RESUMEN
A male infant, who underwent radical resection of a large glial heterotopia at the nasopharynx at 8 days, developed delayed postoperative bacterial meningitis at 9 months. Neuroradiological examination clearly demonstrated that meningitis had occurred because of the intracranial and extracranial connections, which were scarcely seen in the perioperative period. A transsphenoidal extension of hypothalamic hamartoma is possible because the connection started from the right optic nerve, running through the transsphenoidal canal in the sphenoid bone and terminating at the recurrent mass in the nasopharyngeal region.
Asunto(s)
Coristoma/complicaciones , Hamartoma/complicaciones , Enfermedades Hipotalámicas/complicaciones , Hipotálamo/patología , Neoplasias Meníngeas/complicaciones , Meningitis Bacterianas/etiología , Neoplasias Nasofaríngeas/complicaciones , Nasofaringe/patología , Coristoma/cirugía , Hamartoma/patología , Hamartoma/cirugía , Humanos , Enfermedades Hipotalámicas/patología , Enfermedades Hipotalámicas/cirugía , Lactante , Masculino , Neoplasias Meníngeas/microbiología , Neoplasias Meníngeas/cirugía , Meninges/microbiología , Meninges/patología , Meningitis Bacterianas/microbiología , Neoplasias Nasofaríngeas/patología , Neoplasias Nasofaríngeas/cirugía , Nasofaringe/cirugía , Nervio Óptico/patología , Complicaciones Posoperatorias , Hueso Esfenoides/patología , Streptococcus/crecimiento & desarrolloRESUMEN
In an effort to develop a safe and effective vaccine for the prevention of Lyme borreliosis that addresses concerns raised over currently available vaccines, dogs were vaccinated twice with a multiantigenic preparation of Borrelia burgdorferi, strain N40, on days 0 and 20 of the experiment. About 70 and 154 days after the first immunization, dogs were challenged by exposing them to field-collected Ixodes scapularis ticks harboring B. burgdorferi. Vaccinated dogs were completely protected from infection by all criteria utilized to assess infection, developed high-titer anti-B. burgdorferi serum antibodies and growth inhibitory activity which persisted for over 200 days, and did not demonstrate any untoward consequence of vaccination. Serum absorption experiments revealed that borreliacidal and most likely protective antibodies in dogs receiving the multiantigenic preparation were not only elicited against the OspA antigen, but were also produced against additional yet to be determined targets on B. burgdorferi organisms. These data demonstrate that a multiantigenic vaccine is effective in preventing Lyme disease transmitted via the natural vector.