RESUMEN
AIM: To study the effect of jujuboside A (JuA), one constituent of Chinese herbal medicine Ziziphus jujuba Mill Var spinosa (Bunge) Hu,on the penicillin sodium induced hyperactivity in rat CA1 neurons in vitro. METHODS: Hippocampal slices were obtained from the Sprague-Dawley rat brain and populational signals were measured from CA1 neurons of hippocampal slices using the extracellular recording technique. RESULTS: Penicillin sodium of 500, 1000, and 2000 kU/L were found to excite hippocampal CA1 neurons in a concentration-dependent manner in vitro. This excitatory effect of penicillin sodium could be inhibited by phenobarbital sodium of 0.02 - 0.05 g/L and JuA of 0.05 - 0.10 g/L. CONCLUSION: A high dose of JuA can inhibit the hyperactivity of hippocampal CA1 area induced by penicillin sodium. The inhibition of the amplitude of the first population spike (PS) and the latency of PS are more pronounced than the slope of the field excitatory post-synaptic potential.
Asunto(s)
Hipocampo/efectos de los fármacos , Penicilina G/antagonistas & inhibidores , Penicilinas/antagonistas & inhibidores , Saponinas/farmacología , Animales , Hipersensibilidad a las Drogas/tratamiento farmacológico , Interacciones Farmacológicas , Femenino , Hipocampo/fisiopatología , Técnicas In Vitro , Masculino , Neuronas/efectos de los fármacos , Neuronas/fisiología , Penicilina G/efectos adversos , Penicilinas/efectos adversos , Terminales Presinápticos/fisiología , Ratas , Ratas Sprague-Dawley , Saponinas/uso terapéuticoRESUMEN
The clinical efficacy of a vilozen and ketotifen (zaditen) combination in the treatment of streptococcal infections along with the routine therapy was studied. The use of the combination was shown advisable in the complex therapy and prevention of relapses in patients with streptococcal infections. The combined pharmacotherapy promoted better clinical indices, normalization of the immune status and a reduction in the incidence of allergic reactions to antibiotics and a decrease in sensitization to bacterial allergens.
Asunto(s)
Hipersensibilidad a las Drogas/prevención & control , Erisipela/tratamiento farmacológico , Inmunosupresores/administración & dosificación , Cetotifen/administración & dosificación , Lincomicina/administración & dosificación , Penicilina G/administración & dosificación , Faringitis/tratamiento farmacológico , Infecciones Estreptocócicas/tratamiento farmacológico , Extractos del Timo/administración & dosificación , Adyuvantes Inmunológicos , Hipersensibilidad a las Drogas/etiología , Erisipela/complicaciones , Erisipela/inmunología , Humanos , Lincomicina/efectos adversos , Lincomicina/antagonistas & inhibidores , Penicilina G/efectos adversos , Penicilina G/antagonistas & inhibidores , Faringitis/complicaciones , Faringitis/inmunología , Infecciones Estreptocócicas/complicaciones , Infecciones Estreptocócicas/inmunologíaRESUMEN
The present study has been performed to investigate the effect of i.v. administration of taurine on the electrical activity of the epileptogenic focus induced by penicillin applied to the right sensory motor cortex of adult rats. Taurine (100 mg/kg body weight) was administered 15, 30, 60, and 120 min before the application of penicillin. The EEG was unipolarly recorded by means of electrodes applied to the pia. Taurine caused a decrease of the frequency as well as the spike amplitude of epileptic discharge. The spread of epileptogenic foci to the opposite hemisphere was retarded when compared to that of control animals. The maximal antiepileptic effect of taurine was observed when the amino acid was administered 30-60 min previous to penicillin. It is suggested that high concentrations of taurine in the brain might be necessary to inhibit the epileptic activity.