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1.
ACS Appl Mater Interfaces ; 13(31): 37535-37544, 2021 Aug 11.
Artículo en Inglés | MEDLINE | ID: mdl-34324300

RESUMEN

Combined therapeutic strategies for bacterial infection have attracted worldwide attention owing to their faster and more effective therapy with fewer side effects compared with monotherapy. In this work, gold-platinum nanodots (AuPtNDs) are simply and quickly synthesized by a one-step method. They not only exhibit powerful peroxidase-like activity but also confer a higher affinity for hydrogen peroxide (H2O2), which is 3.4 times that of horseradish peroxidase. Under 808 nm laser irradiation, AuPtNDs also have excellent photothermal conversion efficiency (50.53%) and strong photothermal stability. Excitingly, they can combat bacterial infection through the combination of chemodynamic and photothermal therapy. In vitro antibacterial results show that the combined antibacterial strategy has a broad-spectrum antibacterial property against both Escherichia coli (Gram negative, 97.1%) and Staphylococcus aureus (Gram positive, 99.3%). Animal experiments further show that nanodots can effectively promote the healing of bacterial infection wounds. In addition, owing to good biocompatibility and low toxicity, they are hardly traceable in the main organs of mice, which indicates that they can be well excreted through metabolism. These results reveal the application potential of AuPtNDs as a simple and magic multifunctional nanoparticle in antibacterial therapy and open up new applications for clinical anti-infective therapy in the near future.


Asunto(s)
Antibacterianos/uso terapéutico , Puntos Cuánticos/uso terapéutico , Infecciones Cutáneas Estafilocócicas/tratamiento farmacológico , Animales , Antibacterianos/síntesis química , Antibacterianos/efectos de la radiación , Antibacterianos/toxicidad , Catálisis , Escherichia coli/efectos de los fármacos , Oro/química , Oro/efectos de la radiación , Oro/uso terapéutico , Oro/toxicidad , Células HEK293 , Humanos , Rayos Infrarrojos , Ratones Endogámicos BALB C , Pruebas de Sensibilidad Microbiana , Terapia Fototérmica , Platino (Metal)/química , Platino (Metal)/efectos de la radiación , Platino (Metal)/uso terapéutico , Platino (Metal)/toxicidad , Puntos Cuánticos/química , Puntos Cuánticos/efectos de la radiación , Puntos Cuánticos/toxicidad , Staphylococcus aureus/efectos de los fármacos , Cicatrización de Heridas/efectos de los fármacos
2.
ACS Appl Mater Interfaces ; 13(30): 35365-35375, 2021 Aug 04.
Artículo en Inglés | MEDLINE | ID: mdl-34286953

RESUMEN

Phototherapy exhibits significant potential as a novel tumor treatment method, and the development of highly active photosensitizers and photothermal agents has drawn considerable attention. In this work, S and N atom co-doped carbon dots (S,N-CDs) with an absorption redshift effect were prepared by hydrothermal synthesis with lysine, o-phenylenediamine, and sulfuric acid as raw materials. The near-infrared (NIR) absorption features of the S,N-CDs resulted in two-photon (TP) emission, which has been used in TP fluorescence imaging of lysosomes and tumor tissue pH and real-time monitoring of apoptosis during tumor phototherapy, respectively. The obtained heteroatom co-doped CDs can be used not only as an NIR imaging probe but also as an effective photodynamic therapy/photothermal therapy (PDT/PTT) therapeutic agent. The efficiencies of different heteroatom-doped CDs in tumor treatment were compared. It was found that the S,N-CDs showed higher therapeutic efficiency than N-doped CDs, the efficiency of producing 1O2 was 27%, and the photothermal conversion efficiency reached 34.4%. The study provides new insight into the synthesis of carbon-based nanodrugs for synergistic phototherapy and accurate diagnosis of tumors.


Asunto(s)
Antineoplásicos/uso terapéutico , Colorantes Fluorescentes/uso terapéutico , Neoplasias/diagnóstico por imagen , Neoplasias/tratamiento farmacológico , Fármacos Fotosensibilizantes/uso terapéutico , Puntos Cuánticos/uso terapéutico , Animales , Antineoplásicos/química , Antineoplásicos/efectos de la radiación , Apoptosis/efectos de los fármacos , Carbono/química , Carbono/efectos de la radiación , Colorantes Fluorescentes/química , Colorantes Fluorescentes/efectos de la radiación , Fluorometría , Células HeLa , Humanos , Concentración de Iones de Hidrógeno , Lisosomas/metabolismo , Ratones Desnudos , Neoplasias/metabolismo , Nitrógeno/química , Nitrógeno/efectos de la radiación , Fotones , Fármacos Fotosensibilizantes/química , Fármacos Fotosensibilizantes/efectos de la radiación , Fototerapia , Puntos Cuánticos/química , Puntos Cuánticos/efectos de la radiación , Oxígeno Singlete/metabolismo , Azufre/química , Azufre/efectos de la radiación
3.
ACS Appl Mater Interfaces ; 13(8): 10564-10573, 2021 Mar 03.
Artículo en Inglés | MEDLINE | ID: mdl-33605723

RESUMEN

Intratumoral hypoxia significantly constrains the susceptibility of solid tumors to oxygen-dependent photodynamic therapy (PDT), and effort to reverse such hypoxia has achieved limited success to date. Herein, we developed a novel engineered bacterial system capable of targeting hypoxic tumor tissues and efficiently mediating the photodynamic treatment of these tumors. For this system, we genetically engineered Escherichia coli to express catalase, after which we explored an electrostatic adsorption approach to link black phosphorus quantum dots (BPQDs) to the surface of these bacteria, thereby generating an engineered E. coli/BPQDs (EB) system. Following intravenous injection, EB was able to target hypoxic tumor tissues. Subsequent 660 nm laser irradiation drove EB to generate reactive oxygen species (ROS) and destroy the membranes of these bacteria, leading to the release of catalase that subsequently degrades hydrogen peroxide to yield oxygen. Increased oxygen levels alleviate intratumoral hypoxia, thereby enhancing BPQD-mediated photodynamic therapy. This system was able to efficiently kill tumor cells in vivo, exhibiting good therapeutic efficacy. In summary, this study is the first to report the utilization of engineered bacteria to facilitate PDT, and our results highlight new avenues for BPQD-mediated cancer treatment.


Asunto(s)
Antineoplásicos/uso terapéutico , Hipoxia/tratamiento farmacológico , Neoplasias/tratamiento farmacológico , Fósforo/uso terapéutico , Fármacos Fotosensibilizantes/uso terapéutico , Puntos Cuánticos/uso terapéutico , Animales , Antineoplásicos/química , Antineoplásicos/efectos de la radiación , Catalasa/genética , Catalasa/metabolismo , Ingeniería Celular , Línea Celular Tumoral , Membrana Celular/efectos de los fármacos , Escherichia coli/efectos de los fármacos , Escherichia coli/enzimología , Escherichia coli/genética , Hipoxia/etiología , Ratones Endogámicos BALB C , Neoplasias/complicaciones , Oxígeno/metabolismo , Fósforo/química , Fósforo/efectos de la radiación , Fotoquimioterapia , Fármacos Fotosensibilizantes/química , Fármacos Fotosensibilizantes/efectos de la radiación , Puntos Cuánticos/química , Puntos Cuánticos/efectos de la radiación , Especies Reactivas de Oxígeno/metabolismo
4.
Langmuir ; 35(47): 15320-15329, 2019 11 26.
Artículo en Inglés | MEDLINE | ID: mdl-31682135

RESUMEN

Use of nanomaterials blessed with both therapeutic and diagnostic properties is a proficient strategy in the treatment of cancer in its early stage. In this context, our paper reports the synthesis of uniform size N-rich mesoporous carbon nanospheres of size 65-70 nm from pyrrole and aniline precursors using Triton-X as a structure-directing agent. Transmission electron microscopy reveals that these carbons spheres contain void spaces in which ultrasmall nitrogen-doped quantum dots (NCQD) are captured within the matrix. These mesoporous hollow NCQD captured carbon spheres (NCQD-HCS) show fluorescence quantum yield up to 14.6% under λex = 340 nm. Interestingly, samples calcined at >800 °C clearly absorb in the wavelength range 700-1000 nm and shows light-to-heat conversion efficiency up to 52%. In vitro experiments in human oral cancer cells (FaDu) show that NCQD-HCS are internalized by the cells and induce a substantial thermal ablation effect in FaDu cells when exposed under a 980 nm near-infrared laser.


Asunto(s)
Antineoplásicos/farmacología , Colorantes Fluorescentes/farmacología , Puntos Cuánticos/química , Antineoplásicos/síntesis química , Antineoplásicos/efectos de la radiación , Apoptosis/efectos de los fármacos , Carbono/química , Carbono/efectos de la radiación , Línea Celular Tumoral , Colorantes Fluorescentes/síntesis química , Colorantes Fluorescentes/efectos de la radiación , Humanos , Hipertermia Inducida/métodos , Rayos Infrarrojos , Microscopía Confocal/métodos , Microscopía Fluorescente/métodos , Neoplasias de la Boca/tratamiento farmacológico , Nitrógeno/química , Nitrógeno/efectos de la radiación , Fototerapia/métodos , Puntos Cuánticos/efectos de la radiación , Nanomedicina Teranóstica/métodos
5.
Analyst ; 144(24): 7421-7431, 2019 Dec 02.
Artículo en Inglés | MEDLINE | ID: mdl-31686073

RESUMEN

Carbon dots (CDs) are a developing stable, conductive, and environmentally friendly fluorescent nanomaterial with potential applications in biomedicine and sensing. In this study, CDs with up- and down-conversion photoluminescence characteristics were prepared via a one-pot hydrothermal method using coffee beans as the sole raw material. Fourier transform infrared spectra and X-ray photoelectron spectroscopy showed the presence of nitrogen and oxygen functional groups on the CDs surfaces. Transmission electron microscopy showed that the CDs were spherical with an average size of 4.6 nm. The CDs precursor and synthesis process are environmentally benign, and the resulting CDs exhibit excellent photostability, reversible fluorescence response to temperature, and good ionic-strength tolerance. Moreover, these CDs can be used as efficient fluorescence probes in selective and sensitive Fe3+ detection by a dual-readout assay. The down- and up-conversion fluorescence measurements from the CDs were in the linear range for 0-0.10 mM Fe3+ with the detection limits of 15.4 and 16.3 nM, respectively. Furthermore, the CDs were successfully applied to intracellular sensing and imaging Fe3+ ions, indicating their potential use in bioscience applications.


Asunto(s)
Café/química , Colorantes Fluorescentes/química , Hierro/análisis , Puntos Cuánticos/química , Semillas/química , Carbono/química , Carbono/efectos de la radiación , Colorantes Fluorescentes/síntesis química , Colorantes Fluorescentes/efectos de la radiación , Tecnología Química Verde/métodos , Luz , Límite de Detección , Microscopía Confocal/métodos , Microscopía Fluorescente/métodos , Puntos Cuánticos/efectos de la radiación , Solubilidad , Espectrometría de Fluorescencia/métodos , Agua/química , Levaduras
7.
J Inorg Biochem ; 193: 166-172, 2019 04.
Artículo en Inglés | MEDLINE | ID: mdl-30772693

RESUMEN

Due to the traditional therapies of cancer inducing huge pains to patients, the non-invasive photo-guided therapies are attracting massive attentions of researchers. Herein, the intelligent-designed carbon-dots/hemin nanoplatforms (HCDs NPs) were developed, owning high-authority photo-therapy for cancer. The fluorescence resonance energy transfer (FRET) effect enhanced the photo-thermal ability of HCDs NPs, endowing the synthesized nanoplatforms with photo-dynamic property simultaneously. Therefore, the obtained HCDs NPs could achieve synergetic photo-thermal and photo-dynamic therapies for cancer. Basing on the experimental results, the prepared HCDs NPs could induce the temperature enhancement high to ca 26 °C under laser irradiation, also with the outstanding photo-dynamic efficacy. More than 90% of cancer cells die after 10 min laser treatment. Thus, the dual-modal photo-therapeutic HCDs NPs are promising and excellent nanomaterials for potential application in synergistic cancer therapy.


Asunto(s)
Antineoplásicos/farmacología , Hemina/farmacología , Puntos Cuánticos/química , Antineoplásicos/efectos de la radiación , Antineoplásicos/toxicidad , Carbono/química , Carbono/efectos de la radiación , Carbono/toxicidad , Transferencia Resonante de Energía de Fluorescencia , Hemina/efectos de la radiación , Hemina/toxicidad , Células Hep G2 , Humanos , Hipertermia Inducida , Luz , Tamaño de la Partícula , Fotoquimioterapia , Puntos Cuánticos/efectos de la radiación , Puntos Cuánticos/toxicidad , Especies Reactivas de Oxígeno/metabolismo , Solubilidad , Temperatura
8.
Anal Chim Acta ; 1048: 42-49, 2019 Feb 07.
Artículo en Inglés | MEDLINE | ID: mdl-30598156

RESUMEN

A novel enhanced photoelectrochemical (PEC) DNA biosensor, based on a compact heterojunction g-C3N4/MoS2 and co-sensitization effect with CdSe quantum dots (QDs), was first proposed for simple and accurate analysis of a short ssDNA. In this work, the g-C3N4/MoS2 was successfully synthesized and used as the electrode matrix material to construct PEC biosensor. 2D/2D heterojunction was formed between g-C3N4 and MoS2, which could promote the separation of photogenerated electron-hole pairs resulting in an enhanced photocurrent. In the presence of target DNA, CdSe QDs labeled reporter DNA was complementary pairing with target DNA which was specific recognized by capture DNA loading on self-assembled CdS QDs film, leading to close contact between CdSe QDs and g-C3N4/MoS2 modified electrode surface, thereby resulting in the enhanced photocurrent intensity due to the co-sensitization effect. Under the optimal operating conditions, the photoelectrochemical biosensor demonstrated favorable accuracy and could respond to 0.32 pM (S/N = 3) with a linear concentration range from 1.0 pM to 2.0 µM. Moreover, the proposed PEC DNA biosensor exhibits high sensitivity, excellent specificity, acceptable reproducibility and accuracy, showing a promising potential in DNA bioanalysis and other relative fields.


Asunto(s)
Técnicas Biosensibles/métodos , ADN de Cadena Simple/análisis , Técnicas Electroquímicas/métodos , Fotoquímica/métodos , Puntos Cuánticos/química , Compuestos de Cadmio/química , Compuestos de Cadmio/efectos de la radiación , ADN de Cadena Simple/genética , Disulfuros/química , Electrodos , Luz , Límite de Detección , Molibdeno/química , Nitrilos/química , Hibridación de Ácido Nucleico , Puntos Cuánticos/efectos de la radiación , Compuestos de Selenio/química , Compuestos de Selenio/efectos de la radiación
9.
Nanoscale Horiz ; 4(1): 117-137, 2019 01 01.
Artículo en Inglés | MEDLINE | ID: mdl-32254148

RESUMEN

Due to the increasing global population, growing contamination of water and air, and wide spread of infectious diseases, antibiotics are extensively used as a major antibacterial drug. However, many microbes have developed resistance to antibiotics through mutation over time. As an alternative to antibiotics, antimicrobial nanomaterials have attracted great attention due to their advantageous properties and unique mechanisms of action toward microbes. They inhibit bacterial growth and destroy cells through complex mechanisms, making it difficult for bacteria to develop drug resistance, though some health concerns related to biocompatibility remain for practical applications. Among various antibacterial nanomaterials, carbon-based materials, especially graphene oxide (GO) and carbon dots (C-Dots), are promising candidates due to the ease of production and functionalization, high dispersibility in aqueous media, and promising biocompatibility. The antibacterial properties of these nanomaterials can be easily adjusted by surface modification. They are promising materials for future applications against multidrug-resistant bacteria based on their strong capacity in disruption of microbial membranes. Though many studies have reported excellent antibacterial activity of carbon nanomaterials, their impact on the environment and living organisms is of concern due to the accumulatory and cytotoxic effects. In this review, we discuss antimicrobial applications of the functional carbon nanomaterials (GO and C-Dots), their antibacterial mechanisms, factors affecting antibacterial activity, and concerns regarding cytotoxicity.


Asunto(s)
Antibacterianos/uso terapéutico , Bacterias/efectos de los fármacos , Grafito/uso terapéutico , Puntos Cuánticos/uso terapéutico , Animales , Antibacterianos/efectos de la radiación , Antibacterianos/toxicidad , Membrana Celular/efectos de los fármacos , Grafito/química , Grafito/efectos de la radiación , Grafito/toxicidad , Peróxido de Hidrógeno/farmacología , Luz , Pruebas de Sensibilidad Microbiana , Puntos Cuánticos/química , Puntos Cuánticos/efectos de la radiación , Puntos Cuánticos/toxicidad , Infecciones Estafilocócicas/tratamiento farmacológico
10.
Curr Med Chem ; 26(10): 1788-1805, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-28933294

RESUMEN

Ascribe to the unique two-dimensional planar nanostructure with exceptional physical and chemical properties, black phosphorous (BP) as the emerging inorganic twodimensional nanomaterial with high biocompatibility and degradability has been becoming one of the most promising materials of great potentials in biomedicine. The exfoliated BP sheets possess ultra-high surface area available for valid bio-conjugation and molecular loading for chemotherapy. Utilizing the intrinsic near-infrared optical absorbance, BPbased photothermal therapy in vivo, photodynamic therapy and biomedical imaging has been realized, achieving unprecedented anti-tumor therapeutic efficacy in animal experiments. Additionally, the BP nanosheets can strongly react with oxygen and water, and finally degrade to non-toxic phosphate and phosphonate in the aqueous solution. This manuscript aimed to summarize the preliminary progresses on theranostic application of BP and its derivatives black phosphorus quantum dots (BPQDs), and discussed the prospects and the state-of-art unsolved critical issues of using BP-based material for theranostic applications.


Asunto(s)
Fósforo/uso terapéutico , Puntos Cuánticos/uso terapéutico , Animales , Técnicas Biosensibles/métodos , Línea Celular Tumoral , Portadores de Fármacos/química , Portadores de Fármacos/efectos de la radiación , Portadores de Fármacos/uso terapéutico , Portadores de Fármacos/toxicidad , Humanos , Luz , Neoplasias/tratamiento farmacológico , Neoplasias/terapia , Imagen Óptica/métodos , Fósforo/química , Fósforo/efectos de la radiación , Fósforo/toxicidad , Puntos Cuánticos/química , Puntos Cuánticos/efectos de la radiación , Puntos Cuánticos/toxicidad , Nanomedicina Teranóstica/métodos
11.
ChemMedChem ; 13(22): 2437-2447, 2018 11 20.
Artículo en Inglés | MEDLINE | ID: mdl-30288948

RESUMEN

In the present study, a pH/redox-responsive cationic polymer dot (CD) was successfully prepared for a near-infrared (NIR)-mediated, simultaneously controllable photothermal temperature guided imaging off/on system to monitor therapeutic delivery. Carbonized disulfide cross-linked branched polyethyleneimine (bPEI) was conjugated with folic acid (FA) as a targeting moiety and partially formed an ionic complex with anionic indocyanine green (ICG) to afford a bPEI-based CD (ICG-CD). This was responsive to mild reductive (glutathione, GSH) and acidic tumor conditions, which enabled the simultaneous biodegradation of those hydrophobic and complex sites. The ICG-CD internalized readily into the cytoplasm of cancer cells by a FA receptor and cationic-mediated endocytosis in the off state, whereas if ICG-CD met intracellular GSH at high concentrations, GSH contributed partially to the recovery of fluorescence and was then internalized into acidic endosomes to induce complete restoration of fluorescence. This tumor-sensitive degradability of the CD not only facilitated ICG release in the tumor location but also allowed controllable photothermal therapy effects of nanoparticles under NIR irradiation, which resulted in improved cancer therapy. Taken together, the results indicate great potential in tumor targeting, intracellular imaging, and controllable therapeutic delivery through a fluorescence off/on assay under the pH/redox conditions of cancer cells.


Asunto(s)
Antineoplásicos/farmacología , Colorantes Fluorescentes/farmacología , Verde de Indocianina/farmacología , Puntos Cuánticos/química , Animales , Antineoplásicos/química , Carbono/química , Línea Celular Tumoral , Perros , Endocitosis/fisiología , Endosomas/metabolismo , Fluorescencia , Colorantes Fluorescentes/química , Colorantes Fluorescentes/metabolismo , Receptores de Folato Anclados a GPI/metabolismo , Ácido Fólico/química , Ácido Fólico/metabolismo , Glutatión/metabolismo , Humanos , Concentración de Iones de Hidrógeno , Hipertermia Inducida/métodos , Verde de Indocianina/química , Verde de Indocianina/metabolismo , Rayos Infrarrojos , Células de Riñón Canino Madin Darby , Oxidación-Reducción , Fototerapia/métodos , Polietilenglicoles/química , Polietilenglicoles/metabolismo , Polietileneimina/química , Polietileneimina/metabolismo , Puntos Cuánticos/efectos de la radiación , Nanomedicina Teranóstica/métodos
12.
Analyst ; 143(23): 5822-5833, 2018 Nov 19.
Artículo en Inglés | MEDLINE | ID: mdl-30371695

RESUMEN

Black phosphorus quantum dots (BPQDs) are gaining popularity for applications in various fields because of their unique advantages. For biomedical applications, good biosafety is a prerequisite for the use of BPQDs in vivo. However, currently, little information is available about their basic properties and biocompatibility, which are of great importance for potential biomedical applications. In this work, we prepared BPQDs by an improved solvothermal method and evaluated their fluorescence, biocompatibility, and photothermal therapy (PTT) effectiveness. First, the structures and functions of the BPQDs were investigated at the cellular and molecular levels. It was found that the fluorescence of the BPQDs is wavelength-dependent and that they absorb in the UV-vis range; also, their quantum yield reached 10.2%. In particular, we considered the morphology and lysis of human red blood cells, in vivo blood coagulation, and plasma recalcification profiles. We found that the BPQDs have excellent biocompatibility and hemocompatibility with blood components. Overall, concentrations of the BPQDs ≤0.5 mg mL-1 had few adverse effects on blood components. The resulting BPQDs can efficiently convert near-infrared (NIR) light into heat; thus, they are suitable as a novel nanotheranostic agent for PTT of cancer. Meanwhile, the results of serum biochemistry tests revealed that the indicators were at similar levels for mice exposed to BPQDs and for control mice. Furthermore, from biodistribution analysis of the BPQDs, no apparent pathological damage was observed in any organs, especially in the spleen and kidneys, during the 30 day period. Our research indicates that the BPQDs have bio-imaging capability and biocompatibility and highlights their great potential in the therapy of cancer.


Asunto(s)
Neoplasias/terapia , Fósforo/química , Puntos Cuánticos/uso terapéutico , Animales , Coagulación Sanguínea/efectos de los fármacos , Peso Corporal/efectos de los fármacos , Eritrocitos/citología , Femenino , Células HeLa , Calefacción , Hemólisis/efectos de los fármacos , Humanos , Luz , Ratones , Tamaño de la Partícula , Fototerapia/métodos , Puntos Cuánticos/química , Puntos Cuánticos/efectos de la radiación , Puntos Cuánticos/toxicidad , Nanomedicina Teranóstica/métodos
13.
Anal Chem ; 90(22): 13356-13364, 2018 11 20.
Artículo en Inglés | MEDLINE | ID: mdl-30234969

RESUMEN

Metallic plasmonic nanoparticles have been intensively exploited as theranostic nanoprobes for plasmonic photothermal therapy (PPT) and surface-enhanced Raman spectroscopy (SERS) applications. But the underlying molecular mechanisms associated with PPT-induced apoptosis between cancerous and normal cells have remained largely unknown or disputed. In this study, we designed an organelle-targeting theranostic plasmonic SERS nanoprobe (CDs-Ag/Au NS) composed of porous Ag/Au nanoshell (p-Ag/Au NSs) and carbon dots (CDs) for nucleus and mitochondria targeted PPT of cells. The differences in molecular stress response in the PPT-induced hyperthermia cell death between cancerous HeLa and normal L929 and H8 cells have been revealed by site-specific single-cell SERS detection. The contents of tryptophan (Trp), phenylalanine (Phe), and tyrosine (Tyr) in HeLa cells were found more evidently increased than L929 and H8 cells during the PPT-induced cell-death process. And from the mitochondria point of view, we found that the PPT-induced cell apoptosis for HeLa cells mainly stems from (or is regulated through) cellular thermal stress-responsive proteins, while for L929 and H8 cells it seems more related to DNA. Understanding molecular stress response difference of the PPT-induced cell apoptosis between cancerous and normal cells is helpful for diagnosis and treatment of cancer, and the method will open an avenue for single-cell studies.


Asunto(s)
Núcleo Celular/metabolismo , Mitocondrias/metabolismo , Nanocáscaras/química , Puntos Cuánticos/química , Espectrometría Raman/métodos , Nanomedicina Teranóstica/métodos , Apoptosis/efectos de los fármacos , Carbono/química , Carbono/efectos de la radiación , Péptidos de Penetración Celular/química , Péptidos de Penetración Celular/metabolismo , ADN/metabolismo , Fragmentación del ADN/efectos de los fármacos , Oro/química , Oro/efectos de la radiación , Células HeLa , Humanos , Hipertermia Inducida/métodos , Rayos Infrarrojos , Nanocáscaras/efectos de la radiación , Neoplasias/metabolismo , Señales de Localización Nuclear/química , Señales de Localización Nuclear/metabolismo , Puntos Cuánticos/efectos de la radiación , Plata/química , Plata/efectos de la radiación
14.
Chem Commun (Camb) ; 54(47): 6060-6063, 2018 Jun 08.
Artículo en Inglés | MEDLINE | ID: mdl-29808876

RESUMEN

Black phosphorus quantum dots are incorporated into liposomal bilayers to produce a drug delivery system with excellent near-infrared (NIR) photothermal properties and drug release capability controlled by light. In vitro experiments demonstrate its good biocompatibility and NIR-light-induced chemo-photothermal antitumor efficiency.


Asunto(s)
Antineoplásicos/farmacología , Doxorrubicina/farmacología , Membrana Dobles de Lípidos/química , Liposomas/química , Fósforo/química , Puntos Cuánticos/efectos de la radiación , Animales , Colesterol/química , Colesterol/toxicidad , Liberación de Fármacos , Calefacción , Humanos , Rayos Infrarrojos , Membrana Dobles de Lípidos/toxicidad , Liposomas/toxicidad , Células MCF-7 , Ratones , Microscopía Confocal , Tamaño de la Partícula , Fosfatidilcolinas/química , Fosfatidilcolinas/toxicidad , Fósforo/toxicidad , Puntos Cuánticos/química , Puntos Cuánticos/toxicidad
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