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Métodos Terapéuticos y Terapias MTCI
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1.
Pak J Pharm Sci ; 30(4): 1251-1256, 2017 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-29039322

RESUMEN

Isolated Salidroside from the leaves of Nigerian mistletoe (Loranthus micranthus Linn) parasitic on Hevea brasiliensis was evaluated for its antiviral activity against respiratory syncytial virus. Semi- preparative HPLC separation of the ethyl acetate fraction of the leave extract of Loranthus micranthus Linn parasitic on Hevea brasiliensis led to the isolation of a polyphenol. Using spectroscopic methods (1D and 2D NMR and mass spectroscopic data) as well as by comparison with literature data the structure of the compound was determined as 6-O-galloyl salidroside. The antiviral activity of the isolated compound was evaluated against the respiratory syncytial virus. The isolated Salidroside showed potent inhibition towards a recombinant straining respiratory syncytial virus with Inhibitory Concentration (IC 50) value of 10.3±1.50 µg/mL. The result indicates that Salidroside is an efficient antiviral agent against RSV infection and might be useful for the management of RSV pathogenesis.


Asunto(s)
Antivirales/aislamiento & purificación , Antivirales/farmacología , Hevea/parasitología , Muérdago/química , Polifenoles/aislamiento & purificación , Polifenoles/farmacología , Virus Sincitiales Respiratorios/efectos de los fármacos , Virus Sincitiales Respiratorios/crecimiento & desarrollo , Línea Celular Tumoral , Supervivencia Celular/efectos de los fármacos , Humanos , Concentración 50 Inhibidora , Muérdago/crecimiento & desarrollo , Extractos Vegetales/química , Hojas de la Planta/química , Ensayo de Placa Viral
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