RESUMEN
This article reviews the pharmacology, toxicology, and treatment of both barbiturate and nonbarbiturate sedative hypnotic overdose. Although poisoning with these agents has declined over recent years, intoxication with them can still result in a life-threatening situation requiring immediate assessment and treatment.
Asunto(s)
Barbitúricos/envenenamiento , Hipnóticos y Sedantes/envenenamiento , Ansiolíticos/envenenamiento , Barbitúricos/metabolismo , Benzodiazepinas , Niño , Terapia Combinada , Etclorvinol/envenenamiento , Lavado Gástrico , Glutetimida/envenenamiento , Humanos , Inactivación Metabólica , Ipeca/uso terapéutico , Meprobamato/envenenamiento , Metacualona/envenenamientoRESUMEN
Dogs were given large doses of barbiturates, glutethimide, ethanol, methaqualone, ethchlorvynol, meprobamate, chloral hydrate, paracetamol and aspirin. These were treated by haemoperfusion using a column packed with charcoal coated with an acrylic hydrogel. Clearances for most drugs were significantly higher than those reported for haemodialysis. Minimal clearances of common biochemical entities were observed and although leucocyte and platelet counts were diminished, no deleterious effects attributable to this were encountered. Careful histological examination of tissues derived from perfused dogs revealed no evidence of charcoal emboli.