RESUMEN
PURPOSE: The aim was to study the association between dietary intake of B vitamins in childhood and the risk of islet autoimmunity (IA) and progression to type 1 diabetes (T1D) by the age of 10 years. METHODS: We followed 8500 T1D-susceptible children born in the U.S., Finland, Sweden, and Germany in 2004 -2010 from the Environmental Determinants of Diabetes in the Young (TEDDY) study, which is a prospective observational birth cohort. Dietary intake of seven B vitamins was calculated from foods and dietary supplements based on 24-h recall at 3 months and 3-day food records collected regularly from 6 months to 10 years of age. Cox proportional hazard models were adjusted for energy, HLA-genotype, first-degree relative with T1D, sex, and country. RESULTS: A total of 778 (9.2) children developed at least one autoantibody (any IA), and 335 (3.9%) developed multiple autoantibodies. 280 (3.3%) children had IAA and 319 (3.8%) GADA as the first autoantibody. 344 (44%) children with IA progressed to T1D. We observed that higher intake of niacin was associated with a decreased risk of developing multiple autoantibodies (HR 0.95; 95% CI 0.92, 0.98) per 1 mg/1000 kcal in niacin intake. Higher intake of pyridoxine (HR 0.66; 95% CI 0.46, 0.96) and vitamin B12 (HR 0.87; 95% CI 0.77, 0.97) was associated with a decreased risk of IAA-first autoimmunity. Higher intake of riboflavin (HR 1.38; 95% CI 1.05, 1.80) was associated with an increased risk of GADA-first autoimmunity. There were no associations between any of the B vitamins and the outcomes "any IA" and progression from IA to T1D. CONCLUSION: In this multinational, prospective birth cohort of children with genetic susceptibility to T1D, we observed some direct and inverse associations between different B vitamins and risk of IA.
Asunto(s)
Autoanticuerpos , Autoinmunidad , Diabetes Mellitus Tipo 1 , Islotes Pancreáticos , Complejo Vitamínico B , Humanos , Diabetes Mellitus Tipo 1/inmunología , Diabetes Mellitus Tipo 1/epidemiología , Masculino , Femenino , Complejo Vitamínico B/administración & dosificación , Estudios Prospectivos , Niño , Preescolar , Lactante , Islotes Pancreáticos/inmunología , Autoanticuerpos/sangre , Factores de Riesgo , Dieta/métodos , Dieta/estadística & datos numéricos , Modelos de Riesgos Proporcionales , Estados Unidos/epidemiología , Finlandia/epidemiología , Suecia/epidemiología , Alemania/epidemiología , Suplementos Dietéticos , Cohorte de Nacimiento , Progresión de la EnfermedadRESUMEN
Foi analisada a freqüência de ICA-IgG em 75 pacientes com diabete insulinodependente, e 129 parentes de 1§ grau. Trinta e seis por cento dos pacientes apresentaram reaçäo positiva. Na constelaçäo familiar, cerca de 7,6% dos pais e 9,8% dos irmäos, respectivamente, apresentaram reaçäo positiva. Constatou-se uma reaçäo positiva muito forte e forte no grupo de irmäos