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Medicinas Complementárias
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1.
Nutrients ; 8(12)2016 Dec 13.
Artículo en Inglés | MEDLINE | ID: mdl-27983572

RESUMEN

The aim of the study was to evaluate the effect of selenium supplementation on the expression of genes associated with glucose metabolism in humans, in order to explain the unclear relationship between selenium and the risk of diabetes. For gene expression analysis we used archival samples of cDNA from 76 non-diabetic subjects supplemented with selenium in the previous study. The supplementation period was six weeks and the daily dose of selenium was 200 µg (as selenium yeast). Blood for mRNA isolation was collected at four time points: before supplementation, after two and four weeks of supplementation, and after four weeks of washout. The analysis included 15 genes encoding selected proteins involved in insulin signaling and glucose metabolism. In addition, HbA1c and fasting plasma glucose were measured at three and four time points, respectively. Selenium supplementation was associated with a significantly decreased level of HbA1c but not fasting plasma glucose (FPG) and significant down-regulation of seven genes: INSR, ADIPOR1, LDHA, PDHA, PDHB, MYC, and HIF1AN. These results suggest that selenium may affect glycemic control at different levels of regulation, linked to insulin signaling, glycolysis, and pyruvate metabolism. Further research is needed to investigate mechanisms of such transcriptional regulation and its potential implication in direct metabolic effects.


Asunto(s)
Glucemia/efectos de los fármacos , Glucemia/genética , Regulación de la Expresión Génica/efectos de los fármacos , Selenio/farmacología , Oligoelementos/farmacología , Adulto , Antígenos CD/sangre , Antígenos CD/metabolismo , Glucemia/metabolismo , Suplementos Dietéticos , Regulación hacia Abajo/efectos de los fármacos , Ayuno/sangre , Femenino , Genes myc/efectos de los fármacos , Hemoglobina Glucada/análisis , Hemoglobina Glucada/efectos de los fármacos , Homeostasis , Humanos , Lactato Deshidrogenasas/sangre , Lactato Deshidrogenasas/metabolismo , Masculino , Oxigenasas de Función Mixta/sangre , Oxigenasas de Función Mixta/metabolismo , Piruvato Deshidrogenasa (Lipoamida)/sangre , Piruvato Deshidrogenasa (Lipoamida)/metabolismo , ARN Mensajero/sangre , ARN Mensajero/aislamiento & purificación , Receptor de Insulina/sangre , Receptor de Insulina/metabolismo , Receptores de Adiponectina/sangre , Receptores de Adiponectina/metabolismo , Proteínas Represoras/sangre , Proteínas Represoras/metabolismo , Selenio/administración & dosificación , Oligoelementos/administración & dosificación
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