Asunto(s)
Antibacterianos/uso terapéutico , Piomiositis/tratamiento farmacológico , Piomiositis/microbiología , Infecciones Estafilocócicas/tratamiento farmacológico , Infecciones Estafilocócicas/microbiología , Staphylococcus aureus , Teicoplanina/análogos & derivados , Diabetes Mellitus Tipo 2/complicaciones , Farmacorresistencia Bacteriana , Humanos , Masculino , Pruebas de Sensibilidad Microbiana , Persona de Mediana Edad , Teicoplanina/uso terapéuticoAsunto(s)
Diabetes Mellitus Tipo 2/complicaciones , Infecciones por Escherichia coli/microbiología , Músculo Esquelético/microbiología , Pielonefritis/microbiología , Piomiositis/microbiología , Enfermedad Aguda , Anciano , Antibacterianos/uso terapéutico , Antiinflamatorios no Esteroideos/uso terapéutico , Nalgas , Desbridamiento , Diabetes Mellitus Tipo 2/diagnóstico , Infecciones por Escherichia coli/diagnóstico , Infecciones por Escherichia coli/tratamiento farmacológico , Femenino , Humanos , Pruebas de Sensibilidad Microbiana , Músculo Esquelético/cirugía , Pielonefritis/diagnóstico , Pielonefritis/tratamiento farmacológico , Piomiositis/diagnóstico , Piomiositis/terapia , Tomografía Computarizada por Rayos X , Resultado del TratamientoRESUMEN
Nitric oxide (NO) is a critical component of host defense against invading pathogens; however, its therapeutic utility is limited due to a lack of practical delivery systems. Recently, a NO-releasing nanoparticulate platform (NO-np) was shown to have in vitro broad-spectrum antimicrobial activity and in vivo pre-clinical efficacy in a dermal abscess model. To extend these findings, both topical (TP) and intralesional (IL) NO-np administration was evaluated in a MRSA intramuscular murine abscess model and compared with vancomycin. All treatment arms accelerated abscess clearance clinically, histologically, and by microbiological assays on both days 4 and 7 following infection. However, abscesses treated with NO-np via either route demonstrated a more substantial, statistically significant decrease in bacterial survival based on colony forming unit assays and histologically revealed less inflammatory cell infiltration and preserved muscular architecture. These data suggest that the NO-np may be an effective addition to our armament for deep soft tissue infections.
Asunto(s)
Absceso/tratamiento farmacológico , Antibacterianos/administración & dosificación , Portadores de Fármacos/química , Nanopartículas/química , Óxido Nítrico/administración & dosificación , Piomiositis/tratamiento farmacológico , Absceso/microbiología , Animales , Antibacterianos/química , Sistemas de Liberación de Medicamentos , Evaluación Preclínica de Medicamentos , Femenino , Humanos , Staphylococcus aureus Resistente a Meticilina/efectos de los fármacos , Staphylococcus aureus Resistente a Meticilina/fisiología , Ratones , Ratones Endogámicos BALB C , Óxido Nítrico/química , Piomiositis/microbiologíaRESUMEN
In absence of risk factors, osteoarticular infections by coagulase-negative staphylococci are very infrequent. We described the case of a immunocompetent 73-year-old-woman that suffered pyomyositis, left sacroiliitis and spondylodiscitis involving the first and second thoracic vertebrae by Staphylococcus hominis. This multifocal infection occurred five-weeks after intramuscular administration of NSAI for treatment of low back pain associated with a herniated disc L4-L5. This is the first know case of a multifocal muscle skeletal infection by Staphylococcus hominis in a patient immunocompetent.