RESUMEN
INTRODUCTION: The frequent recolonization of treated sites by periodontopathogens and the emergence of antibiotic resistance have led to a call for new therapeutic approaches for managing periodontal diseases. As probiotics are considered a new tool for combating infectious diseases, we systematically reviewed the evidences for their effectiveness in the management of periodontitis. AREAS COVERED: An electronic search was performed in the MEDLINE, SCOPUS and Cochrane Library databases up to March 2016 using the terms 'periodontitis', 'chronic periodontitis', 'probiotic(s)', 'prebiotic(s)', 'symbiotic(s)', 'Bifidobacterium and 'Lactobacillus'. Only randomized controlled trials (RCTs) were included in the present study. Analysis of 12 RCTs revealed that in general, oral administration of probiotics improved the recognized clinical signs of chronic and aggressive periodontitis such as probing pocket depth, bleeding on probing, and attachment loss, with a concomitant reduction in the levels of major periodontal pathogens. Continuous probiotic administration, laced mainly with Lactobacillus species, was necessary to maintain these benefits. Expert commentary: Oral administration of probiotics is a safe and effective adjunct to conventional mechanical treatment (scaling) in the management of periodontitis, specially the chronic disease entity. Their adjunctive use is likely to improve disease indices and reduce the need for antibiotics.
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Bifidobacterium , Raspado Dental , Lactobacillus , Periodontitis/tratamiento farmacológico , Probióticos/uso terapéutico , Terapia Combinada , Suplementos Dietéticos , Humanos , Pérdida de la Inserción Periodontal/prevención & control , Bolsa Periodontal/prevención & control , Periodontitis/terapia , Probióticos/administración & dosificación , Ensayos Clínicos Controlados Aleatorios como Asunto , Resultado del TratamientoRESUMEN
BACKGROUND: Numerous studies have documented the clinical outcomes of laser therapy for untreated periodontitis, but very few have reported on lasers treating inflamed pockets during maintenance therapy. The aim of this study is to compare the effectiveness of scaling and root planing (SRP) plus the adjunctive use of diode laser therapy to SRP alone on changes in the clinical parameters of disease and on the gingival crevicular fluid (GCF) inflammatory mediator interleukin-1ß (IL-1ß) in patients receiving regular periodontal maintenance therapy. METHODS: This single-masked and randomized, controlled, prospective study includes 22 patients receiving regular periodontal maintenance therapy who had one or more periodontal sites with a probing depth (PD) ≥ 5 mm with bleeding on probing (BOP). Fifty-six sites were treated with SRP and adjunctive laser therapy (SRP + L). Fifty-eight sites were treated with SRP alone. Clinical parameters, including PD, clinical attachment level (CAL), and BOP, and GCF IL-1ß levels were measured immediately before treatment (baseline) and 3 months after treatment. RESULTS: Sites treated with SRP + L and SRP alone resulted in statistically significant reductions in PD and BOP and gains in CAL. These changes were not significantly different between the two therapies. Similarly, differences in GCF IL-1ß levels between SRP + L and SRP alone were not statistically significant. CONCLUSION: In periodontal maintenance patients, SRP + L did not enhance clinical outcomes compared to SRP alone in the treatment of inflamed sites with ≥ 5 mm PD.
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Láseres de Semiconductores/uso terapéutico , Terapia por Luz de Baja Intensidad/métodos , Bolsa Periodontal/radioterapia , Periodontitis/radioterapia , Anciano , Anciano de 80 o más Años , Terapia Combinada , Raspado Dental/métodos , Femenino , Estudios de Seguimiento , Líquido del Surco Gingival/química , Hemorragia Gingival/prevención & control , Hemorragia Gingival/radioterapia , Humanos , Interleucina-1beta/análisis , Masculino , Persona de Mediana Edad , Pérdida de la Inserción Periodontal/prevención & control , Pérdida de la Inserción Periodontal/radioterapia , Bolsa Periodontal/prevención & control , Periodontitis/prevención & control , Estudios Prospectivos , Aplanamiento de la Raíz/métodos , Método Simple Ciego , Resultado del TratamientoRESUMEN
BACKGROUND AND OBJECTIVE: Green tea extract exerts a variety of biological effects, including anti-inflammatory activities. However, there has been no report on the effect of green tea extract on loss of attachment, which is an important characteristic of periodontitis. Here, we examined the inhibitory effects of green tea extract on the onset of periodontitis in a rat model. MATERIAL AND METHODS: Rats were immunized intraperitoneally with Escherichia coli lipopolysaccharide (LPS). The LPS group (n = 12) received a topical application of LPS onto the palatal gingival sulcus every 24 h. The green tea extract group (n = 12) received a topical application of LPS mixed with green tea extract, sunphenon BG, every 24 h. The phosphate-buffered saline (PBS) group (n = 6) received a topical application of PBS every 24 h. The levels of anti-LPS immunoglobulin G (IgG) in serum were determined using ELISA. Rats in the LPS and green tea extract groups were killed after the 10th and 20th applications. Rats in the PBS group were killed after the 20th application. Loss of attachment, level of alveolar bone and inflammatory cell infiltration were investigated histopathologically and histometrically. RANKL-positive cells and the formation of immune complexes were evaluated immunohistologically. RESULTS: There was no significant difference in the serum levels of anti-LPS IgG between the LPS group and the green tea extract group. In contrast, loss of attachment, level of alveolar bone, inflammatory cell infiltration and RANKL expression in the green tea extract group were significantly decreased compared with those in the LPS group. CONCLUSION: These findings demonstrate that green tea extract suppresses the onset of loss of attachment and alveolar bone resorption in a rat model of experimental periodontitis.
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Antiinflamatorios/uso terapéutico , Camellia sinensis , Periodontitis/prevención & control , Fenoles/uso terapéutico , Extractos Vegetales/uso terapéutico , Pérdida de Hueso Alveolar/patología , Pérdida de Hueso Alveolar/prevención & control , Animales , Anticuerpos Antibacterianos/sangre , Complejo Antígeno-Anticuerpo/análisis , Tejido Conectivo/patología , Modelos Animales de Enfermedad , Inserción Epitelial/patología , Escherichia coli/inmunología , Inmunización , Inmunoglobulina G/sangre , Lipopolisacáridos/inmunología , Masculino , Osteoclastos/patología , Pérdida de la Inserción Periodontal/patología , Pérdida de la Inserción Periodontal/prevención & control , Periodontitis/patología , Fitoterapia , Ligando RANK/análisis , Ratas , Ratas Endogámicas LewRESUMEN
PURPOSE: The purpose of this study was to determine if a Health Coaching (HC) approach compared with formal health education (HE) resulted in better health outcomes among type II diabetes (T2DM) patients in improving glycaemic control and oral health, by use of clinical and subjective outcome measures. METHODS: The study is part of a prospective intervention among randomly selected T2DM patients (n = 186) in Istanbul, Turkey. The data analysed were clinical [glycated haemoglobin (HbA(1C)), clinical attachment loss (CAL)] and psychological measures [tooth-brushing self efficacy (TBSES)]. Data were collected initially and at the end of intervention. Participants were allocated randomly to HC (intervention) (n = 77) and HE (control) (n = 111) groups. RESULTS: At baseline, there was no statistical difference between HC and HE regarding clinical and psychological measures, (P > 0.05). At post-intervention the HC group had significantly lower HBA(1C) and CAL (reduction: 7%, 56%) than the HE group (reduction: HbA(1C) 0%; CAL 26%), (P ≤ 0.01). Similarly, HC group, compared with HE group, had better TBSES (increase: 61% vs. 25%) and stress (reduction: 16% vs. 1%), (P ≤ 0.01). Among high-risk group patients, the HC patients had significant improvements compared with the HE group (reduction: HbA(1C) 16% vs. 5%; CAL 63% vs. 18%; stress 39% vs. 2%; fold increase: TBSES 6.6 vs. 3.6) (P ≤ 0.01). CONCLUSIONS: The present findings may imply that HC has a significantly greater impact on better management of oral health and glycaemic control than HE. It is notable that the impact was more significant among high-risk group patients, thus HC may be recommended especially for high-risk group patients.
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Diabetes Mellitus Tipo 2/prevención & control , Educación en Salud/métodos , Promoción de la Salud/métodos , Enfermedades Periodontales/prevención & control , Adulto , Anciano , Glucemia/análisis , Diabetes Mellitus Tipo 2/sangre , Hemoglobina Glucada/análisis , Conductas Relacionadas con la Salud , Humanos , Estilo de Vida , Persona de Mediana Edad , Programación Neurolingüística , Higiene Bucal , Pérdida de la Inserción Periodontal/prevención & control , Poder Psicológico , Estudios Prospectivos , Autoeficacia , Estrés Fisiológico/fisiología , Estrés Psicológico/prevención & control , Cepillado DentalRESUMEN
AIM: This 3-month double-blind randomized placebo-controlled study evaluated the clinical and microbial effects of an essential oil mouth rinse used as an adjunct to mechanical plaque control by patients in supportive periodontal care. MATERIAL AND METHODS: Fifty patients were randomly allocated to an essential oil group (Listerine(®) Coolmint; Johnson & Johnson, New Brunswick, NJ, USA) or placebo group to rinse twice per day as an adjunct to mechanical plaque control. At baseline and after 3 months, plaque index (PI), gingivitis index (GI), probing pocket depth, bleeding on probing (BoP) and clinical attachment level were registered. Subgingival plaque samples were collected for the detection and quantification of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Micromonas micros, Prevotella intermedia, Fusobacterium genus and Streptococcus mutans by means of real-time PCR (qPCR). Patient's compliance, satisfaction and side effects were registered. RESULTS: Twenty-three patients in the essential oil group (mean age: 57) and 21 in the placebo group (mean age: 55) with acceptable oral hygiene at intake (mean PI <1.5 on a scale of 5) adhered to the study protocol. Gingivitis index, PI and BoP significantly reduced over time (P ≤ 0.029); however, between group analyses revealed no significant differences. There was no significant change over time neither in detection frequency nor load for any of the microbiota. Daily rinsing with an essential oil rinse was found safe and perceived beneficial by the patients. CONCLUSION: Patients in supportive periodontal care who are fairly compliant with oral hygiene may not benefit from additional mouth rinsing using an essential oil solution.
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Antiinfecciosos Locales/uso terapéutico , Antisépticos Bucales/uso terapéutico , Aceites Volátiles/uso terapéutico , Enfermedades Periodontales/prevención & control , Salicilatos/uso terapéutico , Terpenos/uso terapéutico , Adulto , Anciano , Anciano de 80 o más Años , Aggregatibacter actinomycetemcomitans/efectos de los fármacos , Bacteroides/efectos de los fármacos , Placa Dental/microbiología , Placa Dental/prevención & control , Placa Dental/terapia , Método Doble Ciego , Combinación de Medicamentos , Femenino , Estudios de Seguimiento , Fusobacterium/efectos de los fármacos , Hemorragia Gingival/prevención & control , Humanos , Masculino , Persona de Mediana Edad , Satisfacción del Paciente , Peptostreptococcus/efectos de los fármacos , Pérdida de la Inserción Periodontal/prevención & control , Enfermedades Periodontales/microbiología , Bolsa Periodontal/prevención & control , Placebos , Porphyromonas gingivalis/efectos de los fármacos , Prevotella intermedia/efectos de los fármacos , Streptococcus mutans/efectos de los fármacos , Resultado del Tratamiento , Treponema denticola/efectos de los fármacosRESUMEN
OBJECTIVE: This randomized controlled clinical trial was carried out to assess the effect of comprehensive nonsurgical periodontal treatment and strict plaque control performed during pregnancy on the reduction of preterm and/or low birth weight rates (PTLBW). MATERIAL AND METHODS: Three hundred and three women were randomly allocated to receive periodontal treatment either during pregnancy (n = 147, test group) or after delivery (n = 156, control group). During pregnancy, the control group received only one session of supragingival scaling and oral hygiene instruction. In contrast, the test group received comprehensive periodontal treatment including multiple sessions of scaling and root planing, oral hygiene instructions, and frequent maintenance visits. RESULTS: At baseline, periodontal inflammation was observed in approximately 50% of sites and attachment loss affected <15% of sites. Compared to controls, women in the test group had significant reductions in the percentage of sites with plaque (48.5% vs. 10.3%, p < 0.001), gingival bleeding (23.3% vs. 2.5%, p < 0.001), calculus (21.3% vs. 4.1%, p < 0.001), bleeding on probing (38.1% vs. 2.6%, p < 0.001) and probing depth ≥3 mm (19.97% vs. −2.45%, p < 0.001). No significant differences were observed between the groups in the occurrence of PT (11.7% vs. 9.1%, p = 0.57), LBW (5.6 % vs. 4.1%, p = 0.59), and PTLBW (4.15% vs. 2.60%, p = 0.53). CONCLUSIONS: Comprehensive periodontal treatment and strict plaque control significantly improved periodontal health; however, no reduction of PTLBW rates was observed. Thus, remaining periodontal inflammation posttreatment cannot explain the lack of effect of periodontal treatment on PTLBW. Clinical relevance This study demonstrated that periodontal diseases may be successfully treated during pregnancy. Our results do not support a potential beneficial effect of periodontal treatment on PTLBW.
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Placa Dental/prevención & control , Recién Nacido de Bajo Peso , Desbridamiento Periodontal/métodos , Enfermedades Periodontales/prevención & control , Complicaciones del Embarazo/prevención & control , Nacimiento Prematuro/prevención & control , Adulto , Atención Odontológica Integral , Cálculos Dentales/prevención & control , Raspado Dental/métodos , Escolaridad , Femenino , Hemorragia Gingival/prevención & control , Humanos , Recién Nacido , Higiene Bucal/educación , Educación del Paciente como Asunto , Pérdida de la Inserción Periodontal/prevención & control , Índice Periodontal , Bolsa Periodontal/prevención & control , Periodontitis/prevención & control , Embarazo , Resultado del Embarazo , Aplanamiento de la Raíz/métodos , Clase Social , Adulto JovenRESUMEN
BACKGROUND: A previous study reported by this group found that patients in periodontal maintenance programs taking vitamin D and calcium supplementation had a trend for better periodontal health compared to patients not taking supplementation. The objective of the present study is to determine, for the same cohort of subjects, whether such differences persist over a 1-year period. METHODS: Fifty-one patients enrolled in maintenance programs from two dental clinics were recruited. Of these, 23 were taking vitamin D (≥400 IU/day) and calcium (≥1,000 mg/day) supplementation, and 28 were not. All subjects had at least two interproximal sites with ≥3 mm clinical attachment loss. For mandibular-posterior teeth, gingival index, plaque index, probing depth, attachment loss, bleeding on probing, calculus index, and furcation involvement were evaluated. Photostimulable-phosphor, posterior bitewing radiographs were taken to assess alveolar bone. Daily vitamin D and calcium intakes were estimated by nutritional analysis. Data were collected at baseline, 6 months, and 12 months. RESULTS: Total daily calcium and vitamin D intakes were 1,769 mg (95% confidence interval, 1,606 to 1,933) and 1,049 IU (781 to 1,317) in the taker group, and 642 mg (505 to 779) and 156 IU (117 to 195) in the non-taker group, respectively (P <0.001 for both). Clinical parameters of periodontal health improved with time in both groups (P <0.001). When clinical measures were considered collectively, the differences between supplement takers and non-takers had the following P values: baseline (P = 0.061); 6 months (P = 0.049); and 12 months (P = 0.114). After adjusting for covariates, the P values for the effect of supplementation were as follows: baseline (P = 0.028); 6 months (P = 0.034); and 12 months (P = 0.058). CONCLUSIONS: Calcium and vitamin D supplementation (≤1,000 IU/day) had a modest positive effect on periodontal health, and consistent dental care improved clinical parameters of periodontal disease regardless of such supplements. Our findings support the possibility that vitamin D may positively impact periodontal health and confirm the need for randomized clinical trials on the effects of vitamin D on periodontitis.
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Calcio de la Dieta/uso terapéutico , Periodontitis Crónica/prevención & control , Suplementos Dietéticos , Vitamina D/uso terapéutico , Vitaminas/uso terapéutico , Anciano , Anciano de 80 o más Años , Pérdida de Hueso Alveolar/clasificación , Pérdida de Hueso Alveolar/prevención & control , Calcio de la Dieta/administración & dosificación , Calcio de la Dieta/análisis , Periodontitis Crónica/clasificación , Estudios de Cohortes , Cálculos Dentales/clasificación , Índice de Placa Dental , Profilaxis Dental , Raspado Dental , Femenino , Estudios de Seguimiento , Análisis de los Alimentos , Defectos de Furcación/clasificación , Defectos de Furcación/prevención & control , Hemorragia Gingival/clasificación , Hemorragia Gingival/prevención & control , Humanos , Masculino , Persona de Mediana Edad , Higiene Bucal , Pérdida de la Inserción Periodontal/clasificación , Pérdida de la Inserción Periodontal/prevención & control , Índice Periodontal , Bolsa Periodontal/clasificación , Bolsa Periodontal/prevención & control , Estudios Prospectivos , Radiografía de Mordida Lateral , Aplanamiento de la Raíz , Vitamina D/administración & dosificación , Vitamina D/análisis , Vitaminas/administración & dosificación , Vitaminas/análisisRESUMEN
BACKGROUND: A low dietary intake of vitamin D and calcium hastens bone loss and osteoporosis. Because vitamin D metabolites may also alter the inflammatory response and have antimicrobial effects, we studied whether the use of vitamin D and calcium supplements affects periodontal disease status. METHODS: A cohort of 51 subjects receiving periodontal maintenance therapy was recruited from two dental clinics; 23 were taking vitamin D (>or=400 IU/day) and calcium (>or=1,000 mg/day) supplementation, and 28 were not taking such supplementation. All subjects had at least two interproximal sites with >or=3 mm clinical attachment loss. Daily calcium and vitamin D intake (from food and supplements) were estimated by nutritional analysis. The following clinical parameters of periodontal disease were recorded for the mandibular posterior teeth: gingival index, probing depth, cemento-enamel junction-gingival margin distance (attachment loss), bleeding on probing, and furcation involvement. Posterior photostimulable-phosphor bitewing radiographs were taken to determine cemento-enamel junction-alveolar crest distances (alveolar crest height loss). Data were analyzed with a repeated-measures multivariate analysis of variance. RESULTS: Compared to subjects who did not take vitamin D and calcium supplementation, supplement takers had shallower probing depths, fewer bleeding sites, lower gingival index values, fewer furcation involvements, less attachment loss, and less alveolar crest height loss. The repeated-measures analysis indicated that collectively these differences were borderline significant (P = 0.08). CONCLUSIONS: In these subjects receiving periodontal maintenance therapy, there was a trend for better periodontal health with vitamin D and calcium supplementation. More expanded longitudinal studies are required to determine the potential of this relationship.
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Calcio de la Dieta/uso terapéutico , Periodontitis Crónica/prevención & control , Suplementos Dietéticos , Vitamina D/uso terapéutico , Vitaminas/uso terapéutico , Anciano , Anciano de 80 o más Años , Pérdida de Hueso Alveolar/clasificación , Pérdida de Hueso Alveolar/prevención & control , Proceso Alveolar/patología , Periodontitis Crónica/clasificación , Estudios de Cohortes , Estudios Transversales , Femenino , Defectos de Furcación/clasificación , Defectos de Furcación/prevención & control , Encía/patología , Hemorragia Gingival/clasificación , Hemorragia Gingival/prevención & control , Humanos , Masculino , Persona de Mediana Edad , Pérdida de la Inserción Periodontal/clasificación , Pérdida de la Inserción Periodontal/prevención & control , Índice Periodontal , Bolsa Periodontal/clasificación , Bolsa Periodontal/prevención & control , Radiografía de Mordida Lateral , Cuello del Diente/patologíaRESUMEN
BACKGROUND: The aim of this study was to evaluate histologically and histometrically the influence of photodynamic therapy (PDT) as an adjuvant treatment on induced periodontitis in rats with diabetes. METHODS: Two hundred forty rats were divided evenly into two groups: non-diabetic (ND; n = 120) and alloxan diabetic (D; n = 120). Periodontal disease was induced in both groups at the first mandibular molar. After 7 days, the ligature was removed, and all animals underwent scaling and root planing (SRP) and were divided according to the following treatments: irrigation with saline solution (SRP); irrigation with a phenothiazinium dye (100 microg/ml) (TBO); laser irradiation (660 nm, 24 J) (LLLT); and PDT (TBO and laser irradiation). Ten animals in each experimental group and treatment subgroup were euthanized at 7, 15, and 30 days. The histometric values were analyzed statistically (P <0.05). RESULTS: In the ND group, the animals treated by PDT showed less bone loss (0.33 +/- 0.05 mm(2), 0.35 +/- 0.06 mm(2), and 0.27 +/- 0.07 mm(2) at 7, 15, and 30 days, respectively; P <0.05) at all experimental periods than the SRP group (1.11 +/- 0.11 mm(2), 0.84 +/- 0.12 mm(2), and 0.97 +/- 0.13 mm(2) at 7, 15, and 30 days, respectively), the TBO group (0.51 +/- 0.12 mm(2), 0.70 +/- 0.13 mm(2), and 0.64 +/- 0.08 mm(2) at 7, 15, and 30 days, respectively), and the LLLT group (0.59 +/- 0.03 mm(2), 0.61 +/- 0.04 mm(2), and 0.60 +/- 0.03 mm(2) at 7, 15, and 30 days, respectively). In the D group, the animals treated by PDT showed less bone loss (0.29 +/- 0.03 mm(2), 0.24 +/- 0.02 mm(2), and 0.27 +/- 0.06 mm(2) at 7, 15, and 30 days, respectively; P <0.05) at all experimental periods than the SRP group (2.27 +/- 0.47 mm(2), 3.23 +/- 0.34 mm(2), and 2.82 +/- 0.75 mm(2) at 7, 15, and 30 days, respectively), the TBO group (0.51 +/- 0.15 mm(2), 0.44 +/- 0.07 mm(2), and 0.57 +/- 0.13 mm(2) at 7, 15, and 30 days, respectively), and the LLLT group (0.37 +/- 0.05 mm(2), 0.35 +/- 0.09 mm(2), and 0.39 +/- 0.12 mm(2) at 7, 15, and 30 days, respectively). CONCLUSION: PDT was a beneficial adjuvant treatment for periodontal diseases induced by bacterial plaque and systemically modified by diabetes mellitus.
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Pérdida de Hueso Alveolar/prevención & control , Diabetes Mellitus Experimental/complicaciones , Defectos de Furcación/tratamiento farmacológico , Pérdida de la Inserción Periodontal/prevención & control , Periodontitis/tratamiento farmacológico , Fotoquimioterapia , Pérdida de Hueso Alveolar/complicaciones , Análisis de Varianza , Animales , Diabetes Mellitus Experimental/fisiopatología , Defectos de Furcación/complicaciones , Terapia por Luz de Baja Intensidad/métodos , Masculino , Pérdida de la Inserción Periodontal/complicaciones , Periodontitis/complicaciones , Fenotiazinas/uso terapéutico , Fármacos Fotosensibilizantes/uso terapéutico , Ratas , Ratas Wistar , Estadísticas no ParamétricasRESUMEN
BACKGROUND: Studies in vitro showed that eucalyptus extracts possess antibacterial activity against cariogenic and periodontopathic bacteria; however, the clinical effects with respect to periodontal health in humans remain unproven. The objective of this study was to evaluate the effect of chewing gum containing eucalyptus extract on periodontal health in a double-masked, randomized, controlled trial. METHODS: Healthy humans with gingivitis but not deep periodontal pockets were randomly assigned to the following groups: high-concentration group (n=32): use of 0.6% eucalyptus extract chewing gum for 12 weeks (90 mg/day); low-concentration group (n=32): use of 0.4% eucalyptus extract chewing gum for 12 weeks (60 mg/day); and placebo group (n=33): use of chewing gum without eucalyptus extract for 12 weeks. Plaque accumulation (PLA), gingival index (GI), bleeding on probing (BOP), periodontal probing depth (PD), and clinical attachment level (CAL) were measured at weeks 0, 4, 8, 12, and 14. Significance was analyzed with repeated-measures two-way analysis of variance followed by the Games-Howell pairwise comparison test. RESULTS: The interaction between the effects of eucalyptus extract chewing gum and the intake period was statistically significant for PLA, GI, BOP, and PD but not for CAL. The low- and high-concentration groups exhibited statistically significant (P <0.05) improvements compared to the placebo group for PLA, GI, BOP, and PD. CONCLUSIONS: Eucalyptus extract chewing gum had a significant effect on PLA, GI, BOP, and PD. The use of eucalyptus extract chewing gum may promote periodontal health.
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Goma de Mascar , Eucalyptus , Gingivitis/tratamiento farmacológico , Fitoterapia , Extractos Vegetales/uso terapéutico , Adulto , Placa Dental/prevención & control , Índice de Placa Dental , Raspado Dental , Método Doble Ciego , Femenino , Hemorragia Gingival/prevención & control , Humanos , Masculino , Persona de Mediana Edad , Pérdida de la Inserción Periodontal/prevención & control , Índice Periodontal , Bolsa Periodontal/prevención & control , Placebos , Extractos Vegetales/administración & dosificaciónAsunto(s)
Antiinfecciosos Locales/uso terapéutico , Implantes Dentales , Antisépticos Bucales/uso terapéutico , Aceites Volátiles/uso terapéutico , Enfermedades Periodontales/prevención & control , Clorhexidina/uso terapéutico , Placa Dental/prevención & control , Combinación de Medicamentos , Gingivitis/prevención & control , Humanos , Higiene Bucal , Pérdida de la Inserción Periodontal/prevención & control , Índice Periodontal , Bolsa Periodontal/prevención & control , Salicilatos/uso terapéutico , Terpenos/uso terapéuticoRESUMEN
The present study was undertaken to investigate if subgingival administration of an EDTA gel has any adjunctive effect to subgingival and supragingival root debridement. The investigation was performed in one study center involving 6 clinical investigators and 91 patients. The patients were selected from 2 patient populations: 41 were included from a consecutive referral material on a voluntary basis, and 50 were included from a maintenance care material at the clinic. No significant differences were found between the EDTA-treated and control groups with respect to clinical attachment gain or probing pocket depth reduction. The referral patients showed a significant improvement of pocket depth and attachment gain compared to maintenance care patients at the clinic. In multiple regression analyses, it was found that patients with small attachment losses at baseline responded better to treatment than patients with severe periodontitis. Also, in multivariate analyses, referral patients responded better than maintenance patients when controlling for other predictors.