RESUMEN
Six new bisabolane-type phenolic sesquiterpenoids, including plakordiols A-D (1-4), (7R, 10R)-hydroxycurcudiol (5) and (7R, 10S)-hydroxycurcudiol (6) were isolated from the marine sponge Plakortis simplex collected from the South China Sea. Their structures were determined based on extensive analysis of spectroscopic data. Their configurations were assigned by coupling constant analysis, NOESY correlations, and the modified Mosher's method. Furthermore, their cytotoxic and antibacterial activities were evaluated.
Asunto(s)
Sesquiterpenos Monocíclicos , Plakortis , Animales , Antibacterianos/farmacología , China , Estructura Molecular , Sesquiterpenos Monocíclicos/farmacología , Océano Pacífico , Plakortis/químicaRESUMEN
Four new polyhydroxylated steroids plaksterols A-D (1-4), together with two known related steroids ergost-7,9(11),22-trien-3ß,5α,6α-triol (5) and ergosta-6ß-methoxy-7,22-diene-3ß,5α-diol (6), were isolated from methanol extract of the South China Sea marine sponge Plakortis sp. Their structures were identified by spectroscopic analysis, including NMR, MS, and IR. The cytotoxicity of the polyhydroxylated steroids were evaluated, and compound 6 showed moderate inhibitory activities against K562, HL-60 and BEL-7402 cells.
Asunto(s)
Plakortis/química , Esteroides/química , Animales , Línea Celular Tumoral , China , Humanos , Estructura Molecular , Océano Pacífico , Esteroides/aislamiento & purificación , Esteroides/farmacologíaRESUMEN
Five new polyketide endoperoxides, manadodioxans A-E, were isolated from the marine sponge Plakortis bergquistae. Manadodioxan E showed antimicrobial activity against Escherichia coli at 10 µg/disk, while its oxo congener, manadodioxan D, was inactive.