RESUMEN
Discoid lupus erythematosus (DLE) is a chronic cutaneous disease characterized by inflammatory plaques that, in the absence of prompt diagnosis and treatment, may lead to disfiguring scarring and skin atrophy. However, there is limited evidence for which treatments are most effective. Currently, no medications have been approved specifically for the treatment of DLE. Many of the drugs described in the literature were developed for use in other immune disorders. This review will summarize current therapeutic options for DLE and their supporting evidence with discussion of prevention, topical measures, physical modalities, and systemic therapies, including newer potential therapies.
Asunto(s)
Lupus Eritematoso Discoide/terapia , Corticoesteroides/administración & dosificación , Inhibidores de la Calcineurina/uso terapéutico , Dapsona/uso terapéutico , Humanos , Hidroxicloroquina/uso terapéutico , Terapia por Láser , Lupus Eritematoso Discoide/prevención & control , Metotrexato/uso terapéutico , Fototerapia , Retinoides/administración & dosificación , Cese del Hábito de Fumar , Talidomida/uso terapéuticoRESUMEN
In lymphocytes of peripheral blood from 46 patients with various forms of lupus erythematosus measurements were made of histone fractions and DNA. It is proved that intranuclear characteristics of lymphoid cells can be used in the choice of treatment and assessment of its efficacy. Lupus erythematosus treatment with glucocorticoids (diprospan, diprospan + celeston) is effective in correction of intranuclear lymphocyte changes in this disease.