Integrative Diagnostics: The Time Is Now-A Report From the International Society for Strategic Studies in Radiology.

Enormous recent progress in diagnostic testing can enable more accurate diagnosis and improved clinical outcomes. Yet these tests are increasingly challenging and frustrating; the volume and diversity of results may overwhelm the diagnostic acumen of even the most dedicated and experienced clinician. Because they are gathered and processed within the "silo" of each diagnostic discipline, diagnostic data are fragmented, and the electronic health record does little to synthesize new and existing data into usable information. Therefore, despite great promise, diagnoses may still be incorrect, delayed, or never made. Integrative diagnostics represents a vision for the future, wherein diagnostic data, together with clinical data from the electronic health record, are aggregated and contextualized by informatics tools to direct clinical action. Integrative diagnostics has the potential to identify correct therapies more quickly, modify treatment when appropriate, and terminate treatment when not effective, ultimately decreasing morbidity, improving outcomes, and avoiding unnecessary costs. Radiology, laboratory medicine, and pathology already play major roles in medical diagnostics. Our specialties can increase the value of our examinations by taking a holistic approach to their selection, interpretation, and application to the patient's care pathway. We have the means and rationale to incorporate integrative diagnostics into our specialties and guide its implementation in clinical practice.

Radiologists' Increasing Role in Population Health Management: AJR Expert Panel Narrative Review.

Population health management (PHM) is the holistic process of improving health outcomes of groups of individuals through the support of appropriate financial and care models. Radiologists' presence at the intersection of many aspects of health care, including screening, diagnostic imaging, and image-guided therapies, provides the opportunity for increased radiologist engagement in PHM. Furthermore, innovations in artificial intelligence and imaging informatics will serve as critical tools to improve value in health care through evidence-based and equitable approaches. Given radiologists' limited engagement in PHM to date, it is imperative to define the PHM priorities of the specialty so that radiologists' full value in improving population health is realized. The purpose of this expert review is to explore programs and future directions for radiologists in PHM.

European guidelines on chronic mesenteric ischaemia - joint United European Gastroenterology, European Association for Gastroenterology, Endoscopy and Nutrition, European Society of Gastrointestinal and Abdominal Radiology, Netherlands Association of Hepatogastroenterologists, Hellenic Society of Gastroenterology, Cardiovascular and Interventional Radiological Society of Europe, and Dutch Mesenteric Ischemia Study group clinical guidelines on the diagnosis and treatment of patients with chronic mesenteric ischaemia.

Chronic mesenteric ischaemia is a severe and incapacitating disease, causing complaints of post-prandial pain, fear of eating and weight loss. Even though chronic mesenteric ischaemia may progress to acute mesenteric ischaemia, chronic mesenteric ischaemia remains an underappreciated and undertreated disease entity. Probable explanations are the lack of knowledge and awareness among physicians and the lack of a gold standard diagnostic test. The underappreciation of this disease results in diagnostic delays, underdiagnosis and undertreating of patients with chronic mesenteric ischaemia, potentially resulting in fatal acute mesenteric ischaemia. This guideline provides a comprehensive overview and repository of the current evidence and multidisciplinary expert agreement on pertinent issues regarding diagnosis and treatment, and provides guidance in the multidisciplinary field of chronic mesenteric ischaemia.

Artificial Intelligence and Clinical Decision Support for Radiologists and Referring Providers.

Recent advances in artificial intelligence (AI) are providing an opportunity to enhance existing clinical decision support (CDS) tools to improve patient safety and drive value-based imaging. We discuss the advantages and potential applications that may be realized with the synergy between AI and CDS systems. From the perspective of both radiologist and ordering provider, CDS could be significantly empowered using AI. CDS enhanced by AI could reduce friction in radiology workflows and can aid AI developers to identify relevant imaging features their tools should be seeking to extract from images. Furthermore, these systems can generate structured data to be used as input to develop machine learning algorithms, which can drive downstream care pathways. For referring providers, an AI-enabled CDS solution could enable an evolution from existing imaging-centric CDS toward decision support that takes into account a holistic patient perspective. More intelligent CDS could suggest imaging examinations in highly complex clinical scenarios, assist on the identification of appropriate imaging opportunities at the health system level, suggest appropriate individualized screening, or aid health care providers to ensure continuity of care. AI has the potential to enable the next generation of CDS, improving patient care and enhancing providers' and radiologists' experience.

Building Imaging Institutes of Patient Care Outcomes: Imaging as a Nidus for Innovation in Clinical Care, Research, and Education.

Traditionally, radiologists have been responsible for the protocol of imaging studies, imaging acquisition, supervision of imaging technologists, and interpretation and reporting of imaging findings. In this article, we outline how radiology needs to change and adapt to a role of providing value-based, integrated health-care delivery. We believe that the way to best serve our specialty and our patients is to undertake a fundamental paradigm shift in how we practice. We describe the need for imaging institutes centered on disease entities (eg, lung cancer, multiple sclerosis) to not only optimize clinical care and patient outcomes, but also spur the development of a new educational focus, which will increase opportunities for medical trainees and other health professionals. These institutes will also serve as unique environments for testing and implementing new technologies and for generating new ideas for research and health-care delivery. We propose that the imaging institutes focus on how imaging practices-including new innovations-improve patient care outcomes within a specific disease framework. These institutes will allow our specialty to lead patient care, provide the necessary infrastructure for state-of-the art-education of trainees, and stimulate innovative and clinically relevant research.

Solución del caso 11. Úlcera plantar secundaria a pie de Charcot de un año de evolución / Solution to case 11: Plantar ulcer secondary to Charcot foot of one year onset

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Impact of provider-led, technology-enabled radiology management program on imaging.

OBJECTIVE: The study objective was to assess the impact of a provider-led, technology-enabled radiology medical management program on high-cost imaging use. METHODS: This study was performed in the ambulatory setting of an integrated healthcare system. After negotiating a risk contract with a major commercial payer, we created a physician-led radiology medical management program to help address potentially inappropriate high-cost imaging use. The radiology medical management program was enabled by a computerized physician order entry system with integrated clinical decision support and accountability tools, including (1) mandatory peer-to-peer consultation with radiologists before order completion when test utility was uncertain on the basis of order requisition; (2) quarterly practice pattern variation reports to providers; and (3) academic detailing for targeted outliers. The primary outcome measure was intensity of high-cost imaging, defined as the number of outpatient computed tomography (CT), magnetic resonance imaging (MRI), and nuclear cardiology studies per 1000 patient-months in the payer's panel. Chi-square test was used to assess trends. RESULTS: In 1.8 million patient-months from January 2004 to December 2009, 50,336 eligible studies were performed (54.1% CT, 40.3% MRI, 5.6% nuclear cardiology). There was a 12.0% sustained reduction in high-cost imaging intensity over the 5-year period (P < .001). The number of CT studies performed decreased from 17.5 per 1000 patient-months to 14.5 (P < .01); nuclear cardiology examinations decreased from 2.4 to 1.4 (P < .01) per 1000 patient-months. The MRI rate remained unchanged at 11 studies per 1000 patient-months. CONCLUSION: A provider-led radiology medical management program enabled through health information technology and accountability tools may produce a significant reduction in high-cost imaging use.

Guidelines for multimodality radiological staging of lung cancer.

Lung cancer is among the most common type of cancers and is a leading cause of cancer-related deaths with smoking representing the leading risk factor. It is classified into non-small cell lung cancer (NSCLC) representing 70-80% of cases and small cell lung cancer (SCLC) which has neuroendocrine properties with poor outcome. Staging of NSCLC is based on the TNM classification system while SCLC was usually classified into limited and extensive disease, though the use of TNM staging system for SCLC is recommended. Imaging studies are used to determine the pre-operative staging of lung cancer. Accurate radiological staging is essential to determine tumor resectability as well as to avoid futile surgeries and to assess patient's outcome. Moreover, radiological examinations are used for the evaluation of tumor response to treatment. This manuscript will review the utilization of imaging studies in the management of lung cancer based on the most recent guidelines by the National Comprehensive Cancer Network (NCCN).

CT Colonography to exclude colorectal cancer in symptomatic patients.

OBJECTIVES: CT Colonography (CTC) is being increasingly used for the radiological evaluation of colorectal symptoms. Aim of this study was to assess the role of CTC in excluding a colorectal cancer (CRC) in older symptomatic patients. METHODS: 1,359 CTC studies performed between March 2002 and December 2007 were analysed retrospectively. Gold standard was an endoscopic examination within 1 year and/or clinical, endoscopic and/or radiological follow-up until the time of data analysis. Patients not diagnosed as having a CRC on CTC were assumed as true-negatives if the gold standard was negative and did not feature on the regional cancer registry (at least 18 months post-CTC). Sensitivity, specificity, positive and negative predictive values were calculated for detection of colorectal cancer. RESULTS: After exclusions, 1,177 CTC studies were included. These were undertaken in 463 men and 714 women. Median age of patients undergoing CTC was 71 (range, 27-96) years. 59 invasive CRC were detected. Median follow-up was 34.5 (range 18-84) months. Three small colorectal cancers were missed. Sensitivity and negative predictive value for CRC were 94.9% (95% CI:84.9%-98.7%) and 99.7% (95% CI:99.1%-99.9%) respectively. CONCLUSIONS: CTC has a high sensitivity and negative predictive value in excluding a CRC in patients with colorectal symptoms.

Manejo del retropié plano valgo flexible con la férula tipo UCBL en pacientes pedátricos: [revisión] / Management of the flexible flat hindfoot valvus with orthesis type UCBL in pediatric patients: [review]

El tratamiento de las diversas deformidades del pie varia según las patologías y es precisamente en el niño por su gran plasticidad biológica, en quien se pueden aplicar los diferentes resursos que se poseen para el tratamiento ortopédico conservador. En el presente trabajo se plantea una alternativa para el tratamiento del retropié valgo, con la férula termo formada tipo UCBL (University of California Biomechanics Laboratory. Demostrar la utilidad de la férula tipo UCBL en el tratamiento conservador del retropié valgo para postegar y/o evitar tratamientos quirúrgicos por deformidades severas. La muestra utilizada fue de 15 pacientes (6 niñas, 9 niños, con edades entre 2 años 6 meses y 10 años) con disfunción del brazo de palanca por pérdida de la rigidez ósea, debido a la subluxación de la articulación sub-astragalina (retropié valgo flexible), en quienes se utilizó la férula termoformada tipo UCBL con seguimiento promedio de 12 a 36 meses. Se evaluó clínicamente la flexibilidad del pié y la maniobra de Silverskiold y radiologicamente en bípeda estación estática, el ángulo Costa-Bertani, Astrágalo calcáneo y astrágalo-1er metatarsiano. 10 pacientes presentaron mejoría clínica y radiológica, 5 de los casos no evidenciaron cambios, sin embargo, mantuvieron su flexibilidad. La férula resultó útil, inclusive en los casos donde no se demostró corrección radiológica, ya que evitó estructuración de la deformidad.

The adequate treatment for foot deformities varies depending on the pathology, and because of the high plasticity found in children, it is in this age group where the available conservative treatment resources can be applied. An alternative for the valgus hindfoot treatment is presented in this paper, using the UCBL (University of California Biomechanies Laboratory) thermoshaped orthesis. To prove utility of the thermoformed UCBL type orthesis in the treatment of flexible pes valgus in orden to avoid fuseverity deformities. The study included 15 patients (6 female, 9 male, ages between 2 years 6 months and 10 years) with lever-arm dysfunction due to loss of bony rigidity with sub-astragaline joint subluxation (flexible valgus hindfoot), in whom UCBL thermoshaped orthesis was indicated with an average follow up between 12 to 36 monts. Foot flexibility was clinical evaluated; also Silverskiold maneuver and static bipedestation x-rays angles were measured. Ten patients showed clinical and radiological improvement, 5 patients showed no change, although flexibility was maintained. The UCBL orthesis was useful, even in cases were no radiological change was observed, because it avoided structuration of bony deformity.

Tumores óseos en el Hospital Escuela: frecuencia y correlación clínica-radiológica e histopatológica / Bone tumors in the Hospital Escuela: frecuency and clinical-radiological and histopathological correlation

OBJETIVO: determinar la frecuencia, características clínicas e histopatológicas y hallazgos radiológicos asociados a alto grado de malignidad, en los tumores óseos diagnosticados en el Departamento de Patología del Hospital Escuela de Tegucigalpa. MATERIALES Y METODOS: estudio prospectivo, descriptivo, desde junio del 2002 hasta junio del 2005. Se evaluaron 143 casos de biopsias con sospecha de neoplasia ósea. Cada biopsia se examinó con el respectivo estudio radiológico. RESULTADOS: 37% (n=53)fueron tumores malignos primarios, 54.5% (n=78),tumores benignos; 8.3%(n=12) tumores metastásicos. El tumor maligno más frecuente fue el osteosarcoma convencional (45.2%), localizado en la región de la rodilla(80%), predominando entre los 16 y los 30 años de edad. De los tumores benignos, 37 (47.4 %) fueron osteocondromas. De los tumores metastáticos el 58.3% fueron carcinomas (adenocarcinoma y carcinoma de sitio no especificado). Los hallazgos radiológicos más relevantes en los tumores malignos fueron: el patrón apolillado, infiltrativo y geográfico de márgenes indefinidos, con zona de transición corta, y afección apartes blandas. Se encontró una buena concordancia clínica- radiológica. CONCLUSIONES: La frecuencia y características clínicas e histopatológicas de los tumores óseos evaluados en el Departamento de Patología del Hospital Escuela no difieren significativamente de los reportados en la literatura mundial. La presencia radiológica de patrón apolillado, infiltrativo, o geográfico de bordes indefinidos, reacción perióstica, con una zona de transición amplia y afectación de partes blandas debe hacer sospechar la presencia de un tumor óseo maligno...

Repeatability over time of posture, radiograph positioning, and radiograph line drawing: an analysis of six control groups.

BACKGROUND: There is debate concerning the repeatability of posture over time, radiograph positioning repeatability, and radiograph line drawing reliability. These ideas seem to negate the use of before-and-after spinal radiographic imaging to detect and correct vertebral subluxations. OBJECTIVE: To review the results of control groups in 6 clinical control trials with before-and-after radiographic measurements taken days, weeks, months, or years apart to accept or reject the hypothesis that radiographic analysis procedures are not repeatable, reliable, or reproducible. DATA SOURCES: Six published control groups from original data. Other data were obtained from searches on MEDLINE, CHIROLARS, MANTIS, and CINAHL on radiographic reliability, posture, and positioning. RESULTS: Comparison of initial and follow-up radiographic data for 6 control groups indicate that measured angles and distances between initial and follow-up radiograph measurements on lateral and anterior to posterior radiographs are not significantly different when utilizing Chiropractic Biophysics radiographic procedures. In 48 out of 50 measurements, the differences between initial and follow-up radiographs are less than 1.5 degrees and 2 mm. These measurements indicate that posture is repeatable, radiographic positioning is repeatable, and radiographic line drawing analysis for spinal displacement is highly reliable. The scientific literature on these topics also indicates the repeatability of posture, radiographic positioning, and radiographic line drawing. CONCLUSIONS: Posture, radiographic positioning, and radiographic line drawing are all very reliable/repeatable. When Chiropractic Biophysics standardized procedures are used, any pre-to-post alignment changes in treatment groups are a result of the treatment procedures applied. These results contradict common claims made by several researchers and clinicians in the indexed literature. Chiropractic radiologic education and publications should reflect the recent literature, provide more support for posture analysis, radiographic positioning, radiographic line drawing analyses, and applications of posture and radiographic procedures for measuring spinal displacement on plain radiographs.

Reliability of spinal displacement analysis of plain X-rays: a review of commonly accepted facts and fallacies with implications for chiropractic education and technique.

BACKGROUND: Current medical, biomechanical, and chiropractic literature indicates that X-ray line drawing analysis for spinal displacement is reliable, with high Interclass Correlation Coefficients (ICCs) found in most studies. Normal sagittal spinal curvatures are being accepted as important clinical outcomes of care; however, just the opposite is taught in many chiropractic college radiology courses. OBJECTIVE: To review the current literature on X-ray line drawing reliability and abnormal static lateral positions. DATA SOURCES: Searches were performed on Medline, Chiro-LARS, MANTIS, and CINAHL on X-ray reliability, normal spinal position, and sagittal spinal curvatures as clinical outcomes. RESULTS: X-ray line drawing analysis for spinal displacement was found to have high reliability with a majority of ICCs in the .8-.9 range. The reliability for determining X-ray pathology was found to be only fair to good by both medical doctors and chiropractors and by both chiropractic and medical radiologists, with a majority of ICCs in the range .40-.75. Muscle spasms, facet hyperplasia, short pedicles and patient positioning errors have not been shown to alter sagittal plane alignment. The sagittal spinal curves are desirable clinical outcomes of care in surgery, physical therapy, rehabilitation and chiropractic. These results contradict common claims found in the indexed literature. CONCLUSION: X-ray line drawing is reliable. Normal values for the sagittal spinal curvatures exist in the literature. The normal sagittal spinal curvatures are important clinical outcomes of care. Patient positioning and postural radiographs are highly reproducible. When these standardized procedures are used, the pre-to-post alignment changes are a result of treatment procedures applied. Chiropractic radiology education and publications should reflect the recent literature, provide more support for X-ray line drawing analyses and applications of line drawing analyses for measuring spinal displacement on plain radiographs.

A comparative study of two methods for obtaining the anteroposterior open mouth cervical view.

OBJECTIVE: To compare two methods of obtaining the anteroposterior (AP) open mouth view. DESIGN: Radiological evaluation of the occiput-C1/C1-C2 structures, as visualized on radiographs obtained using two different radiographic position set-ups. SETTING: The Anglo-European College of Chiropractic Clinic. PATIENTS: A total of 60 patients. Each method used on 30 patients. CRITERIA ASSESSED: Visualization of: (a) occiput-C1 joints, (b) atlantoaxial joints, (c) lateral masses C1 and (d) odontoid process. RESULTS: The visualization of the occiput-C1 joints was increased almost 100% using method 2. The atlantoaxial joints were seen in 7% more cases using method 2 and the lateral masses were seen in 10% more cases. The only structure seen more consistently using method 1 was the odontoid process, which was seen in 7% more cases using that method. CONCLUSION: This study shows that there is an easier and more consistent method of obtaining the AP open mouth view than that traditionally used in many institutions.

Radiography of the lumbosacral spine: characteristics of examinations performed in hospitals and other facilities.

A survey of 523 facilities performing radiographic lumbosacral spine examinations was conducted as a part of the Nationwide Evaluation of X-Ray Trends program in 1987 and 1989. Average patient radiation exposure was measured by using a standard phantom developed by the Center for Devices and Radiological Health of the Food and Drug Administration, U.S. Public Health Service. Data pertaining to radiographic equipment, film processing, and radiographic techniques were obtained. The overall average entrance skin air kerma was 3.65 mGy (420 mR). Ninety-eight percent (496 of 506) of observed facilities used a grid, 89% (466 of 523) had tube potentials between 70 and 89 kVp, and 67% (280 of 418) used screen-film systems with a speed of 400. The most important finding is that underprocessing of film remains a major concern. Thirty-three percent (78 of 234) of the hospitals, 25% of the radiologists in private practice (four of 16), 33% of the nonradiologist private practitioners (27 of 82), and 48% (69 of 143) of the chiropractors underprocessed their film.