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1.
Neurosurg Rev ; 44(2): 753-762, 2021 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-32318922

RESUMEN

Hypothalamic hamartomas are aberrant masses, composed of abnormally distributed neurons and glia. Along endocrine and cognitive symptoms, they may cause epileptic seizures, including the specific gelastic and dacrystic seizures. Surgery is the treatment of drug-resistant hamartoma epilepsy, with associated positive results on endocrine, psychiatric, and cognitive symptoms. Recently, alternatives to open microsurgical treatment have been proposed. We review these techniques and compare their efficacy and safety. Open resection or disconnection of the hamartoma, either through pterional, transcallosal, or transventricular approach, leads to good epileptological control, but its high complication rate, up to 30%, limits its indications. The purely cisternal peduncular forms remain the only indication of open, pterional approach, while other strategies have been developed to overcome the neurological, endocrine, behavioral, or cognitive complications. Laser and radiofrequency thermocoagulation-based disconnection through robot-guided stereo-endoscopy has been proposed as an alternative to open microsurgical resection and stereotactic destruction. The goal is to allow safe and complete disconnection of a possibly complex attachment zone, through a single intraparenchymal trajectory which allows multiple laser or radiofrequency probe trajectory inside the ventricle. The efficacy was high, with 78% of favorable outcome, and the overall complication rate was 8%. It was especially effective in patients with isolated gelastic seizures and pure intraventricular hamartomas. Stereotactic radiosurgery has proved as efficacious and safer than open microsurgery, with around 60% of seizure control and a very low complication rate. Multiple stereotactic thermocoagulation showed very interesting results with 71% of seizure freedom and 2% of permanent complications. Stereotactic laser interstitial thermotherapy (LiTT) seems as effective as open microsurgery (from 76 to 81% of seizure freedom) but causes up to 20% of permanent complications. This technique has however been highly improved by targeting only the epileptogenic onset zone in the hamartoma, as shown on preoperative functional MRI, leading to an improvement of epilepsy control by 45% (92% of seizure freedom) with no postoperative morbidity. All these results suggest that the impact of the surgical procedure does not depend on purely technical matters (laser vs radiofrequency thermocoagulation or stereotactic vs robot-guided stereo-endoscopy) but relies on the understanding of the epileptic network, including inside the hamartoma, the aim being to plan an effective disconnection or lesion of the epileptogenic part while sparing the adjacent functional structures.


Asunto(s)
Epilepsia Refractaria/cirugía , Hamartoma/cirugía , Enfermedades Hipotalámicas/cirugía , Procedimientos Neuroquirúrgicos/métodos , Convulsiones/cirugía , Ventrículos Cerebrales/diagnóstico por imagen , Ventrículos Cerebrales/cirugía , Epilepsia Refractaria/diagnóstico por imagen , Epilepsia Refractaria/etiología , Femenino , Hamartoma/complicaciones , Hamartoma/diagnóstico por imagen , Humanos , Enfermedades Hipotalámicas/complicaciones , Enfermedades Hipotalámicas/diagnóstico por imagen , Imagenología Tridimensional/métodos , Imagenología Tridimensional/tendencias , Imagen por Resonancia Magnética/métodos , Imagen por Resonancia Magnética/tendencias , Masculino , Neuroendoscopía/métodos , Neuroendoscopía/tendencias , Procedimientos Neuroquirúrgicos/tendencias , Radiocirugia/métodos , Radiocirugia/tendencias , Convulsiones/diagnóstico por imagen , Convulsiones/etiología , Resultado del Tratamiento
2.
Neurosurg Rev ; 44(3): 1569-1582, 2021 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-32651708

RESUMEN

The endoscopic endonasal approach to suprasellar craniopharyngiomas has become popular as alternative to transcranial approaches. However, the literature lacks data regarding quality of life and olfactory function. The assessment of the long-term quality of life and olfactory function of all patients harboring a suprasellar craniopharyngioma who underwent surgery in our department has been done. Patient characteristics and perioperative data were gathered in a prospectively maintained database. At the last follow-up visit, the olfactory function and the quality of life (ASBQ, SNOT-22) as well as visual and pituitary function were assessed. Thirteen and 17 patients underwent surgery via a transcranial (T) and endonasal (E) route, respectively. No differences were seen in ASBQ, SNOT-22, and olfactory function between T and E, but in E were more full-time worker and less obesity. CSF leaks occurred in 15% of T and 29% of E (p = 0.43). Patients from group E had a superior visual outcome which was most pronounced in the visual field. The degree of new anterior and posterior pituitary gland deficiency after surgery and in the follow-up was lower in group E. The general and sinonasal quality of life and the olfactory function are equal in E and T. E is associated with a superior visual outcome, lower rates of diabetes insipidus, and lower rates of obesity, but has a higher risk for postoperative CSF leaks.


Asunto(s)
Craneofaringioma/cirugía , Craneotomía/métodos , Neuroendoscopía/métodos , Neoplasias Hipofisarias/cirugía , Calidad de Vida , Olfato/fisiología , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Niño , Preescolar , Craneofaringioma/diagnóstico por imagen , Craneofaringioma/psicología , Craneotomía/tendencias , Femenino , Estudios de Seguimiento , Humanos , Lactante , Masculino , Persona de Mediana Edad , Neuroendoscopía/tendencias , Neoplasias Hipofisarias/diagnóstico por imagen , Neoplasias Hipofisarias/psicología , Calidad de Vida/psicología , Resultado del Tratamiento , Adulto Joven
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