RESUMEN
In 58 patients with chronic conjunctivitis of greater than two weeks' duration, examination included obtaining an ocular and general medical history and performing a complete ophthalmic examination of the external eye. Conjunctival smears were obtained for Gram and Giemsa staining, direct immunofluorescent monoclonal antibody staining for Chlamydia trachomatis and herpes simplex virus, and chlamydial culture. Cultures for bacteria and viruses were obtained in 33 patients. The cause of the chronic conjunctivitis based on clinical and laboratory criteria was established in 40 of 58 (69%) patients: chlamydia, 11 (19%); virus, eight (14%); irritant, six (10%); allergen, four (7%); contact lens, four (7%); bacteria, four (7%); acne rosacea, two (3%); and floppy eyelid syndrome, one (2%). In 18 of 58 (31%) patients, no specific cause was detected. We recommend a systematic approach in the investigation of chronic conjunctivitis. Direct immunofluorescent monoclonal antibody staining is an effective and rapid technique for detecting chronic chlamydial conjunctivitis.
Asunto(s)
Conjuntivitis , Adulto , Alérgenos/inmunología , Anticuerpos Monoclonales , Infecciones por Chlamydia/complicaciones , Infecciones por Chlamydia/diagnóstico , Chlamydia trachomatis/inmunología , Chlamydia trachomatis/aislamiento & purificación , Enfermedad Crónica , Conjuntivitis/diagnóstico , Conjuntivitis/tratamiento farmacológico , Conjuntivitis/etiología , Lentes de Contacto/efectos adversos , Cromolin Sódico/uso terapéutico , Estudios de Evaluación como Asunto , Femenino , Técnica del Anticuerpo Fluorescente , Fluorometolona/uso terapéutico , Humanos , Queratitis Dendrítica/complicaciones , Queratitis Dendrítica/diagnóstico , Masculino , Estudios Prospectivos , Simplexvirus/inmunología , Simplexvirus/aislamiento & purificación , Infecciones Estafilocócicas/complicaciones , Infecciones Estafilocócicas/diagnóstico , Staphylococcus epidermidis , Tetraciclina/uso terapéuticoAsunto(s)
Ceguera/etiología , Ceguera/prevención & control , Úlcera de la Córnea/etiología , Sarampión/complicaciones , África , Niño , Úlcera de la Córnea/tratamiento farmacológico , Úlcera de la Córnea/prevención & control , Humanos , Recién Nacido , Queratitis Dendrítica/complicaciones , Sarampión/prevención & control , Medicina Tradicional , Oftalmía Neonatal/complicaciones , Oftalmía Neonatal/tratamiento farmacológico , Deficiencia de Vitamina A/complicacionesRESUMEN
One hundred and thirty Tanzanian children with corneal ulceration were clinically examined to determine the cause of the ulceration. 37% of the ulcers were associated with recent measles infection and 38% of the children had bilateral ulceration. Herpes simplex virus infection was the commonest cause of ulceration in the series, but vitamin A deficiency was the major cause of bilateral ulceration, subsequent blindness, and mortality in this series. Other significant causes of childhood corneal ulceration were the use of traditional eye medicines, confluent measles keratitis, and ophthalmia neonatorum. We discuss the various mechanisms by which measles causes corneal ulceration, and the priorities in prevention and management of corneal ulceration in African children.
Asunto(s)
Ceguera/etiología , Úlcera de la Córnea/etiología , Sarampión/complicaciones , Niño , Preescolar , Femenino , Humanos , Lactante , Recién Nacido , Queratitis Dendrítica/complicaciones , Masculino , Medicina Tradicional , Tanzanía , Deficiencia de Vitamina A/complicaciones , Xeroftalmia/complicacionesRESUMEN
A promising new nucleoside analog, 9-[[2-hydroxy-1-(hydroxymethyl)ethoxy] methyl]-guanine (BW759), which is structurally similar to acyclovir, was tested against acute herpetic keratitis in the rabbit ocular model. Topical 1-0.1% BW759 given 3-5x per day gave beneficial results in that corneal epithelial involvement, conjunctivitis, iritis, and corneal clouding were reduced even when chemotherapy was initiated at 3 days postinoculation. Under the same conditions, topical BW759 therapy gave slightly better results than acyclovir, and both were better than idoxuridine therapy. Mortality rate and colonization of the trigeminal ganglia by HSV-1 were unaffected by BW759 therapy. Duration of virus, shed into the tear film was reduced by BW759.