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1.
Hum Brain Mapp ; 42(4): 978-992, 2021 03.
Artículo en Inglés | MEDLINE | ID: mdl-33156569

RESUMEN

Signal-to-noise ratio (SNR) maps are a good way to visualize electroencephalography (EEG) and magnetoencephalography (MEG) sensitivity. SNR maps extend the knowledge about the modulation of EEG and MEG signals by source locations and orientations and can therefore help to better understand and interpret measured signals as well as source reconstruction results thereof. Our work has two main objectives. First, we investigated the accuracy and reliability of EEG and MEG finite element method (FEM)-based sensitivity maps for three different head models, namely an isotropic three and four-compartment and an anisotropic six-compartment head model. As a result, we found that ignoring the cerebrospinal fluid leads to an overestimation of EEG SNR values. Second, we examined and compared EEG and MEG SNR mappings for both cortical and subcortical sources and their modulation by source location and orientation. Our results for cortical sources show that EEG sensitivity is higher for radial and deep sources and MEG for tangential ones, which are the majority of sources. As to the subcortical sources, we found that deep sources with sufficient tangential source orientation are recordable by the MEG. Our work, which represents the first comprehensive study where cortical and subcortical sources are considered in highly detailed FEM-based EEG and MEG SNR mappings, sheds a new light on the sensitivity of EEG and MEG and might influence the decision of brain researchers or clinicians in their choice of the best modality for their experiment or diagnostics, respectively.


Asunto(s)
Amígdala del Cerebelo/fisiología , Cerebelo/fisiología , Corteza Cerebral/fisiología , Cuerpo Estriado/fisiología , Electroencefalografía/normas , Potenciales Evocados Somatosensoriales/fisiología , Magnetoencefalografía/normas , Tálamo/fisiología , Adulto , Electroencefalografía/métodos , Hipocampo/fisiología , Humanos , Imagen por Resonancia Magnética , Magnetoencefalografía/métodos , Reproducibilidad de los Resultados , Relación Señal-Ruido
2.
J Clin Neurophysiol ; 37(6): 574-584, 2020 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-33165230

RESUMEN

Auditory evoked fields (AEFs) are well suited for studies of auditory processing in patients. Their sources have been localized to Heschl's gyri and to the supratemporal auditory cortices. Auditory evoked fields are known to be modulated by peripheral and central lesions of auditory pathways and to reflect group-level pathophysiology of neurodevelopmental and psychiatric disorders. They are useful in lateralization of language processes for planning neurosurgery and for localization of language-related cortex. The recently developed artifact rejection and movement compensation methods will enhance and extend the use of AEFs in studies of clinical patients and pediatric groups. New pediatric magnetoencephalography systems will facilitate clinical AEF studies of developmental disorders. In addition to their established use in planning neurosurgery, AEF findings in several new clinical patient groups suffering, e.g., from developmental, neurodegenerative, or psychiatric disorders have been reported. Several recent investigations report the correlations with clinical symptoms and sensitivity and specificity profiles of AEFs in studies of these disorders; this development is mandatory in gaining wider clinical approval for the use of AEFs in clinical practice dealing with individual patients. Most promising future research lines of clinical applicability of AEFs focus on developmental and psychiatric disorders.


Asunto(s)
Corteza Auditiva/fisiología , Percepción Auditiva/fisiología , Mapeo Encefálico/normas , Potenciales Evocados Auditivos/fisiología , Magnetoencefalografía/normas , Guías de Práctica Clínica como Asunto/normas , Estimulación Acústica/métodos , Estimulación Acústica/normas , Corteza Auditiva/diagnóstico por imagen , Investigación Biomédica/métodos , Investigación Biomédica/normas , Mapeo Encefálico/métodos , Discapacidades del Desarrollo/diagnóstico por imagen , Discapacidades del Desarrollo/fisiopatología , Humanos , Magnetoencefalografía/métodos
3.
Clin Neurophysiol ; 122(6): 1238-45, 2011 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-21147549

RESUMEN

OBJECTIVE: To determine if there is an optimum spatial extent for the detection of moving objects in humans. METHODS: We investigated human brain responses to motion at various speeds (2.9-23.5 deg/s) and stimulus sizes (2.2 × 2.9 deg to 44.8 × 57.4 deg) using magnetoencephalography. The results were compared with those for the flickers with the same stimulus sizes and temporal frequencies. RESULTS: For every size, response latency was inversely related to speed. Further, the latency was lowest at a stimulus size of 16.8 × 22.4 deg for every speed. Although response latency was inversely related to the temporal frequency of the flicker stimulation for all stimulus sizes, it was not affected by stimulus size as much as motion stimulus. CONCLUSIONS: For visual motion detection, the most efficient stimulus size is around 16.8 × 22.4 deg. SIGNIFICANCE: The results suggest that spatial summation mechanism is important for the detection of visual motion but a loss of reference frame information affects the detection of larger motion stimuli, supporting the view that illusory self-motion (vection) is caused by poor reference frame information for motion detection.


Asunto(s)
Encéfalo/fisiología , Magnetoencefalografía , Percepción de Movimiento/fisiología , Movimiento (Física) , Estimulación Acústica , Adulto , Análisis de Varianza , Biofisica , Mapeo Encefálico , Femenino , Lateralidad Funcional , Humanos , Magnetoencefalografía/métodos , Magnetoencefalografía/normas , Masculino , Persona de Mediana Edad , Estimulación Luminosa/métodos , Tiempo de Reacción/fisiología
4.
Clin Neurophysiol ; 120(11): 1958-1970, 2009 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-19782641

RESUMEN

OBJECTIVE: To investigate the accurate localisation of weak, transient, neural sources under conditions of varying difficulty. METHODS: Multiple dipolar sources placed within a head-shaped phantom at superficial and deep locations were driven separately or simultaneously by a short-lasting current with varied amplitudes. Artificial MEG signals that were very similar to the human High Frequency Oscillations (HFO) were produced. MEG signals of HFO were also recorded from median nerve stimulation. Different inverse techniques were used to localise the phantom dipoles and the human HFO generators. RESULTS: The human HFO were measured around 200 and 600Hz by using only 120 trials. The 200Hz HFO were localised to BA3b. The superficial phantom's source was localised with an accuracy of 2-3mm by all inverse techniques (120 trials). The 'subcortical' source was localised with an error of approximately 5mm. Localisation of deeper 'thalamic' sources required more trials. CONCLUSION: MEG can detect and localise weak transient activations and the human HFO with an accuracy of a few mm at cortical and subcortical regions even when a small number of trials are used. SIGNIFICANCE: Localizing HFO to specific anatomical structures has high clinical utility, for example in epilepsy, where discrete HFO appears to be generated just before focal epileptic activity.


Asunto(s)
Encéfalo/fisiología , Magnetoencefalografía/métodos , Adulto , Mapeo Encefálico/métodos , Humanos , Magnetoencefalografía/normas , Masculino , Nervio Mediano/fisiología , Estimulación Eléctrica Transcutánea del Nervio/métodos , Estimulación Eléctrica Transcutánea del Nervio/normas
5.
Brain Topogr ; 20(2): 55-61, 2007.
Artículo en Inglés | MEDLINE | ID: mdl-17899352

RESUMEN

Acoustic complexity of a stimulus has been shown to modulate the electromagnetic N1 (latency approximately 110 ms) and P2 (latency 190 ms) auditory evoked responses. We compared the relative sensitivity of electroencephalography (EEG) and magnetoencephalography (MEG) to these neural correlates of sensation. Simultaneous EEG and MEG were recorded while participants listened to three variants of a piano tone. The piano stimuli differed in their number of harmonics: the fundamental frequency (f ( 0 )), only, or f ( 0 ) and the first two or eight harmonics. The root mean square (RMS) of the amplitude of P2 but not N1 increased with spectral complexity of the piano tones in EEG and MEG. The RMS increase for P2 was more prominent in EEG than MEG, suggesting important radial sources contributing to the P2 only in EEG. Source analysis revealing contributions from radial and tangential sources was conducted to test this hypothesis. Source waveforms revealed a significant increase in the P2 radial source amplitude in EEG with increased spectral complexity of piano tones. The P2 of the tangential source waveforms also increased in amplitude with increased spectral complexity in EEG and MEG. The P2 auditory evoked response is thus represented by both tangential (gyri) and radial (sulci) activities. The radial contribution is expressed preferentially in EEG, highlighting the importance of combining EEG with MEG where complex source configurations are suspected.


Asunto(s)
Corteza Auditiva/fisiología , Percepción Auditiva/fisiología , Electroencefalografía/métodos , Potenciales Evocados Auditivos/fisiología , Magnetoencefalografía/métodos , Estimulación Acústica , Adulto , Corteza Auditiva/anatomía & histología , Vías Auditivas/anatomía & histología , Vías Auditivas/fisiología , Mapeo Encefálico/métodos , Electroencefalografía/normas , Femenino , Humanos , Magnetoencefalografía/normas , Masculino , Percepción de la Altura Tonal/fisiología , Tiempo de Reacción/fisiología
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