Vitamin C and human wound healing.

Clinical studies provide evidence that wound healing in subjects judged not deficient in vitamin C can be significantly accelerated with supplements of this nutrient above the recommended daily allowance (RDA). The authors administered daily dosages of 500 to 3,000 mg., which is roughly 8 to 50 times the RDA of 60 mg., to subjects recovering from surgery, other injuries, decubital ulcers, and leg ulcers induced by hemolytic anemia. Genetic impairment of collagen synthesis has also been observed to be responsive to ascorbic acid supplementation in an 8-year-old boy with Type VI Ehlers-Danlos syndrome. Four grams of ascorbic acid daily produced a significant improvement in the quality of newly synthesized collagen but did not alter that formed prior to the supplementation of C. The combined evidence in this review provides a substantial base for further research, both clinical and experimental trials, concerning the interrelationships between vitamin C and the body's healing potential.

[Efficacy of prolonged therapy with vitamins C and A and radiologic changes in the Ehlers-Danlos syndrome]. / Efficacité d'une thérapie prolongée aux vitamines C et A et modifications radiologiques dans le syndrome d'Ehlers-Danlos.

Two children of the same sex, almost of equal age, and suffering from the Ehlers-Danlos syndrome were followed up for a period of seven years. One of the children was subjected to a systematic treatment with vitamins C and A, Lipovitan, sulphuric mineral waters, and kinesitherapy. The non-treated child is serving as control person for the treated one. Thus it has been possible to evaluate the efficacy of the therapy administered to the first child and also to state the osseous progressive changes in the non-treated child.