elasticities of VPHI in Spain considering personal and family characteristics (age, sex, level of health, education, composition of the household), i.e. changes in the probability of buying VPHI as result of 1% change in income or wealth. We estimated cross-sectional models for each wave and longitudinal models for families remaining for at least two waves, taking account of possible selection bias due to attrition. RESULTS: Cross-sectional models suggest that the income effect on the probability of buying a VPHI increased from 2008 to 2014. The positive impact was observed for, wealth. In 2008 a 1% increase in income is associated with an increase in the probability of having VPHI of 0.064 [95%-CI: 0.023; 0.104] - on the probability scale (0.1) - whereas in 2014, this effect is of 0.116 [95%-CI, 0.094; 0.139]. In 2011 and 2014 the wealth effect is not significant at 5%. The estimation of the longitudinal model leads to different results where both, income and wealth are associated with non- significant results. CONCLUSION: Our three main conclusions are: 1) Cross-sectional estimates of semi-elasticities of VPHI might be biased upwards; 2) Wealth is alongside income are economic determinants, of the decision to buy VPHI in high-income countries; 3) The effects of income and wealth on the probability of buying VHPI are neither linear nor log-linear. There are no significant differences among 60% of the most disadvantaged families, while the families of the two upper wealth quintiles show clearly differentiated behaviour with a higher probability of insurance.
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Renta/estadística & datos numéricos , Seguro de Salud/estadística & datos numéricos , Sector Privado/estadística & datos numéricos , Estudios Transversales , Bases de Datos Factuales , Investigación Empírica , Femenino , Humanos , Estudios Longitudinales , Masculino , Persona de Mediana Edad , Programas Nacionales de Salud , España , Cobertura Universal del Seguro de SaludRESUMEN
Development of predictive models of fatty acid (FA) use by dairy cattle still faces challenges due to high variation in FA composition among feedstuffs and fat supplements. Two meta-analytical studies were carried out to develop empirical models for estimating (1) the total FA concentration of feedstuffs, and (2) the apparent total-tract digestibility of total FA (DCFATTa) in dairy cows fed different fat types. In study 1, individual feedstuff data for total crude fat (EE) and FA were taken from commercial laboratories (total of 203 feeds, 1,170,937 samples analyzed for total FA, 1,510,750 samples analyzed for total EE), and data for FA composition were collected from the Cornell Net Carbohydrate and Protein System feed library. All feedstuffs were grouped into 7 classes based on their nutritional components. To predict total FA concentration (% of dry matter) for groups of feeds, the total EE (% of dry matter) was used as an independent variable in the model, and all models were linear. For forages, data were weighted using the inverse of the standard error (SE). Regression coefficients for predicting total FA from EE (% of dry matter) were 0.73 (SE, 0.04), 0.98 (0.02), 0.80 (0.02), 0.61 (0.04), 0.92 (0.03), and 0.93 (0.03), for animal protein, plant protein, energy sources, grain crop forage, by-product feeds, and oilseeds, respectively. The intercepts for plant protein and by-product groups were different from zero and included in the models. As expected, forages had the lowest total FA concentration (slope = 0.57, SE = 0.02). In study 2, data from 30 studies (130 treatment means) that reported DCFATTa in dairy cows were used. Data for animal description, diet composition, intakes of total FA, and DCFATTa, were collected. Dietary sources of fat were grouped into 11 categories based on their fat characteristic and FA profile. A mixed model including the random effect of study was used to regress digested FA on FA intake with studies weighted according to the inverse of their variance (SE). Dietary intake of extensively saturated triglycerides resulted in markedly lower total FA digestion (DCFATTa = 44%) compared with animals consuming unsaturated FA, such as Ca-salts of palm (DCFATTa = 76%) and oilseeds (DCFATTa = 73%). Cows fed saturated fats had lower total FA digestion among groups, but it was dependent on the FA profile of each fat source. The derived models provide additional insight into FA digestion in ruminants. Predictions of total FA supply and its digestion can be used to adjust fat supplementation programs for dairy cows.
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Bovinos/fisiología , Suplementos Dietéticos/análisis , Ácidos Grasos/metabolismo , Alimentación Animal/análisis , Animales , Dieta/veterinaria , Digestión , Ingestión de Alimentos , Grano Comestible/química , Investigación Empírica , Ácidos Grasos/análisis , Femenino , Lactancia , Modelos Lineales , Metadatos , Triglicéridos/metabolismoAsunto(s)
Infecciones por Coronavirus , Cuidados Críticos , Vías Clínicas , Medicina Basada en la Evidencia , Pandemias , Neumonía Viral , Síndrome de Dificultad Respiratoria , Betacoronavirus/aislamiento & purificación , COVID-19 , Infecciones por Coronavirus/epidemiología , Infecciones por Coronavirus/fisiopatología , Infecciones por Coronavirus/terapia , Cuidados Críticos/ética , Cuidados Críticos/métodos , Cuidados Críticos/normas , Resultados de Cuidados Críticos , Enfermedad Crítica/terapia , Vías Clínicas/ética , Vías Clínicas/normas , Investigación Empírica , Medicina Basada en la Evidencia/métodos , Medicina Basada en la Evidencia/organización & administración , Humanos , Neumonía Viral/epidemiología , Neumonía Viral/fisiopatología , Neumonía Viral/terapia , Respiración Artificial/métodos , Respiración Artificial/normas , Síndrome de Dificultad Respiratoria/etiología , Síndrome de Dificultad Respiratoria/terapia , SARS-CoV-2 , Nivel de AtenciónRESUMEN
Gene and protein expressions are key determinants of cellular function. Neurons are the building blocks of brain circuits, yet the relationship between their molecular identity and the spatial distribution of their dendritic inputs and axonal outputs remains incompletely understood. The open-source knowledge base Hippocampome.org amasses such transcriptomic data from the scientific literature for morphologically defined neuron types in the rodent hippocampal formation: dentate gyrus, CA3, CA2, CA1, subiculum, and entorhinal cortex. Positive, negative, or mixed expression reports were initially obtained from published articles directly connecting molecular evidence to neurons with known axonal and dendritic patterns across hippocampal layers. Here, we supplement this information by collating, formalizing, and leveraging relational expression inferences that link a gene or protein expression or lack thereof to that of another molecule or to an anatomical location. With these additional interpretations, we freely release online a comprehensive human- and machine-readable molecular profile for more than 100 neuron types in Hippocampome.org. Analysis of these data ascertains the ability to distinguish unequivocally most neuron types in each of the major subdivisions of the hippocampus based on currently known biochemical markers. Moreover, grouping neuron types by expression similarity reveals eight superfamilies characterized by a few defining molecules.
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Minería de Datos/métodos , Investigación Empírica , Hipocampo/fisiología , Bases del Conocimiento , Neuronas/fisiología , Transcriptoma/fisiología , HumanosRESUMEN
The percent transfer of pesticide residue from tea to infusion is an important factor that should be taken into consideration for setting realistic Maximum Residue Levels (MRLs) and risk assessment, as infusion prepared from dry tea is generally consumed, rather than the dry tea. The aim of this study is to investigate the inherent regularity of pesticides' transfer behavior, and to understand the effects of pesticide's physico-chemical parameters on its transfer behavior. A series of field trials, manufacturing and brewing experiments of 42 pesticides were conducted. Results indicated that transfer potential of a pesticide is related to its physical-chemical properties but not much to its type. Regression of transfer rate (TR) prediction model was logTRâ¯=â¯1.242â¯+â¯0.306log(Ws) (R2â¯=â¯0.893). Thus, water solubility (Ws) can be used to predict the drinking safety of pesticides potentially introduced into tea plantation. Furthermore, as a case study on tea, this approach could also provide references for other beverage crops.
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Residuos de Plaguicidas/análisis , Té/química , Camellia sinensis/química , Fenómenos Químicos , Productos Agrícolas/química , Investigación Empírica , Contaminación de Alimentos/análisis , Manipulación de Alimentos , Plaguicidas/análisis , Reproducibilidad de los Resultados , Medición de Riesgo , Espectrometría de Masas en TándemRESUMEN
Plantas nativas são utilizadas na alimentação humana e na cura de enfermidades. No que diz respeito às plantas medicinais, o emprego das substâncias nelas contidas, advém do conhecimento empírico. Já as PANCs são conhecidas pela infinidade de benefícios à saúde, no entanto, há uma variedade de compostos desconhecidos por parte da comunidade científica. Diante do mencionado, objetivou-se coletar informações acerca das plantas com propriedades benéficas e, posteriormente dissipar este conhecimento. Foram feitas visitas in loco para obtenção de dados, e estes tratados pela técnica estatística de análise de correspondência. Foi feito, ainda, uma pesquisa na literatura para a comprovação dos dados encontrados na análise, e, por fim foram criadas cartilhas contendo as informações em relação a utilização das plantas endêmicas da região.